NHP2 (NHP2 ribonucleoprotein) - Rat Genome Database

Name: NHP2
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: NHP2 (NHP2 ribonucleoprotein) Pan paniscus

Analyze

Symbol:

NHP2

Name:

NHP2 ribonucleoprotein

RGD ID:

11768527

Description:

ENCODES a protein that exhibits mRNA 3'-UTR binding (ortholog); U3 snoRNA binding (ortholog); INVOLVED IN positive regulation of telomerase RNA localization to Cajal body (ortholog); snoRNA guided rRNA pseudouridine synthesis (ortholog); PARTICIPATES IN ribosome biogenesis pathway; ASSOCIATED WITH Autosomal Recessive Dyskeratosis Congenita (ortholog); autosomal recessive dyskeratosis congenita 1 (ortholog); autosomal recessive dyskeratosis congenita 2 (ortholog); FOUND IN box H/ACA snoRNP complex (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

H/ACA ribonucleoprotein complex subunit 2; NHP2 ribonucleoprotein homolog

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	NHP2 (NHP2 ribonucleoprotein)	NCBI	Ortholog
Mus musculus (house mouse):	Nhp2 (NHP2 ribonucleoprotein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Nhp2 (NHP2 ribonucleoprotein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Nhp2 (NHP2 ribonucleoprotein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	NHP2 (NHP2 ribonucleoprotein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Nhp2 (NHP2 ribonucleoprotein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	NHP2 (NHP2 ribonucleoprotein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	NHP2 (NHP2 ribonucleoprotein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Nhp2 (NHP2 ribonucleoprotein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	173,090,862 - 173,095,371 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	171,230,398 - 171,234,909 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	173,308,560 - 173,313,046 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	180,566,008 - 180,570,502 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	180,566,008 - 180,570,502 (-)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Autosomal Recessive Dyskeratosis Congenita (ISO)

autosomal recessive dyskeratosis congenita 1 (ISO)

autosomal recessive dyskeratosis congenita 2 (ISO)

dyskeratosis congenita (ISO)

Ehlers-Danlos syndrome dermatosparaxis type (ISO)

Ehlers-Danlos syndrome spondylodysplastic type 2 (ISO)

genetic disease (ISO)

Sotos syndrome (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

maturation of LSU-rRNA (IEA)

mRNA splicing, via spliceosome (IEA)

positive regulation of telomerase RNA localization to Cajal body (ISO)

ribosome biogenesis (IEA)

rRNA processing (IEA)

rRNA pseudouridine synthesis (IEA)

snoRNA guided rRNA pseudouridine synthesis (ISO)

snRNA pseudouridine synthesis (IEA)

telomere maintenance via telomerase (IEA)

Cellular Component

box H/ACA snoRNP complex (IEA,ISO)

box H/ACA telomerase RNP complex (IEA)

cytosolic large ribosomal subunit (IEA)

nucleolus (IEA)

nucleus (IEA)

ribonucleoprotein complex (IEA)

telomerase holoenzyme complex (IEA)

Molecular Function

box H/ACA snoRNA binding (IEA)

mRNA 3'-UTR binding (ISO)

protein binding (ISO)

RNA binding (IEA)

telomerase RNA binding (IEA)

U3 snoRNA binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

ribosome biogenesis pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

NHP2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	173,090,862 - 173,095,371 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	171,230,398 - 171,234,909 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	173,308,560 - 173,313,046 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	180,566,008 - 180,570,502 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	180,566,008 - 180,570,502 (-)	Ensembl	panpan1.1		panPan2

NHP2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	178,149,463 - 178,153,885 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	178,149,463 - 178,153,894 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	5	177,576,464 - 177,580,886 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	177,509,070 - 177,513,567 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	5	177,509,073 - 177,513,567	NCBI
Celera	5	173,203,446 - 173,207,943 (-)	NCBI		Celera
Cytogenetic Map	5	q35.3	NCBI
HuRef	5	172,302,433 - 172,306,930 (-)	NCBI		HuRef
CHM1_1	5	177,007,842 - 177,012,339 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	5	178,699,722 - 178,704,144 (-)	NCBI		T2T-CHM13v2.0

Nhp2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	51,510,600 - 51,514,545 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	51,510,562 - 51,514,541 (+)	Ensembl		GRCm39 Ensembl
GRCm38	11	51,619,773 - 51,623,718 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	51,619,735 - 51,623,714 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	51,433,275 - 51,437,216 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	51,463,196 - 51,467,137 (+)	NCBI		MGSCv36	mm8
Celera	11	56,191,112 - 56,195,057 (+)	NCBI		Celera
Cytogenetic Map	11	B1.3	NCBI
cM Map	11	31.14	NCBI

Nhp2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	36,378,020 - 36,381,362 (+)	NCBI		GRCr8
mRatBN7.2	10	35,877,057 - 35,880,399 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	35,877,054 - 35,882,545 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	63,415,455 - 63,415,690 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	71,999,106 - 71,999,341 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
Rnor_6.0	10	34,975,701 - 34,979,082 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	34,975,708 - 34,979,082 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0 Ensembl	10	37,069,344 - 37,072,733 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	36,841,672 - 36,845,050 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	37,137,277 - 37,140,651 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	10	35,233,774 - 35,237,148 (+)	NCBI		Celera
Cytogenetic Map	10	q22	NCBI

Nhp2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955408	2,090,772 - 2,094,453 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955408	2,090,772 - 2,094,453 (+)	NCBI	ChiLan1.0	ChiLan1.0

NHP2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	11	3,389,549 - 3,393,010 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	11	3,389,591 - 3,395,313 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	11	3,532,480 - 3,535,984 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	11	3,365,217 - 3,368,723 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	11	3,365,309 - 3,368,720 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	11	3,335,883 - 3,337,251 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	11	3,413,347 - 3,416,848 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	11	3,654,898 - 3,659,015 (+)	NCBI		UU_Cfam_GSD_1.0

Nhp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	113,517,778 - 113,522,464 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936647	520,494 - 525,226 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936647	520,542 - 525,226 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

NHP2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	2	80,223,439 - 80,227,614 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	81,839,915 - 81,844,092 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

NHP2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	23	79,842,690 - 79,847,138 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	23	79,842,948 - 79,846,984 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666075	11,143,336 - 11,147,779 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Nhp2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624733	41,371,897 - 41,375,363 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624733	41,371,897 - 41,375,360 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_008970518	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034961118	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSPPAT00000033576 ⟹ ENSPPAP00000010922

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	5	180,566,008 - 180,570,502 (-)	Ensembl

RefSeq Acc Id:

ENSPPAT00000033577 ⟹ ENSPPAP00000010923

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	5	180,566,341 - 180,570,357 (-)	Ensembl

RefSeq Acc Id:

XM_008970518 ⟹ XP_008968766

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	4	173,090,862 - 173,095,371 (-)	NCBI
NHGRI_mPanPan1	5	171,230,398 - 171,234,909 (-)	NCBI
Mhudiblu_PPA_v0	5	173,308,560 - 173,313,007 (-)	NCBI
PanPan1.1	5	180,566,008 - 180,570,502 (-)	NCBI

Sequence:

show sequence

CGATTGGGCTGAGTCGGAGACTTCCTTTCCTGATTGGCCGTGTTGTACGGCGGCTTCTCGCGCA
GCTGATGACCTGGAAGTGATGCCTAAAGCTGTGGACCGCGTGGGCTCGCCTCCCTGGGACTAGG
TTTCAGCGGCCGCTGCGATGACCAAAATAAAGGCAGATCCCGACGGGCCCGAGGCTCAGGCGGA
GGCGTGTTCCGGGGAGCGCACCTACCAGGAGCTGCTGGTCAACCAGAACCCCATCGCGCAGCCC
CTGGCTTCTCGCCGCCTCACGCGGAAGCTCTACAAATGCATCAAGAAAGCGGTGAAGCAGAAGC
AGATTCGGCGCGGGGTGAAAGAGGTTCAGAAATTTGTCAACAAAGGAGAAAAAGGGATCATGGT
TTTGGCAGGAGACACACTGCCCATTGAGGTATACTGCCATCTCCCAGTCATGTGTGAGGACCGA
AATTTGCCCTATGTCTATATCCCCTCTAAGACGGACCTGGGTGCAGCCGCAGGCTCCAAGCGCC
CCACCTGTGTGATAATGGTCAAGCCCCATGAGGAGTACCAGGAGGCTTACGATGAGTGCCTGGA
GGAGGTGCAGTCCCTGCCCCTACCACTATGAGGGGCTCCGGTAGCACCTGGGCACCTGCCGCTG
GAAGCTATTGGGCTGGCGGCAGGACGACTGGCTGTCCTCCTGCCCACCCACACTGACGGCATCT
TCCCAGTTCCCCAAGGCACGCCTTCTTCCCAGGCAGCTCTAACAGCCCTTTCATGAAGGTAATG
CTAGTCTTCTGTCCATCAGTGCCATTTCCTGTAGAACTAAAGGCTGTTCCAAGAATGTGGGGTG
GGGAAAGTAAATGCTAAGACTAAAA

hide sequence

RefSeq Acc Id:

XM_034961118 ⟹ XP_034817009

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	4	173,090,862 - 173,095,345 (-)	NCBI
NHGRI_mPanPan1	5	171,230,398 - 171,234,862 (-)	NCBI
Mhudiblu_PPA_v0	5	173,308,560 - 173,313,046 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_008968766	(Get FASTA)	NCBI Sequence Viewer
	XP_034817009	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000010922
	ENSPPAP00000010922.1
	ENSPPAP00000010923.1

RefSeq Acc Id:	XP_008968766 ⟸ XM_008970518
- Peptide Label:	isoform X1
- UniProtKB:	A0A2R9A0Y9 (UniProtKB/TrEMBL)
- Sequence:	show sequence MTKIKADPDGPEAQAEACSGERTYQELLVNQNPIAQPLASRRLTRKLYKCIKKAVKQKQIRRGV KEVQKFVNKGEKGIMVLAGDTLPIEVYCHLPVMCEDRNLPYVYIPSKTDLGAAAGSKRPTCVIM VKPHEEYQEAYDECLEEVQSLPLPL hide sequence

RefSeq Acc Id:	XP_034817009 ⟸ XM_034961118
- Peptide Label:	isoform X2
- UniProtKB:	A0A2R9A113 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSPPAP00000010923 ⟸ ENSPPAT00000033577

RefSeq Acc Id:

ENSPPAP00000010922 ⟸ ENSPPAT00000033576

Protein Domains

Ribosomal protein eL8/eL30/eS12/Gadd45

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000028668	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000033576.1	UniProtKB/TrEMBL
	ENSPPAT00000033577.1	UniProtKB/TrEMBL
Gene3D-CATH	3.30.1330.30	UniProtKB/TrEMBL
InterPro	H/ACA_rnp_Nhp2_euk	UniProtKB/TrEMBL
	L30e-like	UniProtKB/TrEMBL
	Ribosomal_L7Ae/L30e/S12e/Gad45	UniProtKB/TrEMBL
	Ribosomal_L7Ae/L8/Nhp2	UniProtKB/TrEMBL
KEGG Report	pps:100990295	UniProtKB/TrEMBL
NCBI Gene	NHP2	ENTREZGENE
PANTHER	H/ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 2	UniProtKB/TrEMBL
	RIBOSOMAL PROTEIN L7AE FAMILY MEMBER	UniProtKB/TrEMBL
Pfam	Ribosomal_L7Ae	UniProtKB/TrEMBL
PRINTS	L7ARS6FAMILY	UniProtKB/TrEMBL
	NUCLEARHMG	UniProtKB/TrEMBL
Superfamily-SCOP	SSF55315	UniProtKB/TrEMBL
UniProt	A0A2R9A0Y9	ENTREZGENE, UniProtKB/TrEMBL
	A0A2R9A113	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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