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ONTOLOGY REPORT - ANNOTATIONS

Term:Mis6-Sim4 complex
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Accession:GO:0031511 term browser browse the term
Definition:A protein complex that forms part of the inner kinetochore, which is involved in the loading of the centromeric histone h3 variant CENP-A onto centromeres and in centromere specific heterochromatin formation. The complex contains about 12 proteins, of which two are known as Mis6 and Sim4 in S. pombe and CENP-I and CENP-H in human.
Synonyms:exact_synonym: Mis6-Mal2-Sim4 centromere complex;   Sim4 complex
 narrow_synonym: Mis6 centromere subcomplex
 related_synonym: Mcm21


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Mis6-Sim4 complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cenpo centromere protein O part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 6:27,203,642...27,218,394
Ensembl chr 6:27,188,537...27,218,314 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20629
    protein-containing complex 6604
      Mis6-Sim4 complex 1
Path 2
Term Annotations click to browse term
  cellular_component 20629
    cellular anatomical entity 20391
      organelle 13803
        non-membrane-bounded organelle 5219
          intracellular non-membrane-bounded organelle 5217
            chromosome 1369
              chromosomal region 333
                chromosome, centromeric region 233
                  condensed chromosome, centromeric region 167
                    kinetochore 155
                      inner kinetochore 18
                        Mis6-Sim4 complex 1
paths to the root