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ONTOLOGY REPORT - ANNOTATIONS

Term:7-methylguanosine mRNA capping
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Accession:GO:0006370 term browser browse the term
Definition:The sequence of enzymatic reactions by which the mRNA 5' cap structure, an inverted 7-methylguanosine linked via a 5'-5' triphosphate bridge (m7G(5')ppp(5')X) to the first transcribed residue, is added to a nascent transcript. Additional methylation can occur on the ribose sugars of the first and second nucleotides adjacent to the m7G nRNA cap. These methylations are often referred to as N6,2'-O-dimethyladenosine (m6,2A) and N6,2'-O-dimethylguanosine (m6,2G), respectively.
Synonyms:exact_synonym: 5' mRNA capping;   5'-end mRNA processing;   mRNA capping
 broad_synonym: 5' end capping;   5'-end processing


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7-methylguanosine mRNA capping term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cmtr1 cap methyltransferase 1 involved_in ISS
IEA
ISO
IBA		 GO_REF:0000024
GO_REF:0000104
(PMID:20713356), (PMID:21310715)
GO_REF:0000033		 UniProt
RGD
GO_Central		 PMID:20713356 PMID:21310715 GO_REF:0000024 GO_REF:0000033 GO_REF:0000104 NCBI chr20:7,722,729...7,782,579
Ensembl chr20:7,709,713...7,766,302 		JBrowse link
G Cmtr2 cap methyltransferase 2 involved_in ISO
IBA		 (PMID:21310715)
GO_REF:0000033		 RGD
GO_Central		 PMID:21310715 GO_REF:0000033 NCBI chr19:38,190,718...38,197,549
Ensembl chr19:38,190,642...38,197,804 		JBrowse link
G Ncbp1 nuclear cap binding protein subunit 1 involved_in ISO
ISS
IEA		 (PMID:12434151)
GO_REF:0000024
GO_REF:0000043		 RGD
UniProt		 PMID:12434151 GO_REF:0000024 GO_REF:0000043 NCBI chr 5:60,416,023...60,449,004
Ensembl chr 5:60,415,982...60,449,089 		JBrowse link
G Ramac RNA guanine-7 methyltransferase activating subunit involved_in ISO (PMID:22099306) RGD PMID:22099306 NCBI chr 1:135,708,529...135,714,417
Ensembl chr 1:135,708,535...135,722,151 		JBrowse link
G Rngtt RNA guanylyltransferase and 5'-phosphatase involved_in ISO
IBA		 (PMID:9473487)
GO_REF:0000033		 RGD
GO_Central		 PMID:9473487 GO_REF:0000033 NCBI chr 5:47,706,929...47,913,297
Ensembl chr 5:47,706,799...47,913,295 		JBrowse link
G Rnmt RNA (guanine-7-) methyltransferase involved_in ISS
ISO
IEA
IBA		 GO_REF:0000024
(PMID:27422871), (PMID:9790902)
GO_REF:0000043
GO_REF:0000107
GO_REF:0000033		 UniProt
RGD
Ensembl
GO_Central		 PMID:9790902 PMID:27422871 GO_REF:0000024 GO_REF:0000033 GO_REF:0000043 GO_REF:0000107 NCBI chr18:61,886,230...61,909,775
Ensembl chr18:61,886,292...61,909,775 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20413
    metabolic process 11835
      organic substance metabolic process 11328
        macromolecule metabolic process 9578
          nucleic acid metabolic process 5144
            nucleic acid biosynthetic process 3542
              7-methylguanosine mRNA capping 6
Path 2
Term Annotations click to browse term
  biological_process 20413
    metabolic process 11835
      organic substance metabolic process 11328
        organic cyclic compound metabolic process 6260
          nucleobase-containing compound metabolic process 5743
            nucleic acid metabolic process 5144
              RNA metabolic process 4542
                RNA processing 1031
                  RNA 5'-end processing 27
                    RNA capping 7
                      7-methylguanosine RNA capping 7
                        7-methylguanosine mRNA capping 6
paths to the root