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ONTOLOGY REPORT - ANNOTATIONS

Term:extracellularly glycine-gated chloride channel activity
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Accession:GO:0016934 term browser browse the term
Definition:Enables the transmembrane transfer of a chloride ion by a channel that opens when glycine is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane.
Synonyms:exact_synonym: extracellular-glycine-gated chloride channel activity
 broad_synonym: glycine receptor
 related_synonym: glycine-inhibited chloride channel activity
 alt_id: GO:0004891
 xref: reactome:R-HSA-975389 "GLRA:GLRB:Gly transports extracellular Cl- to cytosol"


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extracellularly glycine-gated chloride channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chrm5 cholinergic receptor, muscarinic 5 enables TAS (PMID:11756520) MGI PMID:11756520 NCBI chr 2:112,306,055...112,365,487
Ensembl chr 2:112,309,516...112,311,114 		JBrowse link
G Glra1 glycine receptor, alpha 1 subunit enables
contributes_to		 ISO
IMP
IDA		 (MGI:5707576|PMID:24801766)
(PMID:8062927)
(PMID:16672662)		 MGI
UniProt
RGD		 PMID:8062927 PMID:12223345 PMID:16672662 PMID:24801766 GO_REF:0000008 GO_REF:0000096 MGI:4417868 MGI:5707576 RGD:625689 NCBI chr11:55,405,065...55,499,024
Ensembl chr11:55,405,064...55,499,024 		JBrowse link
G Glra2 glycine receptor, alpha 2 subunit enables ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr  X:163,912,013...164,110,863
Ensembl chr  X:163,912,013...164,110,389 		JBrowse link
G Glra3 glycine receptor, alpha 3 subunit enables ISO MGI
RGD		 PMID:2176214 GO_REF:0000096 GO_REF:0000119 MGI:4417868 MGI:4834177 RGD:728440 NCBI chr 8:56,393,454...56,583,111
Ensembl chr 8:56,393,495...56,583,105 		JBrowse link
G Glra4 glycine receptor, alpha 4 subunit enables IDA (MGI:5751681|PMID:10762330) UniProt PMID:10762330 MGI:5751681 NCBI chr  X:135,655,107...135,680,935
Ensembl chr  X:135,658,423...135,680,890 		JBrowse link
G Glrb glycine receptor, beta subunit contributes_to
enables		 ISS
ISO
IMP		 (MGI:78784|PMID:8717357)
(PMID:12809985), (PMID:16672662)		 UniProt
MGI		 PMID:8717357 PMID:12809985 PMID:16672662 GO_REF:0000119 MGI:4834177 MGI:78784 NCBI chr 3:80,750,905...80,820,994
Ensembl chr 3:80,750,906...80,820,967 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 28831
    transporter activity 1198
      transmembrane transporter activity 1108
        monoatomic ion transmembrane transporter activity 733
          monoatomic anion transmembrane transporter activity 151
            monoatomic anion channel activity 103
              chloride channel activity 89
                extracellularly glycine-gated chloride channel activity 6
Path 2
Term Annotations click to browse term
  molecular_function 28831
    transporter activity 1198
      transmembrane transporter activity 1108
        passive transmembrane transporter activity 513
          channel activity 513
            gated channel activity 323
              ligand-gated channel activity 188
                ligand-gated monoatomic ion channel activity 184
                  extracellular ligand-gated monoatomic ion channel activity 72
                    excitatory extracellular ligand-gated monoatomic ion channel activity 39
                      extracellularly glycine-gated ion channel activity 6
                        extracellularly glycine-gated chloride channel activity 6
paths to the root