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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:warfarin pharmacodynamics pathway
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Accession:PW:0000731 term browser browse the term
Definition:The pathway of warfarin-target interaction and of the biochemical or physiological responses to drug. Warfarin is used as anticoagulant that antagonizes the vitamin K dependent clotting pathway. Genetic variations can cause differences in the response of the organism to the drug.
Synonyms:related_synonym: SMP:00268
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warfarin pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Col1a1 collagen type I alpha 1 chain ISO SMPDB SMP:00268 NCBI chrNW_004624795:6,167,504...6,183,208
Ensembl chrNW_004624795:6,168,797...6,183,071 		JBrowse link
G F10 coagulation factor X ISO SMPDB SMP:00268 NCBI chrNW_004624793:762,306...777,511
Ensembl chrNW_004624793:762,330...778,282 		JBrowse link
G F11 coagulation factor XI ISO SMPDB SMP:00268 NCBI chrNW_004624769:17,093,643...17,115,716
Ensembl chrNW_004624769:17,094,169...17,115,222 		JBrowse link
G F12 coagulation factor XII ISO SMPDB SMP:00268 NCBI chrNW_004624733:12,666,410...12,683,273
Ensembl chrNW_004624733:12,675,966...12,683,117 		JBrowse link
G F13a1 coagulation factor XIII A chain ISO SMPDB SMP:00268 NCBI chrNW_004624756:19,103,064...19,259,632
Ensembl chrNW_004624756:19,103,327...19,259,964 		JBrowse link
G F13b coagulation factor XIII B chain ISO SMPDB SMP:00268 NCBI chrNW_004624798:3,231,592...3,261,500
Ensembl chrNW_004624798:3,231,462...3,274,186 		JBrowse link
G F2 coagulation factor II, thrombin ISO SMPDB SMP:00268 NCBI chrNW_004624767:1,876,974...1,887,720
Ensembl chrNW_004624767:1,877,024...1,887,958 		JBrowse link
G F3 coagulation factor III, tissue factor ISO SMPDB SMP:00268 NCBI chrNW_004624742:3,112,827...3,123,424
Ensembl chrNW_004624742:3,112,801...3,124,301 		JBrowse link
G F5 coagulation factor V ISO SMPDB SMP:00268 NCBI chrNW_004624826:7,438,632...7,507,322
Ensembl chrNW_004624826:7,438,682...7,507,012 		JBrowse link
G F7 coagulation factor VII ISO SMPDB SMP:00268 NCBI chrNW_004624793:780,057...788,105
Ensembl chrNW_004624793:780,059...788,095 		JBrowse link
G F8 coagulation factor VIII ISO SMPDB SMP:00268 NCBI chrNW_004624963:252,943...424,718 JBrowse link
G F9 coagulation factor IX ISO SMPDB SMP:00268 NCBI chrNW_004624808:7,137,482...7,175,255
Ensembl chrNW_004624808:7,136,703...7,175,709 		JBrowse link
G Fga fibrinogen alpha chain ISO SMPDB SMP:00268 NCBI chrNW_004624858:5,848,817...5,856,448 JBrowse link
G Fgb fibrinogen beta chain ISO SMPDB SMP:00268 NCBI chrNW_004624858:5,866,104...5,874,173
Ensembl chrNW_004624858:5,864,784...5,874,869 		JBrowse link
G Fgg fibrinogen gamma chain ISO SMPDB SMP:00268 NCBI chrNW_004624858:5,828,334...5,836,382
Ensembl chrNW_004624858:5,827,316...5,838,170 		JBrowse link
G Ggcx gamma-glutamyl carboxylase ISO SMPDB SMP:00268 NCBI chrNW_004624749:17,579,690...17,595,111
Ensembl chrNW_004624749:17,579,661...17,593,150 		JBrowse link
G Klkb1 kallikrein B1 ISO SMPDB SMP:00268 NCBI chrNW_004624769:17,066,055...17,088,587
Ensembl chrNW_004624769:17,067,342...17,087,408 		JBrowse link
G Plat plasminogen activator, tissue type ISO SMPDB SMP:00268 NCBI chrNW_004624780:1,014,429...1,063,636
Ensembl chrNW_004624780:1,028,085...1,063,649 		JBrowse link
G Plg plasminogen ISO SMPDB SMP:00268 NCBI chrNW_004624855:2,362,793...2,401,519
Ensembl chrNW_004624855:2,360,229...2,402,079 		JBrowse link
G Vkorc1 vitamin K epoxide reductase complex subunit 1 ISO RGD
SMPDB		 PMID:26287237 RGD:11354881 SMP:00268 NCBI chrNW_004624782:14,141,545...14,144,181
Ensembl chrNW_004624782:14,141,545...14,144,177 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 3915
    drug pathway 349
      blood and blood forming organs drug pathway 44
        antithrombotic drug pathway 44
          anticoagulant drug pathway 22
            vitamin K antagonist drug pathway 21
              warfarin drug pathway 21
                warfarin pharmacodynamics pathway 20
paths to the root