EPO (erythropoietin) - Rat Genome Database

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Gene: EPO (erythropoietin) Chlorocebus sabaeus
Analyze
Symbol: EPO
Name: erythropoietin
RGD ID: 18668756
Description: ENCODES a protein that exhibits cytokine activity (inferred); erythropoietin receptor binding (inferred); hormone activity (inferred); INVOLVED IN acute-phase response (ortholog); apoptotic process (ortholog); embryo implantation (ortholog); PARTICIPATES IN erythropoietin signaling pathway; hypoxia inducible factor pathway; ASSOCIATED WITH acute kidney failure (ortholog); Acute Subdural Hematoma (ortholog); Acute-Phase Reaction (ortholog); FOUND IN cell body (ortholog); extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12812,487,222 - 12,491,986 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2812,489,766 - 12,491,908 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660703,816,537 - 3,820,180 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
Acute Subdural Hematoma  (ISO)
Acute-Phase Reaction  (ISO)
AIDS Dementia Complex  (ISO)
Albuminuria  (ISO)
Alzheimer's disease  (ISO)
amyotrophic lateral sclerosis  (ISO)
Anastomotic Leak  (ISO)
anemia  (ISO)
beta thalassemia  (ISO)
Brain Hypoxia  (ISO)
Brain Hypoxia-Ischemia  (ISO)
Brain Injuries  (ISO)
breast cancer  (ISO)
calcinosis  (ISO)
Cardiogenic Shock  (ISO)
cardiomyopathy  (ISO)
central nervous system disease  (ISO)
cholangiocarcinoma  (ISO)
cognitive disorder  (ISO)
congenital diaphragmatic hernia  (ISO)
congestive heart failure  (ISO)
coronary artery disease  (ISO)
diabetic angiopathy  (ISO)
Diabetic Nephropathies  (ISO)
diabetic neuropathy  (ISO)
diabetic retinopathy  (ISO)
Diamond-Blackfan Anemia-Like  (ISO)
end stage renal disease  (ISO)
Endotoxemia  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Neuritis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Mammary Neoplasms  (ISO)
Experimental Sarcoma  (ISO)
familial erythrocytosis 5  (ISO)
Fatigue  (ISO)
Fetal Distress  (ISO)
gastric ulcer  (ISO)
genetic disease  (ISO)
glaucoma  (ISO)
heart disease  (ISO)
hemolytic anemia  (ISO)
hemolytic-uremic syndrome  (ISO)
Hemorrhagic Shock  (ISO)
hepatocellular carcinoma  (ISO)
high grade glioma  (ISO)
hypertension  (ISO)
hypoglycemia  (ISO)
Inflammation  (ISO)
kidney disease  (ISO)
kidney failure  (ISO)
Kidney Reperfusion Injury  (ISO)
Knee Osteoarthritis  (ISO)
limb ischemia  (ISO)
Liver Reperfusion Injury  (ISO)
macular retinal edema  (ISO)
melanoma  (ISO)
Micronuclei, Chromosome-Defective  (ISO)
middle cerebral artery infarction  (ISO)
myelodysplastic syndrome  (ISO)
myocardial infarction  (ISO)
Necrosis  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
nephrotic syndrome  (ISO)
Nerve Degeneration  (ISO)
neurodegenerative disease  (ISO)
pancytopenia  (ISO)
Paraneoplastic Syndromes  (ISO)
Parkinson's disease  (ISO)
Penetrating Wounds  (ISO)
placental insufficiency  (ISO)
pleomorphic xanthoastrocytoma  (ISO)
Poisoning  (ISO)
polyneuropathy  (ISO)
porphyria  (ISO)
Pregnancy Complications  (ISO)
pulmonary embolism  (ISO)
pulmonary hypertension  (ISO)
retinal degeneration  (ISO)
retinal detachment  (ISO)
retinopathy of prematurity  (ISO)
severe combined immunodeficiency  (ISO)
Spinal Cord Compression  (ISO)
Spinal Cord Injuries  (ISO)
status epilepticus  (ISO)
Subarachnoid Hemorrhage  (ISO)
thrombocytopenia  (ISO)
thrombosis  (ISO)
Thyroid Neoplasms  (ISO)
transient cerebral ischemia  (ISO)
Tubulointerstitial Fibrosis  (ISO)
type 2 diabetes mellitus  (ISO)
uremia  (ISO)
vascular dementia  (ISO)
vascular disease  (ISO)
Venous Thrombosis  (ISO)
Ventricular Fibrillation  (ISO)
ventricular septal defect  (ISO)
Ventricular Tachycardia  (ISO)
visual epilepsy  (ISO)
Weight Loss  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acute-phase response  (ISO)
apoptotic process  (IEA,ISO)
cellular hyperosmotic response  (IEA)
embryo implantation  (IEA,ISO)
erythrocyte differentiation  (IEA,ISO)
erythrocyte maturation  (IEA)
erythropoietin-mediated signaling pathway  (IEA)
hemoglobin biosynthetic process  (IEA,ISO)
myeloid cell apoptotic process  (IEA,ISO)
negative regulation of apoptotic process  (IEA)
negative regulation of calcium ion transport into cytosol  (IEA)
negative regulation of cellular process  (ISO)
negative regulation of erythrocyte apoptotic process  (IEA)
negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress  (IEA)
negative regulation of myeloid cell apoptotic process  (IEA,ISO)
negative regulation of transcription by RNA polymerase II  (IEA)
nucleate erythrocyte development  (IEA)
positive regulation of activated T cell proliferation  (ISO)
positive regulation of cell population proliferation  (IEA,ISO)
positive regulation of DNA-templated transcription  (IEA)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of neuron differentiation  (ISO)
positive regulation of neuron projection development  (ISO)
positive regulation of Ras protein signal transduction  (IEA)
positive regulation of tyrosine phosphorylation of STAT protein  (IEA)
regulation of transcription by RNA polymerase II  (IEA,ISO)
response to axon injury  (ISO)
response to dexamethasone  (ISO)
response to electrical stimulus  (ISO)
response to estrogen  (ISO)
response to hyperoxia  (ISO)
response to hypoxia  (IEA,ISO)
response to interleukin-1  (ISO)
response to lipopolysaccharide  (ISO)
response to nutrient  (ISO)
response to salt stress  (ISO)
response to testosterone  (ISO)
response to vitamin A  (ISO)
signal transduction  (IEA)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
EPO
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12812,487,222 - 12,491,986 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2812,489,766 - 12,491,908 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660703,816,537 - 3,820,180 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
EPO
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387100,720,468 - 100,723,700 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7100,720,468 - 100,723,700 (+)EnsemblGRCh38hg38GRCh38
GRCh377100,318,091 - 100,321,323 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367100,156,359 - 100,159,259 (+)NCBINCBI36Build 36hg18NCBI36
Build 34799,963,073 - 99,965,972NCBI
Celera795,048,997 - 95,051,893 (+)NCBICelera
Cytogenetic Map7q22.1NCBI
HuRef794,949,230 - 94,952,126 (+)NCBIHuRef
CHM1_17100,248,723 - 100,251,623 (+)NCBICHM1_1
T2T-CHM13v2.07101,960,533 - 101,963,765 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2799,678,028 - 99,680,928 (+)NCBI
Epo
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395137,481,282 - 137,484,078 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5137,481,282 - 137,531,504 (-)EnsemblGRCm39 Ensembl
GRCm385137,483,020 - 137,485,816 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5137,483,020 - 137,533,242 (-)EnsemblGRCm38mm10GRCm38
MGSCv375137,924,248 - 137,927,044 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365137,712,873 - 137,715,533 (-)NCBIMGSCv36mm8
Celera5134,466,358 - 134,469,154 (-)NCBICelera
Cytogenetic Map5G2NCBI
cM Map576.5NCBI
Epo
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81224,841,285 - 24,844,725 (+)NCBIGRCr8
mRatBN7.21219,204,258 - 19,207,948 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1219,204,508 - 19,207,946 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1220,360,727 - 20,364,164 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01220,973,647 - 20,977,085 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01220,037,993 - 20,041,431 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01222,274,828 - 22,278,268 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1222,274,828 - 22,278,266 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01224,291,481 - 24,294,921 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41219,551,768 - 19,555,208 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11219,541,291 - 19,544,730 (-)NCBI
Celera1221,009,353 - 21,012,793 (+)NCBICelera
Cytogenetic Map12q12NCBI
Epo
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955573203,441 - 206,355 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955573203,875 - 206,078 (-)NCBIChiLan1.0ChiLan1.0
EPO
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26118,631,018 - 118,635,765 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17166,895,649 - 166,900,396 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0792,747,671 - 92,750,886 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17106,148,062 - 106,150,974 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7106,148,062 - 106,150,974 (+)Ensemblpanpan1.1panPan2
EPO
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.168,994,211 - 8,995,954 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl68,994,211 - 8,996,144 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha610,698,441 - 10,700,425 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.068,928,384 - 8,930,368 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl68,928,625 - 8,931,073 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.168,780,936 - 8,782,920 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.068,759,117 - 8,761,101 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.068,940,837 - 8,942,821 (-)NCBIUU_Cfam_GSD_1.0
Epo
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344133,290,130 - 133,295,627 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936543743,537 - 745,343 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936543742,722 - 745,332 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EPO
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl38,620,508 - 8,622,936 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.138,620,508 - 8,622,936 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.238,014,859 - 8,017,287 (+)NCBISscrofa10.2Sscrofa10.2susScr3


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium
Low 20 13 20
Below cutoff 16 4 26

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000016033   ⟹   ENSCSAP00000013958
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl2812,489,766 - 12,491,908 (-)Ensembl
RefSeq Acc Id: ENSCSAT00000016034   ⟹   ENSCSAP00000013959
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl2812,489,766 - 12,491,908 (-)Ensembl
RefSeq Acc Id: XM_008018517   ⟹   XP_008016708
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12812,489,099 - 12,491,986 (-)NCBI
Vero_WHO_p1.0NW_0236660703,816,537 - 3,820,180 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_008016708 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000013958
  ENSCSAP00000013958.1
  ENSCSAP00000013959.1
Reference Protein Sequences
RefSeq Acc Id: XP_008016708   ⟸   XM_008018517
- UniProtKB: A0A0D9RZB9 (UniProtKB/TrEMBL),   A0A0D9RZC0 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000013958   ⟸   ENSCSAT00000016033
RefSeq Acc Id: ENSCSAP00000013959   ⟸   ENSCSAT00000016034


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000017939 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000016033.1 UniProtKB/TrEMBL
  ENSCSAT00000016034.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1250.10 UniProtKB/TrEMBL
InterPro 4_helix_cytokine-like_core UniProtKB/TrEMBL
  EPO/TPO_CS UniProtKB/TrEMBL
  EPO_TPO UniProtKB/TrEMBL
  Erythroptn UniProtKB/TrEMBL
KEGG Report csab:103246719 UniProtKB/TrEMBL
NCBI Gene EPO ENTREZGENE
PANTHER ERYTHROPOIETIN UniProtKB/TrEMBL
  PTHR10370 UniProtKB/TrEMBL
Pfam EPO_TPO UniProtKB/TrEMBL
PIRSF EPO UniProtKB/TrEMBL
PRINTS ERYTHROPTN UniProtKB/TrEMBL
PROSITE EPO_TPO UniProtKB/TrEMBL
Superfamily-SCOP SSF47266 UniProtKB/TrEMBL
UniProt A0A0D9RZB9 ENTREZGENE, UniProtKB/TrEMBL
  A0A0D9RZC0 ENTREZGENE, UniProtKB/TrEMBL