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ONTOLOGY REPORT - ANNOTATIONS

Term:AMPA glutamate receptor activity
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Accession:GO:0004971 term browser browse the term
Definition:An ionotropic glutamate receptor activity that exhibits fast gating by glutamate and acts by opening a cation channel permeable to sodium, potassium, and, in the absence of a GluR2 subunit, calcium.
Comment:Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function terms 'ionotropic glutamate receptor activity ; GO:0004970' and 'cation channel activity ; GO:0005261'.
Synonyms:exact_synonym: AMPA receptor activity;   alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity


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AMPA glutamate receptor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 enables IEA
IDA
IBA
ISO		 GO_REF:0000107
PMID:19265014
GO_REF:0000033
(PMID:1311100), (PMID:20805473), (PMID:21172611), (PMID:28628100), (PMID:35675825)
(PMID:29490264)		 Ensembl
GO_Central
RGD		 PMID:1311100 PMID:20805473 PMID:21172611 PMID:28628100 PMID:29490264 More... GO_REF:0000033 GO_REF:0000107, RGD:8554136 NCBI chr10:41,210,713...41,527,283
Ensembl chr10:41,210,713...41,527,283 		JBrowse link
G Gria2 glutamate ionotropic receptor AMPA type subunit 2 enables TAS
IDA
IBA		 PMID:21172611
PMID:19265014
GO_REF:0000033		 GO_Central
RGD		 PMID:12554656 PMID:21172611 PMID:19265014 GO_REF:0000033, RGD:728773, RGD:8554236, RGD:8554136 NCBI chr 2:165,949,379...166,069,510
Ensembl chr 2:165,947,521...166,069,510 		JBrowse link
G Gria3 glutamate ionotropic receptor AMPA type subunit 3 enables IDA
IEA
ISO
IBA		 GO_REF:0000107
(PMID:21172611)
GO_REF:0000033		 Ensembl
RGD
GO_Central		 PMID:21172611 PMID:11834304 GO_REF:0000033 GO_REF:0000107, RGD:728843 NCBI chr  X:120,238,515...120,504,106
Ensembl chr  X:120,238,534...120,504,096 		JBrowse link
G Gria4 glutamate ionotropic receptor AMPA type subunit 4 enables TAS
IMP
ISO
IEA
IBA		 (PMID:21172611)
GO_REF:0000107
GO_REF:0000033		 RGD
Ensembl
GO_Central		 PMID:21172611 PMID:1699275 PMID:2166337 GO_REF:0000033 GO_REF:0000107, RGD:728417, RGD:728438 NCBI chr 8:1,562,118...2,035,035
Ensembl chr 8:1,562,119...2,034,979 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20626
    transporter activity 1253
      transmembrane transporter activity 1153
        inorganic molecular entity transmembrane transporter activity 713
          inorganic cation transmembrane transporter activity 601
            AMPA glutamate receptor activity 4
Path 2
Term Annotations click to browse term
  molecular_function 20626
    transporter activity 1253
      transmembrane transporter activity 1153
        passive transmembrane transporter activity 511
          channel activity 511
            gated channel activity 334
              ligand-gated channel activity 190
                ligand-gated monoatomic ion channel activity 185
                  extracellular ligand-gated monoatomic ion channel activity 70
                    transmitter-gated monoatomic ion channel activity 60
                      glutamate-gated receptor activity 16
                        AMPA glutamate receptor activity 4
paths to the root