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Gene: Abcc2 (ATP binding cassette subfamily C member 2) Chinchilla lanigera

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Symbol:

Abcc2

Name:

ATP binding cassette subfamily C member 2

RGD ID:

8997399

Description:

ENCODES a protein that exhibits ABC-type glutathione S-conjugate transporter activity (ortholog); ABC-type xenobiotic transporter activity (ortholog); ATPase-coupled transmembrane transporter activity (ortholog); INVOLVED IN antibiotic metabolic process (ortholog); benzylpenicillin metabolic process (ortholog); bile acid and bile salt transport (ortholog); PARTICIPATES IN docetaxel pharmacodynamics pathway; doxorubicin pharmacokinetics pathway; irinotecan pharmacodynamics pathway; ASSOCIATED WITH Acute Liver Failure (ortholog); acute lymphoblastic leukemia (ortholog); alopecia (ortholog); FOUND IN apical plasma membrane (ortholog); brush border membrane (ortholog); cell surface (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

ATP-binding cassette, sub-family C (CFTR/MRP), member 2; canalicular multispecific organic anion transporter 1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955507	5,724,762 - 5,790,812 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955507	5,724,788 - 5,791,281 (+)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Acute Liver Failure (ISO)

acute lymphoblastic leukemia (ISO)

alopecia (ISO)

bilirubin metabolic disorder (ISO)

cardiomyopathy (ISO)

Chemical and Drug Induced Liver Injury (ISO)

cholangiocarcinoma (ISO)

cholestasis (ISO)

chronic myeloid leukemia (ISO)

Colorectal Neoplasms (ISO)

diarrhea (ISO)

drug allergy (ISO)

drug-induced hepatitis (ISO)

Drug-Induced Immune Thrombocytopenia (ISO)

Drug-induced Neutropenia (ISO)

Dubin-Johnson syndrome (ISO)

end stage renal disease (ISO)

Endotoxemia (ISO)

epilepsy (ISO)

esophagus squamous cell carcinoma (ISO)

Experimental Diabetes Mellitus (ISO)

Experimental Liver Cirrhosis (ISO)

gastrointestinal system disease (ISO)

genetic disease (ISO)

head and neck squamous cell carcinoma (ISO)

heart disease (ISO)

lung non-small cell carcinoma (ISO)

metabolic dysfunction-associated steatotic liver disease (ISO)

nervous system disease (ISO)

pancreatic cancer (ISO)

primary biliary cholangitis (ISO)

pseudoxanthoma elasticum (ISO)

rheumatoid arthritis (ISO)

status epilepticus (ISO)

steatotic liver disease (ISO)

type 2 diabetes mellitus (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

antibiotic metabolic process (ISO)

benzylpenicillin metabolic process (ISO)

bile acid and bile salt transport (ISO)

bilirubin transport (ISO)

canalicular bile acid transport (ISO)

cellular response to dexamethasone stimulus (ISO)

cellular response to interleukin-1 (ISO)

cellular response to interleukin-6 (ISO)

cellular response to lipopolysaccharide (ISO)

cellular response to tumor necrosis factor (ISO)

cellular response to xenobiotic stimulus (ISO)

detoxification of mercury ion (ISO)

female pregnancy (ISO)

intracellular chloride ion homeostasis (ISO)

leukotriene transport (ISO)

mercury ion transport (ISO)

negative regulation of gene expression (ISO)

organic anion transport (ISO)

prostaglandin transport (ISO)

response to antineoplastic agent (ISO)

response to arsenic-containing substance (ISO)

response to estradiol (ISO)

response to estrogen (ISO)

response to glucagon (ISO)

response to lipopolysaccharide (ISO)

response to oxidative stress (ISO)

response to steroid hormone (ISO)

response to xenobiotic stimulus (ISO)

thyroid hormone transport (ISO)

transepithelial transport (ISO)

xenobiotic catabolic process (ISO)

xenobiotic detoxification by transmembrane export across the plasma membrane (ISO)

xenobiotic export from cell (ISO)

xenobiotic transmembrane transport (ISO)

xenobiotic transport across blood-brain barrier (ISO)

Cellular Component

apical plasma membrane (ISO)

brush border membrane (ISO)

cell surface (ISO)

intercellular canaliculus (ISO)

intracellular canaliculus (ISO)

membrane (ISO)

plasma membrane (ISO)

Molecular Function

ABC-type glutathione S-conjugate transporter activity (ISO)

ABC-type xenobiotic transporter activity (ISO)

ATPase-coupled transmembrane transporter activity (ISO)

bilirubin transmembrane transporter activity (ISO)

protein binding (ISO)

protein domain specific binding (ISO)

xenobiotic transmembrane transporter activity (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

docetaxel pharmacodynamics pathway (ISO)

doxorubicin pharmacokinetics pathway (ISO)

irinotecan pharmacodynamics pathway (ISO)

irinotecan pharmacokinetics pathway (ISO)

lamivudine pharmacokinetics pathway (ISO)

multidrug resistance-associated protein mediated transport pathway (ISO)

mycophenolic acid pharmacokinetics pathway (ISO)

paracetamol pharmacokinetics pathway (ISO)

statin pharmacokinetics pathway (ISO)

tramadol pharmacokinetics pathway (ISO)

tyrosinemia type III pathway (ISO)

vinblastine pharmacodynamics pathway (ISO)

vincristine pharmacodynamics pathway (ISO)

vindesine pharmacodynamics pathway (ISO)

vinorelbine pharmacodynamics pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species
2.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Abcc2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955507	5,724,762 - 5,790,812 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955507	5,724,788 - 5,791,281 (+)	NCBI	ChiLan1.0	ChiLan1.0

ABCC2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	10	99,782,640 - 99,852,594 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	10	99,782,640 - 99,852,594 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	10	101,542,397 - 101,612,351 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	10	101,532,493 - 101,601,571 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	10	101,532,562 - 101,601,571	NCBI
Celera	10	95,279,806 - 95,349,643 (+)	NCBI		Celera
Cytogenetic Map	10	q24.2	NCBI
HuRef	10	95,169,835 - 95,239,503 (+)	NCBI		HuRef
CHM1_1	10	101,824,911 - 101,894,368 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	10	100,665,562 - 100,736,331 (+)	NCBI		T2T-CHM13v2.0

Abcc2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	19	43,770,747 - 43,826,771 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	19	43,770,631 - 43,829,179 (+)	Ensembl		GRCm39 Ensembl
GRCm38	19	43,782,308 - 43,838,332 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	19	43,782,192 - 43,840,740 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	19	43,856,798 - 43,912,708 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	19	43,835,715 - 43,891,248 (+)	NCBI		MGSCv36	mm8
Celera	19	44,567,463 - 44,621,438 (+)	NCBI		Celera
Cytogenetic Map	19	C3	NCBI
cM Map	19	36.67	NCBI

Abcc2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	252,613,875 - 252,672,459 (+)	NCBI		GRCr8
mRatBN7.2	1	242,664,657 - 242,723,239 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	242,664,657 - 242,723,238 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	250,813,581 - 250,872,198 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	257,510,469 - 257,569,198 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	250,163,726 - 250,222,340 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	263,554,426 - 263,612,556 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	263,554,453 - 263,613,252 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	270,999,832 - 271,057,750 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	1	238,483,399 - 238,539,595 (+)	NCBI		Celera
Cytogenetic Map	1	q54	NCBI

ABCC2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	8	111,665,912 - 111,749,129 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	10	111,688,214 - 111,755,876 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	10	96,385,534 - 96,458,571 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	10	99,889,021 - 99,947,452 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	10	99,889,160 - 99,947,270 (+)	Ensembl	panpan1.1		panPan2

ABCC2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	28	12,670,885 - 12,740,124 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	28	12,670,885 - 12,740,740 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	28	12,854,192 - 12,923,368 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	28	13,138,667 - 13,208,016 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	28	13,138,667 - 13,208,633 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	28	12,685,440 - 12,754,683 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	28	12,716,120 - 12,786,599 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	28	12,857,984 - 12,927,300 (+)	NCBI		UU_Cfam_GSD_1.0

Abcc2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	34,253,163 - 34,302,933 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936636	292,709 - 340,393 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936636	292,631 - 341,999 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ABCC2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	110,955,582 - 111,038,898 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	110,955,698 - 111,038,898 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	120,400,787 - 120,484,137 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ABCC2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	9	92,826,423 - 92,902,389 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	9	92,841,818 - 92,902,265 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666048	53,844,985 - 53,909,244 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Abcc2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624737	11,593,864 - 11,688,460 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624737	11,593,701 - 11,686,790 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005407678	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01065688	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBCQ01067528	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCLAT00000004354 ⟹ ENSCLAP00000004272

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955507	5,724,762 - 5,790,812 (+)	Ensembl

RefSeq Acc Id:

XM_005407678 ⟹ XP_005407735

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955507	5,724,788 - 5,791,281 (+)	NCBI

Sequence:

show sequence

TCAGATCATCAGGTGGGGAAAGAACACATTGCTACTTGCCAGCCACCTTCTCCAAGGAAAAGAG
TAAAGAAGAAACAACATAGTCCTAGAGAAGTCTTCATGCCAGAAGTGCTCCAGGAGTCATGGTG
GACAAATTCTGCAATTCTACTTTTTGGAATTCTTCATTCCTGGACAGACCAGATGCAGACCTGC
CACTTTGTTTTGAACAAACTGTCCTGGTATGGATTCCTTTGTGCTTCCTTTGGCTCTTGGCCCC
TTGGCAGCTTTTCCACGTATATAGATCCAGGACCAAGACATCTTCTATAACTAAGTTTTACATT
GCTAAACAGGTGCTCGTTGGGTTTCTTCTTATTCTGGCAGTCATAGAGCTGGCCCTTGCACTCA
CAGAAGACTCTGGACAAGCCACGATTCCTCCCGTGAAATATGTCAACCCGATCCTCTACCTAGT
CACATGGCTCCTGGTTTTGCTGATCCAGTACAGCAGGCAATGGTGCATACAGAAAAATTCTTGG
TTCCTGACAATATTCTGGATTCTCTCGATCTGCTGTGACACTTTCCAATTTCAGACTCTTGTCC
GGGCACTCCTACAGGACAAAAGTTCCAATCTGGCCTATTCCTGCCTGTTCTTCATCTCTTATGG
ATTACAGATCCTGATCCTGATCCTTTCAGCATTCTCAGAAAAAAGTGACTTATCAAGTAATCCA
TCATCCACAGCTTCATTTTTGAGTAGAATTACCTTCAATTGGTATAACAGGGTTGTTCGGAAAG
GTTACAAGCACCCTTTGACACTTGAAGATGTCTGGGAACTTGATGAAGAGTTTAAAACCAAACT
GGTGGTGAGCAAGTTTAAAGTAGTCATGGAAAAGGAGCTTCAGAAAGCTAAGCGGGCATTCCAG
AGACGGCAGCAGAAGTCCCAGCGGAACTCTGGCGCCAAGTCACATGGCTTGGACAAGAACCAGA
GCCAAAGCCAAGATGTCCTTGTCCTGGAAGAAGCTAAGAAGAAAAAGAAGTCTAAGGCTACAAA
AGACTTTCCCAAATCCTGGCTGACCAAGACCCTCTTCAAAACTTTCTCCATGGTGCTTCTGAAG
TCATTCATACTGAAACTAGTGTATGACGTCTCTATGTTTCTGAATCCTCAGCTGCTGAAATGGC
TGATTGCCTTTGTGAGTGACTATGACTCATATGTGTGGCATGGATATGTCTACGCCATCCTCTT
ATTAGTTATTAGTCTCCTCCAATCTCTCTGCCTTCAGGCTTATTTTCAAATGTGTTTCATTCTG
GGAATGAGTGTACGGACAACCGTCATGGCTTCTGTATATAAGAAGGCACTGACCCTGTCCAACT
TGAACAGGAAGCAGTACACCATCGGGGAAACAGTGAACCTGATGTCTGTGGATGCCCAGAAGCT
GATGGATGTGACCAACTTCATTCACTTGCTGTGGTCAACTTTCCTGCAGATTGCCTTATCCATC
TTCTTCCTGTGGAGAGAGTTGGGACCCTCAGTCTTAGCAGGTGTAGGGGTGATGGTTCTCCTAG
TTCCAATTAATGGAATACTTGCCACCAAGAATAGAAATATTCAGTTCAAAAACATGAAGTATAA
GGACAAACGTTTGAAGACCATGAATGAGATTCTCAGTGGAATCAAGATCCTGAAATATTTTGCC
TGGGAACCTTCATTCGAAGACCAAGTCAACTATCTTCGAAAGAAAGAGCTGAAGAACCTGCTGA
CCTTTGGTCAGCTGCAGAGTATGATTATATTCTTCTTACAGTTAGCTCCTATCCTGGTGTCTGT
GACAACATTTTCAGTTTATGTTCTGGTGGATAGCAACAATATTTTGGATGCAGAAAAGGCCTTC
ACCTCCATCACCCTCTTCAATATCCTGCGTTTTCCCCTAACCACGCTTCCCATGGTGATCTCTT
CCGTGCTGCAGGCCAGTGTCTCGATAGAACGTCTAGAGAAATACTTGGGAGGGGATGACTTGGA
CACATCTGCCATTCGGCATGTCTGCAATTTTGACAAAGCTGTGCAGTTTTCTGAGGCCTCCTTT
ACCTGGGACCTGGACTCGGAAGCCACGATCAGAGACGTGAACCTGGATGTTATGCCAGGCCAAC
TGGTGGCTGTGGTGGGTACTGTGGGCTCTGGGAAATCTTCCTTGATGGCAGCTATGCTGGGAGA
AATGGAAAATGTCCACGGGCACATCACCATCAAGGGCACTACAGCTTATGTCCCTCAGCAGTCC
TGGATTCAGAATGGCACCATAAAAGACAACATCCTTTTTGGATCAGAGTTGAATGAAAAGAAGT
ATCAGCAAGTTCTGGAGGCCTGTGCTCTCCTCCCAGACTTGGAAATATTACCTGGAGGAGACAT
GGCTGAAATTGGAGAGAAGGGTATAAATCTCAGTGGTGGCCAGAAGCAGCGAATCAGCCTGGCC
AGAGCTGCCTACCAAGACTTAGACATCTACATTCTGGATGACCCTCTATCAGCTGTGGATGCTC
ATGTAGGAAAACATATTTTCGATAAGGTCTTGGGCCCCCATGGCCTGTTGAATGGCAAGACCCG
ACTGTTGGTTACACATAGCATTCACTTTCTTCCCCAAGTGGATGAGATTGTGGTTCTGGGGAAT
GGCACTGTCTTGGAGAAAGGATCCTACAAGGCTTTGCTGGCCAAGAAAGGAGTATTTGCTAAGA
ATCTGAAGACATTCATAAGACATTCAAGTTCTGAAGGGGAGGCCACAGTAAATGACGGTAGTGA
AGAAGAAGACGACGACTGTGGACTGATACCCAGCATAGAGGAAATCCCTGAGGATGCAGCCTCC
TTGACCATGAAAAGAGAGAACAGCCTTCATCGAACTATGAGCCGCAGCTCTAGGTCCAGTAGAA
GGCATCTGAAGTCCTTGAAAAACTCCTTGAAAACTCAAAATGTGAATGCCCTGAAGGAGGAAGA
AGAAGTAGTGAAAGGACAAAAACTAATTAAGAAAGAATTCATGGAACGTGGAAAGGTGAAGTTC
TCTGTCTACATAAAATACCTACGAGCAATGAGATGGTGTTCGATAGCCTTCATCGTCTGTTTCT
TCATGATGAATTCTGTGGCTTTTATTGGGTCCAACCTTTGGCTTAGTGCTTGGACCAGAGACTC
TCTGATCTACAACGGCACCAACTATCCAGCCTCTCAGAGGGACATGAGAATTGGAGTCTATGGA
GGTCTGGGAGTAGCACAAGCTGTATTTGTGGTCATAGCAAGTATGTGCAGTGTATTCAGCTGCA
ACCATGCATCAAAAACCTTGCATCAGCAACTGCTAAGCAATATCCTCCATGCACCTATGAGGTT
TTTTGATACAACACCCACAGGCCGGATTGTGAACAGATTTGCTGGTGATATTTCCACCGTGGAT
GAAACCCTCCCTCAGACCTTGCGCAGCTGGCTGCTGTGCTTCCTGGGGATAATTAGCACCCTTG
TAATGATCTGCATGGCCACCCCTGTGTTCATCGTCATTATCATTCCTCTTGGCATTATTTACGT
GGCTATCCAGATATTTTATGTGGCAACTTCCCGCCAGCTGAGACGTCTGGACTCTGTCACTAGA
TCCCCAGTCTACTCTCACTTTAGTGAGACAGTAACAGGTTTGCCCGTTATCCGTGCCTTTGAAC
ACCAGCAGCGATTTCTAATGTCCAACGAGAAGTTAATAGACATCAACCAGAAATGTGTCTTTTC
TTGGATTATAGCCAACAGGTGGCTTGCAGTTCGCCTGGAGTTTGTTGGGAACCTGATTGTCTTC
TTTGCTTCCTTGCTGCTGGTTATTTATAAAAATACCCAAACTGGAGACACCGTCGGCTTTGTTC
TGTCCAATGCCCTTAATATCACACAAACCCTGAACTGGCTAGTGAGGATGACATCAGAAACAGA
GACCAACATTGTAGCTGTTGAGCGCATAAATGAGTACATCAATGTGGAAAAGGAGGCATCCTGG
ATGACGGATAAGAGGCCTCCAGCAGATTGGCCCAGCAAAGGTGAAATCCAGTTTAGCAACTACC
AAGTACGGTACCGACCTGAGCTGGATCTGGTTCTGAAGGGGATCACTTGTCACATCAAGAGCAC
TGAGAAGATTGGTGTAGTGGGCAGGACAGGAGCTGGGAAGTCATCCCTCACAAACTGCCTCTTC
AGAATCTTAGAGTCTGCAGGTGGCCAGATCATCATTGATGGAATAGATATTGCTTCTATTGGGC
TCCACGACCTCCGAGGGAAACTGACCATCATCCCCCAGGACCCCGTCCTGTTCTCTGGAAACCT
AAGGATGAATCTTGACCCTTTCAACAAATACTCAGATGAGGAGATTTGGAAAGCCCTGGAGCTG
GCTCATCTCAAGTCCTTTGTGGCCGGCCTGCAACTTGGGTTGTCCCACGAAGTGACAGAGGCTG
GTGAAAACCTGAGCATTGGGCAGAGGCAGCTCCTGTGCCTGGGCAGGGCTCTCCTTCAGAAGTC
CAAGATTCTGGTGCTGGATGAGGCCACTGCTGCTGTGGATCTAGAGACAGATCAACTCATCCAG
AAGACCATCCGGGACGAGTTCTCCCACTGCACTGTTATCACCATTGCCCACCGGCTGCACACCA
TCATGGACAGCGACAAGATAATGGTCCTAGACAGTGGGAATATTGTAGAGTACGGCAGCCCTGA
AGAACTGCTGGGAAAGTCTGGCCCCTTCTATTTTATGGCCAAAGAAGCTGGCATTGAGAACATA
GACAACACAGCACTCTAGCAGCAAATCGCATGGGGGAGAAAAGGACTATACAAATCAGTTCTCT
GTGTGTGCGCAGGCATGTGTGTGAAGTTATGTCATGTGCAGAGCTAGGTATAAAATACACATTT
TTTATCTAGGTCTGACTATGTTGCCCAGGCTGGCATCAAACTCTTGGGCTCTAGTGATCCTCCT
GCCTCAGCCTGTTGAGTAAAAATGTACATTTTATGGAATGATAAGTGAATACCCATGTGCCCAT
TATCCAGATAAAGAAAATGAATATTATTAGGAGCCTCAGAAACCCCTGAGTTGTCCCACTTTGA
TCATAACTTCTTGCCCGCCTCTCTTCCAGACAGTCACTCTCCTGAATTTCATGATAATTGTTCC
CTCACCCTTTGTTTTAGTTTCACCACCTTTGCATGCATCCGTAAACAATGTGTACCTTTTAAAA
ATCTTATCTAAATAGACTCACTCTGCATGGATTCTTTTA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005407735	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000004272
	ENSCLAP00000004272.1

RefSeq Acc Id:

XP_005407735 ⟸ XM_005407678

- UniProtKB:

A0A8C2URN8 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MVDKFCNSTFWNSSFLDRPDADLPLCFEQTVLVWIPLCFLWLLAPWQLFHVYRSRTKTSSITKF
YIAKQVLVGFLLILAVIELALALTEDSGQATIPPVKYVNPILYLVTWLLVLLIQYSRQWCIQKN
SWFLTIFWILSICCDTFQFQTLVRALLQDKSSNLAYSCLFFISYGLQILILILSAFSEKSDLSS
NPSSTASFLSRITFNWYNRVVRKGYKHPLTLEDVWELDEEFKTKLVVSKFKVVMEKELQKAKRA
FQRRQQKSQRNSGAKSHGLDKNQSQSQDVLVLEEAKKKKKSKATKDFPKSWLTKTLFKTFSMVL
LKSFILKLVYDVSMFLNPQLLKWLIAFVSDYDSYVWHGYVYAILLLVISLLQSLCLQAYFQMCF
ILGMSVRTTVMASVYKKALTLSNLNRKQYTIGETVNLMSVDAQKLMDVTNFIHLLWSTFLQIAL
SIFFLWRELGPSVLAGVGVMVLLVPINGILATKNRNIQFKNMKYKDKRLKTMNEILSGIKILKY
FAWEPSFEDQVNYLRKKELKNLLTFGQLQSMIIFFLQLAPILVSVTTFSVYVLVDSNNILDAEK
AFTSITLFNILRFPLTTLPMVISSVLQASVSIERLEKYLGGDDLDTSAIRHVCNFDKAVQFSEA
SFTWDLDSEATIRDVNLDVMPGQLVAVVGTVGSGKSSLMAAMLGEMENVHGHITIKGTTAYVPQ
QSWIQNGTIKDNILFGSELNEKKYQQVLEACALLPDLEILPGGDMAEIGEKGINLSGGQKQRIS
LARAAYQDLDIYILDDPLSAVDAHVGKHIFDKVLGPHGLLNGKTRLLVTHSIHFLPQVDEIVVL
GNGTVLEKGSYKALLAKKGVFAKNLKTFIRHSSSEGEATVNDGSEEEDDDCGLIPSIEEIPEDA
ASLTMKRENSLHRTMSRSSRSSRRHLKSLKNSLKTQNVNALKEEEEVVKGQKLIKKEFMERGKV
KFSVYIKYLRAMRWCSIAFIVCFFMMNSVAFIGSNLWLSAWTRDSLIYNGTNYPASQRDMRIGV
YGGLGVAQAVFVVIASMCSVFSCNHASKTLHQQLLSNILHAPMRFFDTTPTGRIVNRFAGDIST
VDETLPQTLRSWLLCFLGIISTLVMICMATPVFIVIIIPLGIIYVAIQIFYVATSRQLRRLDSV
TRSPVYSHFSETVTGLPVIRAFEHQQRFLMSNEKLIDINQKCVFSWIIANRWLAVRLEFVGNLI
VFFASLLLVIYKNTQTGDTVGFVLSNALNITQTLNWLVRMTSETETNIVAVERINEYINVEKEA
SWMTDKRPPADWPSKGEIQFSNYQVRYRPELDLVLKGITCHIKSTEKIGVVGRTGAGKSSLTNC
LFRILESAGGQIIIDGIDIASIGLHDLRGKLTIIPQDPVLFSGNLRMNLDPFNKYSDEEIWKAL
ELAHLKSFVAGLQLGLSHEVTEAGENLSIGQRQLLCLGRALLQKSKILVLDEATAAVDLETDQL
IQKTIRDEFSHCTVITIAHRLHTIMDSDKIMVLDSGNIVEYGSPEELLGKSGPFYFMAKEAGIE
NIDNTAL

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Ensembl Acc Id:

ENSCLAP00000004272 ⟸ ENSCLAT00000004354

Protein Domains

ABC transmembrane type-1 ABC transporter

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000003041	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000004354	ENTREZGENE
	ENSCLAT00000004354.1	UniProtKB/TrEMBL
Gene3D-CATH	1.20.1560.10	UniProtKB/TrEMBL
	3.40.50.300	UniProtKB/TrEMBL
InterPro	AAA+_ATPase	UniProtKB/TrEMBL
	ABC1_TM_dom	UniProtKB/TrEMBL
	ABC1_TM_sf	UniProtKB/TrEMBL
	ABC_transporter-like_ATP-bd	UniProtKB/TrEMBL
	ABC_transporter-like_CS	UniProtKB/TrEMBL
	ABC_transporter_C	UniProtKB/TrEMBL
	Multidrug-R_assoc	UniProtKB/TrEMBL
	P-loop_NTPase	UniProtKB/TrEMBL
NCBI Gene	Abcc2	ENTREZGENE
PANTHER	ATP-BINDING CASSETTE SUB-FAMILY C	UniProtKB/TrEMBL
	PTHR24223:SF176	UniProtKB/TrEMBL
Pfam	ABC_membrane	UniProtKB/TrEMBL
	ABC_tran	UniProtKB/TrEMBL
PROSITE	ABC_TM1F	UniProtKB/TrEMBL
	ABC_TRANSPORTER_1	UniProtKB/TrEMBL
	ABC_TRANSPORTER_2	UniProtKB/TrEMBL
SMART	AAA	UniProtKB/TrEMBL
Superfamily-SCOP	SSF52540	UniProtKB/TrEMBL
	SSF90123	UniProtKB/TrEMBL
UniProt	A0A8C2URN8	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-08-16	Abcc2	ATP binding cassette subfamily C member 2		ATP-binding cassette, sub-family C (CFTR/MRP), member 2	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB