LGALS9 (galectin 9) - Rat Genome Database

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Gene: LGALS9 (galectin 9) Pan paniscus
Analyze
Symbol: LGALS9
Name: galectin 9
RGD ID: 11836060
Description: ENCODES a protein that exhibits carbohydrate binding (ortholog); disaccharide binding (ortholog); enzyme binding (ortholog); INVOLVED IN cellular response to interferon-gamma (ortholog); cellular response to virus (ortholog); ERK1 and ERK2 cascade (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); nephritis (ortholog); Pneumococcal Meningitis (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: galectin-9; LOC100977210
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11729,623,398 - 29,642,959 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1729,623,398 - 29,642,959 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01729,125,460 - 29,145,028 (-)NCBIMhudiblu_PPA_v0panPan3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to interferon-gamma  (ISO)
cellular response to virus  (ISO)
ERK1 and ERK2 cascade  (ISO)
female pregnancy  (ISO)
inflammatory response  (ISO)
maintenance of protein location  (ISO)
maternal process involved in female pregnancy  (ISO)
mature conventional dendritic cell differentiation  (ISO)
natural killer cell tolerance induction  (ISO)
negative regulation of activated T cell proliferation  (ISO)
negative regulation of CD4-positive, alpha-beta T cell proliferation  (ISO)
negative regulation of chemokine production  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of inflammatory response  (ISO)
negative regulation of interferon-gamma production  (ISO)
negative regulation of mast cell degranulation  (ISO)
negative regulation of natural killer cell activation  (ISO)
negative regulation of natural killer cell degranulation  (ISO)
negative regulation of natural killer cell mediated cytotoxicity  (ISO)
negative regulation of tumor necrosis factor production  (ISO)
p38MAPK cascade  (ISO)
positive regulation of activated T cell autonomous cell death  (ISO)
positive regulation of CD4-positive, alpha-beta T cell proliferation  (ISO)
positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response  (ISO)
positive regulation of chemokine production  (ISO)
positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway  (ISO)
positive regulation of cytokine production  (ISO)
positive regulation of defense response to bacterium  (ISO)
positive regulation of dendritic cell apoptotic process  (ISO)
positive regulation of dendritic cell chemotaxis  (ISO)
positive regulation of dendritic cell differentiation  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of I-kappaB kinase/NF-kappaB signaling  (ISO)
positive regulation of innate immune response  (ISO)
positive regulation of interferon-gamma production  (ISO)
positive regulation of interleukin-1 beta production  (ISO)
positive regulation of interleukin-1 production  (ISO)
positive regulation of interleukin-10 production  (ISO)
positive regulation of interleukin-12 production  (ISO)
positive regulation of interleukin-13 production  (ISO)
positive regulation of interleukin-4 production  (ISO)
positive regulation of interleukin-6 production  (ISO)
positive regulation of interleukin-8 production  (ISO)
positive regulation of macrophage activation  (ISO)
positive regulation of monocyte chemotactic protein-1 production  (ISO)
positive regulation of NF-kappaB transcription factor activity  (ISO)
positive regulation of NIK/NF-kappaB signaling  (ISO)
positive regulation of oxidoreductase activity  (ISO)
positive regulation of pathway-restricted SMAD protein phosphorylation  (ISO)
positive regulation of regulatory T cell differentiation  (ISO)
positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell  (ISO)
positive regulation of T cell migration  (ISO)
positive regulation of transcription regulatory region DNA binding  (ISO)
positive regulation of transforming growth factor beta production  (ISO)
positive regulation of tumor necrosis factor production  (ISO)
positive regulation of viral entry into host cell  (ISO)
regulation of interleukin-4 production  (ISO)
regulation of interleukin-5 production  (ISO)
regulation of natural killer cell differentiation  (ISO)
regulation of p38MAPK cascade  (ISO)
regulation of T cell chemotaxis  (ISO)
regulation of T cell differentiation in thymus  (ISO)
regulation of T-helper 17 type immune response  (ISO)
response to interleukin-1  (ISO)
response to lipopolysaccharide  (ISO)
toll-like receptor 2 signaling pathway  (ISO)
toll-like receptor 3 signaling pathway  (ISO)
toll-like receptor 4 signaling pathway  (ISO)

Cellular Component

Molecular Function

References

Genomics

Comparative Map Data
LGALS9
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11729,623,398 - 29,642,959 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1729,623,398 - 29,642,959 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01729,125,460 - 29,145,028 (-)NCBIMhudiblu_PPA_v0panPan3
LGALS9
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1727,629,798 - 27,649,560 (+)EnsemblGRCh38hg38GRCh38
GRCh381727,631,172 - 27,649,560 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371725,958,214 - 25,976,586 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361722,982,301 - 23,000,713 (+)NCBINCBI36hg18NCBI36
Build 341722,982,362 - 23,000,707NCBI
Celera1722,819,983 - 22,838,398 (+)NCBI
Cytogenetic Map17q11.2NCBI
HuRef1722,165,323 - 22,183,730 (+)NCBIHuRef
CHM1_11726,020,900 - 26,039,300 (+)NCBICHM1_1
Lgals9
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391178,853,805 - 78,875,750 (-)NCBIGRCm39mm39
GRCm39 Ensembl1178,853,800 - 78,875,772 (-)Ensembl
GRCm381178,962,979 - 78,984,924 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1178,962,974 - 78,984,946 (-)EnsemblGRCm38mm10GRCm38
MGSCv371178,776,481 - 78,798,426 (-)NCBIGRCm37mm9NCBIm37
MGSCv361178,779,590 - 78,801,026 (-)NCBImm8
Celera1188,596,004 - 88,617,949 (-)NCBICelera
Cytogenetic Map11B5NCBI
Lgals9
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21063,907,018 - 63,930,224 (-)NCBI
Rnor_6.0 Ensembl1064,737,022 - 64,760,201 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01064,737,022 - 64,760,195 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01066,863,438 - 66,886,611 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41065,129,006 - 65,152,052 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11065,142,629 - 65,165,675 (-)NCBI
Celera1062,879,287 - 62,902,249 (-)NCBICelera
Cytogenetic Map10q24NCBI
Lgals9
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554815,234,125 - 5,249,564 (-)NCBIChiLan1.0ChiLan1.0
LGALS9
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1942,154,613 - 42,170,423 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl942,154,702 - 42,170,391 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha941,311,855 - 41,327,548 (+)NCBI
ROS_Cfam_1.0942,972,410 - 42,988,232 (+)NCBI
UMICH_Zoey_3.1941,753,711 - 41,769,401 (+)NCBI
UNSW_CanFamBas_1.0942,048,540 - 42,064,220 (+)NCBI
UU_Cfam_GSD_1.0942,125,818 - 42,141,545 (+)NCBI
Lgals9
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560241,156,490 - 41,172,295 (+)NCBI
SpeTri2.0NW_0049365384,034,467 - 4,050,240 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LGALS9
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11244,155,079 - 44,173,634 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21246,002,236 - 46,021,360 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103242599
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11621,421,034 - 21,439,583 (+)NCBI
Vero_WHO_p1.0NW_0236660758,702,594 - 8,721,093 (-)NCBI
Lgals9
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624786478,048 - 491,086 (+)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000058163   ⟹   ENSPPAP00000035275
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1729,623,398 - 29,642,959 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000058168   ⟹   ENSPPAP00000035280
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1729,623,398 - 29,641,614 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000058178   ⟹   ENSPPAP00000035290
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1729,624,055 - 29,641,496 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000058181   ⟹   ENSPPAP00000035293
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1729,624,055 - 29,641,496 (-)Ensembl
RefSeq Acc Id: XM_003812654   ⟹   XP_003812702
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.11729,623,398 - 29,642,959 (-)NCBI
Mhudiblu_PPA_v01729,125,460 - 29,145,028 (-)NCBI
Sequence:
RefSeq Acc Id: XM_003812655   ⟹   XP_003812703
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.11729,623,398 - 29,641,614 (-)NCBI
Mhudiblu_PPA_v01729,125,466 - 29,143,683 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008965084   ⟹   XP_008963332
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.11729,623,428 - 29,641,590 (-)NCBI
Mhudiblu_PPA_v01729,126,038 - 29,143,682 (-)NCBI
Sequence:
RefSeq Acc Id: XM_024926079   ⟹   XP_024781847
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.11729,624,055 - 29,641,614 (-)NCBI
Mhudiblu_PPA_v01729,126,106 - 29,143,683 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003812702 (Get FASTA)   NCBI Sequence Viewer  
  XP_003812703 (Get FASTA)   NCBI Sequence Viewer  
  XP_008963332 (Get FASTA)   NCBI Sequence Viewer  
  XP_024781847 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_003812702   ⟸   XM_003812654
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_003812703   ⟸   XM_003812655
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_008963332   ⟸   XM_008965084
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_024781847   ⟸   XM_024926079
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: ENSPPAP00000035280   ⟸   ENSPPAT00000058168
RefSeq Acc Id: ENSPPAP00000035275   ⟸   ENSPPAT00000058163
RefSeq Acc Id: ENSPPAP00000035290   ⟸   ENSPPAT00000058178
RefSeq Acc Id: ENSPPAP00000035293   ⟸   ENSPPAT00000058181
Protein Domains
Galectin


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000040444 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSPPAP00000035275 ENTREZGENE, UniProtKB/TrEMBL
  ENSPPAP00000035280 ENTREZGENE, UniProtKB/TrEMBL
  ENSPPAP00000035290 ENTREZGENE, UniProtKB/TrEMBL
  ENSPPAP00000035293 UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000058163 UniProtKB/TrEMBL
  ENSPPAT00000058168 UniProtKB/TrEMBL
  ENSPPAT00000058178 ENTREZGENE, UniProtKB/TrEMBL
  ENSPPAT00000058181 UniProtKB/TrEMBL
InterPro ConA-like_dom_sf UniProtKB/TrEMBL
  Galectin-like UniProtKB/TrEMBL
  Galectin_CRD UniProtKB/TrEMBL
KEGG Report pps:100977210 UniProtKB/TrEMBL
NCBI Gene LOC100977210 ENTREZGENE
PANTHER PTHR11346 UniProtKB/TrEMBL
Pfam Gal-bind_lectin UniProtKB/TrEMBL
PROSITE GALECTIN UniProtKB/TrEMBL
SMART Gal-bind_lectin UniProtKB/TrEMBL
  GLECT UniProtKB/TrEMBL
Superfamily-SCOP SSF49899 UniProtKB/TrEMBL
UniProt A0A2R9C034_PANPA UniProtKB/TrEMBL
  A0A2R9C379_PANPA UniProtKB/TrEMBL
  A0A2R9C383_PANPA UniProtKB/TrEMBL
  A0A2R9C394_PANPA UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-07-01 LGALS9  galectin 9  LOC100977210  galectin-9  Symbol and/or name change 5135510 APPROVED