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Gene: SPO11 (SPO11 initiator of meiotic double strand breaks) Pan paniscus

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Symbol:

SPO11

Name:

SPO11 initiator of meiotic double strand breaks

RGD ID:

11949226

Description:

ENCODES a protein that exhibits ATP binding (inferred); DNA binding (inferred); DNA topoisomerase activity (inferred); INVOLVED IN double-strand break repair involved in meiotic recombination (ortholog); homologous chromosome pairing at meiosis (ortholog); male meiosis I (ortholog); ASSOCIATED WITH spermatogenic failure 3 (ortholog); FOUND IN chromosome (inferred); chromosome, telomeric region (inferred); nuclear chromosome (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

meiotic recombination protein SPO11; SPO11 initiator of meiotic double stranded breaks; SPO11 meiotic protein covalently bound to DSB homolog; SPO11, initiator of meiotic double stranded breaks

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	21	63,080,959 - 63,095,174 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	20	63,074,078 - 63,088,293 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	20	53,669,128 - 53,684,328 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	20	54,948,664 - 54,962,908 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	20	54,948,661 - 54,963,384 (+)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

spermatogenic failure 3 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

double-strand break repair involved in meiotic recombination (IEA,ISO)

homologous chromosome pairing at meiosis (IEA,ISO)

male meiosis I (IEA,ISO)

meiotic DNA double-strand break formation (IEA)

meiotic DNA double-strand break processing (IEA)

meiotic telomere clustering (IEA,ISO)

oogenesis (IEA,ISO)

ovarian follicle development (IEA,ISO)

protein localization to chromosome (IEA,ISO)

reciprocal meiotic recombination (IEA,ISO)

sexual reproduction (IEA)

spermatid development (IEA,ISO)

synaptonemal complex assembly (IEA,ISO)

Cellular Component

chromosome (IEA)

chromosome, telomeric region (IEA)

nuclear chromosome (IEA)

nucleus (IEA)

Molecular Function

ATP binding (IEA)

DNA binding (IEA)

DNA topoisomerase activity (IEA)

DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity (IEA)

metal ion binding (IEA)

protein binding (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

SPO11
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	21	63,080,959 - 63,095,174 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	20	63,074,078 - 63,088,293 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	20	53,669,128 - 53,684,328 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	20	54,948,664 - 54,962,908 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	20	54,948,661 - 54,963,384 (+)	Ensembl	panpan1.1		panPan2

SPO11
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	20	57,329,803 - 57,343,993 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	20	57,329,803 - 57,343,994 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	20	55,904,859 - 55,919,049 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	20	55,338,238 - 55,352,456 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	20	55,338,237 - 55,352,455	NCBI
Celera	20	52,645,068 - 52,659,286 (+)	NCBI		Celera
Cytogenetic Map	20	q13.31	NCBI
HuRef	20	52,686,790 - 52,701,008 (+)	NCBI		HuRef
CHM1_1	20	55,805,942 - 55,820,160 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	20	59,107,550 - 59,121,740 (+)	NCBI		T2T-CHM13v2.0

Spo11
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	172,819,172 - 172,835,369 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	172,819,493 - 172,835,369 (+)	Ensembl		GRCm39 Ensembl
GRCm38	2	172,977,379 - 172,993,576 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	172,977,700 - 172,993,576 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	172,805,343 - 172,819,077 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	172,622,784 - 172,636,504 (+)	NCBI		MGSCv36	mm8
MGSCv36	2	174,209,775 - 174,223,792 (+)	NCBI		MGSCv36	mm8
Celera	2	178,918,642 - 178,957,539 (+)	NCBI		Celera
Cytogenetic Map	2	H3	NCBI
cM Map	2	95.64	NCBI

Spo11
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	182,173,615 - 182,189,273 (+)	NCBI		GRCr8
mRatBN7.2	3	161,755,299 - 161,770,930 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	161,757,519 - 161,770,925 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	165,571,645 - 165,582,906 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	174,070,591 - 174,081,852 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	171,812,404 - 171,823,665 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	170,991,573 - 171,008,226 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	170,994,038 - 171,013,185 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	177,058,150 - 177,081,041 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	163,842,817 - 163,854,067 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	163,746,748 - 163,759,641 (+)	NCBI
Celera	3	160,953,190 - 160,964,440 (+)	NCBI		Celera
Cytogenetic Map	3	q42	NCBI

Spo11
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955445	2,088,144 - 2,103,385 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955445	2,088,144 - 2,103,385 (-)	NCBI	ChiLan1.0	ChiLan1.0

SPO11
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	24	42,345,595 - 42,360,851 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	24	42,345,547 - 42,384,481 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	24	41,593,229 - 41,608,456 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	24	43,211,094 - 43,226,379 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	24	43,211,048 - 43,250,014 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	24	42,296,075 - 42,311,271 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	24	42,435,814 - 42,451,039 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	24	43,093,993 - 43,109,232 (+)	NCBI		UU_Cfam_GSD_1.0

Spo11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	183,108,577 - 183,122,976 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936530	183,271 - 197,335 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936530	183,271 - 197,549 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SPO11
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	17	57,730,675 - 57,745,875 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	17	57,730,676 - 57,745,875 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	17	64,894,962 - 64,910,090 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SPO11
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	2	6,778,442 - 6,792,736 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	2	6,778,985 - 6,792,643 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666050	54,840,590 - 54,854,921 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Spo11
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624741	23,784,298 - 23,800,168 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624741	23,784,362 - 23,800,127 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003806159	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_003806160	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_055104884	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000021	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSPPAT00000048855 ⟹ ENSPPAP00000026023

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	20	54,948,661 - 54,963,384 (+)	Ensembl

Ensembl Acc Id:

ENSPPAT00000048857 ⟹ ENSPPAP00000026025

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	20	54,948,661 - 54,963,384 (+)	Ensembl

RefSeq Acc Id:

XM_003806159 ⟹ XP_003806207

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	21	63,080,959 - 63,095,174 (+)	NCBI
NHGRI_mPanPan1	20	63,074,078 - 63,088,293 (+)	NCBI
Mhudiblu_PPA_v0	20	53,669,128 - 53,684,320 (+)	NCBI
PanPan1.1	20	54,948,664 - 54,962,900 (+)	NCBI

Sequence:

show sequence

GGCGTGGGCACGCCGGCCGCTCAGAAAGCGCGGGAAAGGCACGCAGCCACGCCCCAAGGGCGCA
GCCTAGGACAGGGGCTTCTGGAGCTTCTGGCAGCCGTCTGCGCTCATGGCCTTTGCACCTATGG
GGCCCGAGGCCTCGTTCTTCGAGGTTTTGGACCGACACAGGGAGTCCCTGCTGGCTGCCCTGAG
GAGAGGTGGCAGGGAGCCCCCAAGTGGGGGAAGCCGCCTGGCCTCGAGTTCTGAGGTTCTTGCA
TCTATAGAAAATATTATCCAAGACATAATCACAAGCTTGGCAAGAAATGAAGCACCTGCATTCA
CGATAGACAACAGATCAAGCTGGGAAAACATAAAGTTTGAAGATTCTGTGGGTCTTCAGATGGT
ATCCCATTGCACCACCAGAAAGATCAAAAGTGATTCACCAAAATCAGCTCAAAAATTTGCTCTA
ATCCTTAAAATATTGTCCATGATTTATAAATTAGTACAGAGCAACACTTATGCAACCAAAAGGG
ACATATATTACACTGACAGTCAACTCTTTGGTAACCAGACTGTCGTCGACAATATTATCAATGA
CATTTCTTGCATGTTAAAAGTGTCAAGGAGGAGTCTACATATATTATCTACATCAAAAGGTTTA
ATTGCTGGCAACTTAAGATATATCGAGGAAGATGGCACCAAAGTGAATTGTACCTGTGGTGCAA
CGGCTGTTGCTGTGCCATCGAATATTCAAGGAATTCGGAATTTAGTTACAGATGCAAAGTTTGT
ATTAATTGTAGAAAAAGATGCAACATTTCAGCGGCTCCTAGATGACAACTTTTGCAACAAATTG
TCTCCTTGCATCATGATTACGGGAAAGGGAGTTCCTGATCTAAACACAAGACTTTTAGTCAAGA
AACTGTGGGATACGTTTCATATTCCTGTTTTCACTCTTGTAGATGCTGATCCACATGGCATAGA
AATAATGTGCATCTATAAGTATGGATCTATGTCTATGTCTTTTGAAGCTCATCATCTCACAGTT
CCAGCTATTAGATGGCTTGGTCTTCTCCCTTCTGATCTTAAAAGATTAAATGTACCTAAAGATA
GTTTGATTCCACTGACAAAAAGGGACCAAATGAAACTTGACAGTATCCTGAGGAGACCTTATGT
TACCTGCCAACCATTTTGGAGAAAAGAAATGGAAATAATGGCAGACTCTAAAATGAAGGCAGAA
ATTCAAGCTTTGACTTTCCTATCATCAGATTATCTTTCCAGAGTGTACTTACCTAACAAATTAA
AATTTGGAGGATGGATATAAAAATAAATCAGAAGAACTTCTGATTGCCAGAGGCTTTTCATTAG
TTTTGTTTTGATTGGCAAATACTATTGTGGAAAGAACATATATTATATTCTTAATTCTGTAAAG
GTGAAATAAAATAACTTTCCGTTAATTATATTTTTTTGTCAAAACAAATGCTGTACTCCAATTT
TCTTTACAGGGCCTTATTCTTGCCTCTATAGAGACAGATTTCTGTCCTATCTTCTAAAGCAAAT
TATAAAAGAATATGTTATTTTGACCCTTAAATTATTTTTGAAAAAATAATATTTTATACATGTC
ATCAAAGTCTACAAAACACTTTATTTACCTTCTACGATACAACTAATGTTAACGCATAAAGTAT
CTTCCTGGTAACAAAAATCATAATGATCTGAATTTGAGATGTTGCAAATGAATTGTGGTGTCCA
GTAGTTTCTTCTTACATTTTCCTTTGCCTTTATACTTTAGGGGTCTTACTCCATTAATTCATTT
GTTACATTAGTAAAATTCAGTATGAATAAATATTTGGA

hide sequence

RefSeq Acc Id:

XM_003806160 ⟹ XP_003806208

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	21	63,080,959 - 63,095,174 (+)	NCBI
NHGRI_mPanPan1	20	63,074,078 - 63,088,293 (+)	NCBI
Mhudiblu_PPA_v0	20	53,669,128 - 53,684,328 (+)	NCBI
PanPan1.1	20	54,948,680 - 54,962,908 (+)	NCBI

Sequence:

show sequence

CCGCTCAGAAAGCGCGGGAAAGGCACGCAGCCACGCCCCAAGGGCGCAGCCTAGGACAGGGGCT
TCTGGAGCTTCTGGCAGCCGTCTGCGCTCATGGCCTTTGCACCTATGGGGCCCGAGGCCTCGTT
CTTCGAGGTTTTGGACCGACACAGGGAGTCCCTGCTGGCTGCCCTGAGGAGAGGTGGCAGGGAG
CCCCCAAGTGGGGGAAGCCGCCTGGCCTCGAGGTTTGAAGATTCTGTGGGTCTTCAGATGGTAT
CCCATTGCACCACCAGAAAGATCAAAAGTGATTCACCAAAATCAGCTCAAAAATTTGCTCTAAT
CCTTAAAATATTGTCCATGATTTATAAATTAGTACAGAGCAACACTTATGCAACCAAAAGGGAC
ATATATTACACTGACAGTCAACTCTTTGGTAACCAGACTGTCGTCGACAATATTATCAATGACA
TTTCTTGCATGTTAAAAGTGTCAAGGAGGAGTCTACATATATTATCTACATCAAAAGGTTTAAT
TGCTGGCAACTTAAGATATATCGAGGAAGATGGCACCAAAGTGAATTGTACCTGTGGTGCAACG
GCTGTTGCTGTGCCATCGAATATTCAAGGAATTCGGAATTTAGTTACAGATGCAAAGTTTGTAT
TAATTGTAGAAAAAGATGCAACATTTCAGCGGCTCCTAGATGACAACTTTTGCAACAAATTGTC
TCCTTGCATCATGATTACGGGAAAGGGAGTTCCTGATCTAAACACAAGACTTTTAGTCAAGAAA
CTGTGGGATACGTTTCATATTCCTGTTTTCACTCTTGTAGATGCTGATCCACATGGCATAGAAA
TAATGTGCATCTATAAGTATGGATCTATGTCTATGTCTTTTGAAGCTCATCATCTCACAGTTCC
AGCTATTAGATGGCTTGGTCTTCTCCCTTCTGATCTTAAAAGATTAAATGTACCTAAAGATAGT
TTGATTCCACTGACAAAAAGGGACCAAATGAAACTTGACAGTATCCTGAGGAGACCTTATGTTA
CCTGCCAACCATTTTGGAGAAAAGAAATGGAAATAATGGCAGACTCTAAAATGAAGGCAGAAAT
TCAAGCTTTGACTTTCCTATCATCAGATTATCTTTCCAGAGTGTACTTACCTAACAAATTAAAA
TTTGGAGGATGGATATAAAAATAAATCAGAAGAACTTCTGATTGCCAGAGGCTTTTCATTAGTT
TTGTTTTGATTGGCAAATACTATTGTGGAAAGAACATATATTATATTCTTAATTCTGTAAAGGT
GAAATAAAATAACTTTCCGTTAATTATATTTTTTTGTCAAAACAAATGCTGTACTCCAATTTTC
TTTACAGGGCCTTATTCTTGCCTCTATAGAGACAGATTTCTGTCCTATCTTCTAAAGCAAATTA
TAAAAGAATATGTTATTTTGACCCTTAAATTATTTTTGAAAAAATAATATTTTATACATGTCAT
CAAAGTCTACAAAACACTTTATTTACCTTCTACGATACAACTAATGTTAACGCATAAAGTATCT
TCCTGGTAACAAAAATCATAATGATCTGAATTTGAGATGTTGCAAATGAATTGTGGTGTCCAGT
AGTTTCTTCTTACATTTTCCTTTGCCTTTATACTTTAGGGGTCTTACTCCATTAATTCATTTGT
TACATTAGTAAAATTCAGTATGAATAAATATTTGGATTGATGTA

hide sequence

RefSeq Acc Id:

XM_055104884 ⟹ XP_054960859

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	21	63,081,005 - 63,095,173 (+)	NCBI
NHGRI_mPanPan1	20	63,074,124 - 63,088,292 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_003806207	(Get FASTA)	NCBI Sequence Viewer
	XP_003806208	(Get FASTA)	NCBI Sequence Viewer
	XP_054960859	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000026023
	ENSPPAP00000026023.1
	ENSPPAP00000026025
	ENSPPAP00000026025.1

RefSeq Acc Id:	XP_003806207 ⟸ XM_003806159
- Peptide Label:	isoform X1
- UniProtKB:	A0A2R9B8U8 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAFAPMGPEASFFEVLDRHRESLLAALRRGGREPPSGGSRLASSSEVLASIENIIQDIITSLAR NEAPAFTIDNRSSWENIKFEDSVGLQMVSHCTTRKIKSDSPKSAQKFALILKILSMIYKLVQSN TYATKRDIYYTDSQLFGNQTVVDNIINDISCMLKVSRRSLHILSTSKGLIAGNLRYIEEDGTKV NCTCGATAVAVPSNIQGIRNLVTDAKFVLIVEKDATFQRLLDDNFCNKLSPCIMITGKGVPDLN TRLLVKKLWDTFHIPVFTLVDADPHGIEIMCIYKYGSMSMSFEAHHLTVPAIRWLGLLPSDLKR LNVPKDSLIPLTKRDQMKLDSILRRPYVTCQPFWRKEMEIMADSKMKAEIQALTFLSSDYLSRV YLPNKLKFGGWI hide sequence

RefSeq Acc Id:	XP_003806208 ⟸ XM_003806160
- Peptide Label:	isoform X3
- UniProtKB:	A0A2R9BGA0 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAFAPMGPEASFFEVLDRHRESLLAALRRGGREPPSGGSRLASRFEDSVGLQMVSHCTTRKIKS DSPKSAQKFALILKILSMIYKLVQSNTYATKRDIYYTDSQLFGNQTVVDNIINDISCMLKVSRR SLHILSTSKGLIAGNLRYIEEDGTKVNCTCGATAVAVPSNIQGIRNLVTDAKFVLIVEKDATFQ RLLDDNFCNKLSPCIMITGKGVPDLNTRLLVKKLWDTFHIPVFTLVDADPHGIEIMCIYKYGSM SMSFEAHHLTVPAIRWLGLLPSDLKRLNVPKDSLIPLTKRDQMKLDSILRRPYVTCQPFWRKEM EIMADSKMKAEIQALTFLSSDYLSRVYLPNKLKFGGWI hide sequence

Ensembl Acc Id:

ENSPPAP00000026025 ⟸ ENSPPAT00000048857

Ensembl Acc Id:

ENSPPAP00000026023 ⟸ ENSPPAT00000048855

RefSeq Acc Id:	XP_054960859 ⟸ XM_055104884
- Peptide Label:	isoform X2

Protein Domains

Meiosis-specific protein Spo11 Spo11/DNA topoisomerase VI subunit A N-terminal Topoisomerase 6 subunit A/Spo11 TOPRIM

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000036133	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000048855.1	UniProtKB/TrEMBL
	ENSPPAT00000048857.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.10.10	UniProtKB/TrEMBL
	3.40.1360.10	UniProtKB/TrEMBL
InterPro	Meiosis_Spo11	UniProtKB/TrEMBL
	Meiotic_Spo11	UniProtKB/TrEMBL
	Spo11/TopoVI_A	UniProtKB/TrEMBL
	Spo11/TopoVI_A_N	UniProtKB/TrEMBL
	Spo11/TopoVI_A_sf	UniProtKB/TrEMBL
	TOPRIM_Topo6A/Spo11	UniProtKB/TrEMBL
	WH-like_DNA-bd_sf	UniProtKB/TrEMBL
KEGG Report	pps:100979971	UniProtKB/TrEMBL
NCBI Gene	SPO11	ENTREZGENE
PANTHER	MEIOTIC RECOMBINATION PROTEIN SPO11	UniProtKB/TrEMBL
	PTHR10848	UniProtKB/TrEMBL
Pfam	SPO11_like	UniProtKB/TrEMBL
	TOP6A-Spo11_Toprim	UniProtKB/TrEMBL
	TP6A_N	UniProtKB/TrEMBL
PRINTS	SPO11HOMOLOG	UniProtKB/TrEMBL
	TOP6AFAMILY	UniProtKB/TrEMBL
Superfamily-SCOP	SSF56726	UniProtKB/TrEMBL
UniProt	A0A2R9B8U8	ENTREZGENE, UniProtKB/TrEMBL
	A0A2R9BGA0	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2023-05-23	SPO11	SPO11 initiator of meiotic double strand breaks	SPO11	SPO11 initiator of meiotic double stranded breaks	Symbol and/or name change	5135510	APPROVED
2019-01-29	SPO11	SPO11 initiator of meiotic double stranded breaks		SPO11, initiator of meiotic double stranded breaks	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar