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Term:Factor XII activation
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Accession:GO:0002542 term browser browse the term
Definition:Any process that activates Factor XII (Hageman factor). Factor XII is a protein synthesized by the liver that circulates in an inactive form until it encounters collagen or basement membrane or activated platelets (as occurs at the site of endothelial injury). Factor XII then undergoes a conformational change (becoming factor XIIa), exposing an active serine center that can subsequently cleave protein substrates and activate a variety of mediator systems. Factor XII is a participant in the clotting cascade as well as the kinin cascade.
Synonyms:exact_synonym: Hageman factor activation

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Factor XII activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F12 coagulation factor XII involved_in ISO
PMID:18725990 GO_REF:0000107 NCBI chr17:9,207,683...9,215,530
Ensembl chr17:9,207,683...9,215,530
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G Hpse heparanase involved_in ISO (PMID:20634491) RGD PMID:20634491 NCBI chr14:8,896,593...8,937,011
Ensembl chr14:8,896,593...8,937,010
JBrowse link
G Kng2 kininogen 2 IDA RGD PMID:6685967 RGD:11062094 NCBI chr11:77,913,876...77,936,247
Ensembl chr11:77,909,612...78,002,971
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19512
    response to stimulus 10490
      protein activation cascade 25
        kinin cascade 4
          plasma kallikrein-kinin cascade 4
            Factor XII activation 3
Path 2
Term Annotations click to browse term
  biological_process 19512
    metabolic process 11791
      organic substance metabolic process 11326
        macromolecule metabolic process 9779
          protein metabolic process 5902
            cellular protein metabolic process 5227
              regulation of cellular protein metabolic process 2504
                positive regulation of cellular protein metabolic process 1483
                  positive regulation of proteolysis 387
                    positive regulation of protein processing 32
                      Factor XII activation 3
paths to the root