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ONTOLOGY REPORT - ANNOTATIONS

Term:DNA-directed 5'-3' RNA polymerase activity
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Accession:GO:0003899 term browser browse the term
Definition:Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.
Synonyms:narrow_synonym: DNA-directed RNA polymerase I activity;   DNA-directed RNA polymerase II activity;   DNA-directed RNA polymerase III activity;   RNA polymerase I activity;   RNA polymerase II activity;   RNA polymerase III activity
 broad_synonym: DNA-directed RNA polymerase activity;   transcriptase
 related_synonym: C RNA formation factors;   C ribonucleic acid formation factors;   DNA-dependent RNA nucleotidyltransferase activity;   DNA-dependent RNA polymerase activity;   DNA-dependent ribonucleate nucleotidyltransferase activity;   RNA nucleotidyltransferase (DNA-directed) activity;   deoxyribonucleic acid-dependent ribonucleic acid polymerase activity;   nucleoside-triphosphate:RNA nucleotidyltransferase (DNA-directed) activity
 alt_id: GO:0000129
 xref: EC:2.7.7.6;   MetaCyc:DNA-DIRECTED-RNA-POLYMERASE-RXN;   Reactome:R-HSA-9670149 "TERRA transcription";   Reactome:R-HSA-9697084 "Defective rpoB in Mtb RNAP transcribes RNA polyanion";   Reactome:R-HSA-9697085 "RNAP transcribes Mtb RNA polyanion";   reactome:R-HSA-111264 "Addition of nucleotides between position +11 and +30";   reactome:R-HSA-167113 "Addition of the fourth nucleotide on the nascent HIV-1 transcript: Second Transition";   reactome:R-HSA-167115 "Addition of nucleotides between position +11 and +30 on HIV-1 transcript";   reactome:R-HSA-167117 "Addition of nucleotides 10 and 11 on the growing HIV-1 transcript: Third Transition";   reactome:R-HSA-167121 "Addition of the third nucleotide on the nascent HIV-1 transcript";   reactome:R-HSA-167136 "Addition of nucleotides 5 through 9 on the growing HIV-1 transcript";   reactome:R-HSA-174425 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere";   reactome:R-HSA-203901 "Pol II mediated transcription of microRNA genes";   reactome:R-HSA-427366 "Transcription of intergenic spacer of the rRNA gene";   reactome:R-HSA-5601926 "RNA polymerase II polymerizes primary piRNA transcript";   reactome:R-HSA-6781824 "Active RNA Pol II complex transcribes lesion-containing DNA template";   reactome:R-HSA-68913 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin";   reactome:R-HSA-74986 "Elongation of pre-rRNA transcript";   reactome:R-HSA-75850 "Addition of the third nucleotide on the nascent transcript";   reactome:R-HSA-75869 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition";   reactome:R-HSA-75873 "Addition of Nucleotides 5 through 9 on the growing Transcript";   reactome:R-HSA-76576 "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition"


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DNA-directed 5'-3' RNA polymerase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ASL argininosuccinate lyase enables IEA Ensembl GO_REF:0000107 NCBI chr 7:59,908,648...59,948,822
Ensembl chr 7:73,142,842...73,157,472
Ensembl chr 7:73,142,842...73,157,472
Ensembl chr 7:73,142,842...73,157,472 		JBrowse link
G CRCP CGRP receptor component enables IEA Ensembl GO_REF:0000107
G LOC103786072 DNA-directed RNA polymerases I and III subunit RPAC2 enables IEA InterPro GO_REF:0000002 NCBI chr13:8,910,717...8,913,420
Ensembl chr13:27,256,567...27,373,830 		JBrowse link
G POLR1A RNA polymerase I subunit A contributes_to
enables		 ISO
IEA		 RGD
Ensembl
InterPro
UniProt		 PMID:9422795 GO_REF:0000002 GO_REF:0000003 GO_REF:0000107 RGD:2312782 NCBI chr2A:86,070,160...86,157,606
Ensembl chr2A:87,622,466...87,705,357 		JBrowse link
G POLR1B RNA polymerase I subunit B contributes_to
enables		 ISO
IEA		 RGD
Ensembl
UniProt
InterPro		 PMID:9422795 GO_REF:0000002 GO_REF:0000003 GO_REF:0000107 RGD:2312782 NCBI chr2A:89,478,133...89,516,559
Ensembl chr2A:113,555,452...113,590,377 		JBrowse link
G POLR1H RNA polymerase I subunit H enables IEA InterPro GO_REF:0000002 NCBI chr 6:29,839,067...29,842,692
Ensembl chr 6:30,509,326...30,512,956 		JBrowse link
G POLR2A RNA polymerase II subunit A enables IEA UniProt
InterPro		 GO_REF:0000002 GO_REF:0000003 NCBI chr17:7,516,940...7,546,989
Ensembl chr17:7,502,807...7,532,521 		JBrowse link
G POLR2B RNA polymerase II subunit B enables IEA InterPro
Ensembl
UniProt		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000107 NCBI chr 4:66,888,215...66,940,702
Ensembl chr 4:73,462,000...73,514,985 		JBrowse link
G POLR2C RNA polymerase II subunit C enables IEA InterPro GO_REF:0000002 NCBI chr16:37,738,641...37,748,055
Ensembl chr16:56,871,707...56,880,102 		JBrowse link
G POLR2E RNA polymerase II, I and III subunit E enables IEA InterPro GO_REF:0000002 NCBI chr19:32,263...41,992
Ensembl chr19:1,065,421...1,073,379 		JBrowse link
G POLR2F RNA polymerase II, I and III subunit F enables IEA InterPro GO_REF:0000002 NCBI chr22:18,868,872...18,988,918
Ensembl chr22:36,796,015...36,814,469 		JBrowse link
G POLR2H RNA polymerase II, I and III subunit H enables IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000104 NCBI chr 3:181,399,136...181,405,680
Ensembl chr 3:189,881,594...189,887,608 		JBrowse link
G POLR2I RNA polymerase II subunit I enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr19:33,032,989...33,034,628
Ensembl chr19:41,780,125...41,781,764 		JBrowse link
G POLR2K RNA polymerase II, I and III subunit K enables IEA InterPro GO_REF:0000002 NCBI chr 8:96,791,485...96,794,913
Ensembl chr 8:98,965,837...98,969,221 		JBrowse link
G POLR3A RNA polymerase III subunit A enables ISO (PMID:34675218) UniProt PMID:34675218 NCBI chr10:74,496,121...74,550,054 JBrowse link
G POLR3B RNA polymerase III subunit B enables IEA InterPro
Ensembl
UniProt		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000107 NCBI chr12:103,936,650...104,083,470
Ensembl chr12:107,330,306...107,477,279 		JBrowse link
G POLR3H RNA polymerase III subunit H enables IEA Ensembl
InterPro		 GO_REF:0000002 GO_REF:0000107 NCBI chr22:22,419,887...22,438,539
Ensembl chr22:40,507,026...40,525,927 		JBrowse link
G POLR3K RNA polymerase III subunit K enables IEA InterPro GO_REF:0000002 Ensembl chr16:37,772...44,598 JBrowse link
G POLRMT RNA polymerase mitochondrial enables IEA UniProt
TreeGrafter
InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000107 GO_REF:0000118 NCBI chr19:504,823...521,281
Ensembl chr19:584,219...599,783 		JBrowse link
DNA primase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G POLRMT RNA polymerase mitochondrial enables IEA Ensembl GO_REF:0000107 NCBI chr19:504,823...521,281
Ensembl chr19:584,219...599,783 		JBrowse link
G PRIM1 DNA primase subunit 1 enables IEA InterPro
TreeGrafter
UniProt
Ensembl		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000117 GO_REF:0000118 NCBI chr12:32,155,541...32,176,363
Ensembl chr12:32,408,929...32,428,734 		JBrowse link
G PRIMPOL primase and DNA directed polymerase enables IEA Ensembl
TreeGrafter
InterPro		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr 4:176,815,122...176,860,682 JBrowse link
RNA polymerase I activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC103786072 DNA-directed RNA polymerases I and III subunit RPAC2 enables IEA TreeGrafter GO_REF:0000118 NCBI chr13:8,910,717...8,913,420
Ensembl chr13:27,256,567...27,373,830 		JBrowse link
G POLR1A RNA polymerase I subunit A enables IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr2A:86,070,160...86,157,606
Ensembl chr2A:87,622,466...87,705,357 		JBrowse link
G POLR1B RNA polymerase I subunit B enables IEA TreeGrafter GO_REF:0000118 NCBI chr2A:89,478,133...89,516,559
Ensembl chr2A:113,555,452...113,590,377 		JBrowse link
G POLR1C RNA polymerase I and III subunit C enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr 6:43,101,771...43,121,460
Ensembl chr 6:44,395,787...44,412,257 		JBrowse link
G POLR1H RNA polymerase I subunit H enables IEA TreeGrafter GO_REF:0000118 NCBI chr 6:29,839,067...29,842,692
Ensembl chr 6:30,509,326...30,512,956 		JBrowse link
G POLR2E RNA polymerase II, I and III subunit E enables IEA TreeGrafter GO_REF:0000118 NCBI chr19:32,263...41,992
Ensembl chr19:1,065,421...1,073,379 		JBrowse link
G POLR2F RNA polymerase II, I and III subunit F enables IEA TreeGrafter GO_REF:0000118 NCBI chr22:18,868,872...18,988,918
Ensembl chr22:36,796,015...36,814,469 		JBrowse link
G POLR2H RNA polymerase II, I and III subunit H enables IEA TreeGrafter GO_REF:0000118 NCBI chr 3:181,399,136...181,405,680
Ensembl chr 3:189,881,594...189,887,608 		JBrowse link
G POLR2K RNA polymerase II, I and III subunit K enables IEA TreeGrafter GO_REF:0000118 NCBI chr 8:96,791,485...96,794,913
Ensembl chr 8:98,965,837...98,969,221 		JBrowse link
RNA polymerase II activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G POLR2A RNA polymerase II subunit A enables IEA TreeGrafter GO_REF:0000118 NCBI chr17:7,516,940...7,546,989
Ensembl chr17:7,502,807...7,532,521 		JBrowse link
G POLR2B RNA polymerase II subunit B enables IEA TreeGrafter GO_REF:0000118 NCBI chr 4:66,888,215...66,940,702
Ensembl chr 4:73,462,000...73,514,985 		JBrowse link
G POLR2C RNA polymerase II subunit C enables IEA TreeGrafter GO_REF:0000118 NCBI chr16:37,738,641...37,748,055
Ensembl chr16:56,871,707...56,880,102 		JBrowse link
G POLR2E RNA polymerase II, I and III subunit E enables IEA TreeGrafter GO_REF:0000118 NCBI chr19:32,263...41,992
Ensembl chr19:1,065,421...1,073,379 		JBrowse link
G POLR2F RNA polymerase II, I and III subunit F enables IEA TreeGrafter GO_REF:0000118 NCBI chr22:18,868,872...18,988,918
Ensembl chr22:36,796,015...36,814,469 		JBrowse link
G POLR2H RNA polymerase II, I and III subunit H enables IEA TreeGrafter GO_REF:0000118 NCBI chr 3:181,399,136...181,405,680
Ensembl chr 3:189,881,594...189,887,608 		JBrowse link
G POLR2K RNA polymerase II, I and III subunit K enables IEA TreeGrafter GO_REF:0000118 NCBI chr 8:96,791,485...96,794,913
Ensembl chr 8:98,965,837...98,969,221 		JBrowse link
RNA polymerase III activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC103786072 DNA-directed RNA polymerases I and III subunit RPAC2 enables IEA TreeGrafter GO_REF:0000118 NCBI chr13:8,910,717...8,913,420
Ensembl chr13:27,256,567...27,373,830 		JBrowse link
G POLR1C RNA polymerase I and III subunit C enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr 6:43,101,771...43,121,460
Ensembl chr 6:44,395,787...44,412,257 		JBrowse link
G POLR2E RNA polymerase II, I and III subunit E enables IEA TreeGrafter GO_REF:0000118 NCBI chr19:32,263...41,992
Ensembl chr19:1,065,421...1,073,379 		JBrowse link
G POLR2F RNA polymerase II, I and III subunit F enables IEA TreeGrafter GO_REF:0000118 NCBI chr22:18,868,872...18,988,918
Ensembl chr22:36,796,015...36,814,469 		JBrowse link
G POLR2H RNA polymerase II, I and III subunit H enables IEA TreeGrafter GO_REF:0000118 NCBI chr 3:181,399,136...181,405,680
Ensembl chr 3:189,881,594...189,887,608 		JBrowse link
G POLR2K RNA polymerase II, I and III subunit K enables IEA TreeGrafter GO_REF:0000118 NCBI chr 8:96,791,485...96,794,913
Ensembl chr 8:98,965,837...98,969,221 		JBrowse link
G POLR3B RNA polymerase III subunit B enables IEA TreeGrafter GO_REF:0000118 NCBI chr12:103,936,650...104,083,470
Ensembl chr12:107,330,306...107,477,279 		JBrowse link
G POLR3K RNA polymerase III subunit K enables IEA TreeGrafter GO_REF:0000118 Ensembl chr16:37,772...44,598 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 17493
    catalytic activity 5389
      catalytic activity, acting on a nucleic acid 593
        catalytic activity, acting on RNA 366
          RNA polymerase activity 23
            5'-3' RNA polymerase activity 23
              DNA-directed 5'-3' RNA polymerase activity 22
                DNA primase activity 3
                RNA polymerase I activity 9
                RNA polymerase II activity 7
                RNA polymerase III activity 8
                RNA polymerase IV activity 0
                RNA polymerase V activity 0
                single subunit type RNA polymerase activity + 0
Path 2
Term Annotations click to browse term
  molecular_function 17493
    catalytic activity 5389
      transferase activity 2182
        transferase activity, transferring phosphorus-containing groups 854
          nucleotidyltransferase activity 115
            RNA polymerase activity 23
              5'-3' RNA polymerase activity 23
                DNA-directed 5'-3' RNA polymerase activity 22
                  DNA primase activity 3
                  RNA polymerase I activity 9
                  RNA polymerase II activity 7
                  RNA polymerase III activity 8
                  RNA polymerase IV activity 0
                  RNA polymerase V activity 0
                  single subunit type RNA polymerase activity + 0
paths to the root