SMG7 (SMG7 nonsense mediated mRNA decay factor) - Rat Genome Database

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Gene: SMG7 (SMG7 nonsense mediated mRNA decay factor) Pan paniscus
Analyze
Symbol: SMG7
Name: SMG7 nonsense mediated mRNA decay factor
RGD ID: 11999050
Description: ENCODES a protein that exhibits protein phosphatase 2A binding (ortholog); INVOLVED IN nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (inferred); ASSOCIATED WITH 1q24 Deletion Syndrome (ortholog); autosomal recessive chronic granulomatous disease 2 (ortholog); gastrointestinal stromal tumor (ortholog); FOUND IN cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: nonsense-mediated mRNA decay factor SMG7; smg-7 homolog, nonsense mediated mRNA decay factor; SMG7, nonsense mediated mRNA decay factor
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2166,163,481 - 66,245,785 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1165,846,613 - 65,928,939 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01159,002,363 - 159,084,572 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11163,159,294 - 163,242,285 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1163,159,362 - 163,242,285 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
SMG7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2166,163,481 - 66,245,785 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1165,846,613 - 65,928,939 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01159,002,363 - 159,084,572 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11163,159,294 - 163,242,285 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1163,159,362 - 163,242,285 (+)Ensemblpanpan1.1panPan2
SMG7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381183,472,499 - 183,554,191 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1183,472,216 - 183,598,246 (+)EnsemblGRCh38hg38GRCh38
GRCh371183,441,634 - 183,523,326 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361181,708,257 - 181,789,949 (+)NCBINCBI36Build 36hg18NCBI36
Build 341180,173,290 - 180,254,982NCBI
Celera1156,552,563 - 156,634,375 (+)NCBICelera
Cytogenetic Map1q25.3NCBI
HuRef1154,677,519 - 154,759,191 (+)NCBIHuRef
CHM1_11184,864,494 - 184,946,346 (+)NCBICHM1_1
T2T-CHM13v2.01182,831,784 - 182,913,482 (+)NCBIT2T-CHM13v2.0
Smg7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391152,712,746 - 152,783,212 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1152,712,746 - 152,778,397 (-)EnsemblGRCm39 Ensembl
GRCm381152,836,995 - 152,903,130 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1152,836,995 - 152,902,646 (-)EnsemblGRCm38mm10GRCm38
MGSCv371154,684,125 - 154,749,776 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361154,599,213 - 154,664,840 (-)NCBIMGSCv36mm8
Celera1155,258,082 - 155,323,736 (-)NCBICelera
Cytogenetic Map1G3NCBI
cM Map165.07NCBI
Smg7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81367,536,016 - 67,600,624 (-)NCBIGRCr8
mRatBN7.21364,986,145 - 65,050,698 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1364,987,434 - 65,050,582 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1367,588,905 - 67,629,946 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01368,875,892 - 68,916,950 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01366,126,955 - 66,168,015 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01370,258,919 - 70,321,886 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1370,258,915 - 70,321,752 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01375,229,500 - 75,292,318 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41367,835,448 - 67,900,289 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11367,849,527 - 67,951,670 (-)NCBI
Celera1364,891,810 - 64,932,829 (-)NCBICelera
Cytogenetic Map13q21NCBI
Smg7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540622,273,298 - 22,352,782 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540622,273,298 - 22,352,782 (+)NCBIChiLan1.0ChiLan1.0
SMG7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1716,820,938 - 16,913,359 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl716,820,882 - 16,911,377 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha716,406,152 - 16,499,070 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0716,552,548 - 16,645,376 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl716,551,996 - 16,645,376 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1716,460,693 - 16,553,547 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0716,570,275 - 16,662,968 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0716,701,145 - 16,793,905 (+)NCBIUU_Cfam_GSD_1.0
Smg7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934488,481,369 - 88,558,329 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364816,326,010 - 6,405,074 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364816,326,211 - 6,405,067 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SMG7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9124,697,093 - 124,775,964 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19124,696,432 - 124,775,739 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29137,052,343 - 137,105,730 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SMG7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12545,808,384 - 45,895,605 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2545,805,689 - 45,866,852 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605547,025,227 - 47,114,190 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Smg7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462481410,137,548 - 10,224,825 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462481410,135,733 - 10,224,991 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_003815611 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_003815612 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008968573 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008968574 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008968575 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008968579 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008968580 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024929251 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024929255 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024929261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034942177 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034942186 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034942195 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034942205 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_055110652 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_055110664 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_055110667 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_055110677 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JARIFH020000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSPPAT00000039911   ⟹   ENSPPAP00000017210
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1163,159,362 - 163,242,285 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000039923   ⟹   ENSPPAP00000017222
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1163,160,373 - 163,242,285 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000039926   ⟹   ENSPPAP00000017224
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1163,160,617 - 163,205,769 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000039942   ⟹   ENSPPAP00000017240
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1163,200,930 - 163,215,784 (+)Ensembl
RefSeq Acc Id: XM_003815611   ⟹   XP_003815659
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2166,163,481 - 66,245,785 (-)NCBI
NHGRI_mPanPan1165,846,613 - 65,928,939 (-)NCBI
Mhudiblu_PPA_v01159,002,363 - 159,084,572 (+)NCBI
PanPan1.11163,160,373 - 163,242,285 (+)NCBI
Sequence:
RefSeq Acc Id: XM_003815612   ⟹   XP_003815660
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2166,163,481 - 66,245,785 (-)NCBI
NHGRI_mPanPan1165,846,613 - 65,928,939 (-)NCBI
Mhudiblu_PPA_v01159,002,363 - 159,084,572 (+)NCBI
PanPan1.11163,160,373 - 163,242,285 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008968575   ⟹   XP_008966823
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2166,163,481 - 66,245,785 (-)NCBI
NHGRI_mPanPan1165,846,613 - 65,928,939 (-)NCBI
Mhudiblu_PPA_v01159,002,363 - 159,084,572 (+)NCBI
PanPan1.11163,159,294 - 163,242,285 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008968580   ⟹   XP_008966828
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2166,163,481 - 66,245,785 (-)NCBI
NHGRI_mPanPan1165,846,613 - 65,928,939 (-)NCBI
Mhudiblu_PPA_v01159,002,363 - 159,084,572 (+)NCBI
PanPan1.11163,160,373 - 163,242,285 (+)NCBI
Sequence:
RefSeq Acc Id: XM_055110652   ⟹   XP_054966627
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2166,163,481 - 66,244,502 (-)NCBI
NHGRI_mPanPan1165,846,613 - 65,927,972 (-)NCBI
RefSeq Acc Id: XM_055110664   ⟹   XP_054966639
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2166,163,481 - 66,244,411 (-)NCBI
NHGRI_mPanPan1165,846,613 - 65,927,881 (-)NCBI
RefSeq Acc Id: XM_055110667   ⟹   XP_054966642
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2166,163,481 - 66,245,106 (-)NCBI
NHGRI_mPanPan1165,846,613 - 65,928,597 (-)NCBI
RefSeq Acc Id: XM_055110677   ⟹   XP_054966652
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2166,163,481 - 66,245,005 (-)NCBI
NHGRI_mPanPan1165,846,613 - 65,928,475 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_008966823   ⟸   XM_008968575
- Peptide Label: isoform X2
- UniProtKB: A0A2R9ANF7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_003815659   ⟸   XM_003815611
- Peptide Label: isoform X6
- UniProtKB: A0A2R9AIN4 (UniProtKB/TrEMBL),   A0A2R9ANF7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008966828   ⟸   XM_008968580
- Peptide Label: isoform X5
- UniProtKB: A0A2R9ANF7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_003815660   ⟸   XM_003815612
- Peptide Label: isoform X8
- UniProtKB: A0A2R9ANF7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSPPAP00000017224   ⟸   ENSPPAT00000039926
RefSeq Acc Id: ENSPPAP00000017222   ⟸   ENSPPAT00000039923
RefSeq Acc Id: ENSPPAP00000017210   ⟸   ENSPPAT00000039911
RefSeq Acc Id: ENSPPAP00000017240   ⟸   ENSPPAT00000039942
RefSeq Acc Id: XP_054966642   ⟸   XM_055110667
- Peptide Label: isoform X4
RefSeq Acc Id: XP_054966652   ⟸   XM_055110677
- Peptide Label: isoform X7
RefSeq Acc Id: XP_054966627   ⟸   XM_055110652
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054966639   ⟸   XM_055110664
- Peptide Label: isoform X3
Protein Domains
DNA/RNA-binding   Telomerase activating protein Est1-like N-terminal


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000031619 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000039911.1 UniProtKB/TrEMBL
  ENSPPAT00000039923.1 UniProtKB/TrEMBL
  ENSPPAT00000039926.1 UniProtKB/TrEMBL
  ENSPPAT00000039942.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.10 UniProtKB/TrEMBL
InterPro DNA/RNA-bd_Est1-type UniProtKB/TrEMBL
  EST1 UniProtKB/TrEMBL
  Est1/Ebs1-like UniProtKB/TrEMBL
  TPR-like_helical_dom_sf UniProtKB/TrEMBL
KEGG Report pps:100993466 UniProtKB/TrEMBL
NCBI Gene SMG7 ENTREZGENE
PANTHER PROTEIN SMG7 UniProtKB/TrEMBL
  PTHR15696 UniProtKB/TrEMBL
Pfam EST1 UniProtKB/TrEMBL
  EST1_DNA_bind UniProtKB/TrEMBL
Superfamily-SCOP SSF48452 UniProtKB/TrEMBL
UniProt A0A2R9AIN4 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9ANF7 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9ANI5_PANPA UniProtKB/TrEMBL
  A0A2R9AQR6_PANPA UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-01-29 SMG7  SMG7 nonsense mediated mRNA decay factor    SMG7, nonsense mediated mRNA decay factor  Symbol and/or name change 5135510 APPROVED