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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:abnormal B cell physiology
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Accession:MP:0002459 term browser browse the term
Definition:any functional anomaly of lymphocytes that expresses membrane-bound antibody, and differentiate into antibody-secreting plasma cells and memory cells upon interaction with antigen; B cells are the primary lymphocyte responsible for humoral immunity, and are most effective against extracellular pathogens
Synonyms:exact_synonym: B cell dysfunction;   B lymphocyte dysfunction;   B lymphocyte functional anomalies


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decreased IgA level term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ighm immunoglobulin heavy constant epsilon IMP RGD PMID:21038471 RGD:150523760 Ensembl chr 6:132,329,269...133,053,426 JBrowse link
G Ighmem1Ang immunoglobulin heavy constant mu; ZFN induced mutant1, Ang IMP RGD PMID:21038471 RGD:150523760
G Ighmem2Ang immunoglobulin heavy constant mu; ZFN induced mutant2, Ang IMP RGD PMID:21038471 RGD:150523760
decreased IgE level term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ighm immunoglobulin heavy constant epsilon IMP RGD PMID:21038471 RGD:150523760 Ensembl chr 6:132,329,269...133,053,426 JBrowse link
G Ighmem1Ang immunoglobulin heavy constant mu; ZFN induced mutant1, Ang IMP RGD PMID:21038471 RGD:150523760
G Ighmem2Ang immunoglobulin heavy constant mu; ZFN induced mutant2, Ang IMP RGD PMID:21038471 RGD:150523760
decreased IgG level term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ighm immunoglobulin heavy constant epsilon IMP RGD PMID:21038471 RGD:150523760 Ensembl chr 6:132,329,269...133,053,426 JBrowse link
G Ighmem1Ang immunoglobulin heavy constant mu; ZFN induced mutant1, Ang IMP RGD PMID:21038471 RGD:150523760
G Ighmem2Ang immunoglobulin heavy constant mu; ZFN induced mutant2, Ang IMP RGD PMID:21038471 RGD:150523760
decreased IgM level term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ighm immunoglobulin heavy constant epsilon IMP RGD PMID:21038471 RGD:150523760 Ensembl chr 6:132,329,269...133,053,426 JBrowse link
G Ighmem1Ang immunoglobulin heavy constant mu; ZFN induced mutant1, Ang IMP RGD PMID:21038471 RGD:150523760
G Ighmem2Ang immunoglobulin heavy constant mu; ZFN induced mutant2, Ang IMP RGD PMID:21038471 RGD:150523760
decreased immunoglobulin level term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Prkdc protein kinase, DNA-activated, catalytic subunit IMP RGD PMID:22981234 RGD:8696027 NCBI chr11:85,040,790...85,258,357
Ensembl chr11:85,040,792...85,257,952 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 5402
    immune system phenotype 502
      abnormal immune system physiology 384
        abnormal cell-mediated immunity 56
          abnormal professional antigen presenting cell physiology 36
            abnormal B cell physiology 31
              abnormal B cell activation + 0
              abnormal B cell apoptosis + 0
              abnormal B lymphocyte antigen presentation 0
              abnormal class switch recombination 0
              abnormal follicular B cell physiology 0
              abnormal germinal center B cell physiology 0
              abnormal immunoglobulin level + 31
              abnormal marginal zone B cell physiology 0
              abnormal memory B cell physiology 0
Path 2
Term Annotations click to browse term
  mammalian phenotype 5402
    immune system phenotype 502
      abnormal immune system physiology 384
        abnormal immune cell physiology 56
          abnormal leukocyte physiology 56
            abnormal lymphocyte physiology 49
              abnormal B cell physiology 31
                abnormal B cell activation + 0
                abnormal B cell apoptosis + 0
                abnormal B lymphocyte antigen presentation 0
                abnormal class switch recombination 0
                abnormal follicular B cell physiology 0
                abnormal germinal center B cell physiology 0
                abnormal immunoglobulin level + 31
                abnormal marginal zone B cell physiology 0
                abnormal memory B cell physiology 0
paths to the root