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ONTOLOGY REPORT - ANNOTATIONS

Term:natural killer cell degranulation
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Accession:GO:0043320 term browser browse the term
Definition:The regulated exocytosis of secretory granules containing preformed mediators such as perforin and granzymes by a natural killer cell.
Synonyms:exact_synonym: NK cell degranulation;   NK cell granule exocytosis;   natural killer cell granule exocytosis


show annotations for term's descendants           Sort by:
natural killer cell degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CORO1A coronin 1A involved_in IEA Ensembl GO_REF:0000107 Ensembl chr16:30,550,383...30,556,196 JBrowse link
G FCGR3A Fc gamma receptor IIIa involved_in ISO (PMID:25786175), (PMID:28652325) UniProt PMID:25786175 PMID:28652325 NCBI chr 1:137,027,943...137,036,738 JBrowse link
G NKG7 natural killer cell granule protein 7 involved_in ISO (PMID:32839608), (PMID:33911019) UniProt PMID:32839608 PMID:33911019 NCBI chr19:48,306,714...48,307,961
Ensembl chr19:57,192,788...57,193,882 		JBrowse link
G RAB27A RAB27A, member RAS oncogene family involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11266473) Ensembl
MGI		 PMID:11266473 GO_REF:0000107 NCBI chr15:34,174,491...34,263,045
Ensembl chr15:52,498,202...52,529,984 		JBrowse link
G STX11 syntaxin 11 acts_upstream_of_or_within ISO (PMID:23042080), (PMID:23190531) MGI PMID:23042080 PMID:23190531 NCBI chr 6:141,924,656...141,974,579
Ensembl chr 6:146,688,670...146,689,533 		JBrowse link
G UNC13D unc-13 homolog D acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:17420270) MGI
Ensembl		 PMID:17420270 GO_REF:0000107 NCBI chr17:69,777,570...69,794,877
Ensembl chr17:75,328,572...75,344,842 		JBrowse link
G VAMP2 vesicle associated membrane protein 2 NOT|involved_in ISO (PMID:18042464) UniProt PMID:18042464 NCBI chr17:43,495,464...43,499,348
Ensembl chr17:48,228,253...48,231,948 		JBrowse link
G VAMP7 vesicle associated membrane protein 7 involved_in ISO (PMID:18042464) UniProt PMID:18042464 NCBI chr  X:145,362,432...145,425,097
Ensembl chr  X:155,257,185...155,320,215 		JBrowse link
negative regulation of natural killer cell degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC100977210 galectin-9 involved_in ISO (PMID:23408620) UniProt PMID:23408620 NCBI chr17:29,125,460...29,145,028
Ensembl chr17:29,623,398...29,642,959 		JBrowse link
G LOC100978457 patr class I histocompatibility antigen, CH28 alpha chain involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:29,523,929...29,529,385
Ensembl chr 6:30,181,133...30,186,082 		JBrowse link
positive regulation of natural killer cell degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AP1G1 adaptor related protein complex 1 subunit gamma 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:53,201,859...53,282,437
Ensembl chr16:71,568,863...71,648,744 		JBrowse link
G LAMP1 lysosomal associated membrane protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:94,442,507...94,464,061
Ensembl chr13:113,507,401...113,530,457 		JBrowse link
G LOC100978457 patr class I histocompatibility antigen, CH28 alpha chain involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:29,523,929...29,529,385
Ensembl chr 6:30,181,133...30,186,082 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16644
    immune system process 2494
      immune effector process 662
        leukocyte degranulation 88
          natural killer cell degranulation 12
            negative regulation of natural killer cell degranulation 2
            positive regulation of natural killer cell degranulation 3
            regulation of natural killer cell degranulation + 4
Path 2
Term Annotations click to browse term
  biological_process 16644
    response to stimulus 8565
      response to external stimulus 2467
        response to external biotic stimulus 1599
          response to other organism 1596
            defense response to other organism 1137
              defense response to symbiont 1024
                innate immune response 821
                  natural killer cell mediated immunity 88
                    natural killer cell mediated cytotoxicity 83
                      natural killer cell degranulation 12
                        negative regulation of natural killer cell degranulation 2
                        positive regulation of natural killer cell degranulation 3
                        regulation of natural killer cell degranulation + 4
paths to the root