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ONTOLOGY REPORT - ANNOTATIONS

Term:retinoic acid 4-hydroxylase activity
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Accession:GO:0008401 term browser browse the term
Definition:Catalysis of the conversion of retinoic acid to 4-hydroxy-retinoic acid.
Synonyms:narrow_synonym: cytochrome P450 CYP261
 xref: Reactome:R-HSA-5602050 "Defective CYP26C1 does not 4-hydroxylate 9cRA";   Reactome:R-HSA-5602063 "Defective CYP26B1 does not 4-hydroxylate atRA";   reactome:R-HSA-211874 "CYP2S1 4-hydroxylates atRA";   reactome:R-HSA-211923 "CYP26C1 4-hydroxylates 9cRA";   reactome:R-HSA-212007 "CYP26A1,B1 4-hydroxylate atRA";   reactome:R-HSA-5362525 "CYP26A1,B1,C1 4-hydroxylate atRA"


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retinoic acid 4-hydroxylase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 enables ISO (PMID:10823918), (PMID:9228017), (PMID:9716180)
(MGI:1195386|PMID:9442090), (PMID:9250660)		 RGD PMID:9228017 PMID:9250660 PMID:9442090 PMID:9716180 PMID:10823918 MGI:1195386 NCBI chr 1:235,471,368...235,475,204
Ensembl chr 1:235,471,298...235,475,204 		JBrowse link
G Cyp26b1 cytochrome P450, family 26, subfamily b, polypeptide 1 enables IMP
ISO		 (PMID:10823918) RGD PMID:10823918 PMID:14592467 RGD:6771357 NCBI chr 4:117,041,808...117,058,628
Ensembl chr 4:117,041,808...117,058,628 		JBrowse link
G Cyp26c1 cytochrome P450, family 26, subfamily C, polypeptide 1 enables ISO (PMID:14532297) RGD PMID:14532297 NCBI chr 1:235,458,961...235,468,433
Ensembl chr 1:235,459,356...235,466,842 		JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 enables ISO (PMID:11093772) RGD PMID:11093772 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066 		JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 enables ISO (PMID:11093772) RGD PMID:11093772
G Cyp2w1 cytochrome P450, family 2, subfamily w, polypeptide 1 enables ISO (PMID:26936974) RGD PMID:26936974 NCBI chr12:15,291,552...15,296,421
Ensembl chr12:15,291,704...15,296,421 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 enables ISO (PMID:11093772) RGD PMID:11093772 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 enables ISO (PMID:11093772) RGD PMID:11093772 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422 		JBrowse link
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Term Annotations click to browse term
  molecular_function 20483
    catalytic activity 6036
      oxidoreductase activity 850
        oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 238
          retinoic acid 4-hydroxylase activity 8
            all-trans retinoic acid 4-hydrolase activity 0
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