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ONTOLOGY REPORT - ANNOTATIONS

Term:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
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Accession:GO:0003918 term browser browse the term
Definition:Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined, driven by ATP hydrolysis. The enzyme changes the linking number in multiples of 2.
Synonyms:exact_synonym: deoxyribonucleic topoisomerase activity
 narrow_synonym: DNA topoisomerase II activity;   DNA topoisomerase IV activity
 broad_synonym: deoxyribonucleate topoisomerase;   topoisomerase
 related_synonym: DNA topoisomerase (ATP-hydrolysing);   DNA topoisomerase II;   DNA topoisomerase type II activity;   topoisomerase II
 alt_id: GO:0061505
 xref: EC:5.6.2.2;   MetaCyc:5.99.1.3-RXN;   Wikipedia:Type_II_topoisomerase


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DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SPO11 SPO11 initiator of meiotic double strand breaks enables IEA InterPro GO_REF:0000002 NCBI chr20:53,669,128...53,684,328
Ensembl chr20:54,948,661...54,963,384 		JBrowse link
G TOP2A DNA topoisomerase II alpha enables ISO
IEA		 RGD
UniProt
InterPro
Ensembl		 PMID:11334111 GO_REF:0000002 GO_REF:0000003 GO_REF:0000104 GO_REF:0000107 GO_REF:0000117 RGD:1580614 NCBI chr17:16,872,169...16,901,605
Ensembl chr17:17,097,778...17,126,207 		JBrowse link
G TOP2B DNA topoisomerase II beta enables IEA UniProt
InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000104 GO_REF:0000107 GO_REF:0000117 NCBI chr 3:25,499,239...25,566,029
Ensembl chr 3:25,828,879...25,896,912 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 17494
    ATP-dependent activity 577
      ATP-dependent activity, acting on DNA 119
        DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity 3
          DNA negative supercoiling activity 0
Path 2
Term Annotations click to browse term
  molecular_function 17494
    catalytic activity 5388
      catalytic activity, acting on a nucleic acid 593
        catalytic activity, acting on DNA 244
          DNA topoisomerase activity 7
            DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity 3
              DNA negative supercoiling activity 0
paths to the root