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ONTOLOGY REPORT - ANNOTATIONS

Term:choline transmembrane transporter activity
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Accession:GO:0015220 term browser browse the term
Definition:Enables the transfer of choline from one side of a membrane to the other. Choline (2-hydroxyethyltrimethylammonium) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine.
Synonyms:exact_synonym: choline permease activity
 narrow_synonym: amino acid/choline transmembrane transporter activity
 alt_id: GO:0005306
 xref: Reactome:R-HSA-5658483 "Defective SLC5A7 does not cotransport Cho, Cl-, Na+ from extracellular region to cytosol";   reactome:R-HSA-429594 "SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol";   reactome:R-HSA-444433 "Cho transports from the extracellular space to the cytosol";   reactome:R-HSA-6797956 "SLC44A1 transports Cho from cytosol to mitochondrial matrix"


show annotations for term's descendants           Sort by:
choline transmembrane transporter activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Flvcr1 FLVCR choline and heme transporter 1 enables ISO (PMID:37100056), (PMID:38693265), (PMID:38778100) RGD PMID:37100056 PMID:38693265 PMID:38778100 NCBI chr13:102,586,263...102,608,647
Ensembl chr13:102,586,257...102,608,661 		JBrowse link
G Flvcr2 FLVCR choline and putative heme transporter 2 enables ISS
ISO
IEA		 GO_REF:0000024
(PMID:38302740), (PMID:38778100)
GO_REF:0000107
(PMID:38302740), (PMID:38693257)		 UniProt
RGD
Ensembl		 PMID:38302740 PMID:38693257 PMID:38778100 GO_REF:0000024 GO_REF:0000107 NCBI chr 6:105,408,355...105,472,355
Ensembl chr 6:105,408,339...105,472,353 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 enables IDA
ISO
IEA		 (PMID:9687576)
GO_REF:0000107		 RGD
Ensembl		 PMID:9687576 PMID:11553644 GO_REF:0000107, RGD:628453 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Slc44a1 solute carrier family 44 member 1 enables ISS
IMP
ISO
IEA
IBA		 GO_REF:0000024
PMID:19519661
(PMID:16319125), (PMID:19357133), (PMID:20410607), (PMID:23651124), (PMID:31855247), (PMID:33789160)
GO_REF:0000107
GO_REF:0000033
(PMID:19519661)		 UniProt
RGD
Ensembl
GO_Central		 PMID:16319125 PMID:19357133 PMID:19519661 PMID:20410607 PMID:23651124 More... GO_REF:0000024 GO_REF:0000033 GO_REF:0000107, RGD:15090833 NCBI chr 5:68,061,941...68,241,912
Ensembl chr 5:68,063,618...68,241,909 		JBrowse link
G Slc44a2 solute carrier family 44 member 2 NOT|enables ISO
ISS
IEA		 (PMID:10677542), (PMID:20665236)
(PMID:20410607), (PMID:23651124), (PMID:33789160)
GO_REF:0000024
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:10677542 PMID:20410607 PMID:20665236 PMID:23651124 PMID:33789160 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:19,870,867...19,905,345
Ensembl chr 8:19,870,888...19,905,342 		JBrowse link
G Slc44a4 solute carrier family 44, member 4 enables ISS
ISO		 GO_REF:0000024
(PMID:23651124), (PMID:28013291)		 UniProt
RGD		 PMID:23651124 PMID:28013291 GO_REF:0000024 NCBI chr20:3,903,099...3,919,215
Ensembl chr20:3,903,099...3,919,215 		JBrowse link
G Slc44a5 solute carrier family 44, member 5 enables ISO (PMID:23651124) RGD PMID:23651124 NCBI chr 2:242,911,050...243,208,018
Ensembl chr 2:242,911,325...243,206,404 		JBrowse link
G Slc5a7 solute carrier family 5 member 7 enables IMP
ISO
IDA
IEA		 PMID:10649566
(PMID:11027560), (PMID:11068039), (PMID:12237312), (PMID:12969261), (PMID:17005849), (PMID:23132865), (PMID:23141292), (PMID:27569547)
GO_REF:0000117
(PMID:11709061), (PMID:15173594), (PMID:17196556)		 RGD
UniProt		 PMID:11027560 PMID:11068039 PMID:11709061 PMID:12237312 PMID:12969261 More... GO_REF:0000117, RGD:68853, RGD:68853 NCBI chr 9:7,595,440...7,626,258
Ensembl chr 9:7,595,444...7,626,258 		JBrowse link
G Slc6a8 solute carrier family 6 member 8 NAS
IDA		 RGD PMID:8297374 PMID:1633856 RGD:634748, RGD:737698 NCBI chr  X:151,384,675...151,393,979
Ensembl chr  X:151,384,675...151,393,979 		JBrowse link
choline:sodium symporter activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc5a7 solute carrier family 5 member 7 enables ISO
IBA
ISS		 (PMID:11068039), (PMID:12237312), (PMID:17005849)
GO_REF:0000033
GO_REF:0000024		 RGD
GO_Central
UniProt		 PMID:11068039 PMID:12237312 PMID:17005849 GO_REF:0000024 GO_REF:0000033 NCBI chr 9:7,595,440...7,626,258
Ensembl chr 9:7,595,444...7,626,258 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20807
    transporter activity 1252
      transmembrane transporter activity 1152
        organic cation transmembrane transporter activity 83
          choline transmembrane transporter activity 9
            ABC-type choline transporter activity 0
            choline:sodium symporter activity 1
paths to the root