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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:doxepin drug pathway
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Accession:PW:0002310 term browser browse the term
Definition:The pharmacokinetics and pharmacodynamics pathway of desipramine, an antidepressant used in the treatment of depression, anxiety disorders, insomnia. Genetic variations can result in changes in drug availability and can cause differences in the response of the organism to the drug.


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doxepin pharmacokinetics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 ISO SMPDB SMP:00641 NCBI chr15:53,692,877...53,699,279
Ensembl chr15:73,311,720...73,319,447 		JBrowse link
G CYP2C19 cytochrome P450 family 2 subfamily C member 19 ISO SMPDB SMP:00641 NCBI chr10:91,375,255...91,465,215
Ensembl chr10:94,884,472...94,970,065 		JBrowse link
G CYP2C9 cytochrome P450 family 2 subfamily C member 9 ISO SMPDB SMP:00641 NCBI chr10:91,547,865...91,598,918
Ensembl chr10:95,022,482...95,105,653 		JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 ISO SMPDB SMP:00641 NCBI chr 7:91,797,037...91,824,696
Ensembl chr 7:105,230,666...105,258,401 		JBrowse link
G LOC100988273 cytochrome P450 2D6-like ISO SMPDB SMP:00641 NCBI chr22:23,022,449...23,031,627 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 4069
    drug pathway 395
      nervous system drug pathway 181
        antidepressant drug pathway 40
          non-selective monoamine reuptake inhibitor drug pathway 35
            doxepin drug pathway 5
              doxepin pharmacodynamics pathway 0
              doxepin pharmacokinetics pathway 5
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