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ONTOLOGY REPORT - ANNOTATIONS

Term:siRNA processing
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Accession:GO:0030422 term browser browse the term
Definition:A process leading to the generation of a functional small interfering RNA (siRNA). Includes the cleavage of double-stranded RNA to form small interfering RNA molecules (siRNAs) of 21-23 nucleotides. May also include amplification of the siRNA by RNA-directed RNA polymerase.
Synonyms:exact_synonym: RNA interference, production of guide RNAs;   RNA interference, production of siRNA;   chromatin silencing by small RNA, production of guide RNAs;   chromatin silencing by small RNA, production of siRNA;   production of guide RNAs involved in RNA interference;   production of guide RNAs involved in chromatin silencing by small RNA;   production of siRNA involved in RNA interference;   production of siRNA involved in chromatin silencing by small RNA;   production of siRNA involved in post-transcriptional gene silencing by RNA
 narrow_synonym: production of siRNA involved in gene silencing by small RNA
 related_synonym: production of siRNA;   production of siRNA involved in PTGS
 alt_id: GO:0070919

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siRNA processing term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ago2 argonaute RISC catalytic component 2 involved_in ISO (PMID:23661684) ComplexPortal PMID:23661684 NCBI chrNW_004955461:14,194,268...14,260,949
Ensembl chrNW_004955461:14,205,748...14,253,861 		JBrowse link
G Dicer1 dicer 1, ribonuclease III involved_in
acts_upstream_of_or_within		 ISO (PMID:15973356), (PMID:17452327), (PMID:23661684)
(PMID:24209619)
(PMID:14528307)
(PMID:19701182)		 UniProt
MGI
BHF-UCL		 PMID:14528307 PMID:15973356 PMID:17452327 PMID:19701182 PMID:23661684 More... NCBI chrNW_004955438:17,374,899...17,431,599
Ensembl chrNW_004955438:17,382,493...17,431,797 		JBrowse link
G Prkra protein activator of interferon induced protein kinase EIF2AK2 involved_in ISO (PMID:17452327) UniProt PMID:17452327 NCBI chrNW_004955403:18,394,609...18,410,381
Ensembl chrNW_004955403:18,373,375...18,410,627 		JBrowse link
G Tarbp2 TARBP2 subunit of RISC loading complex involved_in ISO (PMID:15973356), (PMID:17452327), (PMID:23661684) UniProt PMID:15973356 PMID:17452327 PMID:23661684 NCBI chrNW_004955458:793,753...798,755
Ensembl chrNW_004955458:793,759...798,806 		JBrowse link
G Tert telomerase reverse transcriptase involved_in ISO (PMID:19701182) BHF-UCL PMID:19701182 NCBI chrNW_004955504:649,248...669,796
Ensembl chrNW_004955504:651,779...670,589 		JBrowse link
G Tsn translin involved_in ISO (PMID:21552258) ComplexPortal PMID:21552258 NCBI chrNW_004955459:8,285,442...8,299,329
Ensembl chrNW_004955459:8,285,442...8,299,397 		JBrowse link
G Tsnax translin associated factor X involved_in ISO (PMID:21552258) ComplexPortal PMID:21552258 NCBI chrNW_004955492:7,304,982...7,335,512
Ensembl chrNW_004955492:7,306,364...7,335,282 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12572
    cellular process 12010
      metabolic process 7974
        primary metabolic process 7007
          RNA processing 593
            regulatory ncRNA processing 64
              siRNA processing 7
                lsiRNA processing 0
                negative regulation of siRNA processing 0
                positive regulation of siRNA processing 0
                regulation of siRNA processing + 0
                ta-siRNA processing 0
Path 2
Term Annotations click to browse term
  biological_process 12572
    biological regulation 9067
      regulation of biological process 8766
        regulation of cellular process 8474
          regulation of metabolic process 5075
            regulation of biosynthetic process 3915
              regulation of macromolecule biosynthetic process 3726
                regulation of gene expression 3616
                  negative regulation of gene expression 973
                    regulatory ncRNA-mediated gene silencing 105
                      regulatory ncRNA processing 64
                        siRNA processing 7
                          lsiRNA processing 0
                          negative regulation of siRNA processing 0
                          positive regulation of siRNA processing 0
                          regulation of siRNA processing + 0
                          ta-siRNA processing 0
paths to the root