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ONTOLOGY REPORT - ANNOTATIONS

Term:complement activation, lectin pathway
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Accession:GO:0001867 term browser browse the term
Definition:Any process involved in the activation of any of the steps of the lectin pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes.
Comment:Note that proteins such as mannose-binding lectin (MBL) and certain serum ficolins can activate the lectin complement pathway.
Synonyms:exact_synonym: complement cascade, lectin pathway

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complement activation, lectin pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Colec10 collectin subfamily member 10 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624763:17,302,075...17,350,682
Ensembl chrNW_004624763:17,301,993...17,352,559 		JBrowse link
G Colec11 collectin subfamily member 11 involved_in ISO (PMID:25912189)
(PMID:24174618)		 UniProt
ComplexPortal		 PMID:24174618 PMID:25912189 NCBI chrNW_004624846:5,173,292...5,185,036
Ensembl chrNW_004624846:5,173,292...5,182,471 		JBrowse link
G Fcn1 ficolin 1 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004624760:2,743,996...2,751,116
Ensembl chrNW_004624760:2,743,996...2,751,110 		JBrowse link
G Fcn3 ficolin 3 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624764:11,265,740...11,269,588
Ensembl chrNW_004624764:11,265,505...11,269,650 		JBrowse link
G Krt1 keratin 1 involved_in ISO (PMID:11549596) UniProt PMID:11549596 NCBI chrNW_004624904:801,979...816,463
Ensembl chrNW_004624904:802,460...807,469 		JBrowse link
G LOC101716245 mannose-binding protein A-like involved_in IEA UniProt GO_REF:0000043 NCBI chrNW_004624841:6,895,594...6,899,930 JBrowse link
G Masp1 MBL associated serine protease 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624730:69,569,046...69,632,401
Ensembl chrNW_004624730:69,568,915...69,632,470 		JBrowse link
G Masp2 MBL associated serine protease 2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624818:1,745,401...1,759,051 JBrowse link
G Mbl2 mannose binding lectin 2 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:15148336) MGI
UniProt		 PMID:15148336 GO_REF:0000043 NCBI chrNW_004624791:10,881,319...10,886,294
Ensembl chrNW_004624791:10,881,268...10,886,297 		JBrowse link
negative regulation of complement activation, lectin pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Serping1 serpin family G member 1 involved_in ISO (PMID:10946292) UniProt PMID:10946292 NCBI chrNW_004624864:3,091,397...3,103,084
Ensembl chrNW_004624864:3,091,083...3,103,090 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15134
    immune system process 2150
      immune response 1338
        innate immune response 682
          complement activation, lectin pathway 10
            negative regulation of complement activation, lectin pathway 1
            positive regulation of complement activation, lectin pathway 0
            regulation of complement activation, lectin pathway + 1
Path 2
Term Annotations click to browse term
  biological_process 15134
    biological regulation 10703
      regulation of biological process 10366
        positive regulation of biological process 5960
          positive regulation of response to stimulus 2210
            positive regulation of immune response 638
              activation of immune response 473
                complement activation 44
                  complement activation, lectin pathway 10
                    negative regulation of complement activation, lectin pathway 1
                    positive regulation of complement activation, lectin pathway 0
                    regulation of complement activation, lectin pathway + 1
paths to the root