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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:corticotropin-releasing hormone signaling pathway
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Accession:PW:0000493 term browser browse the term
Definition:Corticotropin-releasing hormone is secreted by the hypothalamus in response to stress or fear and signaling through its receptors stimulates secretion of corticotropic (adrenocorticotropic, ACTH) hormone by the anterior pituitary. ACTH is one of the cleavage products of pro-opiomelanocortin (POMC).
Synonyms:related_synonym: CRH
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corticotropin-releasing hormone signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arrb1 arrestin beta 1 ISO RGD PMID:16918397 RGD:5147673 NCBI chrNW_004624817:1,750,448...1,828,399
Ensembl chrNW_004624817:1,750,156...1,823,309 		JBrowse link
G Arrb2 arrestin beta 2 ISO RGD PMID:16918397 RGD:5147673 NCBI chrNW_004624786:8,568,102...8,576,445
Ensembl chrNW_004624786:8,568,198...8,577,914 		JBrowse link
G Crh corticotropin releasing hormone ISO RGD PMID:12942143 PMID:16484629 RGD:1358326 RGD:5147387 NCBI chrNW_004624744:25,194,458...25,196,658
Ensembl chrNW_004624744:25,194,495...25,196,488 		JBrowse link
G Crhbp corticotropin releasing hormone binding protein ISO RGD PMID:16484629 RGD:5147387 NCBI chrNW_004624869:1,412,541...1,423,891
Ensembl chrNW_004624869:1,412,499...1,423,932 		JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 ISO RGD PMID:12942143 PMID:16484629 RGD:1358326 RGD:5147387 NCBI chrNW_004624849:2,484,144...2,528,130
Ensembl chrNW_004624849:2,484,109...2,528,223 		JBrowse link
G Crhr2 corticotropin releasing hormone receptor 2 ISO RGD PMID:12942143 PMID:16484629 RGD:1358326 RGD:5147387 NCBI chrNW_004624739:114,383...161,010
Ensembl chrNW_004624739:114,342...161,044 		JBrowse link
G Gnas GNAS complex locus ISO RGD PMID:16484629 RGD:5147387 NCBI chrNW_004624741:25,138,678...25,197,194
Ensembl chrNW_004624741:25,183,329...25,196,880 		JBrowse link
G Grk3 G protein-coupled receptor kinase 3 ISO RGD PMID:16484629 RGD:5147387 NCBI chrNW_004624747:1,567,540...1,758,251
Ensembl chrNW_004624747:1,576,681...1,758,201 		JBrowse link
G Grk6 G protein-coupled receptor kinase 6 ISO RGD PMID:16484629 RGD:5147387 NCBI chrNW_004624733:12,633,565...12,661,284 JBrowse link
G Ucn urocortin ISO RGD PMID:16484629 RGD:5147387 NCBI chrNW_004624738:9,393,004...9,393,966
Ensembl chrNW_004624738:9,393,329...9,393,706 		JBrowse link
G Ucn2 urocortin 2 ISO RGD PMID:16484629 RGD:5147387 NCBI chrNW_004624730:2,567,154...2,568,387 JBrowse link
G Ucn3 urocortin 3 ISO RGD PMID:16484629 RGD:5147387 NCBI chrNW_004624796:130,924...131,886 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 3917
    signaling pathway 1875
      hormone signaling pathway 368
        peptide and protein hormone signaling pathway 265
          corticotropin-releasing hormone signaling pathway 12
paths to the root