Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

ONTOLOGY REPORT - ANNOTATIONS

Term:aspartic endopeptidase activity, intramembrane cleaving
go back to main search page
Accession:GO:0042500 term browser browse the term
Definition:Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain, occurring within a membrane.
Comment:Note that although GO generally avoids the use of localization information in terms, in this case an exception was made. This is because the fact that the cleavage occurs within the membrane is integral to its function, as it is the only thing that distinguishes this group from other aspartic endopeptidases.
Synonyms:xref: EC:3.4.23;   Reactome:R-HSA-9708457 "HM13 cleaves HMOX1 dimer";   reactome:R-HSA-8863101 "SPPL2a/b cleaves TNF(1-76)"


show annotations for term's descendants           Sort by:
aspartic endopeptidase activity, intramembrane cleaving term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HM13 histocompatibility minor 13 enables IEA Ensembl
InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr24:21,026,851...21,067,773
Ensembl chr24:21,026,366...21,071,165 		JBrowse link
G NCSTN nicastrin enables
contributes_to		 IEA
ISO		 (PMID:16371134) Ensembl
MGI		 PMID:16371134 GO_REF:0000107 NCBI chr38:21,878,071...21,891,362
Ensembl chr38:21,685,868...21,892,097 		JBrowse link
G PSEN1 presenilin 1 enables
contributes_to		 IEA
ISS
IBA
ISO		 (PMID:16371134) Ensembl
UniProt
InterPro
GO_Central
MGI		 PMID:16371134 GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 8:46,495,551...46,569,532
Ensembl chr 8:46,495,624...46,569,532 		JBrowse link
G PSEN2 presenilin 2 enables IEA InterPro GO_REF:0000002 NCBI chr 7:38,147,157...38,163,023
Ensembl chr 7:38,147,173...38,166,722 		JBrowse link
G SPPL2A signal peptide peptidase like 2A enables IEA Ensembl
InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr30:16,593,834...16,638,435
Ensembl chr30:16,596,967...16,745,608 		JBrowse link
G SPPL2B signal peptide peptidase like 2B NOT|enables ISO
IEA		 (PMID:16873890) UniProt
Ensembl
InterPro
TreeGrafter		 PMID:16873890 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr20:56,714,306...56,730,388
Ensembl chr20:56,712,390...56,757,938 		JBrowse link
G SPPL2C signal peptide peptidase like 2C enables IEA Ensembl
InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr 9:9,703,119...9,705,300
Ensembl chr 9:9,703,230...9,705,212 		JBrowse link
G SPPL3 signal peptide peptidase like 3 enables IEA Ensembl
InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr26:16,620,236...16,760,616
Ensembl chr26:16,621,455...16,760,623 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 18798
    catalytic activity 5740
      hydrolase activity 2444
        peptidase activity 638
          endopeptidase activity 413
            aspartic-type endopeptidase activity 30
              aspartic endopeptidase activity, intramembrane cleaving 8
paths to the root