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5'-nucleotidase activity - Ontology Report - Rat Genome Database

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ONTOLOGY REPORT - ANNOTATIONS

Term:5'-nucleotidase activity
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Accession:GO:0008253 term browser browse the term
Definition:Catalysis of the reaction: a 5'-ribonucleotide + H2O = a ribonucleoside + phosphate.
Synonyms:narrow_synonym: 5'-AMP nucleotidase;   5'-AMPase;   5'-adenylic phosphatase;   AMP phosphatase;   AMP phosphohydrolase;   AMPase;   UMPase;   adenosine 5'-phosphatase;   adenosine monophosphatase;   snake venom 5'-nucleotidase;   thimidine monophosphate nucleotidase;   uridine 5'-nucleotidase
 related_synonym: 5'-mononucleotidase activity;   5'-ribonucleotide phosphohydrolase activity
 xref: EC:3.1.3.5;   MetaCyc:5-NUCLEOTID-RXN;   RHEA:12484;   Reactome:R-HSA-9755078 "NT5C2 tetramer dephosphorylates RBV-MP";   reactome:R-HSA-109278 "NT5E:Zn2+ hydrolyses AMP,dAMP,GMP, IMP";   reactome:R-HSA-109291 "CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E]";   reactome:R-HSA-109380 "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A)";   reactome:R-HSA-109387 "(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A)";   reactome:R-HSA-109415 "AMP + H2O => adenosine + orthophosphate [NT5C1B]";   reactome:R-HSA-109449 "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3)";   reactome:R-HSA-109470 "(d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C)";   reactome:R-HSA-109480 "TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C]";   reactome:R-HSA-109514 "TMP, (d)UMP, uridine 2' monophosphate, or uridine 3'-monophosphate + H2O => thymidine, deoxyuridine, or uridine + orthophosphate [NT5M]";   reactome:R-HSA-5694126 "NT5C3B hydrolyses 7MGP to 7MG";   reactome:R-HSA-74248 "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2)";   reactome:R-HSA-8940070 "NT5E:Zn2+ hydrolyses NAD+";   reactome:R-HSA-8940074 "NT5E:Zn2+ hydrolyses NMN"

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5'-nucleotidase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acp3 acid phosphatase 3 enables IEA
ISO		 GO_REF:0000107
(PMID:18940592)
GO_REF:0000003
GO_REF:0000116		 Ensembl
RGD
UniProt
RHEA		 PMID:18940592 GO_REF:0000003 GO_REF:0000107 GO_REF:0000116 NCBI chr 8:113,784,372...113,833,033
Ensembl chr 8:104,905,586...104,954,236 		JBrowse link
G Entpd3 ectonucleoside triphosphate diphosphohydrolase 3 NOT|enables ISO (PMID:15130768) RGD PMID:15130768 NCBI chr 8:120,246,412...120,277,943
Ensembl chr 8:120,247,121...120,277,943 		JBrowse link
G Nt5c 5', 3'-nucleotidase, cytosolic enables IBA
ISO
IEA		 GO_REF:0000033
(PMID:10681516), (PMID:6301357)
GO_REF:0000002		 GO_Central
RGD
InterPro		 PMID:6301357 PMID:10681516 GO_REF:0000002 GO_REF:0000033 NCBI chr10:100,739,591...100,742,276
Ensembl chr10:100,739,588...100,741,954 		JBrowse link
G Nt5c1a 5'-nucleotidase, cytosolic IA enables IDA
ISO
IBA
IEA		 (PMID:11133996), (PMID:34814800), (PMID:599155), (PMID:8967393)
GO_REF:0000033
GO_REF:0000002
GO_REF:0000107		 RGD
GO_Central
InterPro
Ensembl		 PMID:599155 PMID:8967393 PMID:11133996 PMID:34814800 PMID:12675911 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107, RGD:2291861 NCBI chr 5:135,473,107...135,494,400
Ensembl chr 5:135,473,231...135,499,338 		JBrowse link
G Nt5c1b 5'-nucleotidase, cytosolic IB enables IDA
IBA
ISO
IEA		 GO_REF:0000033
(PMID:11690631)
GO_REF:0000002		 GO_Central
RGD
InterPro		 PMID:11690631 PMID:12675911 GO_REF:0000002 GO_REF:0000033, RGD:2291861 NCBI chr 6:33,139,053...33,156,489
Ensembl chr 6:33,139,064...33,156,481 		JBrowse link
G Nt5c2 5'-nucleotidase, cytosolic II enables IDA
ISO
IEA
IBA		 PMID:6260203
(PMID:1659319), (PMID:21873433), (PMID:9371705)
GO_REF:0000117
GO_REF:0000033
GO_REF:0000107
(PMID:5560407)		 RGD
UniProt
GO_Central
Ensembl		 PMID:1659319 PMID:5560407 PMID:9371705 PMID:21873433 PMID:12675911 More... GO_REF:0000033 GO_REF:0000107 GO_REF:0000117, RGD:2291861, RGD:151356611 NCBI chr 1:245,770,993...245,896,925
Ensembl chr 1:245,772,277...245,897,913 		JBrowse link
G Nt5c3a 5'-nucleotidase, cytosolic IIIA enables IDA
ISO
IEA		 (PMID:10942414)
(PMID:22925580), (PMID:6301357)
GO_REF:0000002
GO_REF:0000107		 RGD
InterPro
Ensembl		 PMID:6301357 PMID:10942414 PMID:22925580 PMID:12675911 GO_REF:0000002 GO_REF:0000107, RGD:2291861 NCBI chr 4:86,161,642...86,204,656
Ensembl chr 4:86,161,643...86,204,628 		JBrowse link
G Nt5c3b 5'-nucleotidase, cytosolic IIIB enables
NOT|enables		 IEA
IBA		 GO_REF:0000002
GO_REF:0000033		 InterPro
GO_Central		 GO_REF:0000002 GO_REF:0000033 NCBI chr10:85,358,483...85,376,340
Ensembl chr10:85,362,148...85,376,328 		JBrowse link
G Nt5dc1 5'-nucleotidase domain containing 1 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr20:38,105,677...38,208,613
Ensembl chr20:38,105,678...38,208,591 		JBrowse link
G Nt5dc2 5'-nucleotidase domain containing 2 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr16:6,322,485...6,330,538
Ensembl chr16:6,322,236...6,330,537 		JBrowse link
G Nt5dc3 5'-nucleotidase domain containing 3 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 7:21,190,554...21,247,374
Ensembl chr 7:21,190,554...21,247,374 		JBrowse link
G Nt5e 5' nucleotidase, ecto enables IDA
ISO
IBA
IEA		 PMID:6017738
PMID:1770988
(PMID:22997138), (PMID:23142347), (PMID:24887587), (PMID:28592560), (PMID:34403084), (PMID:7595232)
GO_REF:0000033
MGI:3522017 (PMID:16547283), (PMID:20430891), (PMID:28746349), (PMID:8224905)
GO_REF:0000116
GO_REF:0000003
GO_REF:0000107		 RGD
GO_Central
RHEA
UniProt
Ensembl		 PMID:7595232 PMID:8224905 PMID:16547283 PMID:20430891 PMID:22997138 More... GO_REF:0000003 GO_REF:0000033 GO_REF:0000107 GO_REF:0000116, RGD:631915, RGD:2291861, RGD:10047240, RGD:155230694 NCBI chr 8:89,271,046...89,314,918
Ensembl chr 8:89,270,696...89,314,881 		JBrowse link
G Nt5m 5',3'-nucleotidase, mitochondrial enables IBA
ISO
IEA		 GO_REF:0000033
(PMID:12234672)
GO_REF:0000002
GO_REF:0000107		 GO_Central
RGD
InterPro
Ensembl		 PMID:12234672 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr10:44,652,845...44,680,549
Ensembl chr10:44,652,975...44,679,150 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 21102
    catalytic activity 7309
      hydrolase activity 3455
        hydrolase activity, acting on ester bonds 979
          phosphoric ester hydrolase activity 501
            phosphatase activity 399
              nucleotidase activity 15
                5'-nucleotidase activity 13
paths to the root