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ONTOLOGY REPORT - ANNOTATIONS

Term:isotype switching to IgA isotypes
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Accession:GO:0048290 term browser browse the term
Definition:The switching of activated B cells from IgM biosynthesis to biosynthesis of an IgA isotype, accomplished through a recombination process involving an intrachromosomal deletion between switch regions that reside 5' of the IgM and one of the IgA constant region gene segments in the immunoglobulin heavy chain locus.
Synonyms:exact_synonym: class switching to IgA isotypes;   isotype switch recombination to IgA isotypes

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isotype switching to IgA isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccr6 C-C motif chemokine receptor 6 involved_in ISO (MGI:5787846|PMID:27174992) UniProt PMID:27174992 MGI:5787846 NCBI chrNW_004955439:14,921,524...14,949,493
Ensembl chrNW_004955439:14,920,601...14,924,191 		JBrowse link
positive regulation of isotype switching to IgA isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mlh1 mutL homolog 1 involved_in ISO (MGI:1342394|PMID:10430621) CAFA PMID:10430621 MGI:1342394 NCBI chrNW_004955421:3,890,291...3,936,892
Ensembl chrNW_004955421:3,890,306...3,936,526 		JBrowse link
G Msh2 mutS homolog 2 involved_in ISO (MGI:1342394|PMID:10430621) CAFA PMID:10430621 MGI:1342394 NCBI chrNW_004955441:14,188,315...14,247,608
Ensembl chrNW_004955441:14,187,805...14,247,698 		JBrowse link
G Nsd2 nuclear receptor binding SET domain protein 2 acts_upstream_of_or_within ISO (PMID:23241889) MGI PMID:23241889 NCBI chrNW_004955514:1,084,522...1,162,624
Ensembl chrNW_004955514:1,069,085...1,162,624 		JBrowse link
G Pms2 PMS1 homolog 2, mismatch repair system component involved_in ISO (MGI:1342394|PMID:10430621) CAFA PMID:10430621 MGI:1342394 NCBI chrNW_004955460:13,762,854...13,791,462 JBrowse link
G Tgfb1 transforming growth factor beta 1 acts_upstream_of_or_within ISO (PMID:14988498) MGI PMID:14988498 NCBI chrNW_004955555:274,405...288,441
Ensembl chrNW_004955555:270,652...288,441 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12362
    immune system process 1980
      leukocyte activation 888
        lymphocyte activation 720
          lymphocyte activation involved in immune response 189
            B cell activation involved in immune response 90
              isotype switching 53
                isotype switching to IgA isotypes 6
                  negative regulation of isotype switching to IgA isotypes 0
                  positive regulation of isotype switching to IgA isotypes 5
                  regulation of isotype switching to IgA isotypes + 5
Path 2
Term Annotations click to browse term
  biological_process 12362
    metabolic process 7489
      organic substance metabolic process 7172
        organic cyclic compound metabolic process 4096
          nucleobase-containing compound metabolic process 3737
            nucleic acid metabolic process 3370
              DNA metabolic process 754
                DNA recombination 253
                  somatic cell DNA recombination 72
                    somatic diversification of immune receptors via germline recombination within a single locus 72
                      somatic recombination of immunoglobulin gene segments 60
                        somatic recombination of immunoglobulin genes involved in immune response 53
                          isotype switching 53
                            isotype switching to IgA isotypes 6
                              negative regulation of isotype switching to IgA isotypes 0
                              positive regulation of isotype switching to IgA isotypes 5
                              regulation of isotype switching to IgA isotypes + 5
paths to the root