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Pathways
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ONTOLOGY REPORT - ANNOTATIONS

Term:MyD88-dependent toll-like receptor 4 signaling pathway
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Accession:GO:0035660 term browser browse the term
Definition:The series of molecular signals initiated by a ligand binding to a toll-like 4 receptor, where the MyD88 adaptor molecule mediates transduction of the signal. Toll-like 4 receptors bind bacterial lipopolysaccharide (LPS) to initiate an innate immune response.
Synonyms:exact_synonym: MyD88-dependent TLR4 signaling pathway;   MyD88-dependent toll-like receptor 4 signalling pathway

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MyD88-dependent toll-like receptor 4 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lrrfip2 LRR binding FLII interacting protein 2 acts_upstream_of_or_within ISO (PMID:19265123) MGI PMID:19265123 NCBI chrNW_004624788:15,158,920...15,294,785 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15093
    immune system process 2103
      activation of immune response 460
        activation of innate immune response 253
          innate immune response-activating signaling pathway 237
            pattern recognition receptor signaling pathway 235
              toll-like receptor signaling pathway 69
                MyD88-dependent toll-like receptor signaling pathway 12
                  MyD88-dependent toll-like receptor 4 signaling pathway 1
Path 2
Term Annotations click to browse term
  biological_process 15093
    response to stimulus 8161
      response to external stimulus 2128
        response to external biotic stimulus 1317
          response to other organism 1314
            defense response to other organism 906
              defense response to symbiont 802
                innate immune response 664
                  regulation of innate immune response 371
                    positive regulation of innate immune response 309
                      activation of innate immune response 253
                        innate immune response-activating signaling pathway 237
                          innate immune response activating cell surface receptor signaling pathway 73
                            cell surface pattern recognition receptor signaling pathway 70
                              cell surface toll-like receptor signaling pathway 66
                                toll-like receptor 4 signaling pathway 58
                                  MyD88-dependent toll-like receptor 4 signaling pathway 1
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