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ONTOLOGY REPORT - ANNOTATIONS

Term:Factor XII activation
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Accession:GO:0002542 term browser browse the term
Definition:Any process that activates Factor XII (Hageman factor). Factor XII is a protein synthesized by the liver that circulates in an inactive form until it encounters collagen or basement membrane or activated platelets (as occurs at the site of endothelial injury). Factor XII then undergoes a conformational change (becoming factor XIIa), exposing an active serine center that can subsequently cleave protein substrates and activate a variety of mediator systems. Factor XII is a participant in the clotting cascade as well as the kinin cascade.
Synonyms:exact_synonym: Hageman factor activation


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Factor XII activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F12 coagulation factor XII involved_in ISO
IEA		 (PMID:18725990)
GO_REF:0000107		 RGD
Ensembl		 PMID:18725990 GO_REF:0000107 NCBI chr17:9,207,683...9,215,530
Ensembl chr17:9,207,683...9,215,530 		JBrowse link
G Kng2 kininogen 2 IDA RGD PMID:6685967 RGD:11062094 NCBI chr11:77,913,876...77,936,247
Ensembl chr11:77,909,612...78,002,971 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19692
    response to stimulus 10511
      response to external stimulus 2701
        regulation of response to external stimulus 1149
          regulation of inflammatory response 421
            regulation of acute inflammatory response 57
              Factor XII activation 2
Path 2
Term Annotations click to browse term
  biological_process 19692
    biological regulation 13305
      regulation of biological process 12902
        regulation of metabolic process 6482
          regulation of biosynthetic process 5325
            regulation of cellular biosynthetic process 5234
              regulation of macromolecule biosynthetic process 5135
                regulation of gene expression 5020
                  regulation of protein maturation 67
                    regulation of protein processing 63
                      positive regulation of protein processing 30
                        Factor XII activation 2
paths to the root