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Pathways
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ONTOLOGY REPORT - ANNOTATIONS

Term:MyD88-dependent toll-like receptor 4 signaling pathway
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Accession:GO:0035660 term browser browse the term
Definition:The series of molecular signals initiated by a ligand binding to a toll-like 4 receptor, where the MyD88 adaptor molecule mediates transduction of the signal. Toll-like 4 receptors bind bacterial lipopolysaccharide (LPS) to initiate an innate immune response.
Synonyms:exact_synonym: MyD88-dependent TLR4 signaling pathway;   MyD88-dependent toll-like receptor 4 signalling pathway

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MyD88-dependent toll-like receptor 4 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lrrfip2 LRR binding FLII interacting protein 2 acts_upstream_of_or_within ISO (PMID:19265123) MGI PMID:19265123 NCBI chrNW_004955421:3,938,054...4,066,701
Ensembl chrNW_004955421:3,938,054...4,066,060 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12362
    immune system process 1980
      activation of immune response 435
        activation of innate immune response 250
          innate immune response-activating signaling pathway 236
            pattern recognition receptor signaling pathway 234
              toll-like receptor signaling pathway 62
                MyD88-dependent toll-like receptor signaling pathway 13
                  MyD88-dependent toll-like receptor 4 signaling pathway 1
Path 2
Term Annotations click to browse term
  biological_process 12362
    response to stimulus 6680
      response to external stimulus 2006
        response to external biotic stimulus 1246
          response to other organism 1243
            defense response to other organism 830
              defense response to symbiont 736
                innate immune response 609
                  regulation of innate immune response 374
                    positive regulation of innate immune response 310
                      activation of innate immune response 250
                        innate immune response-activating signaling pathway 236
                          innate immune response activating cell surface receptor signaling pathway 71
                            cell surface pattern recognition receptor signaling pathway 68
                              cell surface toll-like receptor signaling pathway 66
                                toll-like receptor 4 signaling pathway 57
                                  MyD88-dependent toll-like receptor 4 signaling pathway 1
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