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ONTOLOGY REPORT - ANNOTATIONS

Term:PRC1 complex
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Accession:GO:0035102 term browser browse the term
Definition:A multiprotein complex that mediates monoubiquitination of lysine residues of histone H2A (lysine-118 in Drosophila or lysine-119 in mammals). The complex is required for stable long-term maintenance of transcriptionally repressed states and is involved in chromatin remodeling.
Comment:In Drosophila the core subunits are Pc (Polycomb), Psc (Posterior sex combs), Ph (Polyhomeotic) and Sce (Sex comb extra). In mammals, which have several orthologs for each of the Drosophila core proteins, a family of distinct PRC1-like complexes seem to exist which contain at least some PcG proteins in mutually exclusive manner.
Synonyms:exact_synonym: Polycomb repressive complex 1


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PRC1 complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMI1 BMI1 proto-oncogene, polycomb ring finger part_of IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr10:52,586,089...52,596,154
Ensembl chr10:52,586,509...52,596,564 		JBrowse link
G CBX2 chromobox 2 part_of IEA
IBA		 InterPro
Ensembl
TreeGrafter
GO_Central		 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr12:2,570,841...2,580,336
Ensembl chr12:2,570,851...2,580,337 		JBrowse link
G CBX4 chromobox 4 part_of IEA
IBA		 Ensembl
GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr12:2,520,913...2,527,245
Ensembl chr12:2,521,027...2,527,241 		JBrowse link
G CBX6 chromobox 6 part_of IEA
IBA		 TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000118 NCBI chr 5:9,180,559...9,191,414
Ensembl chr 5:9,180,684...9,188,620 		JBrowse link
G CBX7 chromobox 7 part_of IEA InterPro GO_REF:0000002 NCBI chr 5:9,070,312...9,090,467
Ensembl chr 5:9,070,353...9,087,634 		JBrowse link
G CBX8 chromobox 8 part_of IEA
IBA		 Ensembl
GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr12:2,562,419...2,565,035
Ensembl chr12:2,562,374...2,565,780 		JBrowse link
G PCGF1 polycomb group ring finger 1 part_of IEA TreeGrafter GO_REF:0000118 NCBI chr 3:68,540,674...68,543,271 JBrowse link
G PCGF2 polycomb group ring finger 2 part_of IEA
IBA		 Ensembl
TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr12:23,362,631...23,375,779
Ensembl chr12:23,362,654...23,375,775 		JBrowse link
G PCGF3 polycomb group ring finger 3 part_of IEA
IBA		 TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000118 NCBI chr 8:140,435...189,796
Ensembl chr 8:140,446...182,261 		JBrowse link
G PCGF5 polycomb group ring finger 5 part_of IEA
IBA		 TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000118 NCBI chr14:102,827,140...102,961,862
Ensembl chr14:102,636,838...102,961,860 		JBrowse link
G PCGF6 polycomb group ring finger 6 part_of IEA
IBA		 Ensembl
TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr14:114,062,457...114,287,458
Ensembl chr14:114,249,820...114,287,434 		JBrowse link
G PHC1 polyhomeotic homolog 1 part_of IEA
IBA		 Ensembl
TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 5:62,557,774...62,580,640
Ensembl chr 5:62,557,776...62,580,651 		JBrowse link
G PHC2 polyhomeotic homolog 2 part_of IEA
IBA		 Ensembl
TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 6:89,574,030...89,685,275
Ensembl chr 6:89,574,035...89,685,272 		JBrowse link
G PHC3 polyhomeotic homolog 3 part_of IEA
IBA		 Ensembl
TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr13:108,791,675...108,883,620
Ensembl chr13:108,776,220...108,883,572 		JBrowse link
G RING1 ring finger protein 1 part_of IEA Ensembl GO_REF:0000107 NCBI chr 7:25,251,507...25,255,526
Ensembl chr 7:25,251,486...25,255,522 		JBrowse link
G RNF2 ring finger protein 2 part_of IEA Ensembl GO_REF:0000107 NCBI chr 9:126,172,637...126,284,567
Ensembl chr 9:126,172,301...126,287,603 		JBrowse link
G SAMD11 sterile alpha motif domain containing 11 part_of ISO (MGI:6512737|PMID:33603070) UniProt PMID:33603070 MGI:6512737 NCBI chr 6:63,287,449...63,308,231
Ensembl chr 6:63,287,713...63,308,482 		JBrowse link
G SAMD7 sterile alpha motif domain containing 7 part_of IEA Ensembl GO_REF:0000107 NCBI chr13:108,622,402...108,641,412
Ensembl chr13:108,610,172...108,642,120 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 18687
    protein-containing complex 6005
      nuclear protein-containing complex 1244
        PcG protein complex 60
          PRC1 complex 18
Path 2
Term Annotations click to browse term
  cellular_component 18687
    cellular anatomical entity 18466
      organelle 12444
        intracellular organelle 12019
          intracellular membrane-bounded organelle 10861
            nucleus 6843
              nuclear protein-containing complex 1244
                nuclear ubiquitin ligase complex 46
                  PRC1 complex 18
paths to the root