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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:erythropoietin signaling pathway
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Accession:PW:0000987 term browser browse the term
Definition:Erythropoietin (EPO) signaling is crucial for the production of blood cell or erythropoiesis and also plays important roles in wound healing and responses to neural injury. EPO is a glycoprotein hormone and also a cytokine whose receptor belongs to type I cytokine receptor. The pathway engages the Jak-Stat intracellular cascade.
Synonyms:exact_synonym: EPO signaling pathway
 related_synonym: PID:200183

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erythropoietin signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCL2 BCL2 apoptosis regulator ISO PID PID:200183 NCBI chr18:16,440,560...16,643,187
Ensembl chr18:16,441,733...16,637,895 		JBrowse link
G BCL2L1 BCL2 like 1 ISO PID PID:200183 NCBI chr 2:36,059,024...36,118,332
Ensembl chr 2:36,058,919...36,116,470 		JBrowse link
G BTK Bruton tyrosine kinase ISO PID PID:200183 NCBI chr  X:89,690,569...89,727,420 JBrowse link
G CBL Cbl proto-oncogene ISO PID PID:200183 NCBI chr 1:110,581,049...110,679,284
Ensembl chr 1:110,581,143...110,674,481 		JBrowse link
G CRKL CRK like proto-oncogene, adaptor protein ISO PID PID:200183
G EPO erythropoietin ISO PID PID:200183 NCBI chr28:12,487,222...12,491,986
Ensembl chr28:12,489,766...12,491,908 		JBrowse link
G EPOR erythropoietin receptor ISO PID PID:200183 NCBI chr 6:10,313,382...10,320,196
Ensembl chr 6:10,313,775...10,320,066 		JBrowse link
G GAB1 GRB2 associated binding protein 1 ISO PID PID:200183 NCBI chr 7:90,197,374...90,323,024
Ensembl chr 7:90,197,620...90,322,077 		JBrowse link
G GRB2 growth factor receptor bound protein 2 ISO PID PID:200183 NCBI chr16:46,264,818...46,346,426
Ensembl chr16:46,264,825...46,347,156 		JBrowse link
G HRAS HRas proto-oncogene, GTPase ISO PID PID:200183 NCBI chr 1:343,613...345,782
Ensembl chr 1:343,506...346,637 		JBrowse link
G INPP5D inositol polyphosphate-5-phosphatase D ISO PID PID:200183 NCBI chr10:119,093,160...119,244,128
Ensembl chr10:119,093,781...119,244,123 		JBrowse link
G IRS2 insulin receptor substrate 2 ISO PID PID:200183 NCBI chr 3:88,045,439...88,076,468 JBrowse link
G JAK2 Janus kinase 2 ISO PID PID:200183 NCBI chr12:74,421,243...74,566,766
Ensembl chr12:74,421,016...74,566,710 		JBrowse link
G LOC103243413 signal transducer and activator of transcription 5B ISO PID PID:200183 NCBI chr16:63,997,486...64,070,392
Ensembl chr16:63,997,441...64,070,445 		JBrowse link
G LYN LYN proto-oncogene, Src family tyrosine kinase ISO PID PID:200183 NCBI chr 8:51,919,656...52,057,376
Ensembl chr 8:51,919,808...52,057,959 		JBrowse link
G MAPK14 mitogen-activated protein kinase 14 ISO PID PID:200183 NCBI chr17:36,012,164...36,095,542
Ensembl chr17:36,014,454...36,095,138 		JBrowse link
G MAPK8 mitogen-activated protein kinase 8 ISO PID PID:200183 NCBI chr 9:43,356,603...43,489,066
Ensembl chr 9:43,356,308...43,393,425 		JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 ISO PID PID:200183 NCBI chr 7:50,589,494...50,711,472
Ensembl chr 7:50,589,856...50,711,498 		JBrowse link
G PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 ISO PID PID:200183 NCBI chr 4:64,321,296...64,406,188
Ensembl chr 4:64,321,078...64,406,519 		JBrowse link
G PLCG1 phospholipase C gamma 1 ISO PID PID:200183 NCBI chr 2:22,599,547...22,638,394 JBrowse link
G PLCG2 phospholipase C gamma 2 ISO PID PID:200183 NCBI chr 5:67,209,268...67,394,865
Ensembl chr 5:67,215,459...67,398,990 		JBrowse link
G PTPN11 protein tyrosine phosphatase non-receptor type 11 ISO PID PID:200183 NCBI chr11:107,658,495...107,754,457
Ensembl chr11:107,658,453...107,752,637 		JBrowse link
G PTPN6 protein tyrosine phosphatase non-receptor type 6 ISO PID PID:200183 NCBI chr11:6,977,480...6,994,525
Ensembl chr11:6,984,710...6,994,545 		JBrowse link
G RAP1A RAP1A, member of RAS oncogene family ISO PID PID:200183 NCBI chr20:21,895,829...21,989,008
Ensembl chr20:21,899,669...21,917,350 		JBrowse link
G RAPGEF1 Rap guanine nucleotide exchange factor 1 ISO PID PID:200183 NCBI chr12:6,407,030...6,566,200
Ensembl chr12:6,437,454...6,567,436 		JBrowse link
G SH2B3 SH2B adaptor protein 3 ISO PID PID:200183 NCBI chr11:106,657,601...106,703,940
Ensembl chr11:106,670,685...106,700,619 		JBrowse link
G SHC1 SHC adaptor protein 1 ISO PID PID:200183 NCBI chr20:8,854,189...8,866,406
Ensembl chr20:8,858,458...8,866,610 		JBrowse link
G SOCS3 suppressor of cytokine signaling 3 ISO PID PID:200183 NCBI chr16:70,353,099...70,356,401
Ensembl chr16:70,354,746...70,355,423 		JBrowse link
G SOS1 SOS Ras/Rac guanine nucleotide exchange factor 1 ISO PID PID:200183 NCBI chr14:68,259,509...68,404,167
Ensembl chr14:68,259,360...68,399,895 		JBrowse link
G STAT1 signal transducer and activator of transcription 1 ISO PID PID:200183 NCBI chr10:76,492,859...76,537,689
Ensembl chr10:76,492,533...76,533,393 		JBrowse link
G STAT5A signal transducer and activator of transcription 5A ISO PID PID:200183 NCBI chr16:63,959,265...63,986,627
Ensembl chr16:63,960,515...63,985,026 		JBrowse link
G TEC tec protein tyrosine kinase ISO PID PID:200183 NCBI chr27:1,982,549...2,118,533
Ensembl chr27:2,024,719...2,117,763 		JBrowse link
G TRPC6 transient receptor potential cation channel subfamily C member 6 ISO PID PID:200183 NCBI chr 1:92,828,546...92,970,224
Ensembl chr 1:92,829,253...92,885,086 		JBrowse link
G VAV2 vav guanine nucleotide exchange factor 2 ISO PID PID:200183 NCBI chr12:4,142,966...4,377,849
Ensembl chr12:4,143,139...4,377,852 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 4028
    signaling pathway 1919
      hormone signaling pathway 377
        peptide and protein hormone signaling pathway 270
          erythropoietin signaling pathway 34
paths to the root