Phenominer Database Results (130 results)

 
 
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Strain Phenotype Conditions Study Experiment Name Sex Age # of Animals Value Units SEM SD Method Method Site Method Duration Post Insult Type Post Insult Time Value Post Insult Time Unit Method Notes Clinical Measurement Notes Record ID Study ID
RCS-p+/LavRrrc scotopic B wave amplitude of ERG waveform gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (30 ug) then controlled exposure to darkness (for 1 days) then visible light stimulus (3 cd x s/m2) Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. rod electrophysiology trait both 87.0 days 5 83.0 uV 7.0 15.65 electroretinography cornea 0.0 plasmid delivery 71 days pVAX2-rGDNF scotopic b-wave ERG 108735 3131
RCS-p+/LavRrrc scotopic A wave amplitude of ERG waveform sham gene transfer using an empty plasmid vector pVAX2 (30 ug) then controlled exposure to darkness (for 1 days) then visible light stimulus (3 cd x s/m2) Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. rod electrophysiology trait both 87.0 days 5 24.5 uV 4.9 10.96 electroretinography cornea 0.0 plasmid delivery 71 days scotopic a-wave ERG 108734 3131
RCS-p+/LavRrrc retinal outer nuclear layer photoreceptor nucleus count to layer length ratio control condition Kang S, et al., Transl Vis Sci Technol. 2019 Aug 7;8(4):19. doi: 10.1167/tvst.8.4.19. eCollection 2019 Jul. retinal photoreceptor quantity not specified 180.0 days 5 3.3 / 100 um 2.8 6.26 ex vivo light microscopy with histochemistry 0.0 contralateral control eye 107362 3082
RCS-p+/LavRrrc retinal outer nuclear layer photoreceptor nucleus count to layer length ratio laser photocoagulation (225 um) (for 0 hours) Kang S, et al., Transl Vis Sci Technol. 2019 Aug 7;8(4):19. doi: 10.1167/tvst.8.4.19. eCollection 2019 Jul. retinal photoreceptor quantity not specified 180.0 days 5 2.1 / 100 um 1.9 4.25 ex vivo light microscopy with histochemistry 0.0 photocoagulation 161 days experimental eye 107371 3082
RCS-p+/LavRrrc retinal outer nuclear layer photoreceptor nucleus count to layer length ratio control condition Kang S, et al., Transl Vis Sci Technol. 2019 Aug 7;8(4):19. doi: 10.1167/tvst.8.4.19. eCollection 2019 Jul. retinal photoreceptor quantity not specified 180.0 days 5 1.8 / 100 um 1.9 4.25 ex vivo light microscopy with histochemistry 0.0 contralateral control eye 107372 3082
RCS-p+/LavRrrc scotopic A wave amplitude of ERG waveform control condition then controlled exposure to darkness (for 12 hours) Tao Z, et al., Oncotarget. 2016 Aug 2;7(31):49368-49383. doi: 10.18632/oncotarget.10343. rod electrophysiology trait both 34.0 days 8 13.0 uV 13.0 36.77 electroretinography 0.0 untreated control electrical activity measurement of retina (CMO:0003653)/A wave 108374 3121
RCS-p+/LavRrrc scotopic A wave amplitude of ERG waveform control condition then controlled exposure to darkness (for 12 hours) Tao Z, et al., Oncotarget. 2016 Aug 2;7(31):49368-49383. doi: 10.18632/oncotarget.10343. rod electrophysiology trait both 48.0 days 5 17.0 uV 5.0 11.18 electroretinography 0.0 untreated control a-wave amplitude ERG 108380 3121
RCS-p+/LavRrrc scotopic B wave amplitude of ERG waveform gene transfer of the enhanced green fluorescent protein gene using an adenovirus vector (5250000 PFU) then controlled exposure to darkness (for 12 hours) Tao Z, et al., Oncotarget. 2016 Aug 2;7(31):49368-49383. doi: 10.18632/oncotarget.10343. rod electrophysiology trait both 48.0 days 5 51.0 uV 33.0 73.79 electroretinography cornea 0.0 subretinal injection 28 days adenovirus b-wave amplitude ERG 108384 3121
RCS-p+/LavRrrc scotopic B wave amplitude of ERG waveform control condition then controlled exposure to darkness (for 12 hours) Tao Z, et al., Oncotarget. 2016 Aug 2;7(31):49368-49383. doi: 10.18632/oncotarget.10343. rod electrophysiology trait both 62.0 days 5 13.0 uV 17.0 38.01 electroretinography 0.0 untreated control b-wave amplitude ERG 108389 3121
RCS-p+/LavRrrc scotopic B wave amplitude of ERG waveform sham gene transfer using an empty plasmid vector pVAX2 (30 ug) then controlled exposure to darkness (for 1 days) then visible light stimulus (3 cd x s/m2) Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. rod electrophysiology trait both 53.0 days 5 352.0 uV 26.0 58.14 electroretinography cornea 0.0 plasmid delivery 37 days scotopic b-wave ERG 108701 3131
RCS-p+/LavRrrc retinal inner nuclear layer thickness gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (30 ug) Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. retinal inner nuclear layer morphology trait both 51.0 days 5 26.3 um 1.5 3.35 ex vivo light microscopy with histochemistry and digital image analysis 0.0 plasmid delivery 35 days pVAX2-rGDNF retinal inner nuclear layer thickness (CMO:0003668) 108707 3131
RCS-p+/LavRrrc retinal inner nuclear layer thickness sham gene transfer using an empty plasmid vector pVAX2 (30 ug) Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. retinal inner nuclear layer morphology trait both 51.0 days 5 19.6 um 0.5 1.12 ex vivo light microscopy with histochemistry and digital image analysis 0.0 plasmid delivery 35 days retinal inner nuclear layer thickness (CMO:0003668) 108708 3131
RCS-p+/LavRrrc photoreceptor inner segment thickness gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (30 ug) Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. photoreceptor inner segment morphology trait both 51.0 days 5 8.1 um 0.4 0.89 ex vivo light microscopy with histochemistry and digital image analysis 0.0 plasmid delivery 35 days pVAX2-rGDNF superior hemisphere - photoreceptor IS 108711 3131
RCS-p+/LavRrrc photoreceptor inner segment thickness gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (15 ug) and gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (15 ug) Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. photoreceptor inner segment morphology trait both 70.0 days 4 8.3 um 1.7 3.4 ex vivo light microscopy with histochemistry and digital image analysis 0.0 plasmid delivery 54 days pVAX2-rGDNF superior hemisphere 108744 3131
RCS-p+/LavRrrc scotopic B wave amplitude of ERG waveform sham gene transfer using an empty plasmid vector pVAX2 (30 ug) and sham gene transfer using an empty plasmid vector pVAX2 (30 ug) then controlled exposure to darkness (for 1 days) then visible light stimulus (3 cd x s/m2) Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. rod electrophysiology trait both 70.0 days 3 231.0 uV 5.0 8.66 electroretinography cornea 0.0 plasmid delivery 54 days pVAX2 scotopic b-wave ERG 108749 3131
RCS-p+/LavRrrc debris zone thickness light phase of controlled light/dark cycle (0-5 lux) (for 12 hours) Bubis E, et al., Transl Vis Sci Technol. 2019 Feb 28;8(1):26. doi: 10.1167/tvst.8.1.26. eCollection 2019 Jan. retinal photoreceptor layer morphology trait not specified 42.0 days 18 44.4 um 0.6 2.55 optical coherence tomography retina 0.0 Heidelberg Spectralis SD-OCT debris zone 110660 3181
RCS-p+/LavRrrc debris zone thickness light phase of controlled light/dark cycle (0-5 lux) (for 12 hours) Bubis E, et al., Transl Vis Sci Technol. 2019 Feb 28;8(1):26. doi: 10.1167/tvst.8.1.26. eCollection 2019 Jan. retinal photoreceptor layer morphology trait not specified 56.0 days 15 36.6 um 1.0 3.87 optical coherence tomography retina 0.0 Heidelberg Spectralis SD-OCT debris zone 110661 3181
RCS-p+/LavRrrc full retina thickness light phase of controlled light/dark cycle (0-5 lux) (for 12 hours) Bubis E, et al., Transl Vis Sci Technol. 2019 Feb 28;8(1):26. doi: 10.1167/tvst.8.1.26. eCollection 2019 Jan. retinal layer morphology trait not specified 70.0 days 12 163.7 um 1.8 6.24 optical coherence tomography retina 0.0 Heidelberg Spectralis SD-OCT 110667 3181
RCS-p+/LavRrrc scotopic B wave amplitude of ERG waveform gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (30 ug) then controlled exposure to darkness (for 1 days) then visible light stimulus (3 cd x s/m2) Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. rod electrophysiology trait both 53.0 days 5 475.0 uV 41.0 91.68 electroretinography cornea 0.0 plasmid delivery 37 days pVAX2-rGDNF scotopic b-wave ERG 108727 3131
RCS-p+/LavRrrc scotopic A wave amplitude of ERG waveform 2-methyl-6-(phenylethynyl)pyridine (200 umol) then controlled exposure to darkness (for 12 hours) then visible light stimulus (0.5 log(cd x m/s2)) Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. rod electrophysiology trait both 39.0 days 7 33.73 uV 9.28 24.55 electroretinography cornea 0.0 subretinal injection 4 days MPEP a-wave amplitude ERG 108540 3123
RCS-p+/LavRrrc scotopic B wave amplitude of ERG waveform 2-methyl-6-(phenylethynyl)pyridine (200 umol) then controlled exposure to darkness (for 12 hours) then visible light stimulus (-0.02 log(cd x m/s2)) Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. rod electrophysiology trait both 39.0 days 7 192.0 uV 14.42 38.15 electroretinography cornea 0.0 subretinal injection 4 days pbs a wave amplitude ERG 108545 3123
RCS-p+/LavRrrc scotopic B wave amplitude of ERG waveform 2-methyl-6-(phenylethynyl)pyridine (200 umol) then controlled exposure to darkness (for 12 hours) then visible light stimulus (0.5 log(cd x m/s2)) Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. rod electrophysiology trait both 39.0 days 7 233.29 uV 18.61 49.24 electroretinography cornea 0.0 subretinal injection 4 days pbs a wave amplitude ERG 108546 3123
RCS-p+/LavRrrc scotopic A wave amplitude of ERG waveform phosphate buffered saline (4 ul) then controlled exposure to darkness (for 12 hours) then visible light stimulus (-0.5 log(cd x m/s2)) Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. rod electrophysiology trait both 39.0 days 7 19.05 uV 3.75 9.92 electroretinography cornea 0.0 subretinal injection 4 days MPEP a-wave amplitude ERG 108550 3123
RCS-p+/LavRrrc scotopic B wave amplitude of ERG waveform phosphate buffered saline (4 ul) then controlled exposure to darkness (for 12 hours) then visible light stimulus (0.5 log(cd x m/s2)) Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. rod electrophysiology trait both 39.0 days 7 159.83 uV 21.35 56.49 electroretinography cornea 0.0 subretinal injection 4 days pbs b-wave amplitude ERG 108558 3123
RCS-p+/LavRrrc retinal outer nuclear layer photoreceptor nucleus count to layer length ratio control condition Kang S, et al., Transl Vis Sci Technol. 2019 Aug 7;8(4):19. doi: 10.1167/tvst.8.4.19. eCollection 2019 Jul. retinal photoreceptor quantity not specified 180.0 days 5 2.4 / 100 um 3.2 7.16 ex vivo light microscopy with histochemistry 0.0 contralateral control eye 107364 3082
RCS-p+/LavRrrc retinal outer nuclear layer photoreceptor nucleus count to layer length ratio control condition Kang S, et al., Transl Vis Sci Technol. 2019 Aug 7;8(4):19. doi: 10.1167/tvst.8.4.19. eCollection 2019 Jul. retinal photoreceptor quantity not specified 180.0 days 5 3.5 / 100 um 3.0 6.71 ex vivo light microscopy with histochemistry 0.0 contralateral control eye 107370 3082
RCS-p+/LavRrrc scotopic B wave amplitude of ERG waveform control condition then controlled exposure to darkness (for 12 hours) Tao Z, et al., Oncotarget. 2016 Aug 2;7(31):49368-49383. doi: 10.18632/oncotarget.10343. rod electrophysiology trait both 34.0 days 8 45.0 uV 42.0 118.79 electroretinography 0.0 untreated control b-wave amplitude ERG 108377 3121
RCS-p+/LavRrrc scotopic A wave amplitude of ERG waveform gene transfer of the enhanced green fluorescent protein gene using an adenovirus vector (5250000 PFU) then controlled exposure to darkness (for 12 hours) Tao Z, et al., Oncotarget. 2016 Aug 2;7(31):49368-49383. doi: 10.18632/oncotarget.10343. rod electrophysiology trait both 48.0 days 5 17.0 uV 18.0 40.25 electroretinography cornea 0.0 subretinal injection 28 days adenovirus a-wave amplitude ERG 108381 3121
RCS-p+/LavRrrc scotopic B wave amplitude of ERG waveform gene transfer of the enhanced green fluorescent protein gene using an adenovirus vector (5250000 PFU) then controlled exposure to darkness (for 12 hours) Tao Z, et al., Oncotarget. 2016 Aug 2;7(31):49368-49383. doi: 10.18632/oncotarget.10343. rod electrophysiology trait both 62.0 days 5 14.0 uV 17.0 38.01 electroretinography cornea 0.0 subretinal injection 42 days adenovirus b-wave amplitude ERG 108390 3121
RCS-p+/LavRrrc scotopic A wave amplitude of ERG waveform 2-methyl-6-(phenylethynyl)pyridine (200 umol) then controlled exposure to darkness (for 12 hours) then visible light stimulus (-2.5 log(cd x m/s2)) Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. rod electrophysiology trait both 39.0 days 7 11.45 uV 3.56 9.42 electroretinography cornea 0.0 subretinal injection 4 days MPEP a-wave amplitude ERG 108537 3123
RCS-p+/LavRrrc retinal inner nuclear layer thickness control condition Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. retinal inner nuclear layer morphology trait both 75.0 days 3 25.1 um 1.3 2.25 ex vivo light microscopy with histochemistry and digital image analysis 0.0 55 days control for age matched plasmid injection 108698 3131
RCS-p+/LavRrrc retinal outer nuclear layer thickness sham gene transfer using an empty plasmid vector pVAX2 (30 ug) Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. retinal outer nuclear layer morphology trait both 75.0 days 5 14.4 um 1.5 3.35 ex vivo light microscopy with histochemistry and digital image analysis 0.0 plasmid delivery 55 days 108699 3131
RCS-p+/LavRrrc scotopic B wave amplitude of ERG waveform control condition then controlled exposure to darkness (for 1 days) then visible light stimulus (3 cd x s/m2) Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. rod electrophysiology trait both 53.0 days 5 186.0 uV 23.8 53.22 electroretinography cornea 0.0 37 days control for age matched plasmid injection scotopic b-wave ERG 108702 3131
RCS-p+/LavRrrc photoreceptor inner segment thickness sham gene transfer using an empty plasmid vector pVAX2 (30 ug) Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. photoreceptor inner segment morphology trait both 51.0 days 5 6.4 um 0.3 0.67 ex vivo light microscopy with histochemistry and digital image analysis 0.0 plasmid delivery 35 days superior hemisphere - photoreceptor IS 108712 3131
RCS-p+/LavRrrc retinal outer nuclear layer thickness sham gene transfer using an empty plasmid vector pVAX2 (30 ug) Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. retinal outer nuclear layer morphology trait both 70.0 days 5 8.5 um 0.7 1.57 ex vivo light microscopy with histochemistry and digital image analysis 0.0 plasmid delivery 54 days superior hemisphere 108718 3131
RCS-p+/LavRrrc scotopic A wave amplitude of ERG waveform sham gene transfer using an empty plasmid vector pVAX2 (30 ug) then controlled exposure to darkness (for 1 days) then visible light stimulus (3 cd x s/m2) Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. rod electrophysiology trait both 53.0 days 5 60.2 uV 8.5 19.01 electroretinography cornea 0.0 plasmid delivery 37 days scotopic a-wave ERG 108726 3131
RCS-p+/LavRrrc retinal inner layer thickness gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (15 ug) and gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (15 ug) Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. retinal inner nuclear layer morphology trait both 70.0 days 4 32.2 um 1.6 3.2 ex vivo light microscopy with histochemistry and digital image analysis 0.0 plasmid delivery 54 days pVAX2-rGDNF superior hemisphere 108738 3131
RCS-p+/LavRrrc photoreceptor inner segment thickness sham gene transfer using an empty plasmid vector pVAX2 (30 ug) and sham gene transfer using an empty plasmid vector pVAX2 (30 ug) Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. photoreceptor inner segment morphology trait both 70.0 days 4 9.2 um 1.0 2.0 ex vivo light microscopy with histochemistry and digital image analysis 0.0 plasmid delivery 54 days superior hemisphere 108743 3131
RCS-p+/LavRrrc scotopic A wave amplitude of ERG waveform gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (30 ug) and gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (30 ug) then controlled exposure to darkness (for 1 days) then visible light stimulus (3 cd x s/m2) Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. rod electrophysiology trait both 70.0 days 3 20.9 uV 3.7 6.41 electroretinography cornea 0.0 plasmid delivery 54 days pVAX2-rGDNF scotopic a-wave ERG 108748 3131
RCS-p+/LavRrrc scotopic A wave amplitude of ERG waveform gene transfer of the enhanced green fluorescent protein gene using an adenovirus vector (5250000 PFU) then controlled exposure to darkness (for 12 hours) Tao Z, et al., Oncotarget. 2016 Aug 2;7(31):49368-49383. doi: 10.18632/oncotarget.10343. rod electrophysiology trait both 62.0 days 5 9.7 uV 9.9 22.14 electroretinography cornea 0.0 subretinal injection 42 days adenovirus a-wave amplitude ERG 108387 3121
RCS-p+/LavRrrc retinal outer nuclear layer photoreceptor nucleus count to layer length ratio control condition Kang S, et al., Transl Vis Sci Technol. 2019 Aug 7;8(4):19. doi: 10.1167/tvst.8.4.19. eCollection 2019 Jul. retinal photoreceptor quantity not specified 180.0 days 8 3.3 / 100 um 2.8 7.92 ex vivo light microscopy with histochemistry 0.0 109122 3082
RCS-p+/LavRrrc retinal outer nuclear layer thickness light phase of controlled light/dark cycle (0-5 lux) (for 12 hours) Bubis E, et al., Transl Vis Sci Technol. 2019 Feb 28;8(1):26. doi: 10.1167/tvst.8.1.26. eCollection 2019 Jan. retinal photoreceptor layer morphology trait not specified 56.0 days 15 0.0 um 0.0 0.0 optical coherence tomography retina 0.0 Heidelberg Spectralis SD-OCT 110656 3181
RCS-p+/LavRrrc retinal outer nuclear layer thickness light phase of controlled light/dark cycle (0-5 lux) (for 12 hours) Bubis E, et al., Transl Vis Sci Technol. 2019 Feb 28;8(1):26. doi: 10.1167/tvst.8.1.26. eCollection 2019 Jan. retinal photoreceptor layer morphology trait not specified 70.0 days 12 0.0 um 0.0 0.0 optical coherence tomography retina 0.0 Heidelberg Spectralis SD-OCT 110657 3181
RCS-p+/LavRrrc full retina thickness light phase of controlled light/dark cycle (0-5 lux) (for 12 hours) Bubis E, et al., Transl Vis Sci Technol. 2019 Feb 28;8(1):26. doi: 10.1167/tvst.8.1.26. eCollection 2019 Jan. retinal layer morphology trait not specified 84.0 days 9 150.7 um 0.8 2.4 optical coherence tomography retina 0.0 Heidelberg Spectralis SD-OCT 110668 3181
RCS-p+/LavRrrc scotopic B wave amplitude of ERG waveform sham gene transfer using an empty plasmid vector pVAX2 (30 ug) then controlled exposure to darkness (for 1 days) then visible light stimulus (3 cd x s/m2) Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. rod electrophysiology trait both 53.0 days 5 352.0 uV 26.0 58.14 electroretinography cornea 0.0 plasmid delivery 37 days scotopic b-wave ERG 108728 3131
RCS-p+/LavRrrc scotopic B wave amplitude of ERG waveform 2-methyl-6-(phenylethynyl)pyridine (200 umol) then controlled exposure to darkness (for 12 hours) then visible light stimulus (-2.5 log(cd x m/s2)) Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. rod electrophysiology trait both 39.0 days 7 83.4 uV 14.8 39.16 electroretinography cornea 0.0 subretinal injection 4 days pbs a wave amplitude ERG 108543 3123
RCS-p+/LavRrrc scotopic B wave amplitude of ERG waveform 2-methyl-6-(phenylethynyl)pyridine (200 umol) then controlled exposure to darkness (for 12 hours) then visible light stimulus (-0.5 log(cd x m/s2)) Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. rod electrophysiology trait both 39.0 days 7 145.24 uV 12.56 33.23 electroretinography cornea 0.0 subretinal injection 4 days pbs a wave amplitude ERG 108544 3123
RCS-p+/LavRrrc scotopic A wave amplitude of ERG waveform phosphate buffered saline (4 ul) then controlled exposure to darkness (for 12 hours) then visible light stimulus (-0.02 log(cd x m/s2)) Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. rod electrophysiology trait both 39.0 days 7 31.22 uV 8.16 21.59 electroretinography cornea 0.0 subretinal injection 4 days MPEP a-wave amplitude ERG 108551 3123
RCS-p+/LavRrrc scotopic B wave amplitude of ERG waveform phosphate buffered saline (4 ul) then controlled exposure to darkness (for 12 hours) then visible light stimulus (1 log(cd x m/s2)) Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. rod electrophysiology trait both 39.0 days 7 179.49 uV 20.75 54.9 electroretinography cornea 0.0 subretinal injection 4 days pbs b-wave amplitude ERG 108559 3123
RCS-p+/LavRrrc photopic B wave amplitude of ERG waveform vehicle control condition (2 ul) then visible light stimulus (25 cd x s/m2) Baranov P, et al., J Ocul Pharmacol Ther. 2017 Jun;33(5):412-422. doi: 10.1089/jop.2016.0121. Epub 2017 Apr 25. cone electrophysiology trait not specified 119.0 days 7 23.1 uV 1.0 2.65 electroretinography cornea 0.0 intravitrial injection 98 days 109739 3154
RCS-p+/LavRrrc retinal outer nuclear layer photoreceptor nucleus count to layer length ratio laser photocoagulation (45 um) (for 0 hours) Kang S, et al., Transl Vis Sci Technol. 2019 Aug 7;8(4):19. doi: 10.1167/tvst.8.4.19. eCollection 2019 Jul. retinal photoreceptor quantity not specified 180.0 days 5 16.2 / 100 um 5.5 12.3 ex vivo light microscopy with histochemistry 0.0 photocoagulation 161 days experimental eye 107363 3082
RCS-p+/LavRrrc retinal outer nuclear layer photoreceptor nucleus count to layer length ratio control condition Kang S, et al., Transl Vis Sci Technol. 2019 Aug 7;8(4):19. doi: 10.1167/tvst.8.4.19. eCollection 2019 Jul. retinal photoreceptor quantity not specified 180.0 days 5 2.9 / 100 um 3.0 6.71 ex vivo light microscopy with histochemistry 0.0 contralateral control eye 107368 3082
RCS-p+/LavRrrc scotopic A wave amplitude of ERG waveform gene transfer of the enhanced green fluorescent protein gene using an adenovirus vector (5250000 PFU) then controlled exposure to darkness (for 12 hours) Tao Z, et al., Oncotarget. 2016 Aug 2;7(31):49368-49383. doi: 10.18632/oncotarget.10343. rod electrophysiology trait both 34.0 days 8 20.0 uV 20.0 56.57 electroretinography cornea 0.0 subretinal injection 14 days adenovirus a-wave amplitude ERG 108375 3121
RCS-p+/LavRrrc retinal inner nuclear layer thickness sham gene transfer using an empty plasmid vector pVAX2 (30 ug) Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. retinal inner nuclear layer morphology trait both 75.0 days 5 29.9 um 1.5 3.35 ex vivo light microscopy with histochemistry and digital image analysis 0.0 plasmid delivery 55 days 108697 3131
RCS-p+/LavRrrc scotopic B wave amplitude of ERG waveform control condition then controlled exposure to darkness (for 1 days) then visible light stimulus (3 cd x s/m2) Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. rod electrophysiology trait both 75.0 days 5 24.7 uV 13.8 30.86 electroretinography cornea 0.0 59 days control for age matched plasmid injection scotopic b-wave ERG 108704 3131
RCS-p+/LavRrrc retinal outer nuclear layer thickness gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (30 ug) Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. retinal outer nuclear layer morphology trait both 51.0 days 5 27.7 um 1.1 2.46 ex vivo light microscopy with histochemistry and digital image analysis 0.0 plasmid delivery 35 days pVAX2-rGDNF superior hemisphere 108709 3131
RCS-p+/LavRrrc photoreceptor inner segment thickness sham gene transfer using an empty plasmid vector pVAX2 (30 ug) Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. photoreceptor inner segment morphology trait both 70.0 days 5 0.9 um 0.2 0.45 ex vivo light microscopy with histochemistry and digital image analysis 0.0 plasmid delivery 54 days superior hemisphere - photoreceptor IS 108716 3131
RCS-p+/LavRrrc photoreceptor inner segment thickness gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (30 ug) Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. photoreceptor inner segment morphology trait both 70.0 days 5 1.8 um 0.4 0.89 ex vivo light microscopy with histochemistry and digital image analysis 0.0 plasmid delivery 54 days pVAX2-rGDNF superior hemisphere - photoreceptor IS 108715 3131
RCS-p+/LavRrrc photoreceptor inner segment thickness gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (30 ug) Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. photoreceptor inner segment morphology trait both 87.0 days 5 1.5 um 0.4 0.89 ex vivo light microscopy with histochemistry and digital image analysis 0.0 plasmid delivery 71 days pVAX2-rGDNF superior hemisphere - photoreceptor IS 108723 3131
RCS-p+/LavRrrc retinal outer nuclear layer thickness sham gene transfer using an empty plasmid vector pVAX2 (30 ug) Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. retinal outer nuclear layer morphology trait both 87.0 days 5 4.7 um 0.7 1.57 ex vivo light microscopy with histochemistry and digital image analysis 0.0 plasmid delivery 71 days superior hemisphere 108722 3131
RCS-p+/LavRrrc retinal outer nuclear layer thickness sham gene transfer using an empty plasmid vector pVAX2 (30 ug) and sham gene transfer using an empty plasmid vector pVAX2 (30 ug) Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. retinal outer nuclear layer morphology trait both 70.0 days 4 17.6 um 1.7 3.4 ex vivo light microscopy with histochemistry and digital image analysis 0.0 plasmid delivery 54 days superior hemisphere 108740 3131
RCS-p+/LavRrrc scotopic B wave amplitude of ERG waveform gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (15 ug) and gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (15 ug) then controlled exposure to darkness (for 1 days) then visible light stimulus (3 cd x s/m2) Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. rod electrophysiology trait both 70.0 days 3 199.0 uV 17.0 29.44 electroretinography cornea 0.0 plasmid delivery 54 days pVAX2-rGDNF scotopic b-wave ERG 108750 3131
RCS-p+/LavRrrc scotopic B wave amplitude of ERG waveform gene transfer of the enhanced green fluorescent protein gene using an adenovirus vector (5250000 PFU) then controlled exposure to darkness (for 12 hours) Tao Z, et al., Oncotarget. 2016 Aug 2;7(31):49368-49383. doi: 10.18632/oncotarget.10343. rod electrophysiology trait both 34.0 days 8 39.0 uV 23.0 65.05 electroretinography cornea 0.0 subretinal injection 14 days adenovirus b-wave amplitude ERG 108378 3121
RCS-p+/LavRrrc scotopic A wave amplitude of ERG waveform gene transfer of the lin-28 homolog B gene using an adenovirus vector (5250000 PFU) then controlled exposure to darkness (for 12 hours) Tao Z, et al., Oncotarget. 2016 Aug 2;7(31):49368-49383. doi: 10.18632/oncotarget.10343. rod electrophysiology trait both 34.0 days 8 34.0 uV 26.0 73.54 electroretinography cornea 0.0 subretinal injection 14 days adenovirus a-wave amplitude ERG 108376 3121
RCS-p+/LavRrrc scotopic A wave amplitude of ERG waveform gene transfer of the lin-28 homolog B gene using an adenovirus vector (5250000 PFU) then controlled exposure to darkness (for 12 hours) Tao Z, et al., Oncotarget. 2016 Aug 2;7(31):49368-49383. doi: 10.18632/oncotarget.10343. rod electrophysiology trait both 48.0 days 5 27.0 uV 22.0 49.19 electroretinography cornea 0.0 subretinal injection 28 days adenovirus a-wave amplitude ERG 108382 3121
RCS-p+/LavRrrc scotopic B wave amplitude of ERG waveform control condition then controlled exposure to darkness (for 12 hours) Tao Z, et al., Oncotarget. 2016 Aug 2;7(31):49368-49383. doi: 10.18632/oncotarget.10343. rod electrophysiology trait both 48.0 days 5 48.0 uV 26.0 58.14 electroretinography 0.0 untreated control b-wave amplitude ERG 108383 3121
RCS-p+/LavRrrc retinal outer nuclear layer thickness light phase of controlled light/dark cycle (0-5 lux) (for 12 hours) Bubis E, et al., Transl Vis Sci Technol. 2019 Feb 28;8(1):26. doi: 10.1167/tvst.8.1.26. eCollection 2019 Jan. retinal photoreceptor layer morphology trait not specified 42.0 days 18 15.3 um 0.7 2.97 optical coherence tomography retina 0.0 Heidelberg Spectralis SD-OCT 110655 3181
RCS-p+/LavRrrc full retina thickness light phase of controlled light/dark cycle (0-5 lux) (for 12 hours) Bubis E, et al., Transl Vis Sci Technol. 2019 Feb 28;8(1):26. doi: 10.1167/tvst.8.1.26. eCollection 2019 Jan. retinal layer morphology trait not specified 28.0 days 21 232.5 um 2.8 12.83 optical coherence tomography retina 0.0 Heidelberg Spectralis SD-OCT 110664 3181
RCS-p+/LavRrrc retinal inner layer thickness sham gene transfer using an empty plasmid vector pVAX2 (30 ug) Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. retinal inner nuclear layer morphology trait both 70.0 days 5 20.1 um 0.6 1.34 ex vivo light microscopy with histochemistry and digital image analysis 0.0 plasmid delivery 54 days superior hemisphere 108714 3131
RCS-p+/LavRrrc scotopic B wave amplitude of ERG waveform sham gene transfer using an empty plasmid vector pVAX2 (30 ug) then controlled exposure to darkness (for 1 days) then visible light stimulus (3 cd x s/m2) Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. rod electrophysiology trait both 75.0 days 5 114.0 uV 16.0 35.78 electroretinography cornea 0.0 plasmid delivery 59 days scotopic b-wave ERG 108732 3131
RCS-p+/LavRrrc scotopic A wave amplitude of ERG waveform sham gene transfer using an empty plasmid vector pVAX2 (30 ug) then controlled exposure to darkness (for 1 days) then visible light stimulus (3 cd x s/m2) Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. rod electrophysiology trait both 75.0 days 5 23.1 uV 4.0 8.94 electroretinography cornea 0.0 plasmid delivery 59 days scotopic a-wave ERG 108730 3131
RCS-p+/LavRrrc scotopic A wave amplitude of ERG waveform 2-methyl-6-(phenylethynyl)pyridine (200 umol) then controlled exposure to darkness (for 12 hours) then visible light stimulus (-4.5 log(cd x m/s2)) Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. rod electrophysiology trait both 39.0 days 7 5.86 uV 0.76 2.01 electroretinography cornea 0.0 subretinal injection 4 days MPEP a-wave amplitude ERG 108536 3123
RCS-p+/LavRrrc scotopic B wave amplitude of ERG waveform 2-methyl-6-(phenylethynyl)pyridine (200 umol) then controlled exposure to darkness (for 12 hours) then visible light stimulus (-4.5 log(cd x m/s2)) Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. rod electrophysiology trait both 39.0 days 7 7.44 uV 1.43 3.78 electroretinography cornea 0.0 subretinal injection 4 days pbs a wave amplitude ERG 108542 3123
RCS-p+/LavRrrc scotopic B wave amplitude of ERG waveform phosphate buffered saline (4 ul) then controlled exposure to darkness (for 12 hours) then visible light stimulus (-0.5 log(cd x m/s2)) Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. rod electrophysiology trait both 39.0 days 7 94.13 uV 15.33 40.56 electroretinography cornea 0.0 subretinal injection 4 days pbs b-wave amplitude ERG 108556 3123
RCS-p+/LavRrrc scotopic A wave amplitude of ERG waveform gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (30 ug) then controlled exposure to darkness (for 1 days) then visible light stimulus (3 cd x s/m2) Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. rod electrophysiology trait both 87.0 days 5 17.1 uV 3.2 7.16 electroretinography cornea 0.0 plasmid delivery 71 days pVAX2-rGDNF scotopic a-wave ERG 108733 3131
RCS-p+/LavRrrc scotopic B wave amplitude of ERG waveform sham gene transfer using an empty plasmid vector pVAX2 (30 ug) then controlled exposure to darkness (for 1 days) then visible light stimulus (3 cd x s/m2) Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. rod electrophysiology trait both 87.0 days 5 110.0 uV 14.0 31.3 electroretinography cornea 0.0 plasmid delivery 71 days scotopic b-wave ERG 108736 3131
RCS-p+/LavRrrc optokinetic reflex GSK-812 (2 ul) then visible light stimulus (25 cd x s/m2) Baranov P, et al., J Ocul Pharmacol Ther. 2017 Jun;33(5):412-422. doi: 10.1089/jop.2016.0121. Epub 2017 Apr 25. eye physiology trait not specified 119.0 days 7 8.2 s 0.4 1.06 optokinetic reflex test method 60.0 intravitrial injection 98 days 109742 3154
RCS-p+/LavRrrc retinal outer nuclear layer photoreceptor nucleus count to layer length ratio laser photocoagulation (180 um) (for 0 hours) Kang S, et al., Transl Vis Sci Technol. 2019 Aug 7;8(4):19. doi: 10.1167/tvst.8.4.19. eCollection 2019 Jul. retinal photoreceptor quantity not specified 180.0 days 5 2.5 / 100 um 1.5 3.35 ex vivo light microscopy with histochemistry 0.0 photocoagulation 161 days experimental eye 107369 3082
RCS-p+/LavRrrc retinal outer nuclear layer photoreceptor nucleus count to layer length ratio laser photocoagulation (67.5 um) (for 0 hours) Kang S, et al., Transl Vis Sci Technol. 2019 Aug 7;8(4):19. doi: 10.1167/tvst.8.4.19. eCollection 2019 Jul. retinal photoreceptor quantity not specified 180.0 days 5 30.8 / 100 um 14.3 31.98 ex vivo light microscopy with histochemistry 0.0 photocoagulation 161 days experimental eye 107365 3082
RCS-p+/LavRrrc scotopic A wave amplitude of ERG waveform gene transfer of the lin-28 homolog B gene using an adenovirus vector (5250000 PFU) then controlled exposure to darkness (for 12 hours) Tao Z, et al., Oncotarget. 2016 Aug 2;7(31):49368-49383. doi: 10.18632/oncotarget.10343. rod electrophysiology trait both 62.0 days 5 11.0 uV 12.0 26.83 electroretinography cornea 0.0 subretinal injection 42 days adenovirus a-wave amplitude ERG 108388 3121
RCS-p+/LavRrrc scotopic B wave amplitude of ERG waveform gene transfer of the lin-28 homolog B gene using an adenovirus vector (5250000 PFU) then controlled exposure to darkness (for 12 hours) Tao Z, et al., Oncotarget. 2016 Aug 2;7(31):49368-49383. doi: 10.18632/oncotarget.10343. rod electrophysiology trait both 62.0 days 5 34.0 uV 27.0 60.37 electroretinography cornea 0.0 subretinal injection 42 days adenovirus b-wave amplitude ERG 108391 3121
RCS-p+/LavRrrc retinal outer nuclear layer thickness gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (30 ug) Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. retinal outer nuclear layer morphology trait both 87.0 days 5 5.4 um 0.6 1.34 ex vivo light microscopy with histochemistry and digital image analysis 0.0 plasmid delivery 71 days pVAX2-rGDNF superior hemisphere 108721 3131
RCS-p+/LavRrrc photoreceptor inner segment thickness sham gene transfer using an empty plasmid vector pVAX2 (30 ug) Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. photoreceptor inner segment morphology trait both 87.0 days 5 1.1 um 0.5 1.12 ex vivo light microscopy with histochemistry and digital image analysis 0.0 plasmid delivery 71 days superior hemisphere - photoreceptor IS 108724 3131
RCS-p+/LavRrrc scotopic A wave amplitude of ERG waveform gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (30 ug) then controlled exposure to darkness (for 1 days) then visible light stimulus (3 cd x s/m2) Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. rod electrophysiology trait both 53.0 days 5 96.3 uV 10.3 23.03 electroretinography cornea 0.0 plasmid delivery 37 days pVAX2-rGDNF scotopic a-wave ERG 108725 3131
RCS-p+/LavRrrc retinal inner layer thickness sham gene transfer using an empty plasmid vector pVAX2 (30 ug) and sham gene transfer using an empty plasmid vector pVAX2 (30 ug) Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. retinal inner nuclear layer morphology trait both 70.0 days 4 30.5 um 1.3 2.6 ex vivo light microscopy with histochemistry and digital image analysis 0.0 plasmid delivery 54 days superior hemisphere 108737 3131
RCS-p+/LavRrrc retinal outer nuclear layer thickness gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (15 ug) and gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (15 ug) Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. retinal outer nuclear layer morphology trait both 70.0 days 4 16.8 um 1.9 3.8 ex vivo light microscopy with histochemistry and digital image analysis 0.0 plasmid delivery 54 days pVAX2-rGDNF superior hemisphere 108741 3131
RCS-p+/LavRrrc scotopic A wave amplitude of ERG waveform sham gene transfer using an empty plasmid vector pVAX2 (30 ug) and sham gene transfer using an empty plasmid vector pVAX2 (30 ug) then controlled exposure to darkness (for 1 days) then visible light stimulus (3 cd x s/m2) Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. rod electrophysiology trait both 70.0 days 3 23.8 uV 1.9 3.29 electroretinography cornea 0.0 plasmid delivery 54 days pVAX2 scotopic a-wave ERG 108746 3131
RCS-p+/LavRrrc retinal outer nuclear layer thickness light phase of controlled light/dark cycle (0-5 lux) (for 12 hours) Bubis E, et al., Transl Vis Sci Technol. 2019 Feb 28;8(1):26. doi: 10.1167/tvst.8.1.26. eCollection 2019 Jan. retinal photoreceptor layer morphology trait not specified 84.0 days 9 0.0 um 0.0 0.0 optical coherence tomography retina 0.0 Heidelberg Spectralis SD-OCT 110658 3181
RCS-p+/LavRrrc debris zone thickness light phase of controlled light/dark cycle (0-5 lux) (for 12 hours) Bubis E, et al., Transl Vis Sci Technol. 2019 Feb 28;8(1):26. doi: 10.1167/tvst.8.1.26. eCollection 2019 Jan. retinal photoreceptor layer morphology trait not specified 70.0 days 12 28.6 um 1.0 3.46 optical coherence tomography retina 0.0 Heidelberg Spectralis SD-OCT 110662 3181
RCS-p+/LavRrrc debris zone thickness light phase of controlled light/dark cycle (0-5 lux) (for 12 hours) Bubis E, et al., Transl Vis Sci Technol. 2019 Feb 28;8(1):26. doi: 10.1167/tvst.8.1.26. eCollection 2019 Jan. retinal photoreceptor layer morphology trait not specified 84.0 days 9 15.66 um 1.6 4.8 optical coherence tomography retina 0.0 Heidelberg Spectralis SD-OCT debris zone 110663 3181
RCS-p+/LavRrrc full retina thickness light phase of controlled light/dark cycle (0-5 lux) (for 12 hours) Bubis E, et al., Transl Vis Sci Technol. 2019 Feb 28;8(1):26. doi: 10.1167/tvst.8.1.26. eCollection 2019 Jan. retinal layer morphology trait not specified 56.0 days 15 175.8 um 1.5 5.81 optical coherence tomography retina 0.0 Heidelberg Spectralis SD-OCT 110666 3181
RCS-p+/LavRrrc scotopic B wave amplitude of ERG waveform gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (30 ug) then controlled exposure to darkness (for 1 days) then visible light stimulus (3 cd x s/m2) Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. rod electrophysiology trait both 75.0 days 5 135.0 uV 38.0 84.97 electroretinography cornea 0.0 plasmid delivery 59 days pVAX2-rGDNF scotopic b-wave ERG 108731 3131
RCS-p+/LavRrrc scotopic A wave amplitude of ERG waveform 2-methyl-6-(phenylethynyl)pyridine (200 umol) then controlled exposure to darkness (for 12 hours) then visible light stimulus (-0.5 log(cd x m/s2)) Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. rod electrophysiology trait both 39.0 days 7 18.53 uV 4.77 12.63 electroretinography cornea 0.0 subretinal injection 4 days MPEP a-wave amplitude ERG 108538 3123
RCS-p+/LavRrrc scotopic A wave amplitude of ERG waveform 2-methyl-6-(phenylethynyl)pyridine (200 umol) then controlled exposure to darkness (for 12 hours) then visible light stimulus (1 log(cd x m/s2)) Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. rod electrophysiology trait both 39.0 days 7 36.49 uV 10.37 27.44 electroretinography cornea 0.0 subretinal injection 4 days MPEP a-wave amplitude ERG 108541 3123
RCS-p+/LavRrrc scotopic A wave amplitude of ERG waveform phosphate buffered saline (4 ul) then controlled exposure to darkness (for 12 hours) then visible light stimulus (-4.5 log(cd x m/s2)) Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. rod electrophysiology trait both 39.0 days 7 3.13 uV 1.81 4.79 electroretinography cornea 0.0 subretinal injection 4 days MPEP a-wave amplitude ERG 108548 3123
RCS-p+/LavRrrc scotopic B wave amplitude of ERG waveform 2-methyl-6-(phenylethynyl)pyridine (200 umol) then controlled exposure to darkness (for 12 hours) then visible light stimulus (1 log(cd x m/s2)) Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. rod electrophysiology trait both 39.0 days 7 251.29 uV 19.14 50.64 electroretinography cornea 0.0 subretinal injection 4 days pbs a wave amplitude ERG 108547 3123
RCS-p+/LavRrrc scotopic A wave amplitude of ERG waveform phosphate buffered saline (4 ul) then controlled exposure to darkness (for 12 hours) then visible light stimulus (0.5 log(cd x m/s2)) Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. rod electrophysiology trait both 39.0 days 7 24.79 uV 7.82 20.69 electroretinography cornea 0.0 subretinal injection 4 days MPEP a-wave amplitude ERG 108552 3123
RCS-p+/LavRrrc scotopic A wave amplitude of ERG waveform phosphate buffered saline (4 ul) then controlled exposure to darkness (for 12 hours) then visible light stimulus (1 log(cd x m/s2)) Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. rod electrophysiology trait both 39.0 days 7 31.96 uV 9.73 25.74 electroretinography cornea 0.0 subretinal injection 4 days MPEP a-wave amplitude ERG 108553 3123
RCS-p+/LavRrrc scotopic B wave amplitude of ERG waveform phosphate buffered saline (4 ul) then controlled exposure to darkness (for 12 hours) then visible light stimulus (-4.5 log(cd x m/s2)) Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. rod electrophysiology trait both 39.0 days 7 10.28 uV 1.69 4.47 electroretinography cornea 0.0 subretinal injection 4 days pbs b-wave amplitude ERG 108554 3123
RCS-p+/LavRrrc scotopic B wave amplitude of ERG waveform phosphate buffered saline (4 ul) then controlled exposure to darkness (for 12 hours) then visible light stimulus (-2.5 log(cd x m/s2)) Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. rod electrophysiology trait both 39.0 days 7 32.75 uV 13.42 35.51 electroretinography cornea 0.0 subretinal injection 4 days pbs b-wave amplitude ERG 108555 3123
RCS-p+/LavRrrc scotopic B wave amplitude of ERG waveform phosphate buffered saline (4 ul) then controlled exposure to darkness (for 12 hours) then visible light stimulus (-0.02 log(cd x m/s2)) Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. rod electrophysiology trait both 39.0 days 7 131.7 uV 16.13 42.68 electroretinography cornea 0.0 subretinal injection 4 days pbs b-wave amplitude ERG 108557 3123
RCS-p+/LavRrrc photopic B wave amplitude of ERG waveform GSK-812 (2 ul) then visible light stimulus (25 cd x s/m2) Baranov P, et al., J Ocul Pharmacol Ther. 2017 Jun;33(5):412-422. doi: 10.1089/jop.2016.0121. Epub 2017 Apr 25. cone electrophysiology trait not specified 119.0 days 7 28.9 uV 2.5 6.61 electroretinography cornea 0.0 intravitrial injection 98 days 109740 3154
RCS-p+/LavRrrc optokinetic reflex vehicle control condition (2 ul) then visible light stimulus (25 cd x s/m2) Baranov P, et al., J Ocul Pharmacol Ther. 2017 Jun;33(5):412-422. doi: 10.1089/jop.2016.0121. Epub 2017 Apr 25. eye physiology trait not specified 119.0 days 7 6.0 s 0.27 0.71 optokinetic reflex test method 60.0 intravitrial injection 98 days 109741 3154
RCS-p+/LavRrrc retinal outer nuclear layer photoreceptor nucleus count to layer length ratio laser photocoagulation (22.5 um) (for 0 hours) Kang S, et al., Transl Vis Sci Technol. 2019 Aug 7;8(4):19. doi: 10.1167/tvst.8.4.19. eCollection 2019 Jul. retinal photoreceptor quantity not specified 180.0 days 5 17.2 / 100 um 5.4 12.07 ex vivo light microscopy with histochemistry 0.0 photocoagulation 161 days experimental eye 107361 3082
RCS-p+/LavRrrc retinal outer nuclear layer photoreceptor nucleus count to layer length ratio laser photocoagulation (135 um) (for 0 hours) Kang S, et al., Transl Vis Sci Technol. 2019 Aug 7;8(4):19. doi: 10.1167/tvst.8.4.19. eCollection 2019 Jul. retinal photoreceptor quantity not specified 180.0 days 5 3.1 / 100 um 2.3 5.14 ex vivo light microscopy with histochemistry 0.0 photocoagulation 161 days experimental eye 107367 3082
RCS-p+/LavRrrc retinal outer nuclear layer photoreceptor nucleus count to layer length ratio control condition Kang S, et al., Transl Vis Sci Technol. 2019 Aug 7;8(4):19. doi: 10.1167/tvst.8.4.19. eCollection 2019 Jul. retinal photoreceptor quantity not specified 180.0 days 5 3.4 / 100 um 3.7 8.27 ex vivo light microscopy with histochemistry 0.0 contralateral control eye 107366 3082
RCS-p+/LavRrrc scotopic A wave amplitude of ERG waveform control condition then controlled exposure to darkness (for 12 hours) Tao Z, et al., Oncotarget. 2016 Aug 2;7(31):49368-49383. doi: 10.18632/oncotarget.10343. rod electrophysiology trait both 62.0 days 5 8.9 uV 9.9 22.14 electroretinography 0.0 untreated control a-wave amplitude ERG 108386 3121
RCS-p+/LavRrrc retinal outer nuclear layer thickness control condition Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. retinal outer nuclear layer morphology trait both 75.0 days 3 8.1 um 1.2 2.08 ex vivo light microscopy with histochemistry and digital image analysis 0.0 55 days control for age matched plasmid injection 108700 3131
RCS-p+/LavRrrc scotopic B wave amplitude of ERG waveform sham gene transfer using an empty plasmid vector pVAX2 (30 ug) then controlled exposure to darkness (for 1 days) then visible light stimulus (3 cd x s/m2) Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. rod electrophysiology trait both 75.0 days 5 114.0 uV 16.1 36.0 electroretinography cornea 0.0 plasmid delivery 59 days scotopic b-wave ERG 108703 3131
RCS-p+/LavRrrc retinal outer nuclear layer thickness sham gene transfer using an empty plasmid vector pVAX2 (30 ug) Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. retinal outer nuclear layer morphology trait both 51.0 days 5 22.2 um 0.9 2.01 ex vivo light microscopy with histochemistry and digital image analysis 0.0 plasmid delivery 35 days superior hemisphere 108710 3131
RCS-p+/LavRrrc retinal inner layer thickness gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (30 ug) Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. retinal inner nuclear layer morphology trait both 70.0 days 5 27.4 um 0.6 1.34 ex vivo light microscopy with histochemistry and digital image analysis 0.0 plasmid delivery 54 days pVAX2-rGDNF superior hemisphere 108713 3131
RCS-p+/LavRrrc retinal inner layer thickness sham gene transfer using an empty plasmid vector pVAX2 (30 ug) Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. retinal inner nuclear layer morphology trait both 87.0 days 5 20.8 um 0.9 2.01 ex vivo light microscopy with histochemistry and digital image analysis 0.0 plasmid delivery 71 days superior hemisphere 108720 3131
RCS-p+/LavRrrc retinal outer nuclear layer thickness gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (30 ug) Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. retinal outer nuclear layer morphology trait both 70.0 days 5 9.4 um 1.0 2.24 ex vivo light microscopy with histochemistry and digital image analysis 0.0 plasmid delivery 54 days pVAX2-rGDNF superior hemisphere 108717 3131
RCS-p+/LavRrrc retinal inner layer thickness gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (30 ug) Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. retinal inner nuclear layer morphology trait both 87.0 days 5 21.4 um 0.7 1.57 ex vivo light microscopy with histochemistry and digital image analysis 0.0 plasmid delivery 71 days pVAX2-rGDNF superior hemisphere 108719 3131
RCS-p+/LavRrrc scotopic A wave amplitude of ERG waveform gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (30 ug) then controlled exposure to darkness (for 1 days) then visible light stimulus (3 cd x s/m2) Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. rod electrophysiology trait both 75.0 days 5 29.7 uV 11.3 25.27 electroretinography cornea 0.0 plasmid delivery 59 days pVAX2-rGDNF scotopic a-wave ERG 108729 3131
RCS-p+/LavRrrc retinal inner layer thickness gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (30 ug) and gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (30 ug) Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. retinal inner nuclear layer morphology trait both 70.0 days 4 28.3 um 1.3 2.6 ex vivo light microscopy with histochemistry and digital image analysis 0.0 plasmid delivery 54 days pVAX2-rGDNF superior hemisphere 108739 3131
RCS-p+/LavRrrc retinal outer nuclear layer thickness gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (30 ug) and gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (30 ug) Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. retinal outer nuclear layer morphology trait both 70.0 days 4 10.6 um 1.7 3.4 ex vivo light microscopy with histochemistry and digital image analysis 0.0 plasmid delivery 54 days pVAX2-rGDNF superior hemisphere 108742 3131
RCS-p+/LavRrrc photoreceptor inner segment thickness gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (30 ug) and gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (30 ug) Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. photoreceptor inner segment morphology trait both 70.0 days 4 5.2 um 1.2 2.4 ex vivo light microscopy with histochemistry and digital image analysis 0.0 plasmid delivery 54 days pVAX2-rGDNF superior hemisphere 108745 3131
RCS-p+/LavRrrc scotopic A wave amplitude of ERG waveform gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (15 ug) and gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (15 ug) then controlled exposure to darkness (for 1 days) then visible light stimulus (3 cd x s/m2) Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. rod electrophysiology trait both 70.0 days 3 26.7 uV 2.7 4.68 electroretinography cornea 0.0 plasmid delivery 54 days pVAX2-rGDNF scotopic a-wave ERG 108747 3131
RCS-p+/LavRrrc scotopic B wave amplitude of ERG waveform gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (30 ug) and gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (30 ug) then controlled exposure to darkness (for 1 days) then visible light stimulus (3 cd x s/m2) Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. rod electrophysiology trait both 70.0 days 3 144.0 uV 29.0 50.23 electroretinography cornea 0.0 plasmid delivery 54 days pVAX2-rGDNF scotopic b-wave ERG 108751 3131
RCS-p+/LavRrrc scotopic B wave amplitude of ERG waveform gene transfer of the lin-28 homolog B gene using an adenovirus vector (5250000 PFU) then controlled exposure to darkness (for 12 hours) Tao Z, et al., Oncotarget. 2016 Aug 2;7(31):49368-49383. doi: 10.18632/oncotarget.10343. rod electrophysiology trait both 34.0 days 8 79.0 uV 43.0 121.62 electroretinography cornea 0.0 subretinal injection 14 days adenovirus b-wave amplitude ERG 108379 3121
RCS-p+/LavRrrc scotopic B wave amplitude of ERG waveform gene transfer of the lin-28 homolog B gene using an adenovirus vector (5250000 PFU) then controlled exposure to darkness (for 12 hours) Tao Z, et al., Oncotarget. 2016 Aug 2;7(31):49368-49383. doi: 10.18632/oncotarget.10343. rod electrophysiology trait both 48.0 days 5 110.0 uV 40.0 89.44 electroretinography cornea 0.0 subretinal injection 28 days adenovirus b-wave amplitude ERG 108385 3121
RCS-p+/LavRrrc retinal outer nuclear layer photoreceptor nucleus count to layer length ratio subthreshold laser therapy (200 um) (for 0 hours) Kang S, et al., Transl Vis Sci Technol. 2019 Aug 7;8(4):19. doi: 10.1167/tvst.8.4.19. eCollection 2019 Jul. retinal photoreceptor quantity not specified 180.0 days 8 3.0 / 100 um 2.5 7.07 ex vivo light microscopy with histochemistry 0.0 SRT 161 days experimental eye 109067 3082
RCS-p+/LavRrrc retinal outer nuclear layer photoreceptor nucleus count to layer length ratio control condition Kang S, et al., Transl Vis Sci Technol. 2019 Aug 7;8(4):19. doi: 10.1167/tvst.8.4.19. eCollection 2019 Jul. retinal photoreceptor quantity not specified 180.0 days 8 2.3 / 100 um 1.3 3.68 ex vivo light microscopy with histochemistry 0.0 contralateral control eye 109068 3082
RCS-p+/LavRrrc retinal outer nuclear layer photoreceptor nucleus count to layer length ratio nondamaging retinal laser therapy (50 um) (for 0 hours) Kang S, et al., Transl Vis Sci Technol. 2019 Aug 7;8(4):19. doi: 10.1167/tvst.8.4.19. eCollection 2019 Jul. retinal photoreceptor quantity not specified 180.0 days 8 2.7 / 100 um 2.0 5.66 ex vivo light microscopy with histochemistry 0.0 NRT 161 days experimental eye 109069 3082
RCS-p+/LavRrrc retinal outer nuclear layer thickness light phase of controlled light/dark cycle (0-5 lux) (for 12 hours) Bubis E, et al., Transl Vis Sci Technol. 2019 Feb 28;8(1):26. doi: 10.1167/tvst.8.1.26. eCollection 2019 Jan. retinal photoreceptor layer morphology trait not specified 28.0 days 21 50.5 um 0.8 3.67 optical coherence tomography retina 0.0 Heidelberg Spectralis SD-OCT 110654 3181
RCS-p+/LavRrrc debris zone thickness light phase of controlled light/dark cycle (0-5 lux) (for 12 hours) Bubis E, et al., Transl Vis Sci Technol. 2019 Feb 28;8(1):26. doi: 10.1167/tvst.8.1.26. eCollection 2019 Jan. retinal photoreceptor layer morphology trait not specified 28.0 days 21 51.7 um 0.8 3.67 optical coherence tomography retina 0.0 Heidelberg Spectralis SD-OCT debris zone 110659 3181
RCS-p+/LavRrrc full retina thickness light phase of controlled light/dark cycle (0-5 lux) (for 12 hours) Bubis E, et al., Transl Vis Sci Technol. 2019 Feb 28;8(1):26. doi: 10.1167/tvst.8.1.26. eCollection 2019 Jan. retinal layer morphology trait not specified 42.0 days 18 193.6 um 1.7 7.21 optical coherence tomography retina 0.0 Heidelberg Spectralis SD-OCT 110665 3181
RCS-p+/LavRrrc scotopic A wave amplitude of ERG waveform 2-methyl-6-(phenylethynyl)pyridine (200 umol) then controlled exposure to darkness (for 12 hours) then visible light stimulus (-0.02 log(cd x m/s2)) Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. rod electrophysiology trait both 39.0 days 7 27.22 uV 4.74 12.54 electroretinography cornea 0.0 subretinal injection 4 days MPEP a-wave amplitude ERG 108539 3123
RCS-p+/LavRrrc scotopic A wave amplitude of ERG waveform phosphate buffered saline (4 ul) then controlled exposure to darkness (for 12 hours) then visible light stimulus (-2.5 log(cd x m/s2)) Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. rod electrophysiology trait both 39.0 days 7 15.31 uV 2.98 7.88 electroretinography cornea 0.0 subretinal injection 4 days MPEP a-wave amplitude ERG 108549 3123