CYP2C9 (cytochrome P450 family 2 subfamily C member 9)

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Gene: CYP2C9 (cytochrome P450 family 2 subfamily C member 9) Pan paniscus

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Symbol:

CYP2C9

Name:

cytochrome P450 family 2 subfamily C member 9

RGD ID:

11971292

Description:

ENCODES a protein that exhibits arachidonate epoxygenase activity (ortholog); caffeine oxidase activity (ortholog); oxidoreductase activity (ortholog); INVOLVED IN epoxygenase P450 pathway (ortholog); estrogen metabolic process (ortholog); icosanoid biosynthetic process (ortholog); PARTICIPATES IN caffeine pharmacokinetics pathway; celecoxib pharmacodynamics pathway; celecoxib pharmacokinetics pathway; ASSOCIATED WITH acute kidney failure (ortholog); alcohol dependence (ortholog); autism spectrum disorder (ortholog); FOUND IN plasma membrane (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

cytochrome P450 2C9; LOC100996034

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	8	106,841,034 - 106,892,628 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	10	106,846,351 - 106,897,945 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	10	91,547,865 - 91,598,918 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	10	95,054,988 - 95,106,016 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	10	95,022,482 - 95,105,653 (+)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

acute kidney failure (ISO)

alcohol dependence (ISO)

autism spectrum disorder (ISO)

Brain Neoplasms (ISO)

cardiomyopathy (ISO)

Chemical and Drug Induced Liver Injury (ISO)

chronic obstructive pulmonary disease (ISO)

Coumarin Sensitivity (ISO)

Diabetes Complications (ISO)

diabetes mellitus (ISO)

drug allergy (ISO)

head and neck squamous cell carcinoma (ISO)

Hemorrhage (ISO)

hyperglycemia (ISO)

hypertension (ISO)

hypoglycemia (ISO)

interstitial nephritis (ISO)

nervous system disease (ISO)

Peptic Ulcer Hemorrhage (ISO)

type 2 diabetes mellitus (ISO)

urinary bladder cancer (ISO)

warfarin resistance (ISO)

warfarin sensitivity (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

epoxygenase P450 pathway (ISO)

estrogen metabolic process (ISO)

icosanoid biosynthetic process (ISO)

monocarboxylic acid metabolic process (ISO)

monoterpenoid metabolic process (ISO)

organic acid metabolic process (IEA)

oxidative demethylation (ISO)

steroid metabolic process (ISO)

urea metabolic process (ISO)

xenobiotic catabolic process (ISO)

xenobiotic metabolic process (IEA)

Cellular Component

cytoplasm (IEA)

intracellular membrane-bounded organelle (IEA)

plasma membrane (ISO)

Molecular Function

arachidonate epoxygenase activity (ISO)

caffeine oxidase activity (ISO)

heme binding (IEA)

iron ion binding (IEA)

metal ion binding (IEA)

monooxygenase activity (IEA)

oxidoreductase activity (ISO)

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen (IEA)

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen (IEA)

steroid hydroxylase activity (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

caffeine pharmacokinetics pathway (ISO)

celecoxib pharmacodynamics pathway (ISO)

celecoxib pharmacokinetics pathway (ISO)

clopidogrel pharmacodynamics pathway (ISO)

clopidogrel pharmacokinetics pathway (ISO)

cyclophosphamide pharmacodynamics pathway (ISO)

cyclophosphamide pharmacokinetics pathway (ISO)

doxepin pharmacokinetics pathway (ISO)

fluoxetine pharmacodynamics pathway (ISO)

fluoxetine pharmacokinetics pathway (ISO)

ibuprofen pharmacodynamics pathway (ISO)

ibuprofen pharmacokinetics pathway (ISO)

ifosfamide pharmacodynamics pathway (ISO)

ifosfamide pharmacokinetics pathway (ISO)

losartan pharmacokinetics pathway (ISO)

nateglinide pharmacokinetics pathway (ISO)

neviparine pharmacokinetics pathway (ISO)

phenytoin pharmacodynamics pathway (ISO)

rosiglitazone pharmacokinetics pathway (ISO)

sorafenib pharmacokinetics pathway (ISO)

statin pharmacokinetics pathway (ISO)

tamoxifen pharmacokinetics pathway (ISO)

valproic acid pharmacokinetics pathway (ISO)

warfarin pharmacokinetics pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

CYP2C9
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	8	106,841,034 - 106,892,628 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	10	106,846,351 - 106,897,945 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	10	91,547,865 - 91,598,918 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	10	95,054,988 - 95,106,016 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	10	95,022,482 - 95,105,653 (+)	Ensembl	panpan1.1		panPan2

CYP2C9
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	10	94,938,658 - 94,990,091 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	10	94,938,658 - 94,990,091 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	10	96,698,415 - 96,749,848 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	10	96,688,430 - 96,739,137 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	10	96,688,429 - 96,739,137	NCBI
Celera	10	90,438,533 - 90,489,263 (+)	NCBI		Celera
Cytogenetic Map	10	q23.33	NCBI
HuRef	10	90,325,093 - 90,375,554 (+)	NCBI		HuRef
CHM1_1	10	96,980,209 - 97,030,927 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	10	95,817,787 - 95,869,223 (+)	NCBI		T2T-CHM13v2.0

Cyp2c65
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	19	39,049,450 - 39,082,392 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	19	39,049,459 - 39,082,388 (+)	Ensembl		GRCm39 Ensembl
GRCm38	19	39,061,006 - 39,093,948 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	19	39,061,015 - 39,093,944 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	19	39,135,496 - 39,168,438 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	19	39,126,059 - 39,158,594 (+)	NCBI		MGSCv36	mm8
Celera	19	39,863,719 - 39,896,736 (+)	NCBI		Celera
Cytogenetic Map	19	C3	NCBI
cM Map	19	33.7	NCBI

Cyp2c66
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	19	39,102,342 - 39,175,200 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	19	39,102,342 - 39,175,516 (+)	Ensembl		GRCm39 Ensembl
GRCm38	19	39,113,898 - 39,186,756 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	19	39,113,898 - 39,187,072 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	19	39,188,388 - 39,261,246 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	19	39,178,942 - 39,240,067 (+)	NCBI		MGSCv36	mm8
Celera	19	39,916,729 - 39,978,061 (+)	NCBI		Celera
Cytogenetic Map	19	C3	NCBI
cM Map	19	33.75	NCBI

CYP2C41
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
UNSW_CanFamBas_1.0	28	8,733,741 - 8,753,965 (+)	NCBI		UNSW_CanFamBas_1.0

CYP2C9
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	9	88,082,124 - 88,125,390 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666048	48,867,040 - 48,902,540 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003825387	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_055093166	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_055093167	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSPPAT00000062108 ⟹ ENSPPAP00000039199

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	10	95,022,482 - 95,105,653 (+)	Ensembl

RefSeq Acc Id:

XM_003825387 ⟹ XP_003825435

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	8	106,841,034 - 106,892,628 (+)	NCBI
NHGRI_mPanPan1	10	106,846,351 - 106,897,945 (+)	NCBI
Mhudiblu_PPA_v0	10	91,547,865 - 91,598,918 (+)	NCBI
PanPan1.1	10	95,054,988 - 95,106,016 (+)	NCBI

Sequence:

show sequence

TACAGAGTGGACAATGGAACGAAGGAGAACAAGGCCAAAGGACATTTTATTTTTATCTCTATCA
GTGGGTCAAAGTCCTTTCAGAAGGAGCATATAGTGGACCTAGGTGATTGGTCAATTTATCCATC
AAAGAGGCACACACCGAATTAGCATGGAGTGTTATAAAAGGCTTGGAGTGCAAGCTCATGGTTG
TCTTAACAAGAAGAGAAGGCTTCAATGGATTCTCTTGTGGTCCTTGTGCTCTGTCTCTCATGTT
TGCTTCTCCTTTCACTCTGGAGACAGAGCTCTGGGAGAGGAAAACTCCCTCCTGGCCCCACTCC
TCTCCCAGTGATTGGAAATATCCTACAGATAGGTATTAAGGACATCAGCAAATCCTTAACCAAT
CTCTCAAAGGTCTATGGCCCTGTGTTCACTCTGTATTTTGGCCTGAAACCCATAGTGGTGCTGC
ATGGATATGAAGCAGTGAAGGAAGCCCTGATTGATCTTGGAGAGGAGTTTTCTGGAAGAGGCAT
TTTCCCACTGGCTGAAAGAGCTAACAGAGGATTTGGAATTGTTTTCAGCAATGGAAAGAAATGG
AAGGAGATCCGGCGTTTCTCCCTCATGACGCTGCGGAATTTTGGGATGGGGAAGAGGAGCATTG
AGGACCGTGTTCAAGAGGAAGCCCGCTGCCTTGTGGAGGAGTTGAGAAAAACCAAGGCCTCACC
CTGTGATCCCACTTTCATCCTGGGCTGTGCTCCCTGCAATGTGATCTGCTCCATTATTTTCCAT
AAACGTTTTGATTATAAAGATCAGCAATTTCTTAACTTGATGGAAAAGTTGAATGAAAACGTCA
AGATTTTGAGCAGCCCCTGGATCCAGATCTGCAATAATTTTTCTCCTATCATTGATTACTTCCC
GGGAACTCACAACAAATTACTTAAAAACGTTGCTTTTATGAAAAGTTATATTTTGGAGAAAGTA
AAAGAACACCAAGAATCGATGGACATGAACAACCCTCAGGACTTTATTGATTGCTTCCTGATGA
AAATGGAGAAGGAAAAGCACAACCAACCATCTGAATTTACTATTGAAAGCTTGGAAAACACTGC
AGTTGACTTGTTTGGAGCTGGGACAGAGACGACAAGCACAACCCTGAGATATGCTCTCCTTCTC
CTGCTGAAGCACCCAGAGGTCACAGCTAAAGTCCAGGAAGAGATTGAACGTGTGATTGGCAGAA
ACCGGAGCCCCTGCATGCAGGACAGGAGCCACATGCCCTACACAGATGCTGTGGTGCACGAGGT
CCAGAGATACATTGACCTTCTCCCCACCAGCCTGCCCCATGCAGTGACCTGTGACATTAAATTC
AGAAACTATCTCATTCCCAAGGGCACAACCATATTAATTTCCCTGACTTCTGTGCTACATGACA
ACAAAGAATTTCCCAACCCAGAGATGTTTGACCCTCATCACTTTCTGGATGAAGGTGGCAATTT
TAAGAAAAGTAACTACTTCATGCCTTTCTCAGCAGGAAAACGGATTTGTGTGGGAGAAGCCCTG
GCCCGCATGGAGCTGTTTTTATTTCTGACCTCCATTTTACAGAACTTTAACCTGAAATCTCTGG
TTGACCCAAAGAACCTTGACACCACTCCAGTTGTCAATGGATTTGCCTCTGTGCCGCCCTTCTA
CCAGCTGTGCTTCATTCCTGTCTGAAGAAGAGCAGATGGCCTGGCTGCTGCTGTGCAGTCCCTG
CAGCTCTCTTTCCTCTGGGGCGTTATCCATCTTTCACTATCTGTAATGCCTTTTCTCACCTGTC
ATCTCACATTTTCCCTTCCCTGAAGATCTAGTGAACATTCGACCTCCATTACGGAGAGTTTCCT
ATGTTTCACTGTGCAAATATATCTGCTATTCTCCATACTCTGTAACAGTTGCATTGACTGTCAC
ATAATGCTCATACTTATCTAATGTTGAGTTATTAATATGTTATTATTAAATAGAGAAATATGAT
TTGTGTATTATAATTCAAAGGCATTTCTTTTCTGCATGTTCTAAATAAAAAGCATTATTATTTG
CTGA

hide sequence

RefSeq Acc Id:

XM_055093166 ⟹ XP_054949141

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	8	106,841,059 - 106,891,531 (+)	NCBI
NHGRI_mPanPan1	10	106,846,376 - 106,896,848 (+)	NCBI

RefSeq Acc Id:

XM_055093167 ⟹ XP_054949142

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	8	106,841,233 - 106,891,531 (+)	NCBI
NHGRI_mPanPan1	10	106,846,550 - 106,896,848 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_003825435	(Get FASTA)	NCBI Sequence Viewer
	XP_054949141	(Get FASTA)	NCBI Sequence Viewer
	XP_054949142	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000039199.1

RefSeq Acc Id:	XP_003825435 ⟸ XM_003825387
- Peptide Label:	isoform X1
- UniProtKB:	A0A2R9CBE7 (UniProtKB/TrEMBL)
- Sequence:	show sequence MDSLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPV FTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRRFSL MTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQ QFLNLMEKLNENVKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMD MNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVT AKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKG TTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSNYFMPFSAGKRICVGEALARMELFLF LTSILQNFNLKSLVDPKNLDTTPVVNGFASVPPFYQLCFIPV hide sequence

Ensembl Acc Id:

ENSPPAP00000039199 ⟸ ENSPPAT00000062108

RefSeq Acc Id:	XP_054949141 ⟸ XM_055093166
- Peptide Label:	isoform X2
- UniProtKB:	A0A2R9CBE7 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_054949142 ⟸ XM_055093167
- Peptide Label:	isoform X3

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000042322	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000062108.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.630.10	UniProtKB/TrEMBL
InterPro	Cyt_P450	UniProtKB/TrEMBL
	Cyt_P450_CS	UniProtKB/TrEMBL
	Cyt_P450_E_grp-I	UniProtKB/TrEMBL
	Cyt_P450_sf	UniProtKB/TrEMBL
	Cytochrome_P450_fam2	UniProtKB/TrEMBL
NCBI Gene	LOC100996034	ENTREZGENE
PANTHER	CYTOCHROME P450 2C9	UniProtKB/TrEMBL
	CYTOCHROME P450 508A4-RELATED	UniProtKB/TrEMBL
Pfam	p450	UniProtKB/TrEMBL
PRINTS	EP450I	UniProtKB/TrEMBL
	P450	UniProtKB/TrEMBL
PROSITE	CYTOCHROME_P450	UniProtKB/TrEMBL
Superfamily-SCOP	SSF48264	UniProtKB/TrEMBL
UniProt	A0A2R9CBE7	ENTREZGENE, UniProtKB/TrEMBL
VGNC ID	VGNC:83057	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2020-02-25	CYP2C9	cytochrome P450 family 2 subfamily C member 9	LOC100996034	cytochrome P450 2C9	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB