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ONTOLOGY REPORT - ANNOTATIONS

Term:ubiquitin-dependent protein catabolic process via the N-end rule pathway
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Accession:GO:0071596 term browser browse the term
Definition:The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the N-end rule pathway. In the N-end rule pathway, destabilizing N-terminal residues (N-degrons) in substrates are recognized by E3 ligases (N-recognins), whereupon the substrates are linked to ubiquitin and then delivered to the proteasome for degradation.
Synonyms:exact_synonym: ubiquitin-dependent protein breakdown via the N-end rule pathway;   ubiquitin-dependent protein catabolism via the N-end rule pathway;   ubiquitin-dependent protein degradation via the N-end rule pathway


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ubiquitin-dependent protein catabolic process via the N-end rule pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G UBR1 ubiquitin protein ligase E3 component n-recognin 1 involved_in IEA UniProt
InterPro		 GO_REF:0000002 GO_REF:0000104 NCBI chr15:21,899,611...22,064,606
Ensembl chr15:40,060,111...40,221,725 		JBrowse link
G UBR2 ubiquitin protein ligase E3 component n-recognin 2 involved_in IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000104 NCBI chr 6:42,150,409...42,282,486
Ensembl chr 6:43,449,154...43,579,224 		JBrowse link
G UBR3 ubiquitin protein ligase E3 component n-recognin 3 involved_in IEA InterPro
UniProt
TreeGrafter		 GO_REF:0000002 GO_REF:0000104 GO_REF:0000118 NCBI chr2B:57,099,882...57,366,981
Ensembl chr2B:174,564,671...174,827,776 		JBrowse link
G UBR4 ubiquitin protein ligase E3 component n-recognin 4 involved_in ISO (PMID:38030679) UniProt PMID:38030679 NCBI chr 1:18,032,528...18,168,954
Ensembl chr 1:19,079,779...19,215,578 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16442
    metabolic process 10307
      primary metabolic process 8924
        protein metabolic process 3923
          protein catabolic process 991
            proteasomal protein catabolic process 520
              proteasome-mediated ubiquitin-dependent protein catabolic process 384
                ubiquitin-dependent protein catabolic process via the N-end rule pathway 4
Path 2
Term Annotations click to browse term
  biological_process 16442
    metabolic process 10307
      organic substance metabolic process 9873
        organic substance catabolic process 2050
          organonitrogen compound catabolic process 1381
            protein catabolic process 991
              proteolysis involved in protein catabolic process 744
                modification-dependent protein catabolic process 583
                  ubiquitin-dependent protein catabolic process 570
                    proteasome-mediated ubiquitin-dependent protein catabolic process 384
                      ubiquitin-dependent protein catabolic process via the N-end rule pathway 4
paths to the root