Phenominer Database Results (1078 results)

 
 
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Strain Phenotype Conditions Study Experiment Name Sex Age # of Animals Formula Value Units SEM SD Method Method Site Method Duration Post Insult Type Post Insult Time Value Post Insult Time Unit Method Notes Clinical Measurement Notes Experiment Notes Record ID Study ID
Hsd:SD partial pressure of blood carbon dioxide (Pco2) resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 10 29.74 mmHg 0.41 1.29 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 15988 381
Hsd:SD partial pressure of blood carbon dioxide (Pco2) control condition PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 1 36.0 mmHg automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15360 381
Hsd:SD minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 5 36.71 ml/min 3.21 7.18 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15488 381
Hsd:SD absolute change in partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 1 5.95 mmHg stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15509 381
Hsd:SD absolute change in partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 7 0.62 mmHg 2.95 7.8 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 15596 381
Hsd:SD absolute change in blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 1 -0.03 null stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15599 381
Hsd:SD absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 19 4.09 mmHg 1.31 5.69 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 50498 481
Hsd:SD body temperature air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 5 37.26 degrees C 0.14 0.32 digital rectal thermometry 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 14173 381
Hsd:SD absolute change in heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 4 43.97 beats/min 15.48 30.96 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 14282 381
Hsd:SD absolute change in heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 9 41.83 beats/min 10.63 31.9 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 14283 381
Hsd:SD absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 7 -5.39 beats/min 12.75 33.74 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 51615 481
Hsd:SD partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 8 111.93 mmHg 2.19 6.2 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 13535 381
Hsd:SD percent change in respiration rate air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 5 169.45 % 19.25 43.04 stop flow air displacement plethysmography 0 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 53855 381
Hsd:SD tidal volume air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 14 0.46 ml 0.02 0.08 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 18751 381
Hsd:SD heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 1 466.17 beats/min vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18793 381
Hsd:SD serum calcium level control condition (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 3 9.1 mg/dl 0.06 0.1 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 36332 401
Hsd:SD serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 3 5.33 g/dl 0.67 1.15 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 36343 401
Hsd:SD body temperature resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 8 38.63 degrees C 0.22 0.62 digital rectal thermometry 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 18980 381
Hsd:SD respiration rate control condition PhysGen Respiratory data respiratory function trait male 82 days-99 days 15 95.93 breaths/min 5.72 22.14 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 16995 381
Hsd:SD partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount female 82 days-99 days 12 27.16 mmHg 0.72 2.48 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 17017 381
Hsd:SD body temperature resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 1 38.3 degrees C digital rectal thermometry 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18800 381
Hsd:SD absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 12 -8.11 mmHg 1.01 3.51 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 18818 381
Hsd:SD partial pressure of blood carbon dioxide (Pco2) resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 8 32.31 mmHg 0.91 2.58 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 18838 381
Hsd:SD body temperature air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 16 37.36 degrees C 0.14 0.55 digital rectal thermometry 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 14408 381
Hsd:SD mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 14 108.56 mmHg 1.93 7.23 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 51789 481
Hsd:SD absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 14 -14.62 beats/min 14.72 55.08 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 51876 481
Hsd:SD absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 15 18.91 mmHg 2.36 9.14 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 51480 481
Hsd:SD urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data urine sodium amount male 87 days-120 days 20 1.19 mEq/d 0.1 0.46 flame atomic emission spectrometry 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 51398 481
Hsd:SD percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 5 98.48 % 7.58 16.96 stop flow air displacement plethysmography 0 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54197 381
Hsd:SD absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 14 -49.54 beats/min 10.68 39.97 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 50974 481
Hsd:SD absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 7 -53.36 beats/min 15.31 40.5 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 50975 481
Hsd:SD mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 14 111.02 mmHg 1.15 4.31 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 51017 481
Hsd:SD absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 7 -1.91 mmHg 0.73 1.92 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 50850 481
Hsd:SD partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 1 114.5 mmHg automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 13818 381
Hsd:SD tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 15 0.4 ml 0.02 0.08 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 13835 381
Hsd:SD heart rate air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 3 348.49 beats/min 13.28 23.01 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18079 381
Hsd:SD blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 1 7.51 null automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18090 381
Hsd:SD body temperature control condition PhysGen Respiratory data body temperature trait female 82 days-99 days 16 37.91 degrees C 0.13 0.54 digital rectal thermometry 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 17592 381
Hsd:SD mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 1 108.91 mmHg vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17598 381
Hsd:SD partial pressure of blood carbon dioxide (Pco2) resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 1 29.4 mmHg automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19683 381
Hsd:SD blood pH control condition PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 13 7.43 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 19702 381
Hsd:SD heart rate resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 7 463.63 beats/min 13.32 35.23 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 17553 381
Hsd:SD blood lymphocyte count control condition (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 1 7.19 x 1000 cells/ul automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 36841 401
Hsd:SD serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 3 105.0 U/l 14.43 25.0 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 36726 401
Hsd:SD body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 19 37.05 degrees C 0.21 0.89 digital rectal thermometry 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 20292 381
Hsd:SD tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 15 0.39 ml 0.02 0.07 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 18248 381
Hsd:SD heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 3 9.47 % 2.98 5.16 digital scale post excision weight measurement 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49037 461
Hsd:SD respiration rate air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 14 152.23 breaths/min 3.25 12.16 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 20572 381
Hsd:SD percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 5 %change=VE during 2-3 min hypoxia/control during standard conditions 187.88 % 14.16 31.67 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19300 381
Hsd:SD heart left ventricle infarction weight to total heart left ventricle weight ratio controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 7 22.94 % 3.95 10.46 digital scale post excision weight measurement 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 50102 461
Hsd:SD percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 3 post-ischemic value/pre-ischemic value x 100% 86.24 % 8.12 14.06 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49265 461
Hsd:SD heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 3 306.3 beats/min 21.43 37.12 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49975 461
Hsd:SD left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 7 77.98 mmHg 13.78 36.46 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 49645 461
Hsd:SD serum aspartate aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 2 98.5 U/l 20.5 28.99 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 42390 401
Hsd:SD blood eosinophil count control condition (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 1 0.0 x 1000 cells/ul automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 38857 401
Hsd:SD serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 18 4.13 mmol/l 0.08 0.35 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 39335 401
Hsd:SD plasma anion gap control condition (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 6 22.0 mmol/l 2.45 6.0 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 42501 401
Hsd:SD mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 4 34.63 g/dl 1.12 2.24 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 42503 401
Hsd:SD serum alanine aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 8 70.63 U/l 10.16 28.73 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 39471 401
Hsd:SD serum phosphate level control condition (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 8 11.0 mg/dl 0.46 1.29 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 39481 401
Hsd:SD blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 16 0.3 x 1000 cells/ul 0.04 0.17 automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 39537 401
Hsd:SD mean corpuscular volume control condition (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 8 58.81 fl 1.2 3.39 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 39369 401
Hsd:SD serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 16 75.13 mg/dl 2.81 11.22 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 43104 401
Hsd:SD serum chloride level control condition (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 2 99.0 mmol/l 1.0 1.41 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 39862 401
Hsd:SD total white blood cell count control condition (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 1 7.9 x 1000 cells/ul automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 39971 401
Hsd:SD total white blood cell count control condition (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 3 4.87 x 1000 cells/ul 0.5 0.86 automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 39972 401
Hsd:SD serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 16 106.0 mmol/l 0.47 1.9 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 40657 401
Hsd:SD serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 16 20.75 mg/dl 0.8 3.19 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 40809 401
Hsd:SD serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 3 0.33 mg/dl 0.09 0.15 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 37578 401
Hsd:SD red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 4 9.01 x 10E6 cells/ul 0.15 0.3 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 37947 401
Hsd:SD blood neutrophil count control condition (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 3 0.61 x 1000 cells/ul 0.19 0.32 automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 37951 401
Hsd:SD blood eosinophil count control condition (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 8 0.13 x 1000 cells/ul 0.06 0.16 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 41160 401
Hsd:SD hematocrit control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 3 44.27 % 0.49 0.85 automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 41165 401
Hsd:SD serum globulin level control condition (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 6 2.17 g/dl 0.11 0.27 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 41168 401
Hsd:SD serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 5 114.4 U/l 38.38 85.82 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 41169 401
Hsd:SD serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 5 144.0 mmol/l 2.35 5.24 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 37785 401
Hsd:SD serum alanine aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 3 66.33 U/l 4.7 8.14 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 38162 401
Hsd:SD serum sodium level control condition (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 2 136.5 mmol/l 0.5 0.71 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 38380 401
Hsd:SD serum sodium level control condition (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 3 136.67 mmol/l 0.33 0.58 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 38381 401
Hsd:SD blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 5 0.1 x 1000 cells/ul 0.03 0.08 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 41608 401
Hsd:SD percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 2 post-ischemic value/pre-ischemic value x 100% 52.78 % 35.43 50.11 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47525 461
Hsd:SD percent change in heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 2 post-ischemic value/pre-ischemic value x 100% 89.71 % 4.41 6.24 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47549 461
Hsd:SD heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 6 17.99 IU/g 4.36 10.69 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 45487 461
Hsd:SD serum total bilirubin level control condition (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 6 0.3 mg/dl 0.12 0.3 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 41845 401
Hsd:SD serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 18 170.72 mg/dl 4.42 18.76 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 38627 401
Hsd:SD mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 10 114.87 mmHg 5.69 17.99 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 16117 381
Hsd:SD methylene blue metabolism-surface area product after auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 9.52 ml/min/kg 1.18 3.34 isolated perfused lung vascular effluent collection 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 57731 526
Hsd:SD heart right ventricle weight to left ventricle weight ratio control condition (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 8 0.22 null 0.01 0.02 digital scale post excision weight measurement 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 58424 526
Hsd:SD logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 14 -8.91 null 0.05 0.19 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 55702 522
Hsd:SD logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 14 -6.95 null 0.07 0.25 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 56225 522
Hsd:SD logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 19 -7.19 null 0.07 0.3 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 56226 522
Hsd:SD dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 5 1.01 mg/kg 0.28 0.63 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58883 526
Hsd:SD lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 6 1.2 g/kg 0.07 0.16 digital scale post excision weight measurement 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58705 526
Hsd:SD hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 12 63.06 % 7.29 25.26 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 56760 522
Hsd:SD hematocrit control condition (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 8 45.95 % 1.28 3.61 microhematocrit tube assay with visual assessment 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 60072 526
Hsd:SD hematocrit control condition (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 8 45.7 % 0.87 2.47 microhematocrit tube assay with visual assessment 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 60073 526
Hsd:SD FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 5 15.62 ml/min/kg 0.67 1.49 isolated perfused lung vascular effluent collection 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 60092 526
Hsd:SD lung dry weight to body weight ratio control condition (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 8 1.1 g/kg 0.03 0.09 digital scale post excision weight measurement 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 60095 526
Hsd:SD mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 6 116.18 mmHg 4.56 11.16 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 17458 381
Hsd:SD left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 3 49.18 mmHg 6.63 11.49 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45940 461
Hsd:SD percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 27.26 % 4.93 15.6 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 46963 461
Hsd:SD left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 2 6.83 mmHg 0.25 0.35 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48165 461
Hsd:SD percent change in left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 2 post-ischemic value/pre-ischemic value x 100% 56.03 % 0.87 1.23 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45049 461
Hsd:SD heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 11 1.3 g 0.1 0.34 digital scale post excision weight measurement 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 45063 461
Hsd:SD left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 3 60.91 mmHg 9.31 16.13 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47396 461
Hsd:SD left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 3 61.36 mmHg 3.02 5.23 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47408 461
Hsd:SD auditory brainstem response threshold thymoquinone (40 mg/kg/d) (for 3 days) then cisplatin (15 mg/kg) Sagit M, et al., Eur Arch Otorhinolaryngol. 2013 Aug;270(8):2231-7. doi: 10.1007/s00405-012-2254-6. Epub 2012 Nov 17. hearing electrophysiology trait female 170 days 10 20.55 dBnHL 2.02 6.39 evoked response audiometry 0.0 0 CT pre 75929 1541
Hsd:SD serum alanine aminotransferase activity level fasting (between 12 and 15 hours) then acetaminophen (1 g/kg) (for 1 days) McGill MR, et al., Toxicol Appl Pharmacol. 2012 Nov 1;264(3):387-94. doi: 10.1016/j.taap.2012.08.015. Epub 2012 Aug 23. blood alanine transaminase amount not specified 56 days-84 days 4 41.0 U/l 11.0 22.0 spectrophotometry 0.0 0 84758 1601
Hsd:SD auditory brainstem response threshold thymoquinone (40 mg/kg/d) (for 5 days) Sagit M, et al., Eur Arch Otorhinolaryngol. 2013 Aug;270(8):2231-7. doi: 10.1007/s00405-012-2254-6. Epub 2012 Nov 17. hearing electrophysiology trait female 173 days 10 19.0 dBnHL 2.69 8.52 evoked response audiometry 0.0 0 T post 75931 1541
Hsd:SD thymus weight to body weight ratio 2,3,7,8-tetrachlorodibenzo-p-dioxin (22 ng/kg/d) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. thymus mass female 84 days 10 1.49 mg/g 0.27 0.85 post excision weight measurement 0 105888 3021
Hsd:SD spleen weight to body weight ratio vehicle control condition (5 ml/kg) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. spleen mass female 84 days 10 0.3 % 0.03 0.09 post excision weight measurement 0 105896 3021
Hsd:SD spleen weight to body weight ratio 2,3,7,8-tetrachlorodibenzo-p-dioxin (22 ng/kg/d) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. spleen mass female 84 days 10 0.28 % 0.03 0.09 post excision weight measurement 0 105900 3021
Hsd:SD spleen weight to body weight ratio 2,3,7,8-tetrachlorodibenzo-p-dioxin (1000 ng/kg/d) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. spleen mass female 84 days 10 0.27 % 0.02 0.05 post excision weight measurement 0 105906 3021
Hsd:SD brain weight to body weight ratio 2,3,7,8-tetrachlorodibenzo-p-dioxin (300 ng/kg/d) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. brain mass female 84 days 10 0.76 % 0.06 0.18 post excision weight measurement 0 105916 3021
Hsd:SD serum alkaline phosphatase activity level control condition (for 84 days) Harrill JA, et al., Toxicol Appl Pharmacol. 2013 Oct 15;272(2):503-18. doi: 10.1016/j.taap.2013.06.024. Epub 2013 Jul 13. blood alkaline phosphatase amount male 84 days 5 74.6 U/l 16.6 37.12 automated serum analysis 0 106370 3025
Hsd:SD serum total bilirubin level control condition (for 84 days) Harrill JA, et al., Toxicol Appl Pharmacol. 2013 Oct 15;272(2):503-18. doi: 10.1016/j.taap.2013.06.024. Epub 2013 Jul 13. blood bilirubin amount male 84 days 5 0.05 mg/dl 0.0 0.0 automated serum analysis 0 106374 3025
Hsd:SD serum albumin level control condition (for 84 days) Harrill JA, et al., Toxicol Appl Pharmacol. 2013 Oct 15;272(2):503-18. doi: 10.1016/j.taap.2013.06.024. Epub 2013 Jul 13. blood albumin amount male 84 days 5 4.5 g/dl 0.3 0.67 automated serum analysis 0 106386 3025
Hsd:SD blood albumin level to blood globulin level ratio control condition (for 84 days) Harrill JA, et al., Toxicol Appl Pharmacol. 2013 Oct 15;272(2):503-18. doi: 10.1016/j.taap.2013.06.024. Epub 2013 Jul 13. blood albumin amount male 84 days 5 1.8 null 0.1 0.22 automated serum analysis 0 106394 3025
Hsd:SD serum total cholesterol level control condition (for 84 days) Harrill JA, et al., Toxicol Appl Pharmacol. 2013 Oct 15;272(2):503-18. doi: 10.1016/j.taap.2013.06.024. Epub 2013 Jul 13. blood cholesterol amount female 84 days 5 106.8 mg/dl 6.6 14.76 automated serum analysis 0 106400 3025
Hsd:SD serum urea nitrogen level control condition (for 84 days) Harrill JA, et al., Toxicol Appl Pharmacol. 2013 Oct 15;272(2):503-18. doi: 10.1016/j.taap.2013.06.024. Epub 2013 Jul 13. blood urea nitrogen amount male 84 days 5 22.4 mg/dl 1.7 3.8 automated serum analysis 0 106406 3025
Hsd:SD serum urea nitrogen level control condition (for 84 days) Harrill JA, et al., Toxicol Appl Pharmacol. 2013 Oct 15;272(2):503-18. doi: 10.1016/j.taap.2013.06.024. Epub 2013 Jul 13. blood urea nitrogen amount female 84 days 5 24.6 mg/dl 1.5 3.35 automated serum analysis 0 106408 3025
Hsd:SD white blood cell count 2,3,7,8-tetrachlorodibenzo-p-dioxin (300 ng/kg/d) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. leukocyte quantity female 84 days 10 10.54 x 1000 cells/ul 1.42 4.49 automated hematology analysis 0 106024 3021
Hsd:SD blood neutrophil count 2,3,7,8-tetrachlorodibenzo-p-dioxin (1000 ng/kg/d) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. neutrophil quantity female 84 days 10 1.08 x 1000 cells/ul 0.47 1.49 automated hematology analysis 0 106038 3021
Hsd:SD blood lymphocyte count 2,3,7,8-tetrachlorodibenzo-p-dioxin (300 ng/kg/d) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. lymphocyte quantity female 84 days 10 8.36 x 1000 cells/ul 1.92 6.07 automated hematology analysis 0 106048 3021
Hsd:SD blood eosinophil count 2,3,7,8-tetrachlorodibenzo-p-dioxin (100 ng/kg/d) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. eosinophil quantity female 84 days 10 0.07 x 1000 cells/ul 0.02 0.06 automated hematology analysis 0 106070 3021
Hsd:SD blood basophil count 2,3,7,8-tetrachlorodibenzo-p-dioxin (22 ng/kg/d) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. basophil quantity female 84 days 10 0.08 x 1000 cells/ul 0.04 0.13 automated hematology analysis 0 106080 3021
Hsd:SD liver weight as percentage of body weight 2,3,7,8-tetrachlorodibenzo-p-dioxin (22 ng/kg/d) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. liver mass female 84 days 10 4.16 % 0.21 0.65 post excision weight measurement 0.0 0 105722 3021
Hsd:SD both ovaries weight to body weight ratio 2,3,7,8-tetrachlorodibenzo-p-dioxin (22 ng/kg/d) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. ovary mass female 84 days 10 0.05 % 0.01 0.04 post excision weight measurement 0 105924 3021
Hsd:SD red blood cell count 2,3,7,8-tetrachlorodibenzo-p-dioxin (100 ng/kg/d) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. erythrocyte quantity female 84 days 10 8.02 x 10E6 cells/ul 0.26 0.82 automated hematology analysis 0 105938 3021
Hsd:SD hematocrit 2,3,7,8-tetrachlorodibenzo-p-dioxin (300 ng/kg/d) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. erythrocyte quantity female 84 days 10 44.79 % 2.21 6.99 automated hematology analysis 0 105964 3021
Hsd:SD hematocrit 2,3,7,8-tetrachlorodibenzo-p-dioxin (1000 ng/kg/d) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. erythrocyte quantity female 84 days 10 48.55 % 3.28 10.37 automated hematology analysis 0 105966 3021
Hsd:SD mean corpuscular hemoglobin concentration 2,3,7,8-tetrachlorodibenzo-p-dioxin (100 ng/kg/d) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. blood hemoglobin amount female 84 days 10 32.37 g/dl 0.52 1.64 automated hematology analysis 0 105998 3021
Hsd:SD mean corpuscular hemoglobin concentration 2,3,7,8-tetrachlorodibenzo-p-dioxin (300 ng/kg/d) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. blood hemoglobin amount female 84 days 10 32.81 g/dl 0.79 2.5 automated hematology analysis 0 106000 3021
Hsd:SD body weight control condition (for 84 days) Harrill JA, et al., Toxicol Appl Pharmacol. 2013 Oct 15;272(2):503-18. doi: 10.1016/j.taap.2013.06.024. Epub 2013 Jul 13. body mass female 84 days 5 257.6 g 27.2 60.82 body weighing method 0 106440 3025
Hsd:SD kidney weight control condition (for 84 days) Harrill JA, et al., Toxicol Appl Pharmacol. 2013 Oct 15;272(2):503-18. doi: 10.1016/j.taap.2013.06.024. Epub 2013 Jul 13. kidney mass female 84 days 5 0.81 g 0.06 0.13 post excision weight measurement 0 106448 3025
Hsd:SD heart weight control condition (for 84 days) Harrill JA, et al., Toxicol Appl Pharmacol. 2013 Oct 15;272(2):503-18. doi: 10.1016/j.taap.2013.06.024. Epub 2013 Jul 13. heart mass female 84 days 5 0.39 g 0.03 0.07 post excision weight measurement 0 106452 3025
Hsd:SD pancreas weight control condition (for 84 days) Harrill JA, et al., Toxicol Appl Pharmacol. 2013 Oct 15;272(2):503-18. doi: 10.1016/j.taap.2013.06.024. Epub 2013 Jul 13. pancreas mass male 84 days 5 280.0 mg 40.0 89.44 post excision weight measurement 0 106454 3025
Hsd:SD pancreas weight control condition (for 84 days) Harrill JA, et al., Toxicol Appl Pharmacol. 2013 Oct 15;272(2):503-18. doi: 10.1016/j.taap.2013.06.024. Epub 2013 Jul 13. pancreas mass female 84 days 5 390.0 mg 40.0 89.44 post excision weight measurement 0 106456 3025
Hsd:SD thymus weight control condition (for 84 days) Harrill JA, et al., Toxicol Appl Pharmacol. 2013 Oct 15;272(2):503-18. doi: 10.1016/j.taap.2013.06.024. Epub 2013 Jul 13. thymus mass male 84 days 5 0.16 g 0.02 0.04 post excision weight measurement 0 106462 3025
Hsd:SD brain weight control condition (for 84 days) Harrill JA, et al., Toxicol Appl Pharmacol. 2013 Oct 15;272(2):503-18. doi: 10.1016/j.taap.2013.06.024. Epub 2013 Jul 13. brain mass female 84 days 5 0.67 g 0.06 0.13 post excision weight measurement 0 106468 3025
Hsd:SD scotopic A wave amplitude of ERG waveform vehicle control condition (2 ul) then controlled exposure to darkness (for 12 hours) then visible light stimulus (5 cd/m2) Conlon TJ, et al., Hum Gene Ther Clin Dev. 2013 Mar;24(1):23-8. doi: 10.1089/humc.2013.037. Epub 2013 Apr 3. rod electrophysiology trait both 0 days 4 142.0 uV electroretinography cornea 0.0 subretinal injection 30 days scotopic a-wave ERG 108642 3128
Hsd:SD scotopic B wave amplitude of ERG waveform gene transfer of the rat MER proto-oncogene, tyrosine kinase gene using an adenovirus vector (40 x 10E8 vg) then controlled exposure to darkness (for 12 hours) then visible light stimulus (5 cd/m2) Conlon TJ, et al., Hum Gene Ther Clin Dev. 2013 Mar;24(1):23-8. doi: 10.1089/humc.2013.037. Epub 2013 Apr 3. rod electrophysiology trait both 0 days 9 397.0 uV electroretinography cornea 0.0 subretinal injection 30 days scotopic b-wave ERG 108652 3128
Hsd:SD scotopic A wave amplitude of ERG waveform gene transfer of the rat MER proto-oncogene, tyrosine kinase gene using an adenovirus vector (4 x 10E8 vg) then controlled exposure to darkness (for 12 hours) then visible light stimulus (5 cd/m2) Conlon TJ, et al., Hum Gene Ther Clin Dev. 2013 Mar;24(1):23-8. doi: 10.1089/humc.2013.037. Epub 2013 Apr 3. rod electrophysiology trait both 0 days 9 154.0 uV electroretinography cornea 0.0 subretinal injection 30 days scotopic a-wave ERG 108648 3128
Hsd:SD photopic B wave amplitude of ERG waveform controlled visible light condition (30 cd x s/m2) then visible light stimulus (12 cd/m2) Conlon TJ, et al., Hum Gene Ther Clin Dev. 2013 Mar;24(1):23-8. doi: 10.1089/humc.2013.037. Epub 2013 Apr 3. cone electrophysiology trait both 0 days 9 75.0 uV electroretinography cornea 0.0 subretinal injection 30 days contralateral control eye photopic b-wave ERG 108651 3128
Hsd:SD scotopic A wave amplitude of ERG waveform controlled exposure to darkness (for 12 hours) then visible light stimulus (5 cd/m2) Conlon TJ, et al., Hum Gene Ther Clin Dev. 2013 Mar;24(1):23-8. doi: 10.1089/humc.2013.037. Epub 2013 Apr 3. rod electrophysiology trait both 0 days 9 195.0 uV electroretinography cornea 0.0 0 scotopic a-wave ERG 108649 3128
Hsd:SD plasma alanine aminotransferase activity level controlled fat content diet (42 %) (for 364 days) Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. blood alanine transaminase amount male 448 days 10 28.0 U/l 4.0 12.65 automated plasma alanine aminotransferase activity assay 0.0 0 138287 3201
Hsd:SD plasma aspartate aminotransferase activity level standard diet Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. blood aspartate transaminase amount male 448 days 9 159.0 U/l 16.0 48.0 automated plasma aspartate aminotransferase activity assay 0.0 0 138289 3201
Hsd:SD plasma creatinine level standard diet Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. blood creatinine amount male 448 days 9 0.59 mg/dl 0.04 0.12 automated plasma creatinine analysis 0.0 0 138298 3201
Hsd:SD plasma creatinine level controlled fat content diet (42 %) (for 364 days) Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. blood creatinine amount male 448 days 10 0.59 mg/dl 0.03 0.09 automated plasma creatinine analysis 0.0 0 138300 3201
Hsd:SD plasma leptin level controlled fat content diet (42 %) (for 364 days) Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. blood leptin amount male 448 days 10 34.72 ng/ml 2.72 8.6 enzyme linked immunosorbent assay 0.0 0 138316 3201
Hsd:SD respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 15 104.23 breaths/min 4.64 17.99 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 15507 381
Hsd:SD body temperature resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 1 37.6 degrees C digital rectal thermometry 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15570 381
Hsd:SD plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity female 87 days-120 days 12 8.82 ng/ml/h 1.04 3.62 radioimmunoassay 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 50896 481
Hsd:SD mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 1 117.54 mmHg vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 20130 381
Hsd:SD absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 14 13.28 mmHg 2.14 8.01 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 50958 481
Hsd:SD percent change in respiration rate air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 5 175.1 % 20.81 46.52 stop flow air displacement plethysmography 0 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54175 381
Hsd:SD mean arterial blood pressure air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 10 106.91 mmHg 4.57 14.44 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 13825 381
Hsd:SD absolute change in body temperature resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 1 0.7 degrees C digital rectal thermometry 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18507 381
Hsd:SD tidal volume air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 17 0.51 ml 0.02 0.08 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 18750 381
Hsd:SD mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 2 126.43 mmHg 0.43 0.6 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18763 381
Hsd:SD partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 10 101.17 mmHg 1.84 5.81 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 14129 381
Hsd:SD serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 5 11.76 mg/dl 0.58 1.31 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 36837 401
Hsd:SD mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 10 108.29 mmHg 2.16 6.83 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 19311 381
Hsd:SD heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 3 260.94 beats/min 12.96 22.44 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45357 461
Hsd:SD left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 3 68.36 mmHg 3.47 6.01 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45910 461
Hsd:SD arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 13 5.82 ml/min/g 0.48 1.72 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 46841 461
Hsd:SD arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 12 8.79 ml/min/g 0.5 1.72 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 46854 461
Hsd:SD percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 3 post-ischemic value/pre-ischemic value x 100% 81.22 % 6.92 11.99 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47887 461
Hsd:SD time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 10 634.09 s 50.65 160.18 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 47895 461
Hsd:SD arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 3 8.32 ml/min/g 1.98 3.42 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 46179 461
Hsd:SD fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 6 0.08 mmHg-1 0.01 0.03 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58096 526
Hsd:SD percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 2 post-ischemic value/pre-ischemic value x 100% 88.39 % 1.7 2.4 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49660 461
Hsd:SD mean corpuscular hemoglobin control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 6 18.62 pg 0.21 0.5 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 39866 401
Hsd:SD methylene blue metabolism-surface area product without auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 15.24 ml/min/kg 1.17 3.32 isolated perfused lung vascular effluent collection 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 58419 526
Hsd:SD heart right ventricle weight to left ventricle weight ratio control condition (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 8 0.23 null 0.01 0.03 digital scale post excision weight measurement 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 58425 526
Hsd:SD methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 7 18.56 ml/min/kg 0.73 1.93 isolated perfused lung vascular effluent collection 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58428 526
Hsd:SD serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 5 105.0 mmol/l 2.47 5.52 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 38374 401
Hsd:SD serum albumin level control condition (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 8 4.04 g/dl 0.07 0.2 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 38511 401
Hsd:SD plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 3 0.37 mg/dl 0.12 0.21 automated plasma creatinine analysis 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 41731 401
Hsd:SD blood monocyte count control condition (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 6 0.12 x 1000 cells/ul 0.04 0.1 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 39975 401
Hsd:SD percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 5 150.44 % 11.99 26.81 stop flow air displacement plethysmography 0 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 53601 381
Hsd:SD heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 3 61.67 mmHg 7.8 13.5 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49596 461
Hsd:SD left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 3 117.54 mmHg 9.47 16.4 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49281 461
Hsd:SD plasma creatinine level control condition (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 3 0.33 mg/dl 0.07 0.12 automated plasma creatinine analysis 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 41849 401
Hsd:SD left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 2 123.77 mmHg 11.21 15.85 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49809 461
Hsd:SD heart left ventricle infarction weight to total heart left ventricle weight ratio controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 2 8.4 % 3.6 5.09 digital scale post excision weight measurement 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49863 461
Hsd:SD heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 7 248.81 beats/min 33.89 89.67 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 45587 461
Hsd:SD serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 3 20.67 mg/dl 0.33 0.58 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 39987 401
Hsd:SD serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 3 6.17 mmol/l 0.52 0.91 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 38861 401
Hsd:SD serum chloride level control condition (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 8 100.25 mmol/l 0.94 2.66 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 40661 401
Hsd:SD serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 5 3.96 g/dl 0.07 0.15 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 42336 401
Hsd:SD serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 2 21.5 mmol/l 0.5 0.71 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 42339 401
Hsd:SD methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 6 0.8 null 0.05 0.12 isolated perfused lung vascular effluent collection 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 59744 526
Hsd:SD serum globulin level control condition (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 8 2.45 g/dl 0.09 0.24 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 41167 401
Hsd:SD thyroid gland weight control condition (for 84 days) Harrill JA, et al., Toxicol Appl Pharmacol. 2013 Oct 15;272(2):503-18. doi: 10.1016/j.taap.2013.06.024. Epub 2013 Jul 13. thyroid gland mass female 84 days 5 0.01 g 0.0 0.0 post excision weight measurement 0 106476 3025
Hsd:SD blood neutrophil count 2,3,7,8-tetrachlorodibenzo-p-dioxin (22 ng/kg/d) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. neutrophil quantity female 84 days 10 1.38 x 1000 cells/ul 0.33 1.04 automated hematology analysis 0 106032 3021
Hsd:SD blood monocyte count vehicle control condition (5 ml/kg) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. monocyte quantity female 84 days 10 0.29 x 1000 cells/ul 0.14 0.44 automated hematology analysis 0 106052 3021
Hsd:SD creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data glomerular filtration trait male 87 days-120 days 11 2.61 ml/min 0.23 0.77 urine creatinine analysis 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 51747 481
Hsd:SD creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data glomerular filtration trait female 87 days-120 days 15 1.81 ml/min 0.13 0.51 urine creatinine analysis 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 51748 481
Hsd:SD absolute change in blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 10 0.01 null 0.0 0.01 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 15754 381
Hsd:SD plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount male 87 days-120 days 11 0.32 mg/dl 0.03 0.11 radioimmunoassay 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 51277 481
Hsd:SD percent change in tidal volume air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 17 150.84 % 4.02 16.56 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 54168 381
Hsd:SD absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 14 2.72 beats/min 8.95 33.48 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 50824 481
Hsd:SD mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 10 113.27 mmHg 6.46 20.44 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 13663 381
Hsd:SD partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 7 106.75 mmHg 4.16 11.0 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 14128 381
Hsd:SD absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 14 3.03 mmHg 1.25 4.68 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 50500 481
Hsd:SD minute ventilation air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 14 69.56 ml/min 3.4 12.72 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 20001 381
Hsd:SD absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 7 0.08 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 20696 381
Hsd:SD absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 1 -6.5 mmHg automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 20980 381
Hsd:SD absolute change in body temperature resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 7 0.57 degrees C 0.24 0.63 digital rectal thermometry 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 18752 381
Hsd:SD heart rate control condition PhysGen Respiratory data heart pumping trait male 82 days-99 days 2 415.03 beats/min 10.24 14.47 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18385 381
Hsd:SD mean arterial blood pressure resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 7 106.11 mmHg 5.77 15.27 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 18925 381
Hsd:SD percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 15 %change=VE during7-9 min hypoxia/control during standard conditions 138.6 % 6.48 25.11 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 17019 381
Hsd:SD serum calcium level control condition (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 2 9.35 mg/dl 0.15 0.21 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 36331 401
Hsd:SD serum urea nitrogen level control condition (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 6 21.83 mg/dl 1.08 2.64 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 37064 401
Hsd:SD mean corpuscular hemoglobin control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 3 18.7 pg 0.35 0.61 automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 37080 401
Hsd:SD partial pressure of blood carbon dioxide (Pco2) resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 12 32.2 mmHg 0.81 2.81 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 18839 381
Hsd:SD heart rate air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 8 377.42 beats/min 7.29 20.61 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 15519 381
Hsd:SD respiration rate control condition PhysGen Respiratory data respiratory function trait male 82 days-99 days 17 96.87 breaths/min 4.25 17.51 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 15483 381
Hsd:SD absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 20 -76.99 beats/min 8.0 35.77 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 52072 481
Hsd:SD urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine sodium amount male 87 days-120 days 15 15.59 mEq/d 0.52 2.03 flame atomic emission spectrometry 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 51941 481
Hsd:SD respiration rate air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 17 154.45 breaths/min 2.97 12.23 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 17297 381
Hsd:SD absolute change in body temperature air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 5 0.32 degrees C 0.12 0.26 digital rectal thermometry 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 13865 381
Hsd:SD percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 15 %change=VE during 2-3 min hypoxia/control during standard conditions 149.13 % 8.25 31.97 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 13899 381
Hsd:SD absolute change in body temperature air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 16 -0.56 degrees C 0.18 0.72 digital rectal thermometry 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 14054 381
Hsd:SD blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 7 7.47 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14097 381
Hsd:SD absolute change in partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 6 5.85 mmHg 5.0 12.24 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 14099 381
Hsd:SD absolute change in heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 1 75.52 beats/min vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 14110 381
Hsd:SD minute ventilation air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 5 94.17 ml/min 8.96 20.04 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17579 381
Hsd:SD absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 1 -50.4 mmHg automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 20686 381
Hsd:SD minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 5 37.83 ml/min 3.24 7.25 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17902 381
Hsd:SD respiration rate air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 5 157.88 breaths/min 5.29 11.83 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17955 381
Hsd:SD blood pH control condition PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 8 7.44 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 19701 381
Hsd:SD tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 5 0.42 ml 0.03 0.07 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19036 381
Hsd:SD serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 18 123.06 U/l 9.73 41.27 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 37280 401
Hsd:SD serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 3 9.43 mg/dl 1.51 2.61 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 36838 401
Hsd:SD heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 3 19.87 % 11.92 20.64 digital scale post excision weight measurement 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49033 461
Hsd:SD left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 11 4.73 mmHg 0.27 0.9 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 49044 461
Hsd:SD absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 12 -47.88 mmHg 2.49 8.64 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 20408 381
Hsd:SD heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 13 49.58 mmHg 4.1 14.78 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 49160 461
Hsd:SD tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 15 0.36 ml 0.02 0.07 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 18249 381
Hsd:SD serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 18 18.17 mmol/l 0.44 1.86 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 36589 401
Hsd:SD percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 66.38 % 10.23 28.94 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 49812 461
Hsd:SD heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 8 349.14 beats/min 30.12 85.19 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 49848 461
Hsd:SD percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 3 post-ischemic value/pre-ischemic value x 100% 58.59 % 29.76 51.55 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49269 461
Hsd:SD red blood cell count control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 8 8.61 x 10E6 cells/ul 0.24 0.69 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 42322 401
Hsd:SD blood eosinophil count control condition (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 3 0.02 x 1000 cells/ul 0.02 0.03 automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 38858 401
Hsd:SD serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 17 117.12 U/l 6.96 28.7 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 42173 401
Hsd:SD serum alanine aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 6 48.83 U/l 3.54 8.68 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 39472 401
Hsd:SD blood neutrophil count control condition (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 6 0.34 x 1000 cells/ul 0.08 0.2 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 39480 401
Hsd:SD serum phosphate level control condition (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 6 11.55 mg/dl 0.92 2.26 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 39482 401
Hsd:SD serum total bilirubin level control condition (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 2 0.25 mg/dl 0.05 0.07 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 39328 401
Hsd:SD blood monocyte count control condition (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 8 0.23 x 1000 cells/ul 0.05 0.15 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 39974 401
Hsd:SD serum total protein level control condition (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 2 5.95 g/dl 0.25 0.35 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 42969 401
Hsd:SD blood hemoglobin level control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 1 15.0 g/dl automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 39759 401
Hsd:SD serum albumin level control condition (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 2 3.85 g/dl 0.15 0.21 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 40374 401
Hsd:SD serum albumin level control condition (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 3 3.87 g/dl 0.13 0.23 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 40375 401
Hsd:SD percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 15 131.46 % 5.91 22.91 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 53542 381
Hsd:SD percent change in respiration rate air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 14 183.64 % 10.34 38.69 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 53567 381
Hsd:SD percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 15 113.26 % 5.31 20.56 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 53569 381
Hsd:SD serum chloride level control condition (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 6 101.83 mmol/l 1.11 2.71 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 40662 401
Hsd:SD serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 18 2.28 g/dl 0.08 0.32 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 40499 401
Hsd:SD blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 15 6.5 x 1000 cells/ul 0.51 1.96 automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 40513 401
Hsd:SD serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 16 0.26 mg/dl 0.02 0.07 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 37532 401
Hsd:SD mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 15 19.85 pg 0.24 0.93 automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 37563 401
Hsd:SD serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 5 364.0 U/l 185.15 414.01 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 37569 401
Hsd:SD serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 3 166.67 U/l 22.42 38.84 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 37570 401
Hsd:SD mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 16 61.14 fl 0.35 1.4 automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 37801 401
Hsd:SD blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 15 0.04 x 1000 cells/ul 0.01 0.05 automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 37805 401
Hsd:SD blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 16 0.07 x 1000 cells/ul 0.03 0.11 automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 37807 401
Hsd:SD serum glucose level control condition (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 7 256.57 mg/dl 25.66 67.88 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 41152 401
Hsd:SD blood eosinophil count control condition (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 5 0.02 x 1000 cells/ul 0.01 0.03 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 41161 401
Hsd:SD blood monocyte count control condition (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 1 0.08 x 1000 cells/ul automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 41173 401
Hsd:SD serum aspartate aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 5 170.8 U/l 47.67 106.6 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 41283 401
Hsd:SD heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 9 9.75 IU/g 1.75 5.24 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 45488 461
Hsd:SD heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 11 271.7 beats/min 24.62 81.65 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 45588 461
Hsd:SD heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 6 0.13 IU/g 0.04 0.09 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 48706 461
Hsd:SD percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 2 post-ischemic value/pre-ischemic value x 100% 55.97 % 5.53 7.82 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47529 461
Hsd:SD serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 16 187.88 mg/dl 5.73 22.93 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 38625 401
Hsd:SD heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 3 261.19 beats/min 14.7 25.46 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 46504 461
Hsd:SD heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 6 333.73 beats/min 31.12 76.22 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 48507 461
Hsd:SD sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 17 99.47 % 0.42 1.74 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 57293 522
Hsd:SD logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 19 -6.96 null 0.11 0.47 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 57306 522
Hsd:SD calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 6 0.12 mmHg x min x kg x ml-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 57773 526
Hsd:SD hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 7 54.11 % 1.48 3.92 microhematocrit tube assay with visual assessment 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 57779 526
Hsd:SD heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 4 482.32 beats/min 17.94 35.89 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 16119 381
Hsd:SD heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 2 410.89 beats/min 17.95 25.39 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 16122 381
Hsd:SD tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 15 0.37 ml 0.02 0.08 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 16325 381
Hsd:SD partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 1 29.5 mmHg automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 16363 381
Hsd:SD methylene blue metabolism-surface area product without auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 7 24.07 ml/min/kg 1.67 4.42 isolated perfused lung vascular effluent collection 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 58420 526
Hsd:SD methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 7 11.96 ml/min/kg 0.33 0.88 isolated perfused lung vascular effluent collection 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58464 526
Hsd:SD fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 7 0.13 mmHg-1 0.02 0.05 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58094 526
Hsd:SD concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 14 0.01 10E-7mol/l 0.0 0.01 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 56014 522
Hsd:SD hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 15 36.52 % 3.87 14.97 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 54635 522
Hsd:SD hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 13 40.71 % 5.21 18.79 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 54636 522
Hsd:SD hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 12 50.17 % 9.89 34.25 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 56256 522
Hsd:SD methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 6 19.67 ml/min/kg 1.66 4.07 isolated perfused lung vascular effluent collection 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 58708 526
Hsd:SD logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 14 -7.49 null 0.09 0.32 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 56492 522
Hsd:SD FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 6 27.62 ml/min/kg 1.83 4.48 isolated perfused lung vascular effluent collection 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 60093 526
Hsd:SD percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 61.65 % 5.68 17.03 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 45712 461
Hsd:SD left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 2 117.08 mmHg 11.54 16.32 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47673 461
Hsd:SD time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 13 699.88 s 51.24 184.76 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 47894 461
Hsd:SD left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 7 35.35 mmHg 4.97 13.14 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 46148 461
Hsd:SD heart contraction pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 7 52.0 mmHg 4.19 11.08 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 47060 461
Hsd:SD heart contraction pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 11 39.18 mmHg 5.05 16.75 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 47061 461
Hsd:SD heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 12 0.41 IU/g 0.07 0.26 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 45132 461
Hsd:SD heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 3 1.37 g 0.05 0.1 digital scale post excision weight measurement 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45033 461
Hsd:SD percent change in left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 3 post-ischemic value/pre-ischemic value x 100% 50.64 % 6.24 10.81 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45045 461
Hsd:SD arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 3 9.99 ml/min/g 1.73 2.99 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45086 461
Hsd:SD percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 13 post-ischemic value/pre-ischemic value x 100% 50.56 % 3.84 13.85 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 48116 461
Hsd:SD heart wet weight control condition PhysGen Cardiac data heart mass female 49 days-63 days 2 1.18 g 0.04 0.05 digital scale post excision weight measurement 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48150 461
Hsd:SD heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 2 295.8 beats/min 14.55 20.57 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48179 461
Hsd:SD heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 3 0.07 IU/g 0.01 0.01 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45235 461
Hsd:SD heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 2 0.08 IU/g 0.01 0.01 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45239 461
Hsd:SD heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 3 0.04 IU/g 0.01 0.02 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48386 461
Hsd:SD auditory brainstem response threshold thymoquinone (40 mg/kg/d) (for 3 days) Sagit M, et al., Eur Arch Otorhinolaryngol. 2013 Aug;270(8):2231-7. doi: 10.1007/s00405-012-2254-6. Epub 2012 Nov 17. hearing electrophysiology trait female 170 days 10 18.0 dBnHL 2.43 7.67 evoked response audiometry 0.0 0 T pre 75928 1541
Hsd:SD both ovaries weight control condition (for 84 days) Harrill JA, et al., Toxicol Appl Pharmacol. 2013 Oct 15;272(2):503-18. doi: 10.1016/j.taap.2013.06.024. Epub 2013 Jul 13. ovary mass female 84 days 12 0.05 g 0.0 0.01 post excision weight measurement 0 106486 3025
Hsd:SD epididymides weight control condition (for 84 days) Harrill JA, et al., Toxicol Appl Pharmacol. 2013 Oct 15;272(2):503-18. doi: 10.1016/j.taap.2013.06.024. Epub 2013 Jul 13. epididymis mass male 84 days 12 0.56 g 0.06 0.21 post excision weight measurement 0 106490 3025
Hsd:SD serum alanine aminotransferase activity level control condition (for 84 days) Harrill JA, et al., Toxicol Appl Pharmacol. 2013 Oct 15;272(2):503-18. doi: 10.1016/j.taap.2013.06.024. Epub 2013 Jul 13. blood alanine transaminase amount female 84 days 5 65.0 U/l 5.4 12.07 automated serum analysis 0 106364 3025
Hsd:SD serum alkaline phosphatase activity level control condition (for 84 days) Harrill JA, et al., Toxicol Appl Pharmacol. 2013 Oct 15;272(2):503-18. doi: 10.1016/j.taap.2013.06.024. Epub 2013 Jul 13. blood alkaline phosphatase amount female 84 days 5 77.0 U/l 8.2 18.34 automated serum analysis 0 106372 3025
Hsd:SD serum total bilirubin level control condition (for 84 days) Harrill JA, et al., Toxicol Appl Pharmacol. 2013 Oct 15;272(2):503-18. doi: 10.1016/j.taap.2013.06.024. Epub 2013 Jul 13. blood bilirubin amount female 84 days 5 0.05 mg/dl 0.0 0.0 automated serum analysis 0 106376 3025
Hsd:SD serum globulin level control condition (for 84 days) Harrill JA, et al., Toxicol Appl Pharmacol. 2013 Oct 15;272(2):503-18. doi: 10.1016/j.taap.2013.06.024. Epub 2013 Jul 13. blood globulin amount female 84 days 5 2.2 g/dl 0.2 0.45 automated serum analysis 0 106392 3025
Hsd:SD serum total cholesterol level control condition (for 84 days) Harrill JA, et al., Toxicol Appl Pharmacol. 2013 Oct 15;272(2):503-18. doi: 10.1016/j.taap.2013.06.024. Epub 2013 Jul 13. blood cholesterol amount male 84 days 5 113.8 mg/dl 8.5 19.01 automated serum analysis 0 106398 3025
Hsd:SD serum triglyceride level control condition (for 84 days) Harrill JA, et al., Toxicol Appl Pharmacol. 2013 Oct 15;272(2):503-18. doi: 10.1016/j.taap.2013.06.024. Epub 2013 Jul 13. blood triglyceride amount male 84 days 5 156.8 mg/dl 12.9 28.85 automated serum analysis 0 106402 3025
Hsd:SD both ovaries weight to body weight ratio 2,3,7,8-tetrachlorodibenzo-p-dioxin (1000 ng/kg/d) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. ovary mass female 84 days 10 0.04 % 0.01 0.03 post excision weight measurement 0 105930 3021
Hsd:SD blood hemoglobin level 2,3,7,8-tetrachlorodibenzo-p-dioxin (22 ng/kg/d) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. blood hemoglobin amount female 84 days 10 14.27 g/dl 0.64 2.02 automated hematology analysis 0 105948 3021
Hsd:SD hematocrit 2,3,7,8-tetrachlorodibenzo-p-dioxin (3 ng/kg/d) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. erythrocyte quantity female 84 days 10 44.34 % 1.82 5.76 automated hematology analysis 0 105958 3021
Hsd:SD mean corpuscular hemoglobin 2,3,7,8-tetrachlorodibenzo-p-dioxin (300 ng/kg/d) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. blood hemoglobin amount female 84 days 10 17.89 pg 0.31 0.98 automated hematology analysis 0 105988 3021
Hsd:SD mean corpuscular hemoglobin concentration 2,3,7,8-tetrachlorodibenzo-p-dioxin (1000 ng/kg/d) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. blood hemoglobin amount female 84 days 10 32.51 g/dl 1.05 3.32 automated hematology analysis 0 106002 3021
Hsd:SD white blood cell count vehicle control condition (5 ml/kg) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. leukocyte quantity female 84 days 10 9.42 x 1000 cells/ul 2.25 7.12 automated hematology analysis 0 106016 3021
Hsd:SD blood lymphocyte count 2,3,7,8-tetrachlorodibenzo-p-dioxin (1000 ng/kg/d) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. lymphocyte quantity female 84 days 10 7.18 x 1000 cells/ul 1.78 5.63 automated hematology analysis 0 106050 3021
Hsd:SD blood eosinophil count 2,3,7,8-tetrachlorodibenzo-p-dioxin (300 ng/kg/d) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. eosinophil quantity female 84 days 10 0.04 x 1000 cells/ul 0.01 0.03 automated hematology analysis 0 106072 3021
Hsd:SD blood eosinophil count 2,3,7,8-tetrachlorodibenzo-p-dioxin (1000 ng/kg/d) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. eosinophil quantity female 84 days 10 0.04 x 1000 cells/ul 0.06 0.19 automated hematology analysis 0 106074 3021
Hsd:SD liver weight as percentage of body weight 2,3,7,8-tetrachlorodibenzo-p-dioxin (100 ng/kg/d) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. liver mass female 84 days 10 4.69 % 0.34 1.06 post excision weight measurement 0.0 0 105723 3021
Hsd:SD liver weight as percentage of body weight 2,3,7,8-tetrachlorodibenzo-p-dioxin (300 ng/kg/d) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. liver mass female 84 days 10 5.03 % 0.37 1.17 post excision weight measurement 0.0 0 105724 3021
Hsd:SD spleen weight to body weight ratio 2,3,7,8-tetrachlorodibenzo-p-dioxin (3 ng/kg/d) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. spleen mass female 84 days 10 0.29 % 0.02 0.07 post excision weight measurement 0 105898 3021
Hsd:SD serum glucose level control condition (for 84 days) Harrill JA, et al., Toxicol Appl Pharmacol. 2013 Oct 15;272(2):503-18. doi: 10.1016/j.taap.2013.06.024. Epub 2013 Jul 13. blood glucose amount male 84 days 5 285.0 mg/dl 47.3 105.77 automated serum analysis 0 106414 3025
Hsd:SD serum sodium level control condition (for 84 days) Harrill JA, et al., Toxicol Appl Pharmacol. 2013 Oct 15;272(2):503-18. doi: 10.1016/j.taap.2013.06.024. Epub 2013 Jul 13. blood sodium amount female 84 days 5 149.0 mmol/l 2.2 4.92 automated serum analysis 0 106420 3025
Hsd:SD serum chloride level control condition (for 84 days) Harrill JA, et al., Toxicol Appl Pharmacol. 2013 Oct 15;272(2):503-18. doi: 10.1016/j.taap.2013.06.024. Epub 2013 Jul 13. blood chloride amount male 84 days 5 100.2 mmol/l 1.6 3.58 automated serum analysis 0 106426 3025
Hsd:SD liver weight control condition (for 84 days) Harrill JA, et al., Toxicol Appl Pharmacol. 2013 Oct 15;272(2):503-18. doi: 10.1016/j.taap.2013.06.024. Epub 2013 Jul 13. liver mass male 84 days 5 4.61 g 0.25 0.56 post excision weight measurement 0 106442 3025
Hsd:SD thyroid gland weight control condition (for 84 days) Harrill JA, et al., Toxicol Appl Pharmacol. 2013 Oct 15;272(2):503-18. doi: 10.1016/j.taap.2013.06.024. Epub 2013 Jul 13. thyroid gland mass male 84 days 5 0.01 g 0.0 0.0 post excision weight measurement 0 106474 3025
Hsd:SD scotopic B wave amplitude of ERG waveform controlled exposure to darkness (for 12 hours) then visible light stimulus (5 cd/m2) Conlon TJ, et al., Hum Gene Ther Clin Dev. 2013 Mar;24(1):23-8. doi: 10.1089/humc.2013.037. Epub 2013 Apr 3. rod electrophysiology trait both 0 days 4 456.0 uV electroretinography cornea 0.0 0 scotopic b-wave ERG 108641 3128
Hsd:SD photopic B wave amplitude of ERG waveform controlled visible light condition (30 cd x s/m2) then visible light stimulus (12 cd/m2) Conlon TJ, et al., Hum Gene Ther Clin Dev. 2013 Mar;24(1):23-8. doi: 10.1089/humc.2013.037. Epub 2013 Apr 3. cone electrophysiology trait both 0 days 9 70.0 uV electroretinography cornea 0.0 subretinal injection 30 days contralateral control eye photopic b-wave ERG 108657 3128
Hsd:SD scotopic A wave amplitude of ERG waveform controlled exposure to darkness (for 12 hours) then visible light stimulus (5 cd/m2) Conlon TJ, et al., Hum Gene Ther Clin Dev. 2013 Mar;24(1):23-8. doi: 10.1089/humc.2013.037. Epub 2013 Apr 3. rod electrophysiology trait both 0 days 4 202.0 uV electroretinography cornea 0.0 0 scotopic a-wave ERG 108643 3128
Hsd:SD artery neointimal hyperplastic lesion area including tunica media balloon angioplasty Assadnia S, etal., Circ Res. 1999 Jun 11;84(11):1252-7. doi: 10.1161/01.res.84.11.1252. iliac artery integrity trait male 119 days-133 days 15 0.14 mm2 0.02 0.06 ex vivo light microscopy with digital image analysis 0.0 0 110456 3107
Hsd:SD plasma total protein level standard diet Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. blood total protein amount male 448 days 9 65.2 mg/ml 2.0 6.0 automated plasma total protein analysis 0.0 0 138280 3201
Hsd:SD plasma aspartate aminotransferase activity level controlled fat content diet (42 %) (for 364 days) Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. blood aspartate transaminase amount male 448 days 10 140.0 U/l 20.0 63.25 automated plasma aspartate aminotransferase activity assay 0.0 0 138291 3201
Hsd:SD plasma creatine kinase activity level controlled fat content diet (42 %) (for 364 days) Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. blood creatine kinase amount male 448 days 10 996.0 U/l 183.0 578.7 automated plasma creatine kinase activity assay 0.0 0 CK 138294 3201
Hsd:SD blood very low density lipoprotein particle diameter controlled fat content diet (42 %) (for 364 days) Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. blood VLDL particle size male 448 days 10 95.0 nm 7.0 22.14 nuclear magnetic resonance spectroscopy 0.0 0 138332 3201
Hsd:SD blood high density lipoprotein particle diameter controlled fat content diet (42 %) (for 364 days) Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. blood HDL particle size male 448 days 16 8.9 nm 0.1 0.4 nuclear magnetic resonance spectroscopy 0.0 0 138341 3201
Hsd:SD liver triglyceride level controlled fat content diet (42 %) (for 364 days) Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. liver triglyceride amount male 448 days 10 7.76 mg/g 0.72 2.28 isolated tissue triglyceride measurement test 0.0 0 138348 3201
Hsd:SD blood urea nitrogen level controlled fat content diet (42 %) (for 364 days) Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. blood urea nitrogen amount male 448 days 10 16.0 mg/dl 1.0 3.16 automated blood urea nitrogen analysis 0.0 0 138304 3201
Hsd:SD plasma plasminogen activator inhibitor 1 level standard diet Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. blood plasminogen activator inhibitor 1 amount male 448 days 9 9.31 ng/ml 0.79 2.37 enzyme linked immunosorbent assay 0.0 0 138306 3201
Hsd:SD blood fibrinogen level controlled fat content diet (42 %) (for 364 days) Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. fibrin formation trait male 448 days 10 3.08 mg/ml 0.09 0.28 enzyme linked immunosorbent assay 0.0 0 138312 3201
Hsd:SD plasma adiponectin level standard diet Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. blood adiponectin amount male 448 days 9 82.96 ug/ml 4.73 14.19 enzyme linked immunosorbent assay 0.0 0 138318 3201
Hsd:SD plasma adiponectin level controlled fat content diet (42 %) (for 364 days) Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. blood adiponectin amount male 448 days 10 83.97 ug/ml 5.17 16.35 enzyme linked immunosorbent assay 0.0 0 138320 3201
Hsd:SD absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 14 1.22 mmHg 1.8 6.74 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 51039 481
Hsd:SD absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 15 37.3 mmHg 2.27 8.81 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 50827 481
Hsd:SD body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 16 37.05 degrees C 0.19 0.76 digital rectal thermometry 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 20293 381
Hsd:SD heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait female 87 days-120 days 14 420.32 beats/min 6.65 24.88 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 50924 481
Hsd:SD respiration rate air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 5 162.25 breaths/min 3.91 8.74 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 20175 381
Hsd:SD absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 7 -51.59 mmHg 1.82 4.8 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 20407 381
Hsd:SD absolute change in partial pressure of blood carbon dioxide resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 6 -3.33 mmHg 1.97 4.82 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 17593 381
Hsd:SD body temperature control condition PhysGen Respiratory data body temperature trait male 82 days-99 days 5 36.94 degrees C 0.18 0.4 digital rectal thermometry 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17780 381
Hsd:SD absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 15 -56.79 beats/min 10.91 42.25 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 51574 481
Hsd:SD absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 7 3.42 mmHg 1.85 4.89 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 50342 481
Hsd:SD absolute change in partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 10 2.95 mmHg 1.72 5.45 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 15597 381
Hsd:SD heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 10 427.86 beats/min 13.06 41.31 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 15755 381
Hsd:SD serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 5 9.06 mg/dl 0.61 1.36 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 36295 401
Hsd:SD partial pressure of blood carbon dioxide (Pco2) resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 7 31.35 mmHg 0.83 2.2 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 15987 381
Hsd:SD absolute change in partial pressure of blood carbon dioxide resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 1 -3.55 mmHg stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17196 381
Hsd:SD absolute change in body temperature resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 11 0.55 degrees C 0.17 0.57 digital rectal thermometry 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 18753 381
Hsd:SD mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 5 65.28 fl 1.27 2.84 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 36713 401
Hsd:SD urine albumin excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine albumin amount male 87 days-120 days 22 4.27 mg/d 0.63 2.93 automated urine analysis 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 51687 481
Hsd:SD urine total protein excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data total urine protein amount male 87 days-120 days 22 34.31 mg/d 2.29 10.73 automated urine analysis 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 51810 481
Hsd:SD minute ventilation air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 17 84.38 ml/min 2.59 10.67 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 19314 381
Hsd:SD heart rate control condition PhysGen Respiratory data heart pumping trait female 82 days-99 days 16 415.13 beats/min 13.11 52.42 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 19296 381
Hsd:SD plasma chylomicron and VLDL cholesterol level controlled fat content diet (42 %) (for 364 days) Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. blood cholesterol amount male 448 days 10 29.0 mg/dl 6.0 18.97 blood cholesterol analysis 0.0 0 138464 3201
Hsd:SD time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 3 1082.73 s 172.33 298.49 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45106 461
Hsd:SD percent change in left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 11 post-ischemic value/pre-ischemic value x 100% 65.39 % 8.7 28.85 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 46293 461
Hsd:SD tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 5 0.41 ml 0.03 0.07 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 16032 381
Hsd:SD left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 119.08 mmHg 9.14 25.86 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 47784 461
Hsd:SD arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 2 7.13 ml/min/g 0.64 0.91 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45898 461
Hsd:SD percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 3 post-ischemic value/pre-ischemic value x 100% 73.83 % 5.99 10.38 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47891 461
Hsd:SD arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 9 10.59 ml/min/g 0.65 1.96 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 46019 461
Hsd:SD left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 3 6.54 mmHg 0.24 0.42 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48015 461
Hsd:SD serum bicarbonate level control condition (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 6 23.5 mmol/l 1.82 4.46 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 42864 401
Hsd:SD total white blood cell count control condition (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 8 4.49 x 1000 cells/ul 0.67 1.89 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 43100 401
Hsd:SD concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 17 0.17 10E-7mol/l 0.05 0.22 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 56013 522
Hsd:SD methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 6 30.66 ml/min/kg 2.45 5.99 isolated perfused lung vascular effluent collection 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58430 526
Hsd:SD body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77 days-91 days 8 212.4 g 4.8 13.6 whole body digital scale 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58436 526
Hsd:SD methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 6 20.29 ml/min/kg 1.74 4.27 isolated perfused lung vascular effluent collection 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58466 526
Hsd:SD time to onset of heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 2 482.34 s 0.0 0.0 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49488 461
Hsd:SD blood lymphocyte count control condition (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 8 3.63 x 1000 cells/ul 0.66 1.86 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 38395 401
Hsd:SD hematocrit control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 6 46.82 % 2.16 5.29 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 38514 401
Hsd:SD serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 18 4.34 g/dl 0.07 0.3 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 42965 401
Hsd:SD serum total protein level control condition (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 3 5.93 g/dl 0.18 0.31 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 42970 401
Hsd:SD calculated pulmonary vascular resistance normalized to body weight Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 7 0.07 mmHg x min x kg x ml-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 58860 526
Hsd:SD serum total bilirubin level control condition (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 8 0.34 mg/dl 0.12 0.35 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 41844 401
Hsd:SD heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 11 307.99 beats/min 46.45 154.04 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 48508 461
Hsd:SD sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 14 99.79 % 0.15 0.58 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 57294 522
Hsd:SD red blood cell count control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 6 8.04 x 10E6 cells/ul 0.41 1.0 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 42323 401
Hsd:SD serum total protein level control condition (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 6 6.45 g/dl 0.27 0.67 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 37568 401
Hsd:SD hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 12 50.13 % 5.58 19.33 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 55008 522
Hsd:SD hematocrit control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 1 45.9 % automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 41164 401
Hsd:SD serum total bilirubin level control condition (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 3 0.2 mg/dl 0.0 0.0 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 39329 401
Hsd:SD mean corpuscular volume control condition (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 6 58.33 fl 0.56 1.36 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 39370 401
Hsd:SD both testes wet weight control condition (for 84 days) Harrill JA, et al., Toxicol Appl Pharmacol. 2013 Oct 15;272(2):503-18. doi: 10.1016/j.taap.2013.06.024. Epub 2013 Jul 13. testis mass male 84 days 12 0.99 g 0.01 0.03 post excision weight measurement 0 106488 3025
Hsd:SD tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 17 0.34 ml 0.02 0.06 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 14388 381
Hsd:SD percent change in ventilation air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 14 %change=VE during7-9 min hypercapnia/control during standard conditions 280.76 % 18.92 70.81 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 14419 381
Hsd:SD respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 15 124.46 breaths/min 7.44 28.81 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 15506 381
Hsd:SD partial pressure of blood carbon dioxide (Pco2) control condition PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 13 35.07 mmHg 0.52 1.88 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 15522 381
Hsd:SD partial pressure of blood oxygen resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 8 104.57 mmHg 4.1 11.59 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 15609 381
Hsd:SD partial pressure of blood oxygen resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 12 98.2 mmHg 2.14 7.4 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 15610 381
Hsd:SD minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 17 32.44 ml/min 1.32 5.46 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 15161 381
Hsd:SD percent change in ventilation air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 5 %change=VE during7-9 min hypercapnia/control during standard conditions 271.74 % 45.31 101.31 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15208 381
Hsd:SD body temperature resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 12 38.09 degrees C 0.12 0.4 digital rectal thermometry 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 15486 381
Hsd:SD absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 20 -41.72 beats/min 7.75 34.65 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 51125 481
Hsd:SD absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 14 16.67 beats/min 10.47 39.18 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 50791 481
Hsd:SD absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 7 10.07 beats/min 3.47 9.18 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 50792 481
Hsd:SD absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 20 21.45 mmHg 1.58 7.06 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 51032 481
Hsd:SD absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 20 -8.4 beats/min 8.54 38.19 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 51573 481
Hsd:SD absolute change in heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait female 87 days-120 days 14 8.24 beats/min 8.8 32.91 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 51401 481
Hsd:SD creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data glomerular filtration trait female 87 days-120 days 13 1.09 ml/min 0.1 0.37 urine creatinine analysis 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 51403 481
Hsd:SD absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 19 1.48 beats/min 8.32 36.25 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 50851 481
Hsd:SD absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 15 -19.44 beats/min 7.37 28.54 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 50852 481
Hsd:SD heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 17 383.46 beats/min 6.17 25.44 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 50923 481
Hsd:SD absolute change in heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 1 152.16 beats/min vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17291 381
Hsd:SD respiration rate air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 14 151.05 breaths/min 3.66 13.7 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 17298 381
Hsd:SD respiration rate control condition PhysGen Respiratory data respiratory function trait male 82 days-99 days 5 92.33 breaths/min 12.66 28.31 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17322 381
Hsd:SD blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 1 7.47 null automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14043 381
Hsd:SD absolute change in body temperature air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 16 -0.44 degrees C 0.17 0.68 digital rectal thermometry 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 14053 381
Hsd:SD mean arterial blood pressure air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 7 110.44 mmHg 2.77 7.34 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 13824 381
Hsd:SD percent change in tidal volume air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 17 163.15 % 5.13 21.15 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 53836 381
Hsd:SD body temperature control condition PhysGen Respiratory data body temperature trait male 82 days-99 days 5 37.34 degrees C 0.18 0.4 digital rectal thermometry 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19941 381
Hsd:SD minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 5 69.69 ml/min 4.23 9.46 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19716 381
Hsd:SD percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 15 132.93 % 5.74 22.25 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 53967 381
Hsd:SD serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 3 7.6 mg/dl 1.69 2.92 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 36296 401
Hsd:SD serum sodium level control condition (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 8 141.88 mmol/l 1.43 4.05 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 36340 401
Hsd:SD serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 5 6.16 g/dl 0.19 0.43 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 36342 401
Hsd:SD partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 1 49.35 mmHg automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17006 381
Hsd:SD heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 6 570.06 beats/min 38.43 94.13 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 18982 381
Hsd:SD blood pH resting on treadmill (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 1 7.5 null automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 18985 381
Hsd:SD hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 5 55.2 % 11.56 25.85 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 36283 401
Hsd:SD heart rate control condition PhysGen Respiratory data heart pumping trait male 82 days-99 days 8 415.31 beats/min 4.45 12.59 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 18748 381
Hsd:SD absolute change in blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 1 -0.06 null stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18811 381
Hsd:SD plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data blood creatinine amount female 87 days-120 days 8 0.32 mg/dl 0.01 0.02 radioimmunoassay 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 51809 481
Hsd:SD absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 7 21.95 mmHg 2.41 6.38 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 51861 481
Hsd:SD urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine sodium amount female 87 days-120 days 8 12.02 mEq/d 0.55 1.55 flame atomic emission spectrometry 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 51942 481
Hsd:SD absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 15 -144.07 beats/min 13.19 51.07 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 52073 481
Hsd:SD plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data renin activity female 87 days-120 days 8 5.34 ng/ml/h 0.79 2.24 radioimmunoassay 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 51621 481
Hsd:SD heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait female 87 days-120 days 15 433.67 beats/min 8.21 31.78 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 51678 481
Hsd:SD mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 15 114.94 mmHg 1.51 5.86 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 50334 481
Hsd:SD partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 1 113.25 mmHg automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 14292 381
Hsd:SD partial pressure of blood oxygen control condition PhysGen Respiratory data blood oxygen amount female 82 days-99 days 13 102.6 mmHg 1.99 7.18 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 13533 381
Hsd:SD body weight control condition PhysGen Respiratory data body mass male 82 days-99 days 19 337.6 g 2.9 12.9 whole body digital scale 0 Moms and pups used in studies were fed Dyets 17589 381
Hsd:SD body weight control condition PhysGen Respiratory data body mass female 82 days-99 days 16 222.6 g 2.1 8.6 whole body digital scale 0 Moms and pups used in studies were fed Dyets 17590 381
Hsd:SD absolute change in partial pressure of blood carbon dioxide resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 8 -5.67 mmHg 1.0 2.84 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 17594 381
Hsd:SD plasma anion gap control condition (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 3 16.67 mmol/l 0.88 1.53 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 36849 401
Hsd:SD mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 4 22.58 pg 0.94 1.88 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 36569 401
Hsd:SD mean corpuscular hemoglobin concentration control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 1 32.7 g/dl automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 36582 401
Hsd:SD mean corpuscular hemoglobin concentration control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 3 32.4 g/dl 0.06 0.1 automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 36583 401
Hsd:SD tidal volume air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 5 0.58 ml 0.05 0.12 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18518 381
Hsd:SD minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 15 37.43 ml/min 1.6 6.19 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 19298 381
Hsd:SD minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 15 54.3 ml/min 3.56 13.81 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 19434 381
Hsd:SD absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 5 0.34 degrees C 0.25 0.56 digital rectal thermometry 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19154 381
Hsd:SD left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 6 3.98 mmHg 0.35 0.86 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 49043 461
Hsd:SD respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 5 144.23 breaths/min 7.06 15.79 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18206 381
Hsd:SD blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 6 7.43 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 20557 381
Hsd:SD left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 3 122.27 mmHg 9.19 15.92 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49785 461
Hsd:SD heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 3 0.31 IU/g 0.07 0.12 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49622 461
Hsd:SD time to onset of heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 7 625.0 s 64.18 169.8 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 49647 461
Hsd:SD time to onset of heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 11 634.93 s 62.43 207.07 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 49648 461
Hsd:SD percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 2 post-ischemic value/pre-ischemic value x 100% 84.42 % 22.3 31.54 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49656 461
Hsd:SD serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 3 1.83 g/dl 0.18 0.31 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 38975 401
Hsd:SD blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 15 18.24 g/dl 0.12 0.47 automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 38874 401
Hsd:SD serum globulin level control condition (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 3 2.07 g/dl 0.07 0.12 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 42188 401
Hsd:SD red blood cell count control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 3 7.66 x 10E6 cells/ul 0.11 0.18 automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 42727 401
Hsd:SD blood hemoglobin level control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 8 16.29 g/dl 0.34 0.97 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 42504 401
Hsd:SD blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 4 20.4 g/dl 1.16 2.33 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 39372 401
Hsd:SD plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 18 22.83 mmol/l 0.78 3.33 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 39487 401
Hsd:SD plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 18 0.47 mg/dl 0.03 0.11 automated plasma creatinine analysis 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 39543 401
Hsd:SD total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 15 7.95 x 1000 cells/ul 0.63 2.44 automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 39547 401
Hsd:SD serum bicarbonate level control condition (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 8 26.63 mmol/l 1.03 2.92 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 42863 401
Hsd:SD total white blood cell count control condition (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 6 2.05 x 1000 cells/ul 0.4 0.98 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 43101 401
Hsd:SD serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 18 92.39 mg/dl 4.17 17.69 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 43106 401
Hsd:SD serum bicarbonate level control condition (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 2 24.5 mmol/l 1.5 2.12 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 43110 401
Hsd:SD percent change in respiration rate air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 17 167.82 % 7.23 29.8 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 54531 381
Hsd:SD percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 15 108.45 % 3.59 13.89 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 54568 381
Hsd:SD calculated pulmonary vascular resistance normalized to body weight Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 0.09 mmHg x min x kg x ml-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 58859 526
Hsd:SD hematocrit control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 8 50.46 % 1.07 3.03 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 38513 401
Hsd:SD serum alkaline phosphatase activity level control condition (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 6 93.83 U/l 9.19 22.52 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 38361 401
Hsd:SD serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 3 104.33 mmol/l 1.2 2.08 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 38375 401
Hsd:SD serum total cholesterol level control condition (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 5 109.6 mg/dl 8.05 18.01 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 38377 401
Hsd:SD red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 15 8.92 x 10E6 cells/ul 0.3 1.18 automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 38192 401
Hsd:SD percent change in left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 36.65 % 6.47 17.11 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 46529 461
Hsd:SD heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 8 264.79 beats/min 37.41 105.8 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 46631 461
Hsd:SD heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 13 15.23 % 2.26 8.15 digital scale post excision weight measurement 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 48739 461
Hsd:SD plasma creatinine level control condition (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 2 0.3 mg/dl 0.0 0.0 automated plasma creatinine analysis 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 41848 401
Hsd:SD heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 9 304.18 beats/min 25.52 76.55 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 46632 461
Hsd:SD sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 16 99.63 % 0.18 0.72 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 57448 522
Hsd:SD fractional change in blood vessel diameter per unit change in intravascular pressure Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 8 0.1 mmHg-1 0.01 0.04 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 57761 526
Hsd:SD methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 6 10.22 ml/min/kg 0.81 1.99 isolated perfused lung vascular effluent collection 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 57783 526
Hsd:SD dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 8 1.52 mg/kg 0.29 0.81 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 57982 526
Hsd:SD acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 10 69.0 % 6.69 21.17 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 55730 522
Hsd:SD acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 14 85.5 % 4.86 18.18 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 55731 522
Hsd:SD body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77 days-91 days 7 323.6 g 4.5 12.0 whole body digital scale 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58434 526
Hsd:SD methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 5 0.95 null 0.07 0.16 isolated perfused lung vascular effluent collection 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 58438 526
Hsd:SD dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 7 1.61 mg/kg 0.31 0.83 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58881 526
Hsd:SD lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 7 1.03 g/kg 0.02 0.05 digital scale post excision weight measurement 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58703 526
Hsd:SD calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 7 0.11 mmHg x min x kg x ml-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58711 526
Hsd:SD hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 12 63.35 % 6.53 22.63 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 56761 522
Hsd:SD hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 13 48.4 % 6.98 25.18 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 56887 522
Hsd:SD blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 12 7.5 null 0.0 0.02 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17455 381
Hsd:SD left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 11 109.91 mmHg 7.73 25.64 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 45885 461
Hsd:SD arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 11 12.69 ml/min/g 1.22 4.04 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 45053 461
Hsd:SD arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 3 9.7 ml/min/g 0.85 1.47 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45090 461
Hsd:SD arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 3 11.22 ml/min/g 1.24 2.14 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 46155 461
Hsd:SD percent change in left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 3 post-ischemic value/pre-ischemic value x 100% 100.78 % 8.56 14.83 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 46167 461
Hsd:SD percent change in left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 2 post-ischemic value/pre-ischemic value x 100% 98.44 % 5.28 7.47 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 46171 461
Hsd:SD time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 2 90.87 s 18.17 25.7 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48123 461
Hsd:SD left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 3 6.66 mmHg 0.17 0.3 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48161 461
Hsd:SD left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 2 58.96 mmHg 6.17 8.73 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47412 461
Hsd:SD percent change in heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 75.04 % 12.04 31.86 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 47417 461
Hsd:SD left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 11 35.73 mmHg 8.44 28.0 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 48390 461
Hsd:SD serum alanine aminotransferase activity level fasting (between 12 and 15 hours) then acetaminophen (2 g/kg) (for 1 days) McGill MR, et al., Toxicol Appl Pharmacol. 2012 Nov 1;264(3):387-94. doi: 10.1016/j.taap.2012.08.015. Epub 2012 Aug 23. blood alanine transaminase amount not specified 56 days-84 days 4 31.0 U/l 4.0 8.0 spectrophotometry 0.0 0 84759 1601
Hsd:SD auditory brainstem response threshold cisplatin (15 mg/kg) Sagit M, et al., Eur Arch Otorhinolaryngol. 2013 Aug;270(8):2231-7. doi: 10.1007/s00405-012-2254-6. Epub 2012 Nov 17. hearing electrophysiology trait female 173 days 10 49.5 dBnHL 6.28 19.86 evoked response audiometry 0.0 0 C post 75930 1541
Hsd:SD thymus weight to body weight ratio 2,3,7,8-tetrachlorodibenzo-p-dioxin (100 ng/kg/d) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. thymus mass female 84 days 10 1.29 mg/g 0.23 0.73 post excision weight measurement 0 105890 3021
Hsd:SD spleen weight to body weight ratio 2,3,7,8-tetrachlorodibenzo-p-dioxin (300 ng/kg/d) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. spleen mass female 84 days 10 0.28 % 0.02 0.07 post excision weight measurement 0 105904 3021
Hsd:SD brain weight to body weight ratio 2,3,7,8-tetrachlorodibenzo-p-dioxin (1000 ng/kg/d) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. brain mass female 84 days 10 0.84 % 0.05 0.16 post excision weight measurement 0 105918 3021
Hsd:SD both ovaries weight to body weight ratio vehicle control condition (5 ml/kg) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. ovary mass female 84 days 10 0.05 % 0.01 0.03 post excision weight measurement 0 105920 3021
Hsd:SD blood neutrophil count vehicle control condition (5 ml/kg) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. neutrophil quantity female 84 days 10 1.48 x 1000 cells/ul 0.85 2.69 automated hematology analysis 0 106028 3021
Hsd:SD blood neutrophil count 2,3,7,8-tetrachlorodibenzo-p-dioxin (100 ng/kg/d) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. neutrophil quantity female 84 days 10 1.16 x 1000 cells/ul 0.26 0.82 automated hematology analysis 0 106034 3021
Hsd:SD blood neutrophil count 2,3,7,8-tetrachlorodibenzo-p-dioxin (300 ng/kg/d) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. neutrophil quantity female 84 days 10 1.62 x 1000 cells/ul 1.38 4.36 automated hematology analysis 0 106036 3021
Hsd:SD blood lymphocyte count 2,3,7,8-tetrachlorodibenzo-p-dioxin (3 ng/kg/d) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. lymphocyte quantity female 84 days 10 7.88 x 1000 cells/ul 1.29 4.08 automated hematology analysis 0 106042 3021
Hsd:SD blood monocyte count 2,3,7,8-tetrachlorodibenzo-p-dioxin (100 ng/kg/d) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. monocyte quantity female 84 days 10 0.27 x 1000 cells/ul 0.05 0.16 automated hematology analysis 0 106058 3021
Hsd:SD serum creatinine level control condition (for 84 days) Harrill JA, et al., Toxicol Appl Pharmacol. 2013 Oct 15;272(2):503-18. doi: 10.1016/j.taap.2013.06.024. Epub 2013 Jul 13. blood creatinine amount male 84 days 5 0.3 mg/dl 0.0 0.0 automated serum analysis 0 106410 3025
Hsd:SD serum creatinine level control condition (for 84 days) Harrill JA, et al., Toxicol Appl Pharmacol. 2013 Oct 15;272(2):503-18. doi: 10.1016/j.taap.2013.06.024. Epub 2013 Jul 13. blood creatinine amount female 84 days 5 0.34 mg/dl 0.05 0.11 automated serum analysis 0 106412 3025
Hsd:SD serum sodium level control condition (for 84 days) Harrill JA, et al., Toxicol Appl Pharmacol. 2013 Oct 15;272(2):503-18. doi: 10.1016/j.taap.2013.06.024. Epub 2013 Jul 13. blood sodium amount male 84 days 5 149.4 mmol/l 1.5 3.35 automated serum analysis 0 106418 3025
Hsd:SD serum phosphate level control condition (for 84 days) Harrill JA, et al., Toxicol Appl Pharmacol. 2013 Oct 15;272(2):503-18. doi: 10.1016/j.taap.2013.06.024. Epub 2013 Jul 13. blood phosphate amount female 84 days 5 12.6 mg/dl 3.0 6.71 automated serum analysis 0 106436 3025
Hsd:SD heart weight control condition (for 84 days) Harrill JA, et al., Toxicol Appl Pharmacol. 2013 Oct 15;272(2):503-18. doi: 10.1016/j.taap.2013.06.024. Epub 2013 Jul 13. heart mass male 84 days 5 0.38 g 0.02 0.04 post excision weight measurement 0 106450 3025
Hsd:SD lung weight control condition (for 84 days) Harrill JA, et al., Toxicol Appl Pharmacol. 2013 Oct 15;272(2):503-18. doi: 10.1016/j.taap.2013.06.024. Epub 2013 Jul 13. lung mass male 84 days 5 0.59 g 0.11 0.25 post excision weight measurement 0 106470 3025
Hsd:SD lung weight control condition (for 84 days) Harrill JA, et al., Toxicol Appl Pharmacol. 2013 Oct 15;272(2):503-18. doi: 10.1016/j.taap.2013.06.024. Epub 2013 Jul 13. lung mass female 84 days 5 0.73 g 0.13 0.29 post excision weight measurement 0 106472 3025
Hsd:SD adrenal gland weight control condition (for 84 days) Harrill JA, et al., Toxicol Appl Pharmacol. 2013 Oct 15;272(2):503-18. doi: 10.1016/j.taap.2013.06.024. Epub 2013 Jul 13. adrenal gland mass female 84 days 5 26.0 mg 2.0 4.47 post excision weight measurement 0 106480 3025
Hsd:SD both ovaries weight to body weight ratio 2,3,7,8-tetrachlorodibenzo-p-dioxin (300 ng/kg/d) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. ovary mass female 84 days 10 0.04 % 0.01 0.04 post excision weight measurement 0 105928 3021
Hsd:SD red blood cell count 2,3,7,8-tetrachlorodibenzo-p-dioxin (300 ng/kg/d) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. erythrocyte quantity female 84 days 10 8.21 x 10E6 cells/ul 0.32 1.01 automated hematology analysis 0 105940 3021
Hsd:SD blood hemoglobin level 2,3,7,8-tetrachlorodibenzo-p-dioxin (300 ng/kg/d) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. blood hemoglobin amount female 84 days 10 14.68 g/dl 0.58 1.83 automated hematology analysis 0 105952 3021
Hsd:SD hematocrit vehicle control condition (5 ml/kg) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. erythrocyte quantity female 84 days 10 43.31 % 1.49 4.71 automated hematology analysis 0 105956 3021
Hsd:SD mean corpuscular volume vehicle control condition (5 ml/kg) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. erythrocyte size trait female 84 days 10 57.96 fl 1.26 3.98 automated hematology analysis 0 105968 3021
Hsd:SD mean corpuscular volume 2,3,7,8-tetrachlorodibenzo-p-dioxin (22 ng/kg/d) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. erythrocyte size trait female 84 days 10 57.82 fl 1.25 3.95 automated hematology analysis 0 105972 3021
Hsd:SD mean corpuscular volume 2,3,7,8-tetrachlorodibenzo-p-dioxin (100 ng/kg/d) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. erythrocyte size trait female 84 days 10 56.27 fl 1.81 5.72 automated hematology analysis 0 105974 3021
Hsd:SD mean corpuscular volume 2,3,7,8-tetrachlorodibenzo-p-dioxin (300 ng/kg/d) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. erythrocyte size trait female 84 days 10 54.57 fl 0.91 2.88 automated hematology analysis 0 105976 3021
Hsd:SD mean corpuscular hemoglobin 2,3,7,8-tetrachlorodibenzo-p-dioxin (3 ng/kg/d) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. blood hemoglobin amount female 84 days 10 18.71 pg 0.44 1.39 automated hematology analysis 0 105982 3021
Hsd:SD mean corpuscular hemoglobin 2,3,7,8-tetrachlorodibenzo-p-dioxin (22 ng/kg/d) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. blood hemoglobin amount female 84 days 10 18.61 pg 0.78 2.47 automated hematology analysis 0 105984 3021
Hsd:SD mean corpuscular hemoglobin 2,3,7,8-tetrachlorodibenzo-p-dioxin (1000 ng/kg/d) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. blood hemoglobin amount female 84 days 10 17.22 pg 0.59 1.87 automated hematology analysis 0 105990 3021
Hsd:SD photopic B wave amplitude of ERG waveform gene transfer of the rat MER proto-oncogene, tyrosine kinase gene using an adenovirus vector (4 x 10E8 vg) then controlled visible light condition (30 cd x s/m2) then visible light stimulus (12 cd/m2) Conlon TJ, et al., Hum Gene Ther Clin Dev. 2013 Mar;24(1):23-8. doi: 10.1089/humc.2013.037. Epub 2013 Apr 3. cone electrophysiology trait both 0 days 9 59.0 uV electroretinography cornea 0.0 subretinal injection 30 days photopic b-wave ERG 108650 3128
Hsd:SD scotopic B wave amplitude of ERG waveform gene transfer of the rat MER proto-oncogene, tyrosine kinase gene using an adenovirus vector (4 x 10E8 vg) then controlled exposure to darkness (for 12 hours) then visible light stimulus (5 cd/m2) Conlon TJ, et al., Hum Gene Ther Clin Dev. 2013 Mar;24(1):23-8. doi: 10.1089/humc.2013.037. Epub 2013 Apr 3. rod electrophysiology trait both 0 days 9 387.0 uV electroretinography cornea 0.0 subretinal injection 30 days scotopic b-wave ERG 108646 3128
Hsd:SD photopic B wave amplitude of ERG waveform vehicle control condition (2 ul) then controlled visible light condition (30 cd x s/m2) then visible light stimulus (12 cd/m2) Conlon TJ, et al., Hum Gene Ther Clin Dev. 2013 Mar;24(1):23-8. doi: 10.1089/humc.2013.037. Epub 2013 Apr 3. cone electrophysiology trait both 0 days 4 51.0 uV electroretinography cornea 0.0 subretinal injection 30 days photopic b-wave ERG 108644 3128
Hsd:SD plasma leptin level standard diet Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. blood leptin amount male 448 days 9 9.83 ng/ml 0.68 2.04 enzyme linked immunosorbent assay 0.0 0 138314 3201
Hsd:SD plasma free fatty acids level controlled fat content diet (42 %) (for 364 days) Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. blood free fatty acid amount male 448 days 10 1.23 mmol/l 0.15 0.47 plasma free fatty acid analysis 0.0 0 138324 3201
Hsd:SD plasma high density lipoprotein cholesterol level controlled fat content diet (42 %) (for 364 days) Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. blood cholesterol amount male 448 days 10 54.0 mg/dl 5.0 15.81 blood cholesterol analysis 0.0 0 138328 3201
Hsd:SD plasma total protein level controlled fat content diet (42 %) (for 364 days) Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. blood total protein amount male 448 days 10 89.7 mg/ml 3.9 12.33 automated plasma total protein analysis 0.0 0 138281 3201
Hsd:SD blood high density lipoprotein particle diameter control condition Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. blood HDL particle size male 448 days 9 11.6 nm 0.3 0.9 nuclear magnetic resonance spectroscopy 0.0 0 138338 3201
Hsd:SD liver triglyceride level standard diet Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. liver triglyceride amount male 448 days 9 13.12 mg/g 1.35 4.05 isolated tissue triglyceride measurement test 0.0 0 138346 3201
Hsd:SD minute ventilation air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 17 80.3 ml/min 2.89 11.93 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 20000 381
Hsd:SD blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 1 7.44 null automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 20848 381
Hsd:SD absolute change in mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 7 2.34 mmHg 3.47 9.17 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 20445 381
Hsd:SD absolute change in heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 6 112.66 beats/min 38.45 94.19 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 17965 381
Hsd:SD creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data glomerular filtration trait male 87 days-120 days 9 1.85 ml/min 0.15 0.44 urine creatinine analysis 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 51402 481
Hsd:SD absolute change in blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 7 0.0 null 0.01 0.01 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 15753 381
Hsd:SD mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 12 114.44 mmHg 1.98 6.87 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 51788 481
Hsd:SD blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 10 7.46 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14098 381
Hsd:SD plasma IDL and LDL cholesterol controlled fat content diet (42 %) (for 364 days) Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. blood cholesterol amount male 448 days 10 139.0 mg/dl 12.0 37.95 blood cholesterol analysis 0.0 0 138465 3201
Hsd:SD heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 3 0.89 IU/g 0.61 1.06 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47177 461
Hsd:SD left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 7 5.57 mmHg 0.9 2.37 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 48168 461
Hsd:SD heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 9 0.28 IU/g 0.06 0.17 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 45131 461
Hsd:SD left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 7 35.12 mmHg 6.77 17.91 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 48389 461
Hsd:SD left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 2 133.65 mmHg 12.39 17.52 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47669 461
Hsd:SD left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 6 103.8 mmHg 8.42 20.62 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 45884 461
Hsd:SD arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 3 8.8 ml/min/g 1.15 1.99 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45894 461
Hsd:SD left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 3 65.05 mmHg 23.59 40.86 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45906 461
Hsd:SD arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 7.09 ml/min/g 0.94 2.97 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 46842 461
Hsd:SD red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 16 9.08 x 10E6 cells/ul 0.18 0.71 automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 38194 401
Hsd:SD serum total cholesterol level control condition (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 3 105.0 mg/dl 7.94 13.75 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 38728 401
Hsd:SD serum total cholesterol level control condition (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 7 88.43 mg/dl 4.58 12.11 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 38376 401
Hsd:SD total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 4 2.08 x 1000 cells/ul 0.47 0.94 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 41733 401
Hsd:SD percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 15 137.4 % 6.97 26.99 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 53541 381
Hsd:SD heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 3 63.33 mmHg 11.57 20.03 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49592 461
Hsd:SD serum chloride level control condition (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 3 100.67 mmol/l 0.88 1.53 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 39863 401
Hsd:SD left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 2 140.09 mmHg 12.52 17.7 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49805 461
Hsd:SD left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 56.3 mmHg 4.75 15.02 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 46532 461
Hsd:SD dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 7 1.75 mg/kg 0.34 0.89 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 58592 526
Hsd:SD body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77 days-91 days 8 317.5 g 3.7 10.4 whole body digital scale 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 58597 526
Hsd:SD heart left ventricle infarction weight to total heart left ventricle weight ratio controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 12 17.71 % 3.01 10.42 digital scale post excision weight measurement 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 50103 461
Hsd:SD heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 11 0.24 IU/g 0.04 0.12 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 48707 461
Hsd:SD hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 7 53.57 % 1.73 4.57 microhematocrit tube assay with visual assessment 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 58816 526
Hsd:SD blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 16 4.77 x 1000 cells/ul 0.4 1.59 automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 40515 401
Hsd:SD logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 16 -7.54 null 0.06 0.26 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 55246 522
Hsd:SD serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 16 54.13 U/l 5.89 23.57 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 42342 401
Hsd:SD serum aspartate aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 3 106.33 U/l 5.33 9.24 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 42391 401
Hsd:SD logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 13 -7.33 null 0.11 0.38 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 56491 522
Hsd:SD serum alkaline phosphatase activity level control condition (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 2 186.0 U/l 54.0 76.37 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 37538 401
Hsd:SD hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 7 57.83 % 0.47 1.24 microhematocrit tube assay with visual assessment 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 57777 526
Hsd:SD concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 14 0.09 umol/l 0.02 0.08 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 56835 522
Hsd:SD acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 19 84.63 % 3.67 16.01 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 56807 522
Hsd:SD methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 7 0.87 null 0.06 0.16 isolated perfused lung vascular effluent collection 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 59742 526
Hsd:SD blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 15 0.41 x 1000 cells/ul 0.08 0.32 automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 39535 401
Hsd:SD serum total protein level control condition (for 84 days) Harrill JA, et al., Toxicol Appl Pharmacol. 2013 Oct 15;272(2):503-18. doi: 10.1016/j.taap.2013.06.024. Epub 2013 Jul 13. blood total protein amount female 84 days 5 67.0 g/dl 3.0 6.71 automated serum analysis 0 106384 3025
Hsd:SD brain weight control condition (for 84 days) Harrill JA, et al., Toxicol Appl Pharmacol. 2013 Oct 15;272(2):503-18. doi: 10.1016/j.taap.2013.06.024. Epub 2013 Jul 13. brain mass male 84 days 5 0.48 g 0.02 0.04 post excision weight measurement 0 106466 3025
Hsd:SD blood lymphocyte count vehicle control condition (5 ml/kg) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. lymphocyte quantity female 84 days 10 7.36 x 1000 cells/ul 1.77 5.6 automated hematology analysis 0 106040 3021
Hsd:SD blood basophil count vehicle control condition (5 ml/kg) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. basophil quantity female 84 days 10 0.07 x 1000 cells/ul 0.03 0.09 automated hematology analysis 0 106076 3021
Hsd:SD thymus weight to body weight ratio 2,3,7,8-tetrachlorodibenzo-p-dioxin (1000 ng/kg/d) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. thymus mass female 84 days 10 0.65 mg/g 0.18 0.57 post excision weight measurement 0 105894 3021
Hsd:SD spleen weight to body weight ratio 2,3,7,8-tetrachlorodibenzo-p-dioxin (100 ng/kg/d) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. spleen mass female 84 days 10 0.28 % 0.03 0.09 post excision weight measurement 0 105902 3021
Hsd:SD brain weight to body weight ratio 2,3,7,8-tetrachlorodibenzo-p-dioxin (100 ng/kg/d) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. brain mass female 84 days 10 0.77 % 0.05 0.15 post excision weight measurement 0 105914 3021
Hsd:SD hematocrit 2,3,7,8-tetrachlorodibenzo-p-dioxin (22 ng/kg/d) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. erythrocyte quantity female 84 days 10 44.42 % 1.74 5.5 automated hematology analysis 0 105960 3021
Hsd:SD liver weight as percentage of body weight vehicle control condition (5 ml/kg) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. liver mass female 84 days 10 3.65 % 0.2 0.63 post excision weight measurement 0.0 0 105720 3021
Hsd:SD plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data blood creatinine amount male 87 days-120 days 7 0.33 mg/dl 0.01 0.02 radioimmunoassay 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 51808 481
Hsd:SD urine total protein excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data total urine protein amount female 87 days-120 days 16 23.01 mg/d 3.28 13.12 automated urine analysis 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 51811 481
Hsd:SD tidal volume air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 14 0.5 ml 0.02 0.07 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 14911 381
Hsd:SD absolute change in heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 12 20.86 beats/min 10.81 37.45 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 51400 481
Hsd:SD heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 14 394.94 beats/min 8.93 33.43 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 50956 481
Hsd:SD absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 12 -0.36 mmHg 1.59 5.52 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 51000 481
Hsd:SD absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 15 33.82 mmHg 2.59 10.04 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 51033 481
Hsd:SD heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 12 397.17 beats/min 12.82 44.43 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 50814 481
Hsd:SD heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait female 87 days-120 days 14 428.56 beats/min 6.77 25.34 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 50815 481
Hsd:SD absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 7 -31.59 beats/min 11.86 31.37 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 50848 481
Hsd:SD plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity male 87 days-120 days 8 6.46 ng/ml/h 0.58 1.64 radioimmunoassay 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 50895 481
Hsd:SD absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 15 -100.68 beats/min 11.02 42.68 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 51126 481
Hsd:SD mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 14 121.87 mmHg 1.99 7.45 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 51300 481
Hsd:SD absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 20 9.53 mmHg 1.49 6.66 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 51479 481
Hsd:SD percent change in tidal volume air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 5 138.54 % 6.31 14.11 stop flow air displacement plethysmography 0 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54186 381
Hsd:SD mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 2 115.72 mmHg 14.37 20.32 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 13876 381
Hsd:SD percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 15 %change=VE during 2-3 min hypoxia/control during standard conditions 149.54 % 7.3 28.27 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 13898 381
Hsd:SD tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 5 0.48 ml 0.02 0.04 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 14008 381
Hsd:SD absolute change in partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 1 7.2 mmHg stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 14056 381
Hsd:SD partial pressure of blood oxygen control condition PhysGen Respiratory data blood oxygen amount male 82 days-99 days 1 99.75 mmHg automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 14075 381
Hsd:SD partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 7 48.46 mmHg 1.59 4.2 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 17311 381
Hsd:SD partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 12 54.19 mmHg 0.97 3.35 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 17312 381
Hsd:SD absolute change in mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 1 16.06 mmHg vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 20103 381
Hsd:SD absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 12 0.07 null 0.0 0.02 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 20697 381
Hsd:SD body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 5 37.68 degrees C 0.32 0.73 digital rectal thermometry 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19990 381
Hsd:SD heart rate control condition PhysGen Respiratory data heart pumping trait female 82 days-99 days 12 467.01 beats/min 10.73 37.15 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 18749 381
Hsd:SD respiration rate control condition PhysGen Respiratory data respiratory function trait female 82 days-99 days 15 77.15 breaths/min 3.51 13.6 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 16996 381
Hsd:SD percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 15 %change=VE during7-9 min hypoxia/control during standard conditions 141.14 % 5.99 23.18 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 17018 381
Hsd:SD absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 7 -8.6 mmHg 1.68 4.44 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 18817 381
Hsd:SD body temperature resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 11 38.66 degrees C 0.18 0.61 digital rectal thermometry 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 18981 381
Hsd:SD serum urea nitrogen level control condition (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 8 24.38 mg/dl 0.73 2.07 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 37063 401
Hsd:SD mean corpuscular hemoglobin control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 1 19.6 pg automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 37079 401
Hsd:SD percent change in ventilation air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 14 %change=VE during 2-3 min hypercapnia/control during standard conditions 303.96 % 15.31 57.28 stop flow air displacement plethysmography 0 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 14643 381
Hsd:SD partial pressure of blood carbon dioxide (Pco2) resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 1 25.85 mmHg automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15624 381
Hsd:SD heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 16 425.19 beats/min 13.38 53.54 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 15756 381
Hsd:SD tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 14 0.3 ml 0.02 0.06 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 14389 381
Hsd:SD body temperature air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 16 37.67 degrees C 0.11 0.45 digital rectal thermometry 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 14409 381
Hsd:SD absolute change in mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 9 10.56 mmHg 2.75 8.24 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 15482 381
Hsd:SD plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data renin activity male 87 days-120 days 5 1.65 ng/ml/h 0.44 0.98 radioimmunoassay 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 51620 481
Hsd:SD mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 20 124.48 mmHg 1.9 8.48 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 50333 481
Hsd:SD absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 15 8.67 mmHg 1.66 6.43 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 50499 481
Hsd:SD absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 7 2.74 mmHg 2.53 6.7 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 50501 481
Hsd:SD partial pressure of blood oxygen control condition PhysGen Respiratory data blood oxygen amount male 82 days-99 days 8 100.53 mmHg 2.05 5.8 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 13532 381
Hsd:SD mean arterial blood pressure air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 3 118.12 mmHg 6.17 10.69 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 13449 381
Hsd:SD absolute change in mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 1 7.43 mmHg vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 14285 381
Hsd:SD partial pressure of blood carbon dioxide (Pco2) resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 6 29.73 mmHg 1.25 3.07 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 14138 381
Hsd:SD heart rate control condition PhysGen Respiratory data heart pumping trait male 82 days-99 days 2 405.93 beats/min 20.9 29.55 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19538 381
Hsd:SD absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 18 -0.47 degrees C 0.26 1.12 digital rectal thermometry 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 20671 381
Hsd:SD absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 16 -0.86 degrees C 0.24 0.97 digital rectal thermometry 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 20672 381
Hsd:SD respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 15 121.58 breaths/min 8.14 31.52 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 17932 381
Hsd:SD respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 15 101.13 breaths/min 4.32 16.73 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 17933 381
Hsd:SD absolute change in heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 8 86.45 beats/min 20.26 57.3 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 17966 381
Hsd:SD mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 5 20.48 pg 0.82 1.84 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 36568 401
Hsd:SD serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 16 17.38 mmol/l 0.64 2.55 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 36587 401
Hsd:SD serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 16 141.94 mmol/l 0.48 1.91 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 36593 401
Hsd:SD serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 16 6.31 g/dl 0.11 0.43 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 37408 401
Hsd:SD serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 18 6.63 g/dl 0.12 0.51 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 37410 401
Hsd:SD serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 16 221.0 U/l 15.8 63.19 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 37278 401
Hsd:SD blood lymphocyte count control condition (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 3 3.95 x 1000 cells/ul 0.26 0.45 automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 36842 401
Hsd:SD heart rate control condition PhysGen Respiratory data heart pumping trait male 82 days-99 days 9 416.89 beats/min 17.44 52.31 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 19295 381
Hsd:SD blood pH resting on treadmill (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 8 7.47 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 19312 381
Hsd:SD minute ventilation air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 14 76.03 ml/min 3.76 14.07 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 19315 381
Hsd:SD blood pH control condition PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 1 7.47 null automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19317 381
Hsd:SD respiration rate control condition PhysGen Respiratory data respiratory function trait male 82 days-99 days 5 98.87 breaths/min 13.75 30.75 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18155 381
Hsd:SD mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 4 65.2 fl 0.92 1.83 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 36714 401
Hsd:SD serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 18 9.51 mg/dl 0.06 0.27 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 36731 401
Hsd:SD heart wet weight control condition PhysGen Cardiac data heart mass male 49 days-63 days 9 1.6 g 0.1 0.31 digital scale post excision weight measurement 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 49153 461
Hsd:SD heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 3 0.33 IU/g 0.14 0.24 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49620 461
Hsd:SD left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 11 75.82 mmHg 11.61 38.5 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 49646 461
Hsd:SD left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 124.98 mmHg 8.52 24.1 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 49649 461
Hsd:SD heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 3 316.28 beats/min 18.91 32.76 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49979 461
Hsd:SD serum globulin level control condition (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 2 2.1 g/dl 0.1 0.14 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 42187 401
Hsd:SD serum glucose level control condition (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 3 150.67 mg/dl 8.29 14.36 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 38847 401
Hsd:SD serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 5 20.4 mmol/l 1.12 2.51 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 42338 401
Hsd:SD blood neutrophil count control condition (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 8 0.55 x 1000 cells/ul 0.05 0.15 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 39479 401
Hsd:SD serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 16 4.46 mmol/l 0.13 0.53 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 39333 401
Hsd:SD serum urea nitrogen level control condition (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 2 16.0 mg/dl 2.0 2.83 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 42497 401
Hsd:SD blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 5 17.64 g/dl 3.77 8.42 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 39371 401
Hsd:SD mean corpuscular hemoglobin control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 8 18.98 pg 0.6 1.69 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 39865 401
Hsd:SD percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 5 163.4 % 14.9 33.32 stop flow air displacement plethysmography 0 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54525 381
Hsd:SD percent change in respiration rate air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 14 184.26 % 9.13 34.18 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 54530 381
Hsd:SD serum bicarbonate level control condition (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 3 23.33 mmol/l 0.88 1.53 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 43111 401
Hsd:SD blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 15 1.0 x 1000 cells/ul 0.13 0.49 automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 43407 401
Hsd:SD blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 16 0.8 x 1000 cells/ul 0.12 0.49 automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 43409 401
Hsd:SD plasma creatinine level control condition (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 8 0.56 mg/dl 0.04 0.11 automated plasma creatinine analysis 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 43307 401
Hsd:SD FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 6 39.48 ml/min/kg 5.03 12.33 isolated perfused lung vascular effluent collection 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 59029 526
Hsd:SD percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 15 118.15 % 4.62 17.89 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 53570 381
Hsd:SD serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 5 0.34 mg/dl 0.02 0.05 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 37577 401
Hsd:SD serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 16 2.26 g/dl 0.08 0.34 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 40497 401
Hsd:SD serum phosphate level control condition (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 2 8.25 mg/dl 0.25 0.35 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 37923 401
Hsd:SD mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 15 32.08 g/dl 0.12 0.46 automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 41117 401
Hsd:SD mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 16 31.77 g/dl 0.16 0.64 automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 41119 401
Hsd:SD mean corpuscular volume control condition (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 1 60.1 fl automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 41149 401
Hsd:SD serum glucose level control condition (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 5 175.2 mg/dl 25.18 56.31 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 41153 401
Hsd:SD blood monocyte count control condition (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 3 0.29 x 1000 cells/ul 0.11 0.18 automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 41174 401
Hsd:SD blood neutrophil count control condition (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 1 0.63 x 1000 cells/ul automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 37950 401
Hsd:SD serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 3 141.0 mmol/l 2.52 4.36 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 37786 401
Hsd:SD mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 15 61.77 fl 0.65 2.53 automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 37799 401
Hsd:SD blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 4 0.06 x 1000 cells/ul 0.03 0.06 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 41609 401
Hsd:SD serum calcium level control condition (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 8 10.33 mg/dl 0.23 0.66 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 38397 401
Hsd:SD serum albumin level control condition (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 6 4.28 g/dl 0.18 0.44 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 38512 401
Hsd:SD total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 5 2.4 x 1000 cells/ul 0.54 1.21 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 41732 401
Hsd:SD blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 4 0.5 x 1000 cells/ul 0.06 0.12 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 41831 401
Hsd:SD left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 63.36 mmHg 7.08 20.02 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 46531 461
Hsd:SD serum total cholesterol level control condition (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 2 104.5 mg/dl 4.5 6.36 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 38727 401
Hsd:SD FAPGG metabolism-surface area product FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 7 13.9 ml/min/kg 1.19 3.15 isolated perfused lung vascular effluent collection 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 57729 526
Hsd:SD logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 16 -7.49 null 0.05 0.22 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 55247 522
Hsd:SD methylene blue to FAPGG metabolism-surface area product ratio methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 7 1.05 null 0.09 0.23 isolated perfused lung vascular effluent collection 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 57566 526
Hsd:SD mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 16 116.49 mmHg 5.67 22.69 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 16118 381
Hsd:SD heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 10 539.93 beats/min 9.38 29.66 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 16120 381
Hsd:SD concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 16 0.33 10E-7mol/l 0.05 0.19 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 55502 522
Hsd:SD heart rate resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 1 314.01 beats/min vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 16428 381
Hsd:SD body weight control condition PhysGen Respiratory data body mass male 82 days-99 days 10 289.3 g 3.9 12.5 whole body digital scale 0 Moms and pups used in studies were fed Dyets 16787 381
Hsd:SD heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 7 0.38 null 0.02 0.05 digital scale post excision weight measurement 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58316 526
Hsd:SD lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 8 1.02 g/kg 0.03 0.09 digital scale post excision weight measurement 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 58196 526
Hsd:SD body weight control condition (for 14 days) PhysGen Lung data body mass female 77 days-91 days 8 218.8 g 3.5 9.9 whole body digital scale 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 58205 526
Hsd:SD hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 12 57.76 % 6.61 22.89 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 56257 522
Hsd:SD concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 10 2.97 E-7mole 0.71 2.23 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 56211 522
Hsd:SD body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77 days-91 days 6 216.7 g 8.0 19.7 whole body digital scale 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 58598 526
Hsd:SD methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 6 14.43 ml/min/kg 0.99 2.42 isolated perfused lung vascular effluent collection 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 58707 526
Hsd:SD calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 6 0.1 mmHg x min x kg x ml-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58713 526
Hsd:SD concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 19 0.83 E-7mole 0.17 0.76 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 56726 522
Hsd:SD acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 14 82.29 % 3.52 13.16 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 56806 522
Hsd:SD lung dry weight to body weight ratio control condition (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 8 0.87 g/kg 0.03 0.08 digital scale post excision weight measurement 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 60094 526
Hsd:SD hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 15 46.28 % 5.65 21.87 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 56886 522
Hsd:SD logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 10 -6.62 null 0.09 0.29 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 57193 522
Hsd:SD concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 13 0.06 umol/l 0.02 0.05 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 57195 522
Hsd:SD absolute change in partial pressure of blood carbon dioxide resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 1 -6.6 mmHg stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17461 381
Hsd:SD left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 11 114.64 mmHg 7.73 25.63 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 44702 461
Hsd:SD arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 9 6.32 ml/min/g 0.41 1.23 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 46853 461
Hsd:SD arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 12 11.48 ml/min/g 0.81 2.81 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 46020 461
Hsd:SD left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 3 121.65 mmHg 4.83 8.37 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45019 461
Hsd:SD left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 2 129.89 mmHg 1.22 1.72 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45023 461
Hsd:SD time to peak heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 7 855.83 s 59.11 156.4 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 45026 461
Hsd:SD time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 3 102.04 s 0.0 0.0 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48127 461
Hsd:SD left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 5.2 mmHg 0.29 0.92 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 48169 461
Hsd:SD percent change in left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 75.21 % 11.82 31.26 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 46292 461
Hsd:SD arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 2 10.98 ml/min/g 0.1 0.13 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 46159 461
Hsd:SD prostate gland weight control condition (for 84 days) Harrill JA, et al., Toxicol Appl Pharmacol. 2013 Oct 15;272(2):503-18. doi: 10.1016/j.taap.2013.06.024. Epub 2013 Jul 13. prostate mass male 84 days 12 0.25 g 0.04 0.14 post excision weight measurement 0 106492 3025
Hsd:SD serum aspartate aminotransferase activity level control condition (for 84 days) Harrill JA, et al., Toxicol Appl Pharmacol. 2013 Oct 15;272(2):503-18. doi: 10.1016/j.taap.2013.06.024. Epub 2013 Jul 13. blood aspartate transaminase amount male 84 days 5 156.2 U/l 18.1 40.47 automated serum analysis 0 106366 3025
Hsd:SD serum aspartate aminotransferase activity level control condition (for 84 days) Harrill JA, et al., Toxicol Appl Pharmacol. 2013 Oct 15;272(2):503-18. doi: 10.1016/j.taap.2013.06.024. Epub 2013 Jul 13. blood aspartate transaminase amount female 84 days 5 134.2 U/l 13.2 29.52 automated serum analysis 0 106368 3025
Hsd:SD serum total protein level control condition (for 84 days) Harrill JA, et al., Toxicol Appl Pharmacol. 2013 Oct 15;272(2):503-18. doi: 10.1016/j.taap.2013.06.024. Epub 2013 Jul 13. blood total protein amount male 84 days 5 70.0 g/dl 5.0 11.18 automated serum analysis 0 106382 3025
Hsd:SD serum albumin level control condition (for 84 days) Harrill JA, et al., Toxicol Appl Pharmacol. 2013 Oct 15;272(2):503-18. doi: 10.1016/j.taap.2013.06.024. Epub 2013 Jul 13. blood albumin amount female 84 days 5 4.5 g/dl 0.2 0.45 automated serum analysis 0 106388 3025
Hsd:SD serum globulin level control condition (for 84 days) Harrill JA, et al., Toxicol Appl Pharmacol. 2013 Oct 15;272(2):503-18. doi: 10.1016/j.taap.2013.06.024. Epub 2013 Jul 13. blood globulin amount male 84 days 5 2.5 g/dl 0.2 0.45 automated serum analysis 0 106390 3025
Hsd:SD platelet count 2,3,7,8-tetrachlorodibenzo-p-dioxin (100 ng/kg/d) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. platelet quantity female 84 days 10 1280.89 x 1000 cells/ul 252.44 798.29 automated hematology analysis 0 106010 3021
Hsd:SD white blood cell count 2,3,7,8-tetrachlorodibenzo-p-dioxin (3 ng/kg/d) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. leukocyte quantity female 84 days 10 10.39 x 1000 cells/ul 2.08 6.58 automated hematology analysis 0 106018 3021
Hsd:SD white blood cell count 2,3,7,8-tetrachlorodibenzo-p-dioxin (100 ng/kg/d) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. leukocyte quantity female 84 days 10 9.64 x 1000 cells/ul 1.27 4.02 automated hematology analysis 0 106022 3021
Hsd:SD blood monocyte count 2,3,7,8-tetrachlorodibenzo-p-dioxin (22 ng/kg/d) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. monocyte quantity female 84 days 10 0.29 x 1000 cells/ul 0.06 0.19 automated hematology analysis 0 106056 3021
Hsd:SD blood eosinophil count 2,3,7,8-tetrachlorodibenzo-p-dioxin (3 ng/kg/d) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. eosinophil quantity female 84 days 10 0.16 x 1000 cells/ul 0.21 0.66 automated hematology analysis 0 106066 3021
Hsd:SD blood basophil count 2,3,7,8-tetrachlorodibenzo-p-dioxin (3 ng/kg/d) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. basophil quantity female 84 days 10 0.08 x 1000 cells/ul 0.03 0.09 automated hematology analysis 0 106078 3021
Hsd:SD both ovaries weight to body weight ratio 2,3,7,8-tetrachlorodibenzo-p-dioxin (3 ng/kg/d) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. ovary mass female 84 days 10 0.05 % 0.01 0.03 post excision weight measurement 0 105922 3021
Hsd:SD red blood cell count vehicle control condition (5 ml/kg) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. erythrocyte quantity female 84 days 10 7.47 x 10E6 cells/ul 0.21 0.66 automated hematology analysis 0 105932 3021
Hsd:SD blood hemoglobin level 2,3,7,8-tetrachlorodibenzo-p-dioxin (3 ng/kg/d) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. blood hemoglobin amount female 84 days 10 14.3 g/dl 0.54 1.71 automated hematology analysis 0 105946 3021
Hsd:SD mean corpuscular volume 2,3,7,8-tetrachlorodibenzo-p-dioxin (3 ng/kg/d) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. erythrocyte size trait female 84 days 10 58.08 fl 1.07 3.38 automated hematology analysis 0 105970 3021
Hsd:SD mean corpuscular volume 2,3,7,8-tetrachlorodibenzo-p-dioxin (1000 ng/kg/d) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. erythrocyte size trait female 84 days 10 52.98 fl 1.49 4.71 automated hematology analysis 0 105978 3021
Hsd:SD mean corpuscular hemoglobin vehicle control condition (5 ml/kg) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. blood hemoglobin amount female 84 days 10 18.82 pg 0.44 1.39 automated hematology analysis 0 105980 3021
Hsd:SD mean corpuscular hemoglobin 2,3,7,8-tetrachlorodibenzo-p-dioxin (100 ng/kg/d) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. blood hemoglobin amount female 84 days 10 18.19 pg 0.55 1.74 automated hematology analysis 0 105986 3021
Hsd:SD mean corpuscular hemoglobin concentration 2,3,7,8-tetrachlorodibenzo-p-dioxin (22 ng/kg/d) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. blood hemoglobin amount female 84 days 10 32.17 g/dl 0.95 3.0 automated hematology analysis 0 105996 3021
Hsd:SD platelet count 2,3,7,8-tetrachlorodibenzo-p-dioxin (3 ng/kg/d) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. platelet quantity female 84 days 10 1291.9 x 1000 cells/ul 200.69 634.64 automated hematology analysis 0 106006 3021
Hsd:SD thymus weight to body weight ratio 2,3,7,8-tetrachlorodibenzo-p-dioxin (3 ng/kg/d) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. thymus mass female 84 days 10 1.47 mg/g 0.24 0.76 post excision weight measurement 0 105886 3021
Hsd:SD thymus weight to body weight ratio 2,3,7,8-tetrachlorodibenzo-p-dioxin (300 ng/kg/d) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. thymus mass female 84 days 10 1.03 mg/g 0.19 0.6 post excision weight measurement 0 105892 3021
Hsd:SD liver weight as percentage of body weight 2,3,7,8-tetrachlorodibenzo-p-dioxin (3 ng/kg/d) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. liver mass female 84 days 10 3.65 % 0.16 0.51 post excision weight measurement 0.0 0 105721 3021
Hsd:SD serum chloride level control condition (for 84 days) Harrill JA, et al., Toxicol Appl Pharmacol. 2013 Oct 15;272(2):503-18. doi: 10.1016/j.taap.2013.06.024. Epub 2013 Jul 13. blood chloride amount female 84 days 5 100.4 mmol/l 4.8 10.73 automated serum analysis 0 106428 3025
Hsd:SD body weight control condition (for 84 days) Harrill JA, et al., Toxicol Appl Pharmacol. 2013 Oct 15;272(2):503-18. doi: 10.1016/j.taap.2013.06.024. Epub 2013 Jul 13. body mass male 84 days 5 386.2 g 20.4 45.62 body weighing method 0 106438 3025
Hsd:SD liver weight control condition (for 84 days) Harrill JA, et al., Toxicol Appl Pharmacol. 2013 Oct 15;272(2):503-18. doi: 10.1016/j.taap.2013.06.024. Epub 2013 Jul 13. liver mass female 84 days 5 4.35 g 0.41 0.92 post excision weight measurement 0 106444 3025
Hsd:SD thymus weight control condition (for 84 days) Harrill JA, et al., Toxicol Appl Pharmacol. 2013 Oct 15;272(2):503-18. doi: 10.1016/j.taap.2013.06.024. Epub 2013 Jul 13. thymus mass female 84 days 5 0.15 g 0.02 0.04 post excision weight measurement 0 106464 3025
Hsd:SD adrenal gland weight control condition (for 84 days) Harrill JA, et al., Toxicol Appl Pharmacol. 2013 Oct 15;272(2):503-18. doi: 10.1016/j.taap.2013.06.024. Epub 2013 Jul 13. adrenal gland mass male 84 days 5 13.0 mg 4.0 8.94 post excision weight measurement 0 106478 3025
Hsd:SD pituitary gland weight control condition (for 84 days) Harrill JA, et al., Toxicol Appl Pharmacol. 2013 Oct 15;272(2):503-18. doi: 10.1016/j.taap.2013.06.024. Epub 2013 Jul 13. pituitary gland mass female 84 days 5 0.01 g 0.0 0.0 post excision weight measurement 0 106484 3025
Hsd:SD scotopic B wave amplitude of ERG waveform vehicle control condition (2 ul) then controlled exposure to darkness (for 12 hours) then visible light stimulus (5 cd/m2) Conlon TJ, et al., Hum Gene Ther Clin Dev. 2013 Mar;24(1):23-8. doi: 10.1089/humc.2013.037. Epub 2013 Apr 3. rod electrophysiology trait both 0 days 4 338.0 uV electroretinography cornea 0.0 subretinal injection 30 days scotopic b-wave ERG 108640 3128
Hsd:SD scotopic A wave amplitude of ERG waveform gene transfer of the rat MER proto-oncogene, tyrosine kinase gene using an adenovirus vector (40 x 10E8 vg) then controlled exposure to darkness (for 12 hours) then visible light stimulus (5 cd/m2) Conlon TJ, et al., Hum Gene Ther Clin Dev. 2013 Mar;24(1):23-8. doi: 10.1089/humc.2013.037. Epub 2013 Apr 3. rod electrophysiology trait both 0 days 9 173.0 uV electroretinography cornea 0.0 subretinal injection 30 days scotopic a-wave ERG 108654 3128
Hsd:SD scotopic B wave amplitude of ERG waveform controlled exposure to darkness (for 12 hours) then visible light stimulus (5 cd/m2) Conlon TJ, et al., Hum Gene Ther Clin Dev. 2013 Mar;24(1):23-8. doi: 10.1089/humc.2013.037. Epub 2013 Apr 3. rod electrophysiology trait both 0 days 9 488.0 uV electroretinography cornea 0.0 0 scotopic b-wave ERG 108647 3128
Hsd:SD scotopic B wave amplitude of ERG waveform controlled exposure to darkness (for 12 hours) then visible light stimulus (5 cd/m2) Conlon TJ, et al., Hum Gene Ther Clin Dev. 2013 Mar;24(1):23-8. doi: 10.1089/humc.2013.037. Epub 2013 Apr 3. rod electrophysiology trait both 0 days 9 491.0 uV electroretinography cornea 0.0 0 scotopic b-wave ERG 108653 3128
Hsd:SD artery neointimal hyperplastic lesion area balloon angioplasty Assadnia S, etal., Circ Res. 1999 Jun 11;84(11):1252-7. doi: 10.1161/01.res.84.11.1252. iliac artery integrity trait male 119 days-133 days 15 0.03 mm2 0.0 0.02 ex vivo light microscopy with digital image analysis 0.0 0 110467 3107
Hsd:SD plasma albumin level controlled fat content diet (42 %) (for 364 days) Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. blood albumin amount male 448 days 10 0.41 g/l 0.01 0.04 automated plasma albumin analysis 0.0 0 138278 3201
Hsd:SD plasma albumin level standard diet Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. blood albumin amount male 448 days 9 0.36 g/l 0.01 0.02 automated plasma albumin analysis 0.0 0 138276 3201
Hsd:SD blood high density lipoprotein particle diameter controlled fat content diet (42 %) (for 364 days) Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. blood HDL particle size male 448 days 10 11.7 nm 0.4 1.26 nuclear magnetic resonance spectroscopy 0.0 0 138340 3201
Hsd:SD liver cholesterol level controlled fat content diet (42 %) (for 364 days) Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. liver cholesterol amount male 448 days 10 21.11 mg/g 3.4 10.75 isolated tissue cholesterol measurement test 0.0 0 138344 3201
Hsd:SD blood urea nitrogen level standard diet Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. blood urea nitrogen amount male 448 days 9 21.0 mg/dl 2.0 6.0 automated blood urea nitrogen analysis 0.0 0 138302 3201
Hsd:SD plasma free fatty acids level standard diet Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. blood free fatty acid amount male 448 days 9 0.52 mmol/l 0.04 0.12 plasma free fatty acid analysis 0.0 0 138322 3201
Hsd:SD plasma high density lipoprotein cholesterol level standard diet Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. blood cholesterol amount male 448 days 9 69.0 mg/dl 11.0 33.0 blood cholesterol analysis 0.0 0 138326 3201
Hsd:SD percent change in tidal volume air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 14 152.01 % 4.84 18.12 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 54167 381
Hsd:SD mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 7 111.52 mmHg 1.62 4.3 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 51301 481
Hsd:SD minute ventilation air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 5 84.21 ml/min 9.85 22.03 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19585 381
Hsd:SD absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 14 -22.14 beats/min 6.77 25.31 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 51614 481
Hsd:SD minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 14 25.63 ml/min 1.63 6.09 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 15162 381
Hsd:SD partial pressure of blood carbon dioxide (Pco2) control condition PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 8 36.59 mmHg 1.24 3.5 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 15521 381
Hsd:SD partial pressure of blood oxygen resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 1 107.3 mmHg automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15559 381
Hsd:SD partial pressure of blood carbon dioxide (Pco2) resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 1 22.8 mmHg automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 14391 381
Hsd:SD heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 1 389.53 beats/min vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15782 381
Hsd:SD mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 2 123.14 mmHg 10.33 14.6 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15793 381
Hsd:SD minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 15 27.32 ml/min 0.99 3.83 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 17596 381
Hsd:SD percent change in ventilation air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 17 %change=VE during 2-3 min hypercapnia/control during standard conditions 264.2 % 9.6 39.58 stop flow air displacement plethysmography 0 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 14642 381
Hsd:SD partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 6 114.77 mmHg 2.34 5.72 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 13534 381
Hsd:SD body temperature control condition PhysGen Respiratory data body temperature trait female 82 days-99 days 16 38.23 degrees C 0.14 0.55 digital rectal thermometry 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 18747 381
Hsd:SD mean arterial blood pressure resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 1 101.48 mmHg vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18774 381
Hsd:SD mean arterial blood pressure resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 10 105.72 mmHg 3.67 11.62 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 18926 381
Hsd:SD hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 4 58.8 % 1.58 3.17 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 36284 401
Hsd:SD tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 15 0.46 ml 0.03 0.1 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 13834 381
Hsd:SD serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 4 162.5 U/l 11.27 22.55 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 36725 401
Hsd:SD plasma chylomicron and VLDL cholesterol level standard diet Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. blood cholesterol amount male 448 days 9 10.0 mg/dl 1.0 3.0 blood cholesterol analysis 0.0 0 138460 3201
Hsd:SD percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 11 post-ischemic value/pre-ischemic value x 100% 49.04 % 6.43 21.32 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 48117 461
Hsd:SD heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 3 1.23 g 0.07 0.11 digital scale post excision weight measurement 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45037 461
Hsd:SD time to peak heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 3 922.41 s 22.76 39.42 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45069 461
Hsd:SD heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 12 10.31 IU/g 1.37 4.76 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 47416 461
Hsd:SD percent change in heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 11 post-ischemic value/pre-ischemic value x 100% 97.27 % 7.51 24.92 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 47418 461
Hsd:SD left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 11 38.82 mmHg 6.49 21.52 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 47420 461
Hsd:SD heart contraction pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 3 72.33 mmHg 3.33 5.77 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47384 461
Hsd:SD heart contraction pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 2 80.0 mmHg 4.0 5.66 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47388 461
Hsd:SD percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 12 post-ischemic value/pre-ischemic value x 100% 80.02 % 6.54 22.66 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 45713 461
Hsd:SD absolute change in partial pressure of blood carbon dioxide resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 10 -2.14 mmHg 0.68 2.16 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 17457 381
Hsd:SD mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 9 117.7 mmHg 2.07 6.2 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 17459 381
Hsd:SD heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 2 264.71 beats/min 0.0 0.0 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45361 461
Hsd:SD percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 3 post-ischemic value/pre-ischemic value x 100% 78.01 % 2.23 3.87 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45857 461
Hsd:SD left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 3 114.45 mmHg 11.98 20.75 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49277 461
Hsd:SD logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 14 -6.98 null 0.11 0.4 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 57194 522
Hsd:SD serum alkaline phosphatase activity level control condition (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 8 122.75 U/l 9.97 28.19 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 38360 401
Hsd:SD percent change in tidal volume air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 5 153.13 % 14.17 31.68 stop flow air displacement plethysmography 0 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54538 381
Hsd:SD percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 15 102.66 % 4.05 15.68 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 54567 381
Hsd:SD percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 5 117.74 % 11.68 26.11 stop flow air displacement plethysmography 0 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 53612 381
Hsd:SD heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 7 0.33 null 0.03 0.07 digital scale post excision weight measurement 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58318 526
Hsd:SD blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 5 0.71 x 1000 cells/ul 0.15 0.33 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 41830 401
Hsd:SD heart left ventricle infarction weight to total heart left ventricle weight ratio controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 3 32.0 % 4.07 7.04 digital scale post excision weight measurement 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49859 461
Hsd:SD blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 4 1.52 x 1000 cells/ul 0.49 0.98 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 40664 401
Hsd:SD heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 6 0.38 null 0.03 0.08 digital scale post excision weight measurement 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 59146 526
Hsd:SD mean corpuscular hemoglobin concentration control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 6 31.98 g/dl 0.23 0.56 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 41852 401
Hsd:SD logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 14 -7.21 null 0.11 0.42 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 57305 522
Hsd:SD calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 6 0.1 mmHg x min x kg x ml-1 0.01 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 57774 526
Hsd:SD hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 13 61.17 % 5.78 20.85 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 56783 522
Hsd:SD serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 3 46.67 U/l 6.67 11.55 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 41170 401
Hsd:SD FAPGG metabolism-surface area product FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 7 23.92 ml/min/kg 2.71 7.16 isolated perfused lung vascular effluent collection 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 57730 526
Hsd:SD mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 5 31.4 g/dl 1.02 2.29 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 42502 401
Hsd:SD blood hemoglobin level control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 6 14.98 g/dl 0.7 1.71 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 42505 401
Hsd:SD serum potassium level control condition (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 5 4.72 mmol/l 0.23 0.52 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 42507 401
Hsd:SD total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 16 5.93 x 1000 cells/ul 0.48 1.94 automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 39549 401
Hsd:SD serum alanine aminotransferase activity level fasting (between 12 and 15 hours) then vehicle control condition (for 1 days) McGill MR, et al., Toxicol Appl Pharmacol. 2012 Nov 1;264(3):387-94. doi: 10.1016/j.taap.2012.08.015. Epub 2012 Aug 23. blood alanine transaminase amount not specified 56 days-84 days 4 30.0 U/l 1.0 2.0 spectrophotometry 0.0 0 84757 1601
Hsd:SD auditory brainstem response threshold thymoquinone (40 mg/kg/d) (for 5 days) then cisplatin (15 mg/kg) Sagit M, et al., Eur Arch Otorhinolaryngol. 2013 Aug;270(8):2231-7. doi: 10.1007/s00405-012-2254-6. Epub 2012 Nov 17. hearing electrophysiology trait female 173 days 10 21.11 dBnHL 2.14 6.76 evoked response audiometry 0.0 0 CT post 75932 1541
Hsd:SD red blood cell count 2,3,7,8-tetrachlorodibenzo-p-dioxin (3 ng/kg/d) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. erythrocyte quantity female 84 days 10 7.63 x 10E6 cells/ul 0.23 0.73 automated hematology analysis 0 105934 3021
Hsd:SD platelet count 2,3,7,8-tetrachlorodibenzo-p-dioxin (300 ng/kg/d) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. platelet quantity female 84 days 10 1160.6 x 1000 cells/ul 192.03 607.25 automated hematology analysis 0 106012 3021
Hsd:SD white blood cell count 2,3,7,8-tetrachlorodibenzo-p-dioxin (22 ng/kg/d) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. leukocyte quantity female 84 days 10 9.63 x 1000 cells/ul 1.4 4.43 automated hematology analysis 0 106020 3021
Hsd:SD blood eosinophil count vehicle control condition (5 ml/kg) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. eosinophil quantity female 84 days 10 0.13 x 1000 cells/ul 0.14 0.44 automated hematology analysis 0 106064 3021
Hsd:SD blood basophil count 2,3,7,8-tetrachlorodibenzo-p-dioxin (300 ng/kg/d) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. basophil quantity female 84 days 10 0.1 x 1000 cells/ul 0.03 0.09 automated hematology analysis 0 106084 3021
Hsd:SD serum glucose level control condition (for 84 days) Harrill JA, et al., Toxicol Appl Pharmacol. 2013 Oct 15;272(2):503-18. doi: 10.1016/j.taap.2013.06.024. Epub 2013 Jul 13. blood glucose amount female 84 days 5 311.2 mg/dl 107.9 241.27 automated serum analysis 0 106416 3025
Hsd:SD absolute change in mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 6 11.05 mmHg 4.96 12.15 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 15481 381
Hsd:SD respiration rate control condition PhysGen Respiratory data respiratory function trait female 82 days-99 days 14 85.39 breaths/min 4.71 17.61 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 15484 381
Hsd:SD body temperature resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 7 38.1 degrees C 0.3 0.81 digital rectal thermometry 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 15485 381
Hsd:SD heart rate air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 11 415.08 beats/min 18.43 61.13 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 15520 381
Hsd:SD tidal volume air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 5 0.53 ml 0.06 0.13 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15524 381
Hsd:SD percent change in ventilation air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 5 %change=VE during 2-3 min hypercapnia/control during standard conditions 235.94 % 30.62 68.47 stop flow air displacement plethysmography 0 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 14398 381
Hsd:SD heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait female 87 days-120 days 7 432.3 beats/min 3.92 10.36 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 50957 481
Hsd:SD absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 7 7.36 mmHg 1.31 3.45 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 50959 481
Hsd:SD absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 14 -2.46 mmHg 2.3 8.59 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 51001 481
Hsd:SD mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 17 116.23 mmHg 1.62 6.67 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 51016 481
Hsd:SD absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 20 -1.58 mmHg 1.98 8.83 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 51038 481
Hsd:SD plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount female 87 days-120 days 13 0.34 mg/dl 0.01 0.04 radioimmunoassay 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 51278 481
Hsd:SD absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 20 30.61 mmHg 1.78 7.98 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 50826 481
Hsd:SD absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 14 -1.05 mmHg 1.42 5.31 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 50849 481
Hsd:SD percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 5 %change=VE during7-9 min hypoxia/control during standard conditions 145.08 % 6.1 13.63 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17333 381
Hsd:SD absolute change in partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 8 12.97 mmHg 2.57 7.26 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 14100 381
Hsd:SD mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 10 109.47 mmHg 3.65 11.54 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 20846 381
Hsd:SD percent change in tidal volume air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 14 168.16 % 7.26 27.15 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 53835 381
Hsd:SD absolute change in blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 6 -0.04 null 0.01 0.03 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 20710 381
Hsd:SD absolute change in blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 9 -0.04 null 0.01 0.04 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 20711 381
Hsd:SD body temperature control condition PhysGen Respiratory data body temperature trait male 82 days-99 days 16 37.81 degrees C 0.15 0.61 digital rectal thermometry 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 18746 381
Hsd:SD heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 9 582.27 beats/min 13.01 39.02 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 18983 381
Hsd:SD partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount male 82 days-99 days 7 28.14 mmHg 1.03 2.73 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 17016 381
Hsd:SD urine albumin excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine albumin amount female 87 days-120 days 17 2.55 mg/d 0.48 1.97 automated urine analysis 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 51688 481
Hsd:SD absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 14 24.92 mmHg 2.29 8.57 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 51860 481
Hsd:SD heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 20 405.19 beats/min 8.56 38.28 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 51677 481
Hsd:SD absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 14 3.31 mmHg 1.5 5.62 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 50341 481
Hsd:SD minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 15 36.45 ml/min 1.62 6.26 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 17595 381
Hsd:SD respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 5 133.26 breaths/min 6.2 13.86 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17556 381
Hsd:SD serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 18 142.56 mmol/l 0.93 3.96 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 36595 401
Hsd:SD plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 5 25.0 mmol/l 0.84 1.87 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 36844 401
Hsd:SD serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 16 9.63 mg/dl 0.17 0.7 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 36729 401
Hsd:SD serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 5 236.6 mg/dl 27.35 61.16 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 36739 401
Hsd:SD serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 3 215.0 mg/dl 55.0 95.26 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 36740 401
Hsd:SD heart wet weight control condition PhysGen Cardiac data heart mass female 49 days-63 days 12 1.01 g 0.02 0.06 digital scale post excision weight measurement 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 49154 461
Hsd:SD absolute change in mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 10 2.58 mmHg 3.73 11.8 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 20446 381
Hsd:SD blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 9 7.41 null 0.01 0.04 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 20558 381
Hsd:SD respiration rate air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 17 158.16 breaths/min 2.98 12.29 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 20571 381
Hsd:SD minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 15 51.25 ml/min 3.04 11.78 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 19297 381
Hsd:SD mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 7 108.45 mmHg 3.18 8.4 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 19310 381
Hsd:SD blood pH resting on treadmill (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 12 7.45 null 0.0 0.01 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 19313 381
Hsd:SD left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 86.7 mmHg 7.37 23.3 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 49624 461
Hsd:SD percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 81.12 % 6.24 19.73 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 49626 461
Hsd:SD left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 116.33 mmHg 7.03 21.09 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 49650 461
Hsd:SD time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 13 1034.7 s 53.29 192.14 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 49663 461
Hsd:SD heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 9 380.39 beats/min 29.41 88.23 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 49849 461
Hsd:SD serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 3 3.5 g/dl 0.5 0.87 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 42337 401
Hsd:SD serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 5 2.2 g/dl 0.18 0.39 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 38974 401
Hsd:SD serum glucose level control condition (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 2 160.0 mg/dl 8.0 11.31 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 38846 401
Hsd:SD hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 15 56.82 % 0.48 1.86 automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 38851 401
Hsd:SD serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 5 6.22 mmol/l 0.2 0.46 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 38860 401
Hsd:SD blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 16 17.64 g/dl 0.3 1.19 automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 38876 401
Hsd:SD serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 16 92.06 U/l 5.43 21.71 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 42171 401
Hsd:SD serum urea nitrogen level control condition (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 3 12.33 mg/dl 2.73 4.73 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 42498 401
Hsd:SD plasma anion gap control condition (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 8 20.5 mmol/l 1.15 3.25 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 42500 401
Hsd:SD serum potassium level control condition (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 8 5.39 mmol/l 0.43 1.22 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 42506 401
Hsd:SD red blood cell count control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 1 7.63 x 10E6 cells/ul automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 42726 401
Hsd:SD plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 16 23.13 mmol/l 0.81 3.22 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 39485 401
Hsd:SD serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 16 4.05 g/dl 0.06 0.24 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 42963 401
Hsd:SD blood hemoglobin level control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 3 14.33 g/dl 0.12 0.21 automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 39760 401
Hsd:SD plasma creatinine level control condition (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 6 0.6 mg/dl 0.13 0.31 automated plasma creatinine analysis 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 43308 401
Hsd:SD FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 7 21.73 ml/min/kg 1.16 3.08 isolated perfused lung vascular effluent collection 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 59027 526
Hsd:SD heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 8 0.37 null 0.02 0.05 digital scale post excision weight measurement 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 59145 526
Hsd:SD serum potassium level control condition (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 3 4.0 mmol/l 0.06 0.1 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 43420 401
Hsd:SD serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 5 26.6 mg/dl 1.69 3.78 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 39986 401
Hsd:SD serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 5 91.0 mg/dl 11.77 26.32 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 37528 401
Hsd:SD serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 2 82.5 mg/dl 2.5 3.54 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 37529 401
Hsd:SD serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 18 0.25 mg/dl 0.01 0.06 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 37534 401
Hsd:SD serum alkaline phosphatase activity level control condition (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 3 151.0 U/l 14.5 25.12 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 37539 401
Hsd:SD serum total protein level control condition (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 8 6.49 g/dl 0.13 0.36 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 37567 401
Hsd:SD serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 16 9.18 mg/dl 0.14 0.57 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 37573 401
Hsd:SD serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 18 8.86 mg/dl 0.16 0.68 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 37575 401
Hsd:SD serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 18 105.67 mmol/l 0.87 3.71 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 40659 401
Hsd:SD blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 5 1.57 x 1000 cells/ul 0.4 0.9 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 40663 401
Hsd:SD serum phosphate level control condition (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 3 7.8 mg/dl 0.57 0.98 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 37924 401
Hsd:SD red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 5 8.55 x 10E6 cells/ul 1.82 4.07 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 37946 401
Hsd:SD mean corpuscular volume control condition (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 3 57.77 fl 1.18 2.04 automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 41150 401
Hsd:SD blood lymphocyte count control condition (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 6 1.57 x 1000 cells/ul 0.31 0.77 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 38396 401
Hsd:SD plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 5 0.54 mg/dl 0.02 0.05 automated plasma creatinine analysis 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 41730 401
Hsd:SD mean corpuscular hemoglobin concentration control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 8 32.25 g/dl 0.37 1.04 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 41851 401
Hsd:SD heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 2 272.73 beats/min 0.0 0.0 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 46508 461
Hsd:SD percent change in heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 3 post-ischemic value/pre-ischemic value x 100% 87.98 % 9.8 16.98 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47545 461
Hsd:SD methylene blue metabolism-surface area product after auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 7 15.1 ml/min/kg 1.34 3.54 isolated perfused lung vascular effluent collection 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 57732 526
Hsd:SD fractional change in blood vessel diameter per unit change in intravascular pressure Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 7 0.09 mmHg-1 0.01 0.03 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 57762 526
Hsd:SD fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 6 0.07 mmHg-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 57781 526
Hsd:SD methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 6 12.87 ml/min/kg 1.13 2.76 isolated perfused lung vascular effluent collection 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 57784 526
Hsd:SD heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 7 21.24 % 3.11 8.22 digital scale post excision weight measurement 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 48740 461
Hsd:SD sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 16 100.0 % 0.0 0.0 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 57447 522
Hsd:SD concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 16 0.37 10E-7mol/l 0.06 0.23 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 55503 522
Hsd:SD dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 4 1.42 mg/kg 0.31 0.63 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 57983 526
Hsd:SD tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 15 0.42 ml 0.02 0.07 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 16324 381
Hsd:SD absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 1 0.04 null automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 16665 381
Hsd:SD lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 5 1.14 g/kg 0.03 0.07 digital scale post excision weight measurement 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 58197 526
Hsd:SD body weight control condition (for 14 days) PhysGen Lung data body mass male 77 days-91 days 8 317.5 g 2.5 7.1 whole body digital scale 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 58204 526
Hsd:SD maximum contractile force per wet weight of aorta potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 20 0.95 g/mg 0.09 0.42 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 56066 522
Hsd:SD maximum contractile force per wet weight of aorta potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 23 1.01 g/mg 0.05 0.26 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 56067 522
Hsd:SD concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 14 1.7 E-7mole 0.61 2.3 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 56212 522
Hsd:SD dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 7 0.8 mg/kg 0.15 0.39 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 58593 526
Hsd:SD hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 12 47.26 % 9.32 32.27 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 55007 522
Hsd:SD hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 5 57.32 % 0.36 0.81 microhematocrit tube assay with visual assessment 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 58817 526
Hsd:SD concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 14 1.29 E-7mole 0.19 0.72 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 56725 522
Hsd:SD hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 15 65.48 % 5.85 22.64 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 56782 522
Hsd:SD concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 19 0.25 umol/l 0.13 0.56 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 56836 522
Hsd:SD maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 16 1.37 g/mg 0.23 0.92 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 57114 522
Hsd:SD absolute change in partial pressure of blood carbon dioxide resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 7 -1.29 mmHg 1.44 3.8 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 17456 381
Hsd:SD concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 14 0.04 umol/l 0.01 0.03 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 57196 522
Hsd:SD left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 3 49.4 mmHg 11.63 20.14 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45936 461
Hsd:SD percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 25.36 % 4.89 13.83 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 46962 461
Hsd:SD left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 111.22 mmHg 7.0 20.99 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 47785 461
Hsd:SD left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 6 107.06 mmHg 8.61 21.09 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 44701 461
Hsd:SD heart wet weight control condition PhysGen Cardiac data heart mass male 49 days-63 days 3 1.45 g 0.1 0.17 digital scale post excision weight measurement 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48146 461
Hsd:SD heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 3 301.07 beats/min 20.19 34.97 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48175 461
Hsd:SD time to peak heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 11 988.67 s 45.4 150.59 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 45027 461
Hsd:SD heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 2 0.31 IU/g 0.04 0.06 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47180 461
Hsd:SD left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 2 68.96 mmHg 1.89 2.67 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47400 461
Hsd:SD heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 9 10.56 IU/g 1.36 4.07 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 47415 461
Hsd:SD left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 6 52.98 mmHg 7.55 18.49 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 47419 461
Hsd:SD heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 3 0.02 IU/g 0.01 0.01 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48382 461
Hsd:SD auditory brainstem response threshold cisplatin (15 mg/kg) Sagit M, et al., Eur Arch Otorhinolaryngol. 2013 Aug;270(8):2231-7. doi: 10.1007/s00405-012-2254-6. Epub 2012 Nov 17. hearing electrophysiology trait female 170 days 10 20.5 dBnHL 2.99 9.44 evoked response audiometry 0.0 0 C pre 75927 1541
Hsd:SD thymus weight to body weight ratio vehicle control condition (5 ml/kg) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. thymus mass female 84 days 10 1.5 mg/g 0.35 1.11 post excision weight measurement 0 105884 3021
Hsd:SD brain weight to body weight ratio vehicle control condition (5 ml/kg) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. brain mass female 84 days 10 0.74 % 0.03 0.1 post excision weight measurement 0 105908 3021
Hsd:SD brain weight to body weight ratio 2,3,7,8-tetrachlorodibenzo-p-dioxin (3 ng/kg/d) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. brain mass female 84 days 10 0.76 % 0.03 0.09 post excision weight measurement 0 105910 3021
Hsd:SD brain weight to body weight ratio 2,3,7,8-tetrachlorodibenzo-p-dioxin (22 ng/kg/d) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. brain mass female 84 days 10 0.75 % 0.06 0.18 post excision weight measurement 0 105912 3021
Hsd:SD serum alanine aminotransferase activity level control condition (for 84 days) Harrill JA, et al., Toxicol Appl Pharmacol. 2013 Oct 15;272(2):503-18. doi: 10.1016/j.taap.2013.06.024. Epub 2013 Jul 13. blood alanine transaminase amount male 84 days 5 56.6 U/l 14.9 33.32 automated serum analysis 0 106362 3025
Hsd:SD platelet count 2,3,7,8-tetrachlorodibenzo-p-dioxin (22 ng/kg/d) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. platelet quantity female 84 days 10 1299.4 x 1000 cells/ul 168.51 532.88 automated hematology analysis 0 106008 3021
Hsd:SD platelet count 2,3,7,8-tetrachlorodibenzo-p-dioxin (1000 ng/kg/d) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. platelet quantity female 84 days 10 870.2 x 1000 cells/ul 189.09 597.96 automated hematology analysis 0 106014 3021
Hsd:SD white blood cell count 2,3,7,8-tetrachlorodibenzo-p-dioxin (1000 ng/kg/d) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. leukocyte quantity female 84 days 10 8.73 x 1000 cells/ul 2.08 6.58 automated hematology analysis 0 106026 3021
Hsd:SD blood neutrophil count 2,3,7,8-tetrachlorodibenzo-p-dioxin (3 ng/kg/d) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. neutrophil quantity female 84 days 10 1.86 x 1000 cells/ul 1.0 3.16 automated hematology analysis 0 106030 3021
Hsd:SD blood lymphocyte count 2,3,7,8-tetrachlorodibenzo-p-dioxin (22 ng/kg/d) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. lymphocyte quantity female 84 days 10 7.73 x 1000 cells/ul 1.37 4.33 automated hematology analysis 0 106044 3021
Hsd:SD blood lymphocyte count 2,3,7,8-tetrachlorodibenzo-p-dioxin (100 ng/kg/d) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. lymphocyte quantity female 84 days 10 7.97 x 1000 cells/ul 1.13 3.57 automated hematology analysis 0 106046 3021
Hsd:SD blood monocyte count 2,3,7,8-tetrachlorodibenzo-p-dioxin (3 ng/kg/d) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. monocyte quantity female 84 days 10 0.33 x 1000 cells/ul 0.08 0.25 automated hematology analysis 0 106054 3021
Hsd:SD blood monocyte count 2,3,7,8-tetrachlorodibenzo-p-dioxin (300 ng/kg/d) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. monocyte quantity female 84 days 10 0.32 x 1000 cells/ul 0.12 0.38 automated hematology analysis 0 106060 3021
Hsd:SD blood monocyte count 2,3,7,8-tetrachlorodibenzo-p-dioxin (1000 ng/kg/d) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. monocyte quantity female 84 days 10 0.24 x 1000 cells/ul 0.09 0.28 automated hematology analysis 0 106062 3021
Hsd:SD blood eosinophil count 2,3,7,8-tetrachlorodibenzo-p-dioxin (22 ng/kg/d) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. eosinophil quantity female 84 days 10 0.08 x 1000 cells/ul 0.02 0.06 automated hematology analysis 0 106068 3021
Hsd:SD blood basophil count 2,3,7,8-tetrachlorodibenzo-p-dioxin (100 ng/kg/d) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. basophil quantity female 84 days 10 0.08 x 1000 cells/ul 0.03 0.09 automated hematology analysis 0 106082 3021
Hsd:SD blood basophil count 2,3,7,8-tetrachlorodibenzo-p-dioxin (1000 ng/kg/d) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. basophil quantity female 84 days 10 0.08 x 1000 cells/ul 0.03 0.09 automated hematology analysis 0 106086 3021
Hsd:SD red blood cell count 2,3,7,8-tetrachlorodibenzo-p-dioxin (22 ng/kg/d) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. erythrocyte quantity female 84 days 10 7.68 x 10E6 cells/ul 0.34 1.08 automated hematology analysis 0 105936 3021
Hsd:SD red blood cell count 2,3,7,8-tetrachlorodibenzo-p-dioxin (1000 ng/kg/d) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. erythrocyte quantity female 84 days 10 9.17 x 10E6 cells/ul 0.65 2.06 automated hematology analysis 0 105942 3021
Hsd:SD blood hemoglobin level vehicle control condition (5 ml/kg) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. blood hemoglobin amount female 84 days 10 14.05 g/dl 0.48 1.52 automated hematology analysis 0 105944 3021
Hsd:SD blood hemoglobin level 2,3,7,8-tetrachlorodibenzo-p-dioxin (100 ng/kg/d) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. blood hemoglobin amount female 84 days 10 14.59 g/dl 0.61 1.93 automated hematology analysis 0 105950 3021
Hsd:SD hematocrit 2,3,7,8-tetrachlorodibenzo-p-dioxin (100 ng/kg/d) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. erythrocyte quantity female 84 days 10 45.1 % 2.05 6.48 automated hematology analysis 0 105962 3021
Hsd:SD mean corpuscular hemoglobin concentration vehicle control condition (5 ml/kg) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. blood hemoglobin amount female 84 days 10 32.48 g/dl 0.68 2.15 automated hematology analysis 0 105992 3021
Hsd:SD mean corpuscular hemoglobin concentration 2,3,7,8-tetrachlorodibenzo-p-dioxin (3 ng/kg/d) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. blood hemoglobin amount female 84 days 10 32.23 g/dl 0.64 2.02 automated hematology analysis 0 105994 3021
Hsd:SD platelet count vehicle control condition (5 ml/kg) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. platelet quantity female 84 days 10 1308.4 x 1000 cells/ul 220.08 695.95 automated hematology analysis 0 106004 3021
Hsd:SD serum calcium level control condition (for 84 days) Harrill JA, et al., Toxicol Appl Pharmacol. 2013 Oct 15;272(2):503-18. doi: 10.1016/j.taap.2013.06.024. Epub 2013 Jul 13. blood calcium amount male 84 days 5 13.2 mg/dl 0.7 1.57 automated serum analysis 0 106430 3025
Hsd:SD serum calcium level control condition (for 84 days) Harrill JA, et al., Toxicol Appl Pharmacol. 2013 Oct 15;272(2):503-18. doi: 10.1016/j.taap.2013.06.024. Epub 2013 Jul 13. blood calcium amount female 84 days 5 13.9 mg/dl 0.7 1.57 automated serum analysis 0 106432 3025
Hsd:SD serum phosphate level control condition (for 84 days) Harrill JA, et al., Toxicol Appl Pharmacol. 2013 Oct 15;272(2):503-18. doi: 10.1016/j.taap.2013.06.024. Epub 2013 Jul 13. blood phosphate amount male 84 days 5 12.3 mg/dl 3.2 7.16 automated serum analysis 0 106434 3025
Hsd:SD kidney weight control condition (for 84 days) Harrill JA, et al., Toxicol Appl Pharmacol. 2013 Oct 15;272(2):503-18. doi: 10.1016/j.taap.2013.06.024. Epub 2013 Jul 13. kidney mass male 84 days 5 0.88 g 0.03 0.07 post excision weight measurement 0 106446 3025
Hsd:SD spleen weight control condition (for 84 days) Harrill JA, et al., Toxicol Appl Pharmacol. 2013 Oct 15;272(2):503-18. doi: 10.1016/j.taap.2013.06.024. Epub 2013 Jul 13. spleen mass male 84 days 5 0.25 g 0.02 0.04 post excision weight measurement 0 106458 3025
Hsd:SD spleen weight control condition (for 84 days) Harrill JA, et al., Toxicol Appl Pharmacol. 2013 Oct 15;272(2):503-18. doi: 10.1016/j.taap.2013.06.024. Epub 2013 Jul 13. spleen mass female 84 days 5 0.3 g 0.02 0.04 post excision weight measurement 0 106460 3025
Hsd:SD pituitary gland weight control condition (for 84 days) Harrill JA, et al., Toxicol Appl Pharmacol. 2013 Oct 15;272(2):503-18. doi: 10.1016/j.taap.2013.06.024. Epub 2013 Jul 13. pituitary gland mass male 84 days 5 0.0 g 0.0 0.0 post excision weight measurement 0 106482 3025
Hsd:SD photopic B wave amplitude of ERG waveform gene transfer of the rat MER proto-oncogene, tyrosine kinase gene using an adenovirus vector (40 x 10E8 vg) then controlled visible light condition (30 cd x s/m2) then visible light stimulus (12 cd/m2) Conlon TJ, et al., Hum Gene Ther Clin Dev. 2013 Mar;24(1):23-8. doi: 10.1089/humc.2013.037. Epub 2013 Apr 3. cone electrophysiology trait both 0 days 9 57.0 uV electroretinography cornea 0.0 subretinal injection 30 days photopic b-wave ERG 108656 3128
Hsd:SD photopic B wave amplitude of ERG waveform controlled visible light condition (30 cd x s/m2) then visible light stimulus (12 cd/m2) Conlon TJ, et al., Hum Gene Ther Clin Dev. 2013 Mar;24(1):23-8. doi: 10.1089/humc.2013.037. Epub 2013 Apr 3. cone electrophysiology trait both 0 days 4 90.0 uV electroretinography cornea 0.0 subretinal injection 30 days contralateral control eye photopic b-wave ERG 108645 3128
Hsd:SD scotopic A wave amplitude of ERG waveform controlled exposure to darkness (for 12 hours) then visible light stimulus (5 cd/m2) Conlon TJ, et al., Hum Gene Ther Clin Dev. 2013 Mar;24(1):23-8. doi: 10.1089/humc.2013.037. Epub 2013 Apr 3. rod electrophysiology trait both 0 days 9 203.0 uV electroretinography cornea 0.0 0 scotopic a-wave ERG 108655 3128
Hsd:SD artery neointimal hyperplastic lesion area to total wall area ratio balloon angioplasty Assadnia S, etal., Circ Res. 1999 Jun 11;84(11):1252-7. doi: 10.1161/01.res.84.11.1252. iliac artery integrity trait male 119 days-133 days 15 20.7 % 3.71 14.37 ex vivo light microscopy with digital image analysis 0.0 0 110478 3107
Hsd:SD plasma alanine aminotransferase activity level standard diet Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. blood alanine transaminase amount male 448 days 9 54.0 U/l 6.0 18.0 automated plasma alanine aminotransferase activity assay 0.0 0 138285 3201
Hsd:SD plasma creatine kinase activity level standard diet Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. blood creatine kinase amount male 448 days 9 670.0 U/l 93.0 279.0 automated plasma creatine kinase activity assay 0.0 0 CK 138293 3201
Hsd:SD blood very low density lipoprotein particle diameter standard diet Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. blood VLDL particle size male 448 days 9 38.0 nm 1.5 4.5 nuclear magnetic resonance spectroscopy 0.0 0 138330 3201
Hsd:SD blood low density lipoprotein particle diameter controlled fat content diet (42 %) (for 364 days) Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. blood LDL particle size male 448 days 10 22.6 nm 0.1 0.32 nuclear magnetic resonance spectroscopy 0.0 0 138336 3201
Hsd:SD liver cholesterol level standard diet Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. liver cholesterol amount male 448 days 9 5.39 mg/g 0.14 0.42 isolated tissue cholesterol measurement test 0.0 0 138342 3201
Hsd:SD blood low density lipoprotein particle diameter standard diet Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. blood LDL particle size male 448 days 9 22.7 nm 0.1 0.3 nuclear magnetic resonance spectroscopy 0.0 0 138334 3201
Hsd:SD plasma plasminogen activator inhibitor 1 level controlled fat content diet (42 %) (for 364 days) Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. blood plasminogen activator inhibitor 1 amount male 448 days 10 12.86 ng/ml 1.6 5.06 enzyme linked immunosorbent assay 0.0 0 138308 3201
Hsd:SD blood fibrinogen level standard diet Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. fibrin formation trait male 448 days 9 3.14 mg/ml 0.13 0.39 enzyme linked immunosorbent assay 0.0 0 138310 3201
Hsd:SD absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 7 3.21 beats/min 10.2 26.99 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 50825 481
Hsd:SD absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 14 -24.64 beats/min 8.37 31.31 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 50847 481
Hsd:SD percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 15 127.71 % 5.44 21.06 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 53968 381
Hsd:SD heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 11 48.89 mmHg 4.88 16.18 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 49161 461
Hsd:SD mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 7 113.37 mmHg 3.55 9.39 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 20845 381
Hsd:SD percent change in ventilation air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 17 %change=VE during7-9 min hypercapnia/control during standard conditions 250.14 % 7.92 32.64 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 14418 381
Hsd:SD tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 5 0.39 ml 0.04 0.09 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 14429 381
Hsd:SD body temperature control condition PhysGen Respiratory data body temperature trait male 82 days-99 days 18 37.53 degrees C 0.15 0.62 digital rectal thermometry 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 17591 381
Hsd:SD urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data urine sodium amount female 87 days-120 days 16 0.74 mEq/d 0.11 0.43 flame atomic emission spectrometry 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 51399 481
Hsd:SD minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 5 54.97 ml/min 5.38 12.04 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18962 381
Hsd:SD serum sodium level control condition (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 6 142.0 mmol/l 1.1 2.68 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 36341 401
Hsd:SD mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 16 113.71 mmHg 3.83 15.33 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 13664 381
Hsd:SD partial pressure of blood carbon dioxide (Pco2) resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 8 26.14 mmHg 1.13 3.19 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 14139 381
Hsd:SD tidal volume air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 17 0.55 ml 0.02 0.08 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 14910 381
Hsd:SD heart rate resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 9 501.86 beats/min 8.02 24.05 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 17554 381
Hsd:SD absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 20 11.22 beats/min 7.91 35.37 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 51875 481
Hsd:SD plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 2 22.0 mmol/l 0.0 0.0 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 36845 401
Hsd:SD plasma anion gap control condition (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 2 17.0 mmol/l 0.0 0.0 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 36848 401
Hsd:SD plasma IDL and LDL cholesterol standard diet Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. blood cholesterol amount male 448 days 9 94.0 mg/dl 16.0 48.0 blood cholesterol analysis 0.0 0 138461 3201
Hsd:SD minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 15 40.2 ml/min 2.09 8.09 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 19435 381
Hsd:SD arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 13 12.15 ml/min/g 1.17 4.22 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 45052 461
Hsd:SD heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 13 1.56 g 0.05 0.18 digital scale post excision weight measurement 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 45062 461
Hsd:SD time to peak heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 2 999.13 s 172.26 243.62 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45073 461
Hsd:SD time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 3 1111.09 s 144.75 250.71 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45110 461
Hsd:SD blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 7 7.52 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17454 381
Hsd:SD percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 2 post-ischemic value/pre-ischemic value x 100% 64.92 % 5.27 7.45 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45861 461
Hsd:SD left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 3 6.53 mmHg 0.12 0.21 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48011 461
Hsd:SD left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 3 119.24 mmHg 4.29 7.43 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 46044 461
Hsd:SD left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 2 123.06 mmHg 1.47 2.07 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 46048 461
Hsd:SD left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 30.4 mmHg 6.89 21.77 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 46149 461
Hsd:SD arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 3 7.07 ml/min/g 0.32 0.55 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 46183 461
Hsd:SD logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 17 -8.25 null 0.17 0.7 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 55701 522
Hsd:SD maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 18 1.39 g/mg 0.15 0.64 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 57115 522
Hsd:SD serum alanine aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 2 70.5 U/l 12.5 17.68 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 38161 401
Hsd:SD left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 7 97.19 mmHg 8.19 21.66 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 49623 461
Hsd:SD percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 75.29 % 7.5 21.2 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 49625 461
Hsd:SD time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 905.67 s 30.38 96.07 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 49664 461
Hsd:SD serum calcium level control condition (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 6 10.57 mg/dl 0.19 0.48 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 38398 401
Hsd:SD time to onset of heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 3 508.47 s 198.52 343.85 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49484 461
Hsd:SD percent change in respiration rate air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 17 163.27 % 6.19 25.53 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 53568 381
Hsd:SD methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 6 0.72 null 0.06 0.16 isolated perfused lung vascular effluent collection 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 58439 526
Hsd:SD percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 76.76 % 4.67 14.77 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 49813 461
Hsd:SD percent change in left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 11 post-ischemic value/pre-ischemic value x 100% 32.31 % 6.95 23.05 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 46530 461
Hsd:SD serum potassium level control condition (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 2 4.0 mmol/l 0.2 0.28 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 43419 401
Hsd:SD left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 2 127.92 mmHg 8.06 11.4 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49789 461
Hsd:SD mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 16 19.41 pg 0.12 0.49 automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 37565 401
Hsd:SD serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 18 21.56 mg/dl 1.12 4.74 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 40811 401
Hsd:SD hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 16 55.51 % 1.05 4.2 automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 38853 401
Hsd:SD methylene blue to FAPGG metabolism-surface area product ratio methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 7 1.08 null 0.04 0.11 isolated perfused lung vascular effluent collection 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 57565 526
Hsd:SD serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 18 44.11 U/l 3.56 15.12 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 42344 401
Hsd:SD serum aspartate aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 8 181.38 U/l 30.15 85.28 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 41282 401
Hsd:SD plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 16 0.41 mg/dl 0.02 0.1 automated plasma creatinine analysis 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 39541 401
Hsd:SD fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 6 0.07 mmHg-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 57782 526
Hsd:SD both ovaries weight to body weight ratio 2,3,7,8-tetrachlorodibenzo-p-dioxin (100 ng/kg/d) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. ovary mass female 84 days 10 0.04 % 0.01 0.02 post excision weight measurement 0 105926 3021
Hsd:SD blood hemoglobin level 2,3,7,8-tetrachlorodibenzo-p-dioxin (1000 ng/kg/d) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. blood hemoglobin amount female 84 days 10 15.76 g/dl 0.88 2.78 automated hematology analysis 0 105954 3021
Hsd:SD blood albumin level to blood globulin level ratio control condition (for 84 days) Harrill JA, et al., Toxicol Appl Pharmacol. 2013 Oct 15;272(2):503-18. doi: 10.1016/j.taap.2013.06.024. Epub 2013 Jul 13. blood albumin amount female 84 days 5 2.1 null 0.1 0.22 automated serum analysis 0 106396 3025
Hsd:SD serum triglyceride level control condition (for 84 days) Harrill JA, et al., Toxicol Appl Pharmacol. 2013 Oct 15;272(2):503-18. doi: 10.1016/j.taap.2013.06.024. Epub 2013 Jul 13. blood triglyceride amount female 84 days 5 130.4 mg/dl 35.4 79.16 automated serum analysis 0 106404 3025