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GENE - TERM ANNOTATION REPORT

RGD ID: 12307590
Species: Canis lupus familiaris
RGD Object: Gene
Symbol: APOE
Name: apolipoprotein E
Acc ID: DOID:9002165
Term: Diabetic Nephropathies
Definition: KIDNEY injuries associated with diabetes mellitus and affecting KIDNEY GLOMERULUS; ARTERIOLES; KIDNEY TUBULES; and the interstitium. Clinical signs include persistent PROTEINURIA, from microalbuminuria progressing to ALBUMINURIA of greater than 300 mg/24 h, leading to reduced GLOMERULAR FILTRATION RATE and END-STAGE RENAL DISEASE.
Definition Source(s): MESH:D003928
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
APOE ISOApoe (Mus musculus)9068941RGDassociated with Diabetes Mellitus, ExperimentalPMID:22859852 REF_RGD_ID:6902935
APOEno_associationISOAPOE (Homo sapiens)9068941RGDassociated with Diabetes Mellitus, type 1;PMID:11495633 REF_RGD_ID:7771553
APOEsusceptibilityISOAPOE (Homo sapiens)9068941RGDDNA:missense mutations, haplotype:cds:p.C112R, p.R158C (human)PMID:21127830 REF_RGD_ID:6903840
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