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ONTOLOGY REPORT - ANNOTATIONS

Term:transport across blood-brain barrier
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Accession:GO:0150104 term browser browse the term
Definition:The directed movement of substances (e.g. macromolecules, small molecules, ions) through the blood-brain barrier.
Synonyms:exact_synonym: transport across BBB
 only_in_taxon: NCBITaxon:6072 ! Eumetazoa

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transport across blood-brain barrier term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ager advanced glycosylation end-product specific receptor involved_in ISO (PMID:23973487) ARUK-UCL PMID:23973487 NCBI chrNW_004955437:645,482...648,607
Ensembl chrNW_004955437:645,897...648,479 		JBrowse link
G Flvcr2 FLVCR choline and putative heme transporter 2 acts_upstream_of_or_within
involved_in		 ISO (PMID:38693257)
(PMID:38302740), (PMID:38693257)		 MGI
UniProt		 PMID:38302740 PMID:38693257 NCBI chrNW_004955612:46,723...99,012
Ensembl chrNW_004955612:46,724...97,729 		JBrowse link
G Lrp1 LDL receptor related protein 1 involved_in ISO (PMID:20630619), (PMID:26619118) ARUK-UCL PMID:20630619 PMID:26619118 NCBI chrNW_004955458:4,861,431...4,941,939
Ensembl chrNW_004955458:4,861,431...4,941,146 		JBrowse link
G Slc16a2 solute carrier family 16 member 2 involved_in ISO (PMID:28526555) ARUK-UCL PMID:28526555 NCBI chrNW_004955562:305,850...455,764
Ensembl chrNW_004955562:306,051...458,889 		JBrowse link
G Slc1a5 solute carrier family 1 member 5 involved_in ISO (PMID:14622120) ARUK-UCL PMID:14622120 NCBI chrNW_004955574:798,004...806,631 JBrowse link
G Slc2a1 solute carrier family 2 member 1 acts_upstream_of_or_within
involved_in		 ISO (PMID:1714544)
(PMID:23975336)
(PMID:28993322)		 ARUK-UCL PMID:1714544 PMID:23975336 PMID:28993322 NCBI chrNW_004955537:2,408,042...2,438,788
Ensembl chrNW_004955537:2,408,042...2,439,511 		JBrowse link
G Slc5a1 solute carrier family 5 member 1 involved_in ISO (PMID:23975336) ARUK-UCL PMID:23975336 NCBI chrNW_004955455:6,158,773...6,236,950
Ensembl chrNW_004955455:6,158,959...6,236,189 		JBrowse link
lipid transport across blood-brain barrier term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd36 CD36 molecule (CD36 blood group) involved_in ISO (PMID:21395585) ARUK-UCL PMID:21395585 NCBI chrNW_004955410:5,003,720...5,120,903
Ensembl chrNW_004955410:5,003,668...5,075,313 		JBrowse link
G Fabp5 fatty acid binding protein 5 involved_in ISO (PMID:21395585) ARUK-UCL PMID:21395585 NCBI chrNW_004955444:325,515...329,248
Ensembl chrNW_004955444:325,515...331,516 		JBrowse link
G Mfsd2a MFSD2 lysolipid transporter A, lysophospholipid involved_in ISO (PMID:26005865)
(PMID:24828044)		 ARUK-UCL
UniProt		 PMID:24828044 PMID:26005865 NCBI chrNW_004955452:17,430,850...17,443,830
Ensembl chrNW_004955452:17,430,219...17,443,830 		JBrowse link
G Slc27a1 solute carrier family 27 member 1 involved_in ISO (PMID:21395585) ARUK-UCL PMID:21395585 NCBI chrNW_004955524:803,793...821,920
Ensembl chrNW_004955524:805,014...821,838 		JBrowse link
G Slc27a4 solute carrier family 27 member 4 involved_in ISO (PMID:21395585) ARUK-UCL PMID:21395585 NCBI chrNW_004955570:853,856...866,383
Ensembl chrNW_004955570:853,849...866,383 		JBrowse link
negative regulation of lipid transport across blood-brain barrier term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoe apolipoprotein E involved_in ISO (PMID:24345162) Alzheimers_University_of_Toronto PMID:24345162 NCBI chrNW_004955555:1,998,170...2,002,003
Ensembl chrNW_004955555:1,999,711...2,001,888 		JBrowse link
positive regulation of lipid transport across blood-brain barrier term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoe apolipoprotein E involved_in ISO (PMID:24345162) Alzheimers_University_of_Toronto PMID:24345162 NCBI chrNW_004955555:1,998,170...2,002,003
Ensembl chrNW_004955555:1,999,711...2,001,888 		JBrowse link
xenobiotic transport across blood-brain barrier term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1 ATP binding cassette subfamily B member 1 involved_in ISO (PMID:28587984)
(PMID:25986174)		 RGD
ARUK-UCL		 PMID:25053619 PMID:25986174 PMID:28587984 RGD:11252095 NCBI chrNW_004955432:4,911,774...5,085,349 JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 (ABCC1 blood group) involved_in ISO (PMID:25986174) ARUK-UCL PMID:25986174 NCBI chrNW_004955442:729,322...858,826
Ensembl chrNW_004955442:729,316...860,290 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 involved_in ISO PMID:12663688
PMID:17437408		 ARUK-UCL PMID:12663688 PMID:17437408 RGD:14929203 RGD:704399 NCBI chrNW_004955507:5,724,788...5,791,281
Ensembl chrNW_004955507:5,724,762...5,790,812 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 (JR blood group) involved_in ISO (PMID:12958161) ARUK-UCL PMID:12958161 NCBI chrNW_004955474:12,365,903...12,408,715 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12571
    localization 4349
      establishment of localization 3691
        transport 3423
          vascular transport 18
            transport across blood-brain barrier 17
              copper ion transport across blood-brain barrier 0
              lipid transport across blood-brain barrier + 6
              negative regulation of transport across blood-brain barrier + 1
              positive regulation of transport across blood-brain barrier + 1
              regulation of transport across blood-brain barrier + 1
              xenobiotic transport across blood-brain barrier 4
Path 2
Term Annotations click to browse term
  biological_process 12571
    multicellular organismal process 6259
      system process 1722
        circulatory system process 518
          vascular process in circulatory system 222
            vascular transport 18
              transport across blood-brain barrier 17
                copper ion transport across blood-brain barrier 0
                lipid transport across blood-brain barrier + 6
                negative regulation of transport across blood-brain barrier + 1
                positive regulation of transport across blood-brain barrier + 1
                regulation of transport across blood-brain barrier + 1
                xenobiotic transport across blood-brain barrier 4
paths to the root