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ONTOLOGY REPORT - ANNOTATIONS

Term:ERBB2-EGFR signaling pathway
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Accession:GO:0038134 term browser browse the term
Definition:The series of molecular signals initiated by binding of a ligand to an epidermal growth factor receptor (EGFR/ERBB1) on the surface of a cell, followed by transmission of the signal by a heterodimeric complex of ERBB2 and EGFR. ERBB2, which does not bind any known ligand, is activated through formation of a heterodimer with another ligand-activated ERBB family member such as EGFR.
Synonyms:exact_synonym: EGFR-HER2 signaling pathway;   ERBB2-EGFR signalling pathway


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ERBB2-EGFR signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AREG amphiregulin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:70,417,935...70,428,106
Ensembl chr 8:70,417,923...70,428,102 		JBrowse link
G BTC betacellulin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:70,645,721...70,697,538
Ensembl chr 8:70,649,317...70,697,420 		JBrowse link
G EGF epidermal growth factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:112,235,607...112,330,062
Ensembl chr 8:112,234,386...112,330,046 		JBrowse link
G EGFR epidermal growth factor receptor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:139,302,410...139,474,632
Ensembl chr 9:139,300,022...139,475,589 		JBrowse link
G ERBB2 erb-b2 receptor tyrosine kinase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:22,591,621...22,621,384
Ensembl chr12:22,590,725...22,621,351 		JBrowse link
G EREG epiregulin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:70,351,316...70,372,530
Ensembl chr 8:70,351,311...70,372,569 		JBrowse link
G HBEGF heparin binding EGF like growth factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:142,102,455...142,115,192
Ensembl chr 2:142,102,458...142,115,174 		JBrowse link
G TGFA transforming growth factor alpha involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:71,948,232...72,054,257
Ensembl chr 3:71,948,137...72,050,474 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18933
    cellular process 18475
      signal transduction 6990
        cell surface receptor signaling pathway 2785
          enzyme-linked receptor protein signaling pathway 1039
            cell surface receptor protein tyrosine kinase signaling pathway 661
              ERBB signaling pathway 179
                ERBB2 signaling pathway 20
                  ERBB2-EGFR signaling pathway 8
Path 2
Term Annotations click to browse term
  biological_process 18933
    biological regulation 13010
      regulation of biological process 12629
        regulation of cellular process 12291
          signal transduction 6990
            cell surface receptor signaling pathway 2785
              enzyme-linked receptor protein signaling pathway 1039
                cell surface receptor protein tyrosine kinase signaling pathway 661
                  ERBB signaling pathway 179
                    ERBB2 signaling pathway 20
                      ERBB2-EGFR signaling pathway 8
paths to the root