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ONTOLOGY REPORT - ANNOTATIONS

Term:telomerase holoenzyme complex
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Accession:GO:0005697 term browser browse the term
Definition:Telomerase is a ribonucleoprotein enzyme complex, with a minimal catalytic core composed of a catalytic reverse transcriptase subunit and an RNA subunit that provides the template for telomeric DNA addition. In vivo, the holoenzyme complex often contains additional subunits.


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telomerase holoenzyme complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACD ACD shelterin complex subunit and telomerase recruitment factor part_of IEA InterPro GO_REF:0000002 NCBI chr16:48,001,408...48,004,620
Ensembl chr16:67,390,703...67,393,685 		JBrowse link
G DKC1 dyskerin pseudouridine synthase 1 part_of IEA Ensembl GO_REF:0000107 NCBI chr  X:144,243,493...144,257,419
Ensembl chr  X:154,084,412...154,098,475 		JBrowse link
G GAR1 GAR1 ribonucleoprotein part_of IEA Ensembl GO_REF:0000107 NCBI chr 4:102,311,275...102,320,579
Ensembl chr 4:112,879,223...112,887,828 		JBrowse link
G GNL3L G protein nucleolar 3 like part_of IEA Ensembl GO_REF:0000107 NCBI chr  X:46,733,431...46,825,139
Ensembl chr  X:54,966,121...55,002,925 		JBrowse link
G HNRNPC heterogeneous nuclear ribonucleoprotein C part_of ISO (PMID:18082603) BHF-UCL PMID:18082603 NCBI chr14:2,022,280...2,083,215 JBrowse link
G HNRNPU heterogeneous nuclear ribonucleoprotein U part_of IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 1:220,450,218...220,461,412
Ensembl chr 1:225,817,899...225,842,031 		JBrowse link
G LOC100974064 small nuclear ribonucleoprotein E part_of IEA Ensembl GO_REF:0000107 NCBI chr 9:67,731,954...67,732,434
Ensembl chr 1:183,755,392...183,764,937 		JBrowse link
G LSM11 LSM11, U7 small nuclear RNA associated part_of ISO (PMID:18082603) BHF-UCL PMID:18082603 NCBI chr 5:153,129,385...153,182,170 JBrowse link
G NAT10 N-acetyltransferase 10 part_of IEA Ensembl GO_REF:0000107 NCBI chr11:34,082,304...34,127,793
Ensembl chr11:33,960,739...34,002,069 		JBrowse link
G NHP2 NHP2 ribonucleoprotein part_of IEA Ensembl GO_REF:0000107 NCBI chr 5:173,308,560...173,313,046
Ensembl chr 5:180,566,008...180,570,502 		JBrowse link
G NOP10 NOP10 ribonucleoprotein part_of IEA Ensembl GO_REF:0000107 NCBI chr15:12,850,708...12,852,171
Ensembl chr15:31,684,833...31,686,305 		JBrowse link
G NVL nuclear VCP like part_of IEA Ensembl GO_REF:0000107 NCBI chr 1:199,695,388...199,798,080
Ensembl chr 1:204,704,371...204,806,959 		JBrowse link
G PTGES3 prostaglandin E synthase 3 part_of ISO (PMID:12135483) UniProt PMID:12135483 NCBI chr12:32,221,908...32,247,228
Ensembl chr12:32,476,835...32,503,181 		JBrowse link
G SMG5 SMG5 nonsense mediated mRNA decay factor part_of IEA TreeGrafter GO_REF:0000118 NCBI chr 1:131,592,368...131,634,443
Ensembl chr 1:135,422,268...135,455,734 		JBrowse link
G SMG6 SMG6 nonsense mediated mRNA decay factor part_of IEA TreeGrafter GO_REF:0000118 NCBI chr17:2,050,825...2,294,892
Ensembl chr17:1,937,630...2,179,535 		JBrowse link
G SMG7 SMG7 nonsense mediated mRNA decay factor part_of IEA TreeGrafter GO_REF:0000118 NCBI chr 1:159,002,363...159,084,572
Ensembl chr 1:163,159,362...163,242,285 		JBrowse link
G SNRPB small nuclear ribonucleoprotein polypeptides B and B1 part_of IEA Ensembl GO_REF:0000107 NCBI chr20:2,571,393...2,580,642
Ensembl chr20:2,335,499...2,344,763 		JBrowse link
G SNRPD3 small nuclear ribonucleoprotein D3 polypeptide part_of IEA Ensembl GO_REF:0000107 NCBI chr22:5,361,886...5,378,465
Ensembl chr22:22,227,328...22,246,676 		JBrowse link
G SNRPE small nuclear ribonucleoprotein polypeptide E part_of IEA Ensembl GO_REF:0000107 NCBI chr 1:179,466,263...179,474,779
Ensembl chr 1:183,755,392...183,764,937 		JBrowse link
G TEP1 telomerase associated protein 1 part_of IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr14:1,240,370...1,285,787
Ensembl chr14:19,293,452...19,332,960 		JBrowse link
G TERT telomerase reverse transcriptase part_of IEA Ensembl GO_REF:0000107 Ensembl chr 5:1,300,960...1,338,872 JBrowse link
G WRAP53 WD repeat containing antisense to TP53 part_of IEA Ensembl GO_REF:0000107 NCBI chr17:7,715,897...7,735,873
Ensembl chr17:7,707,221...7,723,394 		JBrowse link
box H/ACA telomerase RNP complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DKC1 dyskerin pseudouridine synthase 1 part_of IEA Ensembl GO_REF:0000107 NCBI chr  X:144,243,493...144,257,419
Ensembl chr  X:154,084,412...154,098,475 		JBrowse link
G GAR1 GAR1 ribonucleoprotein part_of IEA Ensembl GO_REF:0000107 NCBI chr 4:102,311,275...102,320,579
Ensembl chr 4:112,879,223...112,887,828 		JBrowse link
G NHP2 NHP2 ribonucleoprotein part_of IEA Ensembl GO_REF:0000107 NCBI chr 5:173,308,560...173,313,046
Ensembl chr 5:180,566,008...180,570,502 		JBrowse link
G NOP10 NOP10 ribonucleoprotein part_of IEA Ensembl GO_REF:0000107 NCBI chr15:12,850,708...12,852,171
Ensembl chr15:31,684,833...31,686,305 		JBrowse link
telomerase catalytic core complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TERT telomerase reverse transcriptase part_of IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 Ensembl chr 5:1,300,960...1,338,872 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 17180
    protein-containing complex 5908
      catalytic complex 1708
        telomerase holoenzyme complex 22
          box H/ACA telomerase RNP complex 4
          telomerase catalytic core complex 1
Path 2
Term Annotations click to browse term
  cellular_component 17180
    cellular anatomical entity 16967
      organelle 12496
        membrane-bounded organelle 11402
          intracellular membrane-bounded organelle 10862
            nucleus 6800
              nuclear protein-containing complex 1236
                telomerase holoenzyme complex 22
                  box H/ACA telomerase RNP complex 4
                  telomerase catalytic core complex 1
paths to the root