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ONTOLOGY REPORT - ANNOTATIONS

Term:tRNA-specific ribonuclease activity
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Accession:GO:0004549 term browser browse the term
Definition:Catalysis of the hydrolysis of phosphodiester bonds in tRNA molecules.
Synonyms:exact_synonym: tRNA-specific RNase activity
 xref: reactome:R-HSA-5696813 "TSEN complex cleaves the intron from pre-tRNA";   reactome:R-HSA-5696815 "ELAC2 cleaves the 3' end of pre-tRNA";   reactome:R-HSA-6785722 "Mitochondrial RNase P (mtRNase P) cleaves the 5' ends of pre-tRNAs and ELAC2 (RNase Z) cleaves the 3' ends of pre-tRNAs in the H strand transcript";   reactome:R-HSA-6786854 "Mitochondrial RNase P (mtRNase P) cleaves the 5' ends of pre-tRNAs and ELAC2 (RNase Z) cleaves the 3' ends of pre-tRNAs in the L strand transcript"


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tRNA-specific ribonuclease activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANG angiogenin enables ISO (MGI:6713610|PMID:33986151) UniProt PMID:33986151 MGI:6713610 NCBI chr14:1,548,693...1,558,528
Ensembl chr14:19,614,950...19,615,393 		JBrowse link
G ELAC1 elaC ribonuclease Z 1 enables IEA Ensembl GO_REF:0000107 NCBI chr18:44,339,868...44,359,150
Ensembl chr18:47,692,305...47,706,019 		JBrowse link
G ELAC2 elaC ribonuclease Z 2 enables ISO (PMID:12711671), (PMID:15317868), (PMID:16361254), (PMID:18809514), (PMID:21559454), (PMID:21593607) Reactome PMID:12711671 PMID:15317868 PMID:16361254 PMID:18809514 PMID:21559454 More... NCBI chr17:38,631,454...38,657,855
Ensembl chr17:43,331,453...43,357,241 		JBrowse link
ribonuclease P activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G POP1 POP1 homolog, ribonuclease P/MRP subunit contributes_to
enables		 ISO
IEA		 (PMID:30454648), (PMID:8918471) UniProt
Ensembl		 PMID:8918471 PMID:30454648 GO_REF:0000107 NCBI chr 8:94,754,028...94,796,374
Ensembl chr 8:96,944,588...96,979,328 		JBrowse link
G POP4 POP4 homolog, ribonuclease P/MRP subunit contributes_to
enables		 ISO
IEA		 (PMID:30454648) UniProt
UniProt
Ensembl		 PMID:30454648 GO_REF:0000003 GO_REF:0000107 NCBI chr19:26,535,196...26,544,747
Ensembl chr19:35,296,084...35,307,002 		JBrowse link
G POP5 POP5 homolog, ribonuclease P/MRP subunit contributes_to
enables		 ISO
IEA		 (PMID:30454648) UniProt
Ensembl
UniProt		 PMID:30454648 GO_REF:0000003 GO_REF:0000107 NCBI chr12:118,162,497...118,165,472
Ensembl chr12:121,535,005...121,537,350 		JBrowse link
G POP7 POP7 homolog, ribonuclease P/MRP subunit contributes_to
enables		 ISO
IEA		 (PMID:30454648) UniProt
UniProt
Ensembl		 PMID:30454648 GO_REF:0000003 GO_REF:0000104 GO_REF:0000107 NCBI chr 7:92,722,839...92,734,708
Ensembl chr 7:106,134,766...106,135,188 		JBrowse link
G PRORP protein only RNase P catalytic subunit enables IEA UniProt
TreeGrafter
Ensembl		 GO_REF:0000003 GO_REF:0000107 GO_REF:0000118 NCBI chr14:15,871,707...16,027,634
Ensembl chr14:34,056,620...34,209,657 		JBrowse link
G RPP14 ribonuclease P/MRP subunit p14 enables
contributes_to		 IEA
ISO		 (PMID:30454648) Ensembl
TreeGrafter
UniProt
UniProt		 PMID:30454648 GO_REF:0000003 GO_REF:0000107 GO_REF:0000118 NCBI chr 3:58,239,048...58,252,810
Ensembl chr 3:59,653,220...59,666,531
Ensembl chr 3:59,653,220...59,666,531 		JBrowse link
G RPP21 ribonuclease P/MRP subunit p21 contributes_to ISO (PMID:30454648) UniProt PMID:30454648 NCBI chr 6:30,122,996...30,124,784
Ensembl chr 6:30,975,260...30,995,764 		JBrowse link
G RPP25 ribonuclease P and MRP subunit p25 contributes_to
enables		 ISO
IEA		 (PMID:30454648) UniProt
Ensembl		 PMID:30454648 GO_REF:0000107 NCBI chr15:53,895,547...53,897,922
Ensembl chr15:73,513,375...73,513,974 		JBrowse link
G RPP30 ribonuclease P/MRP subunit p30 contributes_to
enables		 ISO
IEA		 (PMID:30454648) UniProt
Ensembl		 PMID:30454648 GO_REF:0000107 NCBI chr10:87,611,699...87,646,239
Ensembl chr10:91,138,993...91,170,517 		JBrowse link
G RPP38 ribonuclease P/MRP subunit p38 contributes_to
enables		 ISO
IEA		 (PMID:30454648) UniProt
TreeGrafter
Ensembl		 PMID:30454648 GO_REF:0000107 GO_REF:0000118 NCBI chr10:15,413,026...15,420,170
Ensembl chr10:15,700,027...15,703,046 		JBrowse link
G RPP40 ribonuclease P/MRP subunit p40 contributes_to
enables		 ISO
IEA		 (PMID:30454648) UniProt
TreeGrafter
Ensembl		 PMID:30454648 GO_REF:0000107 GO_REF:0000118 NCBI chr 6:4,828,155...4,838,680
Ensembl chr 6:5,015,953...5,024,540 		JBrowse link
tRNA-intron endonuclease activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TSEN2 tRNA splicing endonuclease subunit 2 enables IEA UniProt
TreeGrafter
InterPro		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000104 GO_REF:0000118 NCBI chr 3:12,410,885...12,463,932
Ensembl chr 3:12,759,375...12,800,201 		JBrowse link
G TSEN34 tRNA splicing endonuclease subunit 34 enables IEA UniProt
TreeGrafter
InterPro		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000104 GO_REF:0000118 NCBI chr19:51,121,560...51,125,768
Ensembl chr19:59,964,174...59,968,453 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 17493
    catalytic activity 5389
      catalytic activity, acting on a nucleic acid 593
        catalytic activity, acting on RNA 366
          RNA nuclease activity 118
            tRNA-specific ribonuclease activity 16
              ribonuclease P activity 11
              tRNA-intron endonuclease activity 2
Path 2
Term Annotations click to browse term
  molecular_function 17493
    catalytic activity 5389
      hydrolase activity 2314
        hydrolase activity, acting on ester bonds 742
          nuclease activity 199
            RNA nuclease activity 118
              tRNA-specific ribonuclease activity 16
                ribonuclease P activity 11
                tRNA-intron endonuclease activity 2
paths to the root