LOC100977210 (galectin-9) - Rat Genome Database

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Gene: LOC100977210 (galectin-9) Pan paniscus
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Symbol: LOC100977210 (Ensembl: LGALS9)
Name: galectin-9 (Ensembl:galectin 9)
RGD ID: 11836060
Description: ENCODES a protein that exhibits protein serine/threonine kinase activator activity (ortholog); signaling receptor binding (ortholog); INVOLVED IN maintenance of protein location (ortholog); mature conventional dendritic cell differentiation (ortholog); negative regulation of inflammatory response (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); nephritis (ortholog); Pneumococcal Meningitis (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); extracellular space (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: galectin 9; LGALS9
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21936,806,560 - 36,824,924 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11738,690,067 - 38,708,285 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01729,125,460 - 29,145,028 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11729,623,398 - 29,642,959 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1729,623,398 - 29,642,959 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to type II interferon  (IEA)
cellular response to virus  (IEA)
ERK1 and ERK2 cascade  (IEA)
female pregnancy  (IEA)
inflammatory response  (IEA)
maintenance of protein location  (ISO)
maternal process involved in female pregnancy  (IEA)
mature conventional dendritic cell differentiation  (ISO)
natural killer cell tolerance induction  (IEA)
negative regulation of activated T cell proliferation  (IEA)
negative regulation of CD4-positive, alpha-beta T cell proliferation  (IEA)
negative regulation of chemokine production  (IEA)
negative regulation of gene expression  (IEA)
negative regulation of inflammatory response  (ISO)
negative regulation of mast cell degranulation  (IEA)
negative regulation of natural killer cell activation  (ISO)
negative regulation of natural killer cell degranulation  (ISO)
negative regulation of natural killer cell mediated cytotoxicity  (IEA)
negative regulation of tumor necrosis factor production  (IEA)
negative regulation of type II interferon production  (IEA)
p38MAPK cascade  (IEA)
positive regulation of activated T cell autonomous cell death  (IEA)
positive regulation of canonical NF-kappaB signal transduction  (ISO)
positive regulation of CD4-positive, alpha-beta T cell proliferation  (IEA)
positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response  (IEA)
positive regulation of chemokine production  (ISO)
positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway  (IEA)
positive regulation of cytokine production  (ISO)
positive regulation of defense response to bacterium  (ISO)
positive regulation of dendritic cell apoptotic process  (IEA)
positive regulation of dendritic cell chemotaxis  (IEA)
positive regulation of dendritic cell differentiation  (IEA)
positive regulation of ERK1 and ERK2 cascade  (IEA)
positive regulation of gene expression  (IEA)
positive regulation of innate immune response  (ISO)
positive regulation of interleukin-1 beta production  (IEA)
positive regulation of interleukin-1 production  (ISO)
positive regulation of interleukin-10 production  (IEA)
positive regulation of interleukin-12 production  (IEA)
positive regulation of interleukin-13 production  (IEA)
positive regulation of interleukin-4 production  (IEA)
positive regulation of interleukin-6 production  (IEA)
positive regulation of interleukin-8 production  (IEA)
positive regulation of macrophage activation  (ISO)
positive regulation of monocyte chemotactic protein-1 production  (IEA)
positive regulation of NF-kappaB transcription factor activity  (IEA)
positive regulation of non-canonical NF-kappaB signal transduction  (IEA)
positive regulation of oxidoreductase activity  (ISO)
positive regulation of regulatory T cell differentiation  (ISO)
positive regulation of SMAD protein signal transduction  (ISO)
positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell  (IEA)
positive regulation of T cell migration  (ISO)
positive regulation of transforming growth factor beta production  (IEA)
positive regulation of tumor necrosis factor production  (IEA)
positive regulation of type II interferon production  (IEA)
positive regulation of viral entry into host cell  (IEA)
receptor clustering  (ISO)
regulation of interleukin-4 production  (ISO)
regulation of interleukin-5 production  (ISO)
regulation of natural killer cell differentiation  (ISO)
regulation of p38MAPK cascade  (ISO)
regulation of T cell chemotaxis  (ISO)
regulation of T cell differentiation in thymus  (ISO)
regulation of T-helper 17 type immune response  (ISO)
response to interleukin-1  (IEA)
response to lipopolysaccharide  (IEA)
toll-like receptor 2 signaling pathway  (ISO)
toll-like receptor 3 signaling pathway  (ISO)
toll-like receptor 4 signaling pathway  (ISO)
transforming growth factor beta receptor signaling pathway  (ISO)

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
LOC100977210
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21936,806,560 - 36,824,924 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11738,690,067 - 38,708,285 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01729,125,460 - 29,145,028 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11729,623,398 - 29,642,959 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1729,623,398 - 29,642,959 (-)Ensemblpanpan1.1panPan2
LGALS9
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381727,631,188 - 27,649,560 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1727,629,798 - 27,649,560 (+)EnsemblGRCh38hg38GRCh38
GRCh371725,958,214 - 25,976,586 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361722,982,301 - 23,000,713 (+)NCBINCBI36Build 36hg18NCBI36
Build 341722,982,362 - 23,000,707NCBI
Celera1722,819,983 - 22,838,398 (+)NCBICelera
Cytogenetic Map17q11.2NCBI
HuRef1722,165,323 - 22,183,730 (+)NCBIHuRef
CHM1_11726,020,900 - 26,039,300 (+)NCBICHM1_1
T2T-CHM13v2.01728,572,662 - 28,591,030 (+)NCBIT2T-CHM13v2.0
Lgals9
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391178,853,805 - 78,875,750 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1178,853,800 - 78,875,772 (-)EnsemblGRCm39 Ensembl
GRCm381178,962,979 - 78,984,924 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1178,962,974 - 78,984,946 (-)EnsemblGRCm38mm10GRCm38
MGSCv371178,776,481 - 78,798,426 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361178,779,590 - 78,801,026 (-)NCBIMGSCv36mm8
Celera1188,596,004 - 88,617,949 (-)NCBICelera
Cytogenetic Map11B5NCBI
cM Map1146.74NCBI
Lgals9
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81064,405,044 - 64,428,249 (-)NCBIGRCr8
mRatBN7.21063,907,018 - 63,930,224 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1063,907,018 - 63,930,045 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1068,537,217 - 68,560,245 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01068,042,557 - 68,065,583 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01063,511,790 - 63,534,653 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01064,737,022 - 64,760,195 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1064,737,022 - 64,760,201 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01066,863,438 - 66,886,611 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41065,129,006 - 65,152,052 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11065,142,629 - 65,165,675 (-)NCBI
Celera1062,879,287 - 62,902,249 (-)NCBICelera
Cytogenetic Map10q25NCBI
Lgals9
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554815,234,125 - 5,249,564 (-)NCBIChiLan1.0ChiLan1.0
LGALS9
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1942,154,613 - 42,170,423 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl942,154,702 - 42,170,391 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha941,311,855 - 41,327,548 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0942,972,410 - 42,988,232 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl942,972,477 - 42,988,200 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1941,753,711 - 41,769,401 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0942,048,540 - 42,064,220 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0942,125,818 - 42,141,545 (+)NCBIUU_Cfam_GSD_1.0
Lgals9
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560241,156,490 - 41,172,295 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365384,034,467 - 4,050,240 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LGALS9
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11244,155,079 - 44,173,634 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21246,002,236 - 46,021,360 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103242599
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11621,421,034 - 21,439,583 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660758,702,594 - 8,721,093 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lgals9
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624786478,048 - 491,086 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Sequence


Ensembl Acc Id: ENSPPAT00000058163   ⟹   ENSPPAP00000035275
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1729,623,398 - 29,642,959 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000058168   ⟹   ENSPPAP00000035280
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1729,623,398 - 29,641,614 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000058178   ⟹   ENSPPAP00000035290
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1729,624,055 - 29,641,496 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000058181   ⟹   ENSPPAP00000035293
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1729,624,055 - 29,641,496 (-)Ensembl
RefSeq Acc Id: XM_003812654   ⟹   XP_003812702
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21936,806,560 - 36,824,924 (-)NCBI
NHGRI_mPanPan11738,690,067 - 38,708,285 (-)NCBI
Mhudiblu_PPA_v01729,125,460 - 29,145,028 (-)NCBI
PanPan1.11729,623,398 - 29,642,959 (-)NCBI
Sequence:
RefSeq Acc Id: XM_003812655   ⟹   XP_003812703
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21936,806,560 - 36,824,782 (-)NCBI
NHGRI_mPanPan11738,690,067 - 38,708,285 (-)NCBI
Mhudiblu_PPA_v01729,125,466 - 29,143,683 (-)NCBI
PanPan1.11729,623,398 - 29,641,614 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008965084   ⟹   XP_008963332
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21936,806,560 - 36,824,781 (-)NCBI
NHGRI_mPanPan11738,690,067 - 38,708,285 (-)NCBI
Mhudiblu_PPA_v01729,126,038 - 29,143,682 (-)NCBI
PanPan1.11729,623,428 - 29,641,590 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063598703   ⟹   XP_063454773
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21936,807,200 - 36,824,899 (-)NCBI
RefSeq Acc Id: XP_003812702   ⟸   XM_003812654
- Peptide Label: isoform X2
- UniProtKB: A0A2R9C379 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_003812703   ⟸   XM_003812655
- Peptide Label: isoform X1
- UniProtKB: A0A2R9C383 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008963332   ⟸   XM_008965084
- Peptide Label: isoform X3
- UniProtKB: A0A2R9C379 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSPPAP00000035280   ⟸   ENSPPAT00000058168
Ensembl Acc Id: ENSPPAP00000035275   ⟸   ENSPPAT00000058163
Ensembl Acc Id: ENSPPAP00000035290   ⟸   ENSPPAT00000058178
Ensembl Acc Id: ENSPPAP00000035293   ⟸   ENSPPAT00000058181
RefSeq Acc Id: XP_063454773   ⟸   XM_063598703
- Peptide Label: isoform X4
- UniProtKB: A0A2R9C394 (UniProtKB/TrEMBL)
Protein Domains
Galectin


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000040444 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000058163.1 UniProtKB/TrEMBL
  ENSPPAT00000058168.1 UniProtKB/TrEMBL
  ENSPPAT00000058178.1 UniProtKB/TrEMBL
  ENSPPAT00000058181.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.200 UniProtKB/TrEMBL
InterPro ConA-like_dom_sf UniProtKB/TrEMBL
  Galectin-like UniProtKB/TrEMBL
  Galectin_CRD UniProtKB/TrEMBL
KEGG Report pps:100977210 UniProtKB/TrEMBL
NCBI Gene LOC100977210 ENTREZGENE
PANTHER GALECTIN-9 UniProtKB/TrEMBL
  PTHR11346 UniProtKB/TrEMBL
Pfam Gal-bind_lectin UniProtKB/TrEMBL
PROSITE GALECTIN UniProtKB/TrEMBL
SMART Gal-bind_lectin UniProtKB/TrEMBL
  GLECT UniProtKB/TrEMBL
Superfamily-SCOP SSF49899 UniProtKB/TrEMBL
UniProt A0A2R9C034_PANPA UniProtKB/TrEMBL
  A0A2R9C379 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9C383 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9C394 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-04-25 LOC100977210  galectin-9  LGALS9  galectin 9  Symbol and/or name change 5135510 APPROVED
2020-07-01 LGALS9  galectin 9  LOC100977210  galectin-9  Symbol and/or name change 5135510 APPROVED