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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Orthostatic Hypotension
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Accession:DOID:9005950 term browser browse the term
Definition:A significant drop in BLOOD PRESSURE after assuming a standing position. Orthostatic hypotension is a finding, and defined as a 20-mm Hg decrease in systolic pressure or a 10-mm Hg decrease in diastolic pressure 3 minutes after the person has risen from supine to standing. Symptoms generally include DIZZINESS, blurred vision, and SYNCOPE.
Synonyms:exact_synonym: postural hypotension
 primary_id: MESH:D007024
 alt_id: RDO:0004625
 xref: EFO:0005252;   OMIM:PS223360

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show annotations for term's descendants           Sort by:
Orthostatic Hypotension term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1 ATP binding cassette subfamily B member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12082591 NCBI chrNW_004955432:4,911,774...5,085,349 JBrowse link
G Col1a2 collagen type I alpha 2 chain ISO ClinVar Annotator: match by term: Orthostatic hypotension ClinVar NCBI chrNW_004955432:11,127,961...11,164,145
Ensembl chrNW_004955432:11,128,112...11,163,302 		JBrowse link
G Gnb3 G protein subunit beta 3 susceptibility ISO DNA:SNP: : 825C>T (human) RGD PMID:11910300 RGD:1580406 NCBI chrNW_004955413:4,440,693...4,447,419
Ensembl chrNW_004955413:4,440,693...4,447,416 		JBrowse link
G Oprd1 opioid receptor delta 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:2981652 NCBI chrNW_004955452:7,866,790...7,913,399
Ensembl chrNW_004955452:7,866,758...7,913,399 		JBrowse link
G Oprm1 opioid receptor mu 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:2981652 NCBI chrNW_004955439:7,870,563...7,923,817
Ensembl chrNW_004955439:7,757,569...7,923,817 		JBrowse link
dopamine beta-hydroxylase deficiency term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dbh dopamine beta-hydroxylase ISO ClinVar Annotator: match by term: Orthostatic hypotension 1 OMIM
ClinVar		 PMID:7715704 PMID:9536098 PMID:11170900 PMID:11857564 PMID:14598346 More... NCBI chrNW_004955513:2,918,085...2,932,481
Ensembl chrNW_004955513:2,918,286...2,932,247 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 ISO RGD PMID:21209083 RGD:5685690 NCBI chrNW_004955419:3,055,420...3,060,208
Ensembl chrNW_004955419:3,055,420...3,062,131 		JBrowse link
Orthostatic Hypotension 2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC102028532 cytochrome b561 ISO ClinVar Annotator: match by term: Orthostatic hypotension 2 OMIM
ClinVar		 NCBI chrNW_004955478:8,362,190...8,366,947 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16063
    disease of anatomical entity 13824
      cardiovascular system disease 4077
        vascular disease 2853
          Hypotension 73
            Orthostatic Hypotension 8
              Idiopathic Orthostatic Hypotension 0
              Orthostatic Hypotension 2 1
              Orthostatic Hypotensive Disorder, Streeten Type 0
              dopamine beta-hydroxylase deficiency 2
Path 2
Term Annotations click to browse term
  disease 16063
    disease of anatomical entity 13824
      nervous system disease 12093
        central nervous system disease 10860
          brain disease 10192
            disease of mental health 7334
              cognitive disorder 1968
                anxiety disorder 108
                  neurocirculatory asthenia 10
                    Orthostatic Intolerance 10
                      Orthostatic Hypotension 8
                        Idiopathic Orthostatic Hypotension 0
                        Orthostatic Hypotension 2 1
                        Orthostatic Hypotensive Disorder, Streeten Type 0
                        dopamine beta-hydroxylase deficiency 2
paths to the root