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ONTOLOGY REPORT - ANNOTATIONS

Term:DNA topoisomerase activity
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Accession:GO:0003916 term browser browse the term
Definition:Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA.
Synonyms:alt_id: GO:0009387


show annotations for term's descendants           Sort by:
DNA topoisomerase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Spo11 SPO11 initiator of meiotic double strand breaks enables IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 3:182,173,615...182,189,273
Ensembl chr 3:182,175,861...182,189,276 		JBrowse link
G Top1 DNA topoisomerase I enables IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 3:169,713,195...169,796,330
Ensembl chr 3:169,713,130...169,796,327 		JBrowse link
G Top1mt DNA topoisomerase I mitochondrial enables IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 7:109,223,269...109,248,855
Ensembl chr 7:109,139,527...109,246,799 		JBrowse link
G Top2a DNA topoisomerase II alpha enables IDA
IEA 		GO_REF:0000043 UniProt
RGD		 PMID:11334111 GO_REF:0000043, RGD:1580614 NCBI chr10:84,441,954...84,473,093
Ensembl chr10:84,441,954...84,473,366 		JBrowse link
G Top2b DNA topoisomerase II beta enables IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr15:11,482,089...11,542,464
Ensembl chr15:11,482,089...11,542,464 		JBrowse link
G Top3a DNA topoisomerase III alpha enables IEA GO_REF:0000002
GO_REF:0000043 		InterPro
UniProt		 GO_REF:0000002 GO_REF:0000043 NCBI chr10:45,915,625...45,956,856
Ensembl chr10:45,915,625...45,956,856 		JBrowse link
G Top3b DNA topoisomerase III beta enables IEA GO_REF:0000043
GO_REF:0000002 		UniProt
InterPro		 GO_REF:0000002 GO_REF:0000043 NCBI chr11:97,601,223...97,629,678
Ensembl chr11:97,601,231...97,629,597 		JBrowse link
DNA topoisomerase type I (single strand cut, ATP-independent) activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Top1 DNA topoisomerase I enables IDA
ISO
IEA
IBA 		(PMID:16261531), (PMID:9094096)
(PMID:7842491)
GO_REF:0000104
GO_REF:0000117
GO_REF:0000107
GO_REF:0000002
GO_REF:0000033
(PMID:14594810), (PMID:14654701), (PMID:17355975), (PMID:8567649), (PMID:8631793), (PMID:8631794), (PMID:9611241)
GO_REF:0000003 		RGD
UniProt
Ensembl
InterPro
GO_Central		 PMID:7842491 PMID:8567649 PMID:8631793 PMID:8631794 PMID:9094096 More... GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 GO_REF:0000104 GO_REF:0000107 GO_REF:0000117, RGD:1580856 NCBI chr 3:169,713,195...169,796,330
Ensembl chr 3:169,713,130...169,796,327 		JBrowse link
G Top1mt DNA topoisomerase I mitochondrial enables IEA
IBA 		GO_REF:0000003
GO_REF:0000104
GO_REF:0000117
GO_REF:0000002
GO_REF:0000033 		UniProt
InterPro
GO_Central		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 GO_REF:0000104 GO_REF:0000117 NCBI chr 7:109,223,269...109,248,855
Ensembl chr 7:109,139,527...109,246,799 		JBrowse link
G Top3a DNA topoisomerase III alpha enables ISO
IEA
IBA 		(PMID:20445207)
GO_REF:0000003
GO_REF:0000002
GO_REF:0000107
GO_REF:0000033 		RGD
UniProt
InterPro
Ensembl
GO_Central		 PMID:20445207 GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 GO_REF:0000107 NCBI chr10:45,915,625...45,956,856
Ensembl chr10:45,915,625...45,956,856 		JBrowse link
G Top3b DNA topoisomerase III beta enables IBA
IEA 		GO_REF:0000033
GO_REF:0000002
GO_REF:0000003 		GO_Central
InterPro
UniProt		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 NCBI chr11:97,601,223...97,629,678
Ensembl chr11:97,601,231...97,629,597 		JBrowse link
DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Spo11 SPO11 initiator of meiotic double strand breaks enables IEA GO_REF:0000002
GO_REF:0000104
GO_REF:0000003 		InterPro
UniProt		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000104 NCBI chr 3:182,173,615...182,189,273
Ensembl chr 3:182,175,861...182,189,276 		JBrowse link
G Top2a DNA topoisomerase II alpha enables IDA
IEA
ISO
IBA 		GO_REF:0000117
(PMID:12711669), (PMID:15491148), (PMID:16611985)
GO_REF:0000003
GO_REF:0000002
GO_REF:0000107
GO_REF:0000104
GO_REF:0000033
SGD:S000005032 (PMID:1331984), (PMID:7842491), (PMID:7937150)
(PMID:9094096) 		UniProt
RGD
InterPro
Ensembl
GO_Central		 PMID:1331984 PMID:7842491 PMID:7937150 PMID:9094096 PMID:12711669 More... GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 GO_REF:0000104 GO_REF:0000107 GO_REF:0000117, RGD:1580614 NCBI chr10:84,441,954...84,473,093
Ensembl chr10:84,441,954...84,473,366 		JBrowse link
G Top2b DNA topoisomerase II beta enables ISO
IEA
IBA 		(PMID:10684600), (PMID:31409799), (PMID:32128574)
GO_REF:0000002
GO_REF:0000117
GO_REF:0000107
GO_REF:0000104
GO_REF:0000033
GO_REF:0000003
(PMID:31409799) 		RGD
InterPro
UniProt
Ensembl
GO_Central		 PMID:10684600 PMID:31409799 PMID:32128574 GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 GO_REF:0000104 GO_REF:0000107 GO_REF:0000117 NCBI chr15:11,482,089...11,542,464
Ensembl chr15:11,482,089...11,542,464 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 19971
    catalytic activity 5918
      catalytic activity, acting on a nucleic acid 681
        catalytic activity, acting on DNA 265
          DNA topoisomerase activity 7
            DNA topoisomerase type I (single strand cut, ATP-independent) activity 4
            DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity + 3
            reverse gyrase activity 0
Path 2
Term Annotations click to browse term
  molecular_function 19971
    catalytic activity 5918
      isomerase activity 455
        macromolecular conformation isomerase activity 281
          nucleic acid conformation isomerase activity 163
            DNA topoisomerase activity 7
              DNA topoisomerase type I (single strand cut, ATP-independent) activity 4
              DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity + 3
              reverse gyrase activity 0
paths to the root