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ONTOLOGY REPORT - ANNOTATIONS

Term:regulation of T cell receptor signaling pathway
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Accession:GO:0050856 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell.
Synonyms:exact_synonym: regulation of T lymphocyte receptor signaling pathway;   regulation of T lymphocyte receptor signalling pathway;   regulation of T-cell receptor signalling pathway;   regulation of TCR signaling pathway

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regulation of T cell receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl10 BCL10 immune signaling adaptor acts_upstream_of_or_within ISO (PMID:14614861) MGI PMID:14614861 NCBI chrNW_004624742:12,210,333...12,222,533
Ensembl chrNW_004624742:12,210,360...12,221,759 		JBrowse link
G Cd300a CD300a molecule involved_in ISO (PMID:22046970) UniProt PMID:22046970 NCBI chrNW_004624801:4,404,376...4,420,836
Ensembl chrNW_004624801:4,404,262...4,421,097 		JBrowse link
G Lck LCK proto-oncogene, Src family tyrosine kinase acts_upstream_of_or_within ISO (PMID:14752163) MGI PMID:14752163 NCBI chrNW_004624764:15,469,582...15,495,351
Ensembl chrNW_004624764:15,472,685...15,495,351 		JBrowse link
G Malt1 MALT1 paracaspase acts_upstream_of_or_within ISO (PMID:14614861) MGI PMID:14614861 NCBI chrNW_004624792:4,148,258...4,223,431
Ensembl chrNW_004624792:4,148,453...4,217,548 		JBrowse link
G Rc3h1 ring finger and CCCH-type domains 1 involved_in ISO (MGI:3580753|PMID:15917799) BHF-UCL PMID:15917799 MGI:3580753 NCBI chrNW_004624771:7,837,547...7,948,217 JBrowse link
G Tespa1 thymocyte expressed, positive selection associated 1 acts_upstream_of
involved_in		 ISO
IEA		 (PMID:28598420) MGI
Ensembl		 PMID:28598420 GO_REF:0000107 NCBI chrNW_004624983:31,552...47,575
Ensembl chrNW_004624983:31,766...45,077 		JBrowse link
negative regulation of T cell receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Btrc beta-transducin repeat containing E3 ubiquitin protein ligase involved_in ISO (PMID:38225265) UniProt PMID:38225265 NCBI chrNW_004624831:868,417...1,065,591
Ensembl chrNW_004624831:868,563...1,060,248 		JBrowse link
G Cblb Cbl proto-oncogene B acts_upstream_of_or_within ISO (PMID:14738763) MGI PMID:14738763 NCBI chrNW_004624731:43,803,743...44,018,682
Ensembl chrNW_004624731:43,803,768...44,015,870 		JBrowse link
G Dgkz diacylglycerol kinase zeta involved_in ISO (MGI:2672999|PMID:12883552) UniProt PMID:12883552 MGI:2672999 NCBI chrNW_004624767:2,173,774...2,210,304
Ensembl chrNW_004624767:2,173,272...2,210,279 		JBrowse link
G Dusp22 dual specificity phosphatase 22 involved_in
acts_upstream_of_or_within		 ISO (PMID:38225265)
(PMID:24714587)		 UniProt
MGI		 PMID:24714587 PMID:38225265 NCBI chrNW_004624756:23,968,148...24,017,340
Ensembl chrNW_004624756:23,968,017...24,017,332 		JBrowse link
G Dusp3 dual specificity phosphatase 3 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624795:994,103...1,001,697 JBrowse link
G Elf1 E74 like ETS transcription factor 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:14738763) Ensembl
MGI		 PMID:14738763 GO_REF:0000107 NCBI chrNW_004624748:13,987,001...14,090,451
Ensembl chrNW_004624748:14,017,621...14,091,619 		JBrowse link
G Ezr ezrin involved_in ISO (PMID:20551903) UniProt PMID:20551903 NCBI chrNW_004624929:827,275...873,743
Ensembl chrNW_004624929:826,531...873,572 		JBrowse link
G Laptm5 lysosomal protein transmembrane 5 involved_in ISO (MGI:3803048|PMID:18619870) ARUK-UCL PMID:18619870 MGI:3803048 NCBI chrNW_004624764:14,208,144...14,277,208
Ensembl chrNW_004624764:14,207,094...14,228,135 		JBrowse link
G Lgals3 galectin 3 involved_in ISO (MGI:4355752|PMID:19706535) BHF-UCL PMID:19706535 MGI:4355752 NCBI chrNW_004624731:14,300,138...14,307,843
Ensembl chrNW_004624731:14,298,201...14,304,637 		JBrowse link
G Pawr pro-apoptotic WT1 regulator acts_upstream_of_or_within ISO (PMID:12970181) MGI PMID:12970181 NCBI chrNW_004624750:18,562,270...18,710,397
Ensembl chrNW_004624750:18,562,221...18,705,540 		JBrowse link
G Prnp prion protein (Kanno blood group) involved_in ISO (MGI:4943618|PMID:20145049) BHF-UCL PMID:20145049 MGI:4943618 NCBI chrNW_004624741:5,785,139...5,802,162
Ensembl chrNW_004624741:5,785,158...5,802,162 		JBrowse link
G Ptpn2 protein tyrosine phosphatase non-receptor type 2 involved_in ISO (MGI:5320871|PMID:22080863) UniProt PMID:22080863 MGI:5320871 NCBI chrNW_004624770:19,808,400...19,877,494
Ensembl chrNW_004624770:19,808,400...19,876,503 		JBrowse link
G Ptpn22 protein tyrosine phosphatase non-receptor type 22 involved_in ISO (PMID:18056643) UniProt PMID:18056643 NCBI chrNW_004624772:9,472,869...9,552,751
Ensembl chrNW_004624772:9,472,913...9,550,990 		JBrowse link
G Ptpn6 protein tyrosine phosphatase non-receptor type 6 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:9064344) MGI
Ensembl		 PMID:9064344 GO_REF:0000107 NCBI chrNW_004624860:3,580,225...3,595,403
Ensembl chrNW_004624860:3,580,560...3,595,090 		JBrowse link
G Ptprj protein tyrosine phosphatase receptor type J involved_in ISO (PMID:11259588), (PMID:9780142)
(MGI:4942249|PMID:12913111)
(PMID:12913111)		 UniProt PMID:9780142 PMID:11259588 PMID:12913111 MGI:4942249 NCBI chrNW_004624767:942,786...1,051,112
Ensembl chrNW_004624767:945,553...1,051,138 		JBrowse link
G Sh2d1a SH2 domain containing 1A involved_in ISO (PMID:9774102) UniProt PMID:9774102 NCBI chrNW_004624797:3,120,123...3,142,564
Ensembl chrNW_004624797:3,120,123...3,142,564 		JBrowse link
G Sla2 Src like adaptor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624842:2,853,183...2,882,269
Ensembl chrNW_004624842:2,853,144...2,881,116 		JBrowse link
G Thy1 Thy-1 cell surface antigen involved_in ISO (MGI:1096761|PMID:9285719) UniProt PMID:9285719 MGI:1096761 NCBI chrNW_004624784:14,779,533...14,784,315
Ensembl chrNW_004624784:14,780,698...14,784,897 		JBrowse link
G Ubash3a ubiquitin associated and SH3 domain containing A involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:14738763) TreeGrafter
MGI		 PMID:14738763 GO_REF:0000118 NCBI chrNW_004624745:28,026,274...28,057,922 JBrowse link
positive regulation of T cell receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ada adenosine deaminase acts_upstream_of_or_within ISO (PMID:11435465) MGI PMID:11435465 NCBI chrNW_004624790:9,809,550...9,829,199
Ensembl chrNW_004624790:9,809,492...9,829,883 		JBrowse link
G Bcl10 BCL10 immune signaling adaptor involved_in ISO (PMID:18287044), (PMID:27777308) UniProt PMID:18287044 PMID:27777308 NCBI chrNW_004624742:12,210,333...12,222,533
Ensembl chrNW_004624742:12,210,360...12,221,759 		JBrowse link
G Card11 caspase recruitment domain family member 11 involved_in ISO (MGI:6695669|PMID:12154356)
(PMID:12154360)		 UniProt PMID:12154356 PMID:12154360 MGI:6695669 NCBI chrNW_004624740:29,974,707...30,085,498
Ensembl chrNW_004624740:29,974,689...30,085,981 		JBrowse link
G Ccr7 C-C motif chemokine receptor 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624795:2,777,766...2,787,664
Ensembl chrNW_004624795:2,779,627...2,788,897 		JBrowse link
G Cd226 CD226 molecule involved_in IEA TreeGrafter
Ensembl		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004624806:11,324,239...11,390,487
Ensembl chrNW_004624806:11,324,344...11,388,206 		JBrowse link
G Cd81 CD81 molecule involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624767:15,192,446...15,210,923
Ensembl chrNW_004624767:15,192,452...15,210,922 		JBrowse link
G Cyld CYLD lysine 63 deubiquitinase acts_upstream_of_or_within ISO (PMID:16501569) MGI PMID:16501569 NCBI chrNW_004624757:5,895,912...5,953,485 JBrowse link
G Ikbkg inhibitor of nuclear factor kappa B kinase regulatory subunit gamma involved_in ISO (PMID:18287044), (PMID:27777308) UniProt PMID:18287044 PMID:27777308 NCBI chrNW_004624946:997,571...1,015,748
Ensembl chrNW_004624946:996,814...1,013,379 		JBrowse link
G Kcnn4 potassium calcium-activated channel subfamily N member 4 involved_in ISO (PMID:18796614) BHF-UCL PMID:18796614 NCBI chrNW_004624907:1,266,348...1,279,258
Ensembl chrNW_004624907:1,266,348...1,278,699 		JBrowse link
G Lipa lipase A, lysosomal acid type acts_upstream_of_or_within ISO (PMID:19179613) MGI PMID:19179613 NCBI chrNW_004624737:49,471...82,981
Ensembl chrNW_004624737:49,371...83,514 		JBrowse link
G LOC101706523 T-cell receptor-associated transmembrane adapter 1 acts_upstream_of_or_within ISO (PMID:11390434) MGI PMID:11390434 NCBI chrNW_004624731:40,281,086...40,319,254
Ensembl chrNW_004624731:40,280,884...40,306,653 		JBrowse link
G LOC101712173 poliovirus receptor homolog involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624907:1,582,636...1,596,528 JBrowse link
G Nectin2 nectin cell adhesion molecule 2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624907:1,713,786...1,739,158
Ensembl chrNW_004624907:1,713,443...1,740,627 		JBrowse link
G Prkd2 protein kinase D2 involved_in ISO (MGI:4849903|PMID:20819079) UniProt PMID:20819079 MGI:4849903 NCBI chrNW_004624832:6,885,627...6,915,316
Ensembl chrNW_004624832:6,886,327...6,915,179 		JBrowse link
G Rab29 RAB29, member RAS oncogene family involved_in ISO (PMID:26021297) ParkinsonsUK-UCL PMID:26021297 NCBI chrNW_004624807:5,478,570...5,483,473
Ensembl chrNW_004624807:5,478,707...5,483,475 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624767:20,732,813...20,742,016
Ensembl chrNW_004624767:20,732,938...20,741,272 		JBrowse link
G Rps3 ribosomal protein S3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624817:1,710,768...1,715,923
Ensembl chrNW_004624817:1,710,768...1,716,224 		JBrowse link
G Tespa1 thymocyte expressed, positive selection associated 1 involved_in IEA TreeGrafter
Ensembl		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004624983:31,552...47,575
Ensembl chrNW_004624983:31,766...45,077 		JBrowse link
G Ubr2 ubiquitin protein ligase E3 component n-recognin 2 involved_in ISO (PMID:38225265) UniProt PMID:38225265 NCBI chrNW_004624754:16,701,950...16,798,293
Ensembl chrNW_004624754:16,701,331...16,798,897 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15093
    immune system process 2103
      regulation of immune system process 1351
        regulation of immune response 762
          regulation of antigen receptor-mediated signaling pathway 60
            regulation of T cell receptor signaling pathway 42
              negative regulation of T cell receptor signaling pathway + 19
              positive regulation of T cell receptor signaling pathway 19
Path 2
Term Annotations click to browse term
  biological_process 15093
    biological regulation 10618
      regulation of biological process 10301
        regulation of immune system process 1351
          regulation of immune response 762
            positive regulation of immune response 617
              activation of immune response 460
                immune response-activating signaling pathway 405
                  immune response-activating cell surface receptor signaling pathway 247
                    antigen receptor-mediated signaling pathway 159
                      T cell receptor signaling pathway 119
                        regulation of T cell receptor signaling pathway 42
                          negative regulation of T cell receptor signaling pathway + 19
                          positive regulation of T cell receptor signaling pathway 19
paths to the root