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ONTOLOGY REPORT - ANNOTATIONS

Term:ATF4-CREB1 transcription factor complex
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Accession:GO:1990589 term browser browse the term
Definition:Transcription factor complex consisting of ATF4 and CREB1 subunits that is capable of binding to cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3') as part of the positive regulation of transcription. Regulatory targets include the GRP78 (HSPA5) promoter in humans, whose activation by this complex is part of the ER stress response pathway.


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ATF4-CREB1 transcription factor complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATF1 activating transcription factor 1 part_of IEA
IBA		 TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000118 NCBI chr 5:16,619,130...16,681,391
Ensembl chr 5:16,618,643...16,681,380 		JBrowse link
G ATF4 activating transcription factor 4 part_of IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 5:8,742,964...8,745,752
Ensembl chr 5:8,742,967...8,745,368 		JBrowse link
G CREB1 cAMP responsive element binding protein 1 part_of IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr15:110,705,548...110,773,037
Ensembl chr15:110,705,496...110,771,728 		JBrowse link
G CREM cAMP responsive element modulator part_of IEA TreeGrafter GO_REF:0000118 NCBI chr10:57,829,523...57,895,610
Ensembl chr10:57,829,518...57,895,610 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 18687
    protein-containing complex 6005
      transcription regulator complex 526
        RNA polymerase II transcription regulator complex 238
          ATF4-CREB1 transcription factor complex 4
Path 2
Term Annotations click to browse term
  cellular_component 18687
    cellular anatomical entity 18466
      intracellular anatomical structure 13504
        intracellular organelle 12019
          intracellular membrane-bounded organelle 10861
            nucleus 6843
              nuclear protein-containing complex 1244
                RNA polymerase II transcription regulator complex 238
                  ATF4-CREB1 transcription factor complex 4
paths to the root