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ONTOLOGY REPORT - ANNOTATIONS

Term:mitotic checkpoint complex
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Accession:GO:0033597 term browser browse the term
Definition:A multiprotein complex that functions as a mitotic checkpoint inhibitor of the anaphase-promoting complex/cyclosome (APC/C). In budding yeast this complex consists of Mad2p, Mad3p, Bub3p and Cdc20p, and in mammalian cells it consists of MAD2, BUBR1, BUB3, and CDC20.
Synonyms:exact_synonym: MCC


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mitotic checkpoint complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bub1b BUB1 mitotic checkpoint serine/threonine kinase B located_in ISO (PMID:27509861) RGD PMID:27509861 NCBI chr 3:105,563,089...105,615,547
Ensembl chr 3:105,563,138...105,615,547 		JBrowse link
G Bub3 BUB3 mitotic checkpoint protein located_in ISO (PMID:27509861) RGD PMID:27509861 NCBI chr 1:186,330,358...186,340,969
Ensembl chr 1:186,327,931...186,395,036 		JBrowse link
G Cdc20 cell division cycle 20 located_in
part_of		 ISO
IEA		 (PMID:27509861)
GO_REF:0000107		 RGD
Ensembl		 PMID:27509861 GO_REF:0000107 NCBI chr 5:131,966,203...131,970,406
Ensembl chr 5:131,966,215...131,970,512 		JBrowse link
G Mad2l1 mitotic arrest deficient 2 like 1 located_in ISO (PMID:27509861) RGD PMID:27509861 NCBI chr 4:95,906,692...95,918,885
Ensembl chr 4:95,906,817...95,913,470 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20624
    protein-containing complex 6602
      nuclear protein-containing complex 1276
        mitotic checkpoint complex 4
          mitotic checkpoint complex, CDC20-MAD2 subcomplex 0
Path 2
Term Annotations click to browse term
  cellular_component 20624
    cellular anatomical entity 20386
      organelle 13799
        membrane-bounded organelle 12396
          intracellular membrane-bounded organelle 11845
            nucleus 7395
              nuclear protein-containing complex 1276
                mitotic checkpoint complex 4
                  mitotic checkpoint complex, CDC20-MAD2 subcomplex 0
paths to the root