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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:abnormal T cell differentiation
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Accession:MP:0002145 term browser browse the term
Definition:atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors
Synonyms:exact_synonym: abnormal T cell development;   abnormal T cell maturation;   abnormal T cell morphology/development;   abnormal T lymphocyte development;   abnormal lymphoid development/ T lymphocyte defects;   immune system: lymphoid development/ T lymphocyte defects
 narrow_synonym: abnormal thymocyte development
 alt_id: MP:0001821;   MP:0001822;   MP:0002431;   MP:0002489
 xref: MGI:2173605


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abnormal CD4-positive T cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp7b ATPase copper transporting beta IAGP RGD PMID:17434290 RGD:15036800 NCBI chr16:69,952,286...70,024,404
Ensembl chr16:69,951,778...70,023,636 		JBrowse link
G Atp7bhts ATPase copper transporting beta; hepatitis IAGP RGD PMID:17434290 RGD:15036800
G Ptprk protein tyrosine phosphatase, receptor type, K IAGP RGD PMID:17434290 RGD:15036800 NCBI chr 1:16,738,896...17,236,687
Ensembl chr 1:16,850,576...17,103,605 		JBrowse link
arrested T cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pon1 paraoxonase 1 IMP compared to SD RGD PMID:30262871 RGD:45073131 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360 		JBrowse link
G Pon1em1Lizh paraoxonase 1; CRISPR/Cas9 induced mutant 1, Lizh IMP compared to SD RGD PMID:30262871 RGD:45073131
decreased double-positive T cell number term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rag2 recombination activating 2 IMP RGD PMID:30206106 RGD:38508903 NCBI chr 3:87,902,373...87,910,227
Ensembl chr 3:87,902,238...87,911,066 		JBrowse link
increased double-positive T cell number term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atm ATM serine/threonine kinase IMP RGD PMID:27895165 RGD:12879393 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437 		JBrowse link
G Atmm1Kyo ATM serine/threonine kinase; ENU induced mutant 1, Kyo IMP RGD PMID:27895165 RGD:12879393
Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 5402
    immune system phenotype 502
      abnormal immune system morphology 194
        abnormal immune system development 21
          abnormal leukopoiesis 18
            abnormal lymphopoiesis 18
              abnormal T cell differentiation 18
                abnormal CD4-positive T cell differentiation + 4
                abnormal CD8-positive, alpha-beta T cell differentiation 0
                abnormal T cell receptor V(D)J recombination + 0
                abnormal T cell selection + 0
                abnormal T-helper 17 cell differentiation 0
                abnormal double-negative T cell morphology + 2
                abnormal double-positive T cell morphology + 9
                abnormal gamma-delta T cell differentiation 0
                arrested T cell differentiation 3
Path 2
Term Annotations click to browse term
  mammalian phenotype 5402
    hematopoietic system phenotype 250
      abnormal hematopoietic system morphology/development 230
        abnormal hematopoietic cell morphology 186
          abnormal blood cell morphology 99
            abnormal hemopoiesis 18
              abnormal definitive hematopoiesis 18
                abnormal leukopoiesis 18
                  abnormal lymphopoiesis 18
                    abnormal T cell differentiation 18
                      abnormal CD4-positive T cell differentiation + 4
                      abnormal CD8-positive, alpha-beta T cell differentiation 0
                      abnormal T cell receptor V(D)J recombination + 0
                      abnormal T cell selection + 0
                      abnormal T-helper 17 cell differentiation 0
                      abnormal double-negative T cell morphology + 2
                      abnormal double-positive T cell morphology + 9
                      abnormal gamma-delta T cell differentiation 0
                      arrested T cell differentiation 3
paths to the root