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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:abnormal class switch recombination
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Accession:MP:0004816 term browser browse the term
Definition:anomaly in the rearrangement of the heavy chain genes of differentiating B cells such that the initially encoded heavy chain IgM molecule is altered to one encoding IgG, IgA or IgE; normally, this allows the body to produce antibodies with different effector functions
Synonyms:exact_synonym: abnormal CSR;   abnormal isotype switching


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  mammalian phenotype 5417
    immune system phenotype 498
      abnormal immune system physiology 384
        abnormal immune cell physiology 56
          abnormal professional antigen presenting cell physiology 36
            abnormal B cell physiology 31
              abnormal class switch recombination 0
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  mammalian phenotype 5417
    hematopoietic system phenotype 246
      abnormal hematopoietic system morphology/development 226
        abnormal hematopoietic cell morphology 182
          abnormal blood cell morphology 95
            abnormal hemopoiesis 16
              abnormal definitive hematopoiesis 16
                abnormal leukopoiesis 16
                  abnormal lymphopoiesis 16
                    abnormal B cell differentiation 0
                      abnormal class switch recombination 0
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