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ONTOLOGY REPORT - ANNOTATIONS

Term:vascular associated smooth muscle contraction
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Accession:GO:0014829 term browser browse the term
Definition:A process, occurring in the vascular tissue, whereby actin/myosin complex activity generates force through ATP hydrolysis resulting in a change in smooth muscle geometry. This process is always coupled to chemo-mechanical energy conversion.
Synonyms:exact_synonym: vascular smooth muscle contraction

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vascular associated smooth muscle contraction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle acts_upstream_of_or_within ISO (PMID:11053242) MGI PMID:11053242 NCBI chrNW_004624791:15,243,074...15,259,362
Ensembl chrNW_004624791:15,242,432...15,259,508 		JBrowse link
G Comp cartilage oligomeric matrix protein acts_upstream_of_or_within ISO (PMID:27498005) MGI PMID:27498005 NCBI chrNW_004624908:1,870,975...1,877,434
Ensembl chrNW_004624908:1,871,002...1,877,369 		JBrowse link
G Rap1gds1 Rap1 GTPase-GDP dissociation stimulator 1 ISO RGD PMID:18348285 RGD:2314690 NCBI chrNW_004624757:26,393,116...26,520,344
Ensembl chrNW_004624757:26,393,106...26,520,785 		JBrowse link
G Slc8a1 solute carrier family 8 member A1 involved_in ISO (PMID:10967099) BHF-UCL PMID:10967099 NCBI chrNW_004624738:21,648,277...22,026,385
Ensembl chrNW_004624738:21,651,489...21,939,927 		JBrowse link
artery smooth muscle contraction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen ISO RGD PMID:21076237 RGD:5129195 NCBI chrNW_004624775:18,846,222...18,856,093
Ensembl chrNW_004624775:18,849,118...18,855,577 		JBrowse link
G Bbs2 Bardet-Biedl syndrome 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:20852044) Ensembl
MGI		 PMID:20852044 GO_REF:0000107 NCBI chrNW_004624757:55,861...88,703
Ensembl chrNW_004624757:55,811...88,562 		JBrowse link
G Cacna1g calcium voltage-gated channel subunit alpha1 G ISO RGD PMID:18759855 RGD:2308879 NCBI chrNW_004624795:6,443,322...6,501,673
Ensembl chrNW_004624795:6,443,781...6,501,050 		JBrowse link
G Cd38 CD38 molecule ISO RGD PMID:21431168 RGD:13506923 NCBI chrNW_004624755:16,035,412...16,093,610
Ensembl chrNW_004624755:16,034,771...16,093,866 		JBrowse link
G Edn1 endothelin 1 involved_in ISO (PMID:8982507) RGD
BHF-UCL		 PMID:7586220 PMID:8982507 RGD:8662314 NCBI chrNW_004624756:13,842,482...13,849,003
Ensembl chrNW_004624756:13,842,164...13,849,029 		JBrowse link
G Edn2 endothelin 2 involved_in ISO (PMID:8982507) BHF-UCL PMID:8982507 NCBI chrNW_004624892:861,976...879,044
Ensembl chrNW_004624892:870,259...877,387 		JBrowse link
G Edn3 endothelin 3 NOT|involved_in ISO (PMID:8982507) BHF-UCL PMID:8982507 NCBI chrNW_004624741:25,658,726...25,680,763 JBrowse link
G Ednra endothelin receptor type A involved_in ISO (PMID:8982507) BHF-UCL PMID:8982507 NCBI chrNW_004624853:6,298,406...6,362,353
Ensembl chrNW_004624853:6,302,751...6,360,089 		JBrowse link
G Grip2 glutamate receptor interacting protein 2 acts_upstream_of_or_within ISO (PMID:23117660) MGI PMID:23117660 NCBI chrNW_004624872:1,215,698...1,264,723
Ensembl chrNW_004624872:1,233,797...1,264,722 		JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A ISO RGD PMID:14752059 RGD:7257678 NCBI chrNW_004624748:8,154,288...8,223,226
Ensembl chrNW_004624748:8,155,107...8,223,259 		JBrowse link
G Mkks MKKS centrosomal shuttling protein acts_upstream_of_or_within ISO (PMID:20852044) MGI PMID:20852044 NCBI chrNW_004624741:11,323,935...11,447,669
Ensembl chrNW_004624741:11,425,368...11,435,706 		JBrowse link
G Scnn1b sodium channel epithelial 1 subunit beta acts_upstream_of_or_within ISO (PMID:19553501) MGI PMID:19553501 NCBI chrNW_004624782:8,521,639...8,580,099
Ensembl chrNW_004624782:8,549,583...8,581,819 		JBrowse link
G Smpd3 sphingomyelin phosphodiesterase 3 ISO RGD PMID:19088082 RGD:10042965 NCBI chrNW_004624746:17,857,779...17,948,469
Ensembl chrNW_004624746:17,920,835...17,948,468 		JBrowse link
negative regulation of vascular associated smooth muscle contraction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arhgap42 Rho GTPase activating protein 42 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:24335996) Ensembl
MGI		 PMID:24335996 GO_REF:0000107 NCBI chrNW_004624878:1,803,353...2,095,767
Ensembl chrNW_004624878:1,811,013...2,095,733 		JBrowse link
G Dock4 dedicator of cytokinesis 4 involved_in ISO (PMID:22158624) BHF-UCL PMID:22158624 NCBI chrNW_004624739:17,705,893...18,152,679
Ensembl chrNW_004624739:17,705,769...18,152,858 		JBrowse link
G Dock5 dedicator of cytokinesis 5 involved_in ISO (PMID:22158624) BHF-UCL PMID:22158624 NCBI chrNW_004624758:20,255,036...20,444,194
Ensembl chrNW_004624758:20,255,062...20,440,370 		JBrowse link
G Stub1 STIP1 homology and U-box containing protein 1 involved_in ISO PMID:19237536 UniProt PMID:19237536 RGD:401901238 NCBI chrNW_004624913:1,491,873...1,494,249
Ensembl chrNW_004624913:1,491,991...1,494,249 		JBrowse link
positive regulation of vascular associated smooth muscle contraction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chrm3 cholinergic receptor muscarinic 3 ISO RGD PMID:8428203 RGD:2303387 NCBI chrNW_004624775:10,948,075...11,427,898
Ensembl chrNW_004624775:10,949,983...10,951,755 		JBrowse link
G Rhoa ras homolog family member A acts_upstream_of_or_within ISO (PMID:24335996) MGI PMID:24335996 NCBI chrNW_004624730:3,316,122...3,361,820 JBrowse link
regulation of vascular associated smooth muscle contraction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra2b adrenoceptor alpha 2B ISO RGD PMID:18054907 RGD:2313547 NCBI chrNW_004624749:2,226,809...2,230,413
Ensembl chrNW_004624749:2,226,738...2,230,381 		JBrowse link
G Atp2b1 ATPase plasma membrane Ca2+ transporting 1 involved_in ISO (PMID:24805951) UniProt PMID:24805951 NCBI chrNW_004624750:16,990,288...17,103,279 JBrowse link
G Map2k1 mitogen-activated protein kinase kinase 1 ISO inhibition decreases both calcium-stimulated and unstimulated myogenic tone in middle cerebral arteries (p<0.001) RGD PMID:10198244 RGD:2293329 NCBI chrNW_004624781:6,222,365...6,285,398
Ensembl chrNW_004624781:6,222,365...6,285,531 		JBrowse link
G P2rx1 purinergic receptor P2X 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16920810) Ensembl
MGI		 PMID:16920810 GO_REF:0000107 NCBI chrNW_004624786:6,503,367...6,520,802
Ensembl chrNW_004624786:6,504,250...6,521,821 		JBrowse link
G Zdhhc21 zinc finger DHHC-type palmitoyltransferase 21 involved_in ISO (PMID:26715683) UniProt PMID:26715683 NCBI chrNW_004624736:18,876,167...18,937,383
Ensembl chrNW_004624736:18,873,563...18,937,704 		JBrowse link
regulation of vein smooth muscle contraction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb2 adrenoceptor beta 2 enables ISO salbutamol, isoproterenol, clenbuterol, norepinephrine RGD PMID:6289140 RGD:2301944 NCBI chrNW_004624774:8,211,723...8,215,962
Ensembl chrNW_004624774:8,211,984...8,213,240 		JBrowse link
G Htr7 5-hydroxytryptamine receptor 7 ISO RGD PMID:31125290 RGD:14696717 NCBI chrNW_004624737:1,960,985...2,067,086
Ensembl chrNW_004624737:1,960,057...2,067,038 		JBrowse link
vein smooth muscle contraction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Edn1 endothelin 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624756:13,842,482...13,849,003
Ensembl chrNW_004624756:13,842,164...13,849,029 		JBrowse link
G Edn2 endothelin 2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624892:861,976...879,044
Ensembl chrNW_004624892:870,259...877,387 		JBrowse link
G Edn3 endothelin 3 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004624741:25,658,726...25,680,763 JBrowse link
G Ednrb endothelin receptor type B involved_in ISO (PMID:8982507) BHF-UCL PMID:8982507 NCBI chrNW_004624751:22,459,613...22,491,409
Ensembl chrNW_004624751:22,459,584...22,491,606 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15172
    multicellular organismal process 7165
      system process 2466
        muscle system process 437
          muscle contraction 306
            smooth muscle contraction 121
              vascular associated smooth muscle contraction 31
                artery smooth muscle contraction + 13
                negative regulation of vascular associated smooth muscle contraction + 4
                positive regulation of vascular associated smooth muscle contraction + 2
                regulation of vascular associated smooth muscle contraction + 13
                vein smooth muscle contraction + 6
Path 2
Term Annotations click to browse term
  biological_process 15172
    biological regulation 10707
      regulation of biological quality 2923
        regulation of anatomical structure size 556
          regulation of tube size 187
            regulation of tube diameter 186
              blood vessel diameter maintenance 186
                vasoconstriction 114
                  vascular associated smooth muscle contraction 31
                    artery smooth muscle contraction + 13
                    negative regulation of vascular associated smooth muscle contraction + 4
                    positive regulation of vascular associated smooth muscle contraction + 2
                    regulation of vascular associated smooth muscle contraction + 13
                    vein smooth muscle contraction + 6
paths to the root