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ONTOLOGY REPORT - ANNOTATIONS

Term:mRNA splicing, via endonucleolytic cleavage and ligation
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Accession:GO:0070054 term browser browse the term
Definition:Splicing of mRNA substrates via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons.
Comment:Note that while typically associated with tRNA splicing, splicing via endonucleolytic cleavages and subsequent ligation of the free exon ends is known to be used for some non-tRNA substrates, e.g. HAC1 (YFL031W) in S. cerevisiae and an intron in the 23S rRNA of the Archaeal species Desulfurococcus mobilis.
Synonyms:related_synonym: cytosolic mRNA splicing
 alt_id: GO:0061012

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mRNA splicing, via endonucleolytic cleavage and ligation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ern1 endoplasmic reticulum to nucleus signaling 1 involved_in ISO (PMID:20625543), (PMID:21317875)
(PMID:11779464), (PMID:19328063), (PMID:19622636), (PMID:21317875)		 ParkinsonsUK-UCL PMID:11779464 PMID:19328063 PMID:19622636 PMID:20625543 PMID:21317875 NCBI chrNW_004955478:7,720,664...7,803,662
Ensembl chrNW_004955478:7,751,830...7,799,460 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12362
    metabolic process 7488
      primary metabolic process 6455
        RNA processing 583
          mRNA processing 280
            mRNA splicing, via endonucleolytic cleavage and ligation 1
Path 2
Term Annotations click to browse term
  biological_process 12362
    metabolic process 7488
      primary metabolic process 6455
        nucleobase-containing compound metabolic process 3737
          nucleic acid metabolic process 3370
            RNA metabolic process 2899
              RNA biosynthetic process 2744
                RNA processing 583
                  RNA splicing 276
                    RNA splicing, via endonucleolytic cleavage and ligation 9
                      mRNA splicing, via endonucleolytic cleavage and ligation 1
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