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ONTOLOGY REPORT - ANNOTATIONS

Term:canonical NF-kappaB signal transduction
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Accession:GO:0007249 term browser browse the term
Definition:An intracellular signaling cassette characterized by the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB, also known as the canonical NF-kappaB signaling cascade. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. The canonical NF-kappaB pathway is mainly stimulated by proinflammatory cytokines such as IL-1beta, tumor necrosis factor (TNF)-alpha, antigen ligands, and toll-like receptors (TLRs).
Synonyms:exact_synonym: I-kappaB kinase/NF-kappaB signal transduction;   I-kappaB kinase/NF-kappaB signaling;   NF-kappaB cascade;   canonical NF-kappaB signaling cascade
 related_synonym: I-kappaB kinase/NF-kappaB cascade;   p50-dependent NF-kappaB signaling

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    Path 1
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      biological_process 180413
        cellular process 159956
          signal transduction 59522
            intracellular signal transduction 26452
              intracellular signaling cassette 18578
                canonical NF-kappaB signal transduction 3076
                  I-kappaB phosphorylation + 86
                  negative regulation of canonical NF-kappaB signal transduction 670
                  positive regulation of canonical NF-kappaB signal transduction 2122
                  regulation of canonical NF-kappaB signal transduction + 2864
    Path 2
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      biological_process 180413
        biological regulation 118873
          regulation of biological process 115328
            signaling 64895
              signal transduction 59522
                intracellular signal transduction 26452
                  intracellular signaling cassette 18578
                    canonical NF-kappaB signal transduction 3076
                      I-kappaB phosphorylation + 86
                      negative regulation of canonical NF-kappaB signal transduction 670
                      positive regulation of canonical NF-kappaB signal transduction 2122
                      regulation of canonical NF-kappaB signal transduction + 2864
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