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ONTOLOGY REPORT - ANNOTATIONS

Term:gamma-aminobutyrate shunt
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Accession:GO:0006540 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of succinate from glutamate. Also known as GABA (gamma-aminobutyrate) shunt since it channels glutamate into the TCA cycle bypassing two steps of that cycle. There are three enzymes involved in the GABA shunt: glutamate decarboxylase (GAD), GABA aminotransferase (GABA-TA), and succinate semialdehyde dehydrogenase (SSADH). These three enzymes acting in concert to convert glutamate into succinate. The GABA shunt is predominantly associated with neurotransmission in the mammalian brain. It is also present in nonneuronal cells, in plants, in unicellular eukaryotes, and in prokaryotes.
Comment:Note that the third step in this pathway (conversion of succinate semialdehyde to succinate) can be catalyzed by NAD-dependent or NADP-dependent succinate semialdehyde dehydrogenase (EC:1.2.1.24 and EC:1.2.1.79, respectively).
Synonyms:exact_synonym: 4-aminobutyrate shunt;   GABA shunt;   degradation of glutamate to succinate through GABA;   glutamate decarboxylation to succinate;   glutamate degradation via 4-aminobutyrate;   glutamate degradation via GABA
 xref: MetaCyc:GLUDEG-I-PWY
 never_in_taxon: NCBITaxon:4896 ! Schizosaccharomyces pombe;   NCBITaxon:4899 ! Schizosaccharomyces octosporus


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gamma-aminobutyrate shunt term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GAD2 glutamate decarboxylase 2 involved_in ISO
IBA		 RGD
GO_Central		 PMID:8999827 GO_REF:0000033 RGD:1625237 NCBI chr 2:7,365,708...7,450,893
Ensembl chr 2:7,365,283...7,450,893 		JBrowse link
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Term Annotations click to browse term
  biological_process 22098
    cellular process 21628
      metabolic process 15371
        catabolic process 2726
          amino acid catabolic process 111
            alpha-amino acid catabolic process 95
              L-amino acid catabolic process 76
                glutamine family amino acid catabolic process 29
                  glutamate catabolic process 8
                    gamma-aminobutyrate shunt 1
Path 2
Term Annotations click to browse term
  biological_process 22098
    cellular process 21628
      metabolic process 15371
        small molecule metabolic process 1808
          organic acid metabolic process 971
            oxoacid metabolic process 958
              carboxylic acid metabolic process 943
                alpha-amino acid metabolic process 213
                  L-amino acid metabolic process 173
                    glutamine family amino acid metabolic process 81
                      glutamate metabolic process 39
                        glutamate catabolic process 8
                          gamma-aminobutyrate shunt 1
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